Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Rob J Center"'
Autor:
Pantelis Poumbourios, Christine Langer, Irene Boo, Tasnim Zakir, Rob J Center, Anouschka Akerman, Vanessa Milogiannakis, Anupriya Aggarwal, Bronte A Johnstone, Jungmin Ha, Fasséli Coulibaly, Stuart G Turville, Heidi E Drummer
Publikováno v:
PLoS Pathogens, Vol 19, Iss 5, p e1010981 (2023)
The spike (S) glycoprotein of SARS CoV-2 is the target of neutralizing antibodies (NAbs) that are crucial for vaccine effectiveness. The S1 subunit binds ACE2 while the S2 subunit mediates virus-cell membrane fusion. S2 is a class I fusion glycoprote
Externí odkaz:
https://doaj.org/article/6d3cf0974e2e42daa96111a1d687d350
Autor:
Hannah A D King, Christopher A Gonelli, Kirsteen M Tullett, Mireille H Lahoud, Damian F J Purcell, Heidi E Drummer, Pantelis Poumbourios, Rob J Center
Publikováno v:
PLoS ONE, Vol 14, Iss 8, p e0220986 (2019)
A promising strategy for the enhancement of vaccine-mediated immune responses is by directly targeting protein antigens to immune cells. Targeting of antigens to the dendritic cell (DC) molecule Clec9A has been shown to enhance antibody affinity and
Externí odkaz:
https://doaj.org/article/d564ce87a08a43f9a3a3f5e3be9de528
Autor:
John M Murray, Stephen Maher, Talia Mota, Kazuo Suzuki, Anthony D Kelleher, Rob J Center, Damian Purcell
Publikováno v:
PLoS ONE, Vol 12, Iss 2, p e0171572 (2017)
Significant progress has been made in characterizing broadly neutralizing antibodies against the HIV envelope glycoprotein Env, but an effective vaccine has proven elusive. Vaccine development would be facilitated if common features of early founder
Externí odkaz:
https://doaj.org/article/295d8285a3374e9e8e5182501c338768
Autor:
Behnaz Heydarchi, Rob J Center, Christopher Gonelli, Brian Muller, Charlene Mackenzie, Georges Khoury, Marit Lichtfuss, Grant Rawlin, Damian F J Purcell
Publikováno v:
PLoS ONE, Vol 11, Iss 6, p e0157353 (2016)
An important feature of a potential vaccine against HIV is the production of broadly neutralising antibodies (BrNAbs) capable of potentially blocking infectivity of a diverse array of HIV strains. BrNAbs naturally arise in some HIV infected individua
Externí odkaz:
https://doaj.org/article/2896f603eac749babe3ca60547b529d6
Autor:
Adam K Wheatley, Marit Kramski, Marina R Alexander, Jesse G Toe, Rob J Center, Damian F J Purcell
Publikováno v:
PLoS ONE, Vol 6, Iss 3, p e18225 (2011)
Small non-coding micro-RNAs (miRNA) are important post-transcriptional regulators of mammalian gene expression that can be used to direct the knockdown of expression from targeted genes. We examined whether DNA vaccine vectors co-expressing miRNA wit
Externí odkaz:
https://doaj.org/article/9db7995f291e4ccbaef92482bf184add
Autor:
Pantelis Poumbourios, Christine Langer, Irene Boo, Tasnim Zakir, Rob J. Center, Anouschka Akerman, Vanessa Milogiannakis, Anupriya Aggarwal, Stuart Turville, Heidi E. Drummer.
The spike (S) glycoprotein of SARS CoV-2 is the target of neutralizing antibodies (NAbs) that are crucial for vaccine effectiveness. The S1 subunit binds ACE2 while the S2 subunit mediates virus-cell membrane fusion. S2 is a class I fusion glycoprote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::608982e7b611af6fd1b23b3bc5bb9612
https://doi.org/10.1101/2022.11.08.515567
https://doi.org/10.1101/2022.11.08.515567
Autor:
Timothy Donnison, Joey McGregor, Senthil Chinnakannan, Claire Hutchings, Rob J. Center, Pantelis Poumbourios, Paul Klenerman, Heidi E. Drummer, Eleanor Barnes
Publikováno v:
Hepatology (Baltimore, Md.). 76(4)
A prophylactic vaccine targeting multiple HCV genotypes (gt) is urgently required to meet World Health Organization elimination targets. Neutralizing antibodies (nAbs) and CD4We show that vaccinating with ChAd-Gt1-6 and E2Δ123These data are an impor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6534b0dde759e1470b08feddd9bdd9b7
https://pubmed.ncbi.nlm.nih.gov/35503709
https://pubmed.ncbi.nlm.nih.gov/35503709
Autor:
Joey McGregor, Joshua M. Hardy, Chan-Sien Lay, Irene Boo, Michael Piontek, Manfred Suckow, Fasséli Coulibaly, Pantelis Poumbourios, Rob J. Center, Heidi E. Drummer
Publikováno v:
Journal of Virology. 96
A vaccine to prevent hepatitis C virus (HCV) infection is urgently needed for use alongside direct-acting antiviral drugs to achieve elimination targets. We have previously shown that a soluble recombinant form of the glycoprotein E2 ectodomain (resi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b2bdfadeb6008786b6dd2bb19c3671a
https://doi.org/10.1128/jvi.01675-21
https://doi.org/10.1128/jvi.01675-21
Autor:
Heidi E Drummer, Huy Van, Ethan Klock, Shuning Zheng, Zihui Wei, Irene Boo, Rob J Center, Fan Li, Purnima Bhat, Rosemary Ffrench, Jillian SY Lau, James McMahon, Oliver Laeyendecker, Reinaldo E. Fernandez, Yukari C. Manabe, Sabra L. Klein, Thomas C. Quinn, David A. Anderson
Publikováno v:
medRxiv
Current tests for SARS-CoV-2 antibodies (IgG, IgM, IgA) cannot differentiate recent and past infections. We describe a point of care, lateral flow assay for SARS-CoV-2 dIgA based on the highly selective binding of dIgA to a chimeric form of secretory
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8dee9a068b476241fb7a9659c0189483
https://doi.org/10.1101/2021.06.28.21259671
https://doi.org/10.1101/2021.06.28.21259671
Autor:
Thomas S. Fulford, Huy Van, Nicholas A. Gherardin, Shuning Zheng, Marcin Ciula, Heidi E. Drummer, Samuel Redmond, Hyon-Xhi Tan, Irene Boo, Rob J. Center, Fan Li, Samantha L. Grimley, Bruce D. Wines, Thi H.O. Nguyen, Francesca L. Mordant, Paula Ellenberg, Louise C. Rowntree, Lukasz Kedzierski, Allen C. Cheng, Denise L. Doolan, Gail Matthews, Katherine Bond, P. Mark Hogarth, Zoe McQuilten, Kanta Subbarao, Katherine Kedzierska, Jennifer A. Juno, Adam K. Wheatley, Stephen J. Kent, Deborah A. Williamson, Damian F.J. Purcell, David A. Anderson, Dale I. Godfrey
Publikováno v:
EBioMedicine, Vol 74, Iss, Pp 103729-(2021)
EBioMedicine
EBioMedicine
Background: As vaccines against SARS-CoV-2 are now being rolled out, a better understanding of immunity to the virus, whether from infection, or passive or active immunisation, and the durability of this protection is required. This will benefit from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83b4a0e84f6d3a275fc4bc0b8d05bd5d
https://doi.org/10.1016/j.ebiom.2021.103729
https://doi.org/10.1016/j.ebiom.2021.103729