Zobrazeno 1 - 10
of 70
pro vyhledávání: '"Rob J Center"'
Autor:
Pantelis Poumbourios, Christine Langer, Irene Boo, Tasnim Zakir, Rob J Center, Anouschka Akerman, Vanessa Milogiannakis, Anupriya Aggarwal, Bronte A Johnstone, Jungmin Ha, Fasséli Coulibaly, Stuart G Turville, Heidi E Drummer
Publikováno v:
PLoS Pathogens, Vol 19, Iss 5, p e1010981 (2023)
The spike (S) glycoprotein of SARS CoV-2 is the target of neutralizing antibodies (NAbs) that are crucial for vaccine effectiveness. The S1 subunit binds ACE2 while the S2 subunit mediates virus-cell membrane fusion. S2 is a class I fusion glycoprote
Externí odkaz:
https://doaj.org/article/6d3cf0974e2e42daa96111a1d687d350
Autor:
Gaoqian Feng, Bruce D. Wines, Liriye Kurtovic, Jo-Anne Chan, Philippe Boeuf, Vanessa Mollard, Anton Cozijnsen, Damien R. Drew, Rob J. Center, Daniel L. Marshall, Sandra Chishimba, Geoffrey I. McFadden, Arlene E. Dent, Kiprotich Chelimo, Michelle J. Boyle, James W. Kazura, P. Mark Hogarth, James G. Beeson
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Antibodies plays critical roles in the adaptive immune response to infectious agents including malaria. Here the authors defined antibody interactions with -Fcγ-receptors expressed on immune cells with sporozoites of Plasmodium falciparum, and ident
Externí odkaz:
https://doaj.org/article/6df085e64a2441099441e81ae6947fa5
Autor:
Thomas S. Fulford, Huy Van, Nicholas A. Gherardin, Shuning Zheng, Marcin Ciula, Heidi E. Drummer, Samuel Redmond, Hyon-Xhi Tan, Irene Boo, Rob J. Center, Fan Li, Samantha L. Grimley, Bruce D. Wines, Thi H.O. Nguyen, Francesca L. Mordant, Paula Ellenberg, Louise C. Rowntree, Lukasz Kedzierski, Allen C. Cheng, Denise L. Doolan, Gail Matthews, Katherine Bond, P. Mark Hogarth, Zoe McQuilten, Kanta Subbarao, Katherine Kedzierska, Jennifer A. Juno, Adam K. Wheatley, Stephen J. Kent, Deborah A. Williamson, Damian F.J. Purcell, David A. Anderson, Dale I. Godfrey
Publikováno v:
EBioMedicine, Vol 74, Iss , Pp 103729- (2021)
Background: As vaccines against SARS-CoV-2 are now being rolled out, a better understanding of immunity to the virus, whether from infection, or passive or active immunisation, and the durability of this protection is required. This will benefit from
Externí odkaz:
https://doaj.org/article/b797a15ea4c145e7a13177048c7b5ebe
Autor:
Hannah A D King, Christopher A Gonelli, Kirsteen M Tullett, Mireille H Lahoud, Damian F J Purcell, Heidi E Drummer, Pantelis Poumbourios, Rob J Center
Publikováno v:
PLoS ONE, Vol 14, Iss 8, p e0220986 (2019)
A promising strategy for the enhancement of vaccine-mediated immune responses is by directly targeting protein antigens to immune cells. Targeting of antigens to the dendritic cell (DC) molecule Clec9A has been shown to enhance antibody affinity and
Externí odkaz:
https://doaj.org/article/d564ce87a08a43f9a3a3f5e3be9de528
Autor:
Christopher A. Gonelli, Hannah A. D. King, Charlene Mackenzie, Secondo Sonza, Rob J. Center, Damian F. J. Purcell
Publikováno v:
Vaccines, Vol 9, Iss 3, p 239 (2021)
An optimal prophylactic vaccine to prevent human immunodeficiency virus (HIV-1) transmission should elicit protective antibody responses against the HIV-1 envelope glycoprotein (Env). Replication-incompetent HIV-1 virus-like particles (VLPs) offer th
Externí odkaz:
https://doaj.org/article/5ef11876bca747c98ffe894363a2ebc4
Autor:
Pantelis Poumbourios, Christine Langer, Irene Boo, Tasnim Zakir, Rob J. Center, Anouschka Akerman, Vanessa Milogiannakis, Anupriya Aggarwal, Stuart Turville, Heidi E. Drummer.
The spike (S) glycoprotein of SARS CoV-2 is the target of neutralizing antibodies (NAbs) that are crucial for vaccine effectiveness. The S1 subunit binds ACE2 while the S2 subunit mediates virus-cell membrane fusion. S2 is a class I fusion glycoprote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::608982e7b611af6fd1b23b3bc5bb9612
https://doi.org/10.1101/2022.11.08.515567
https://doi.org/10.1101/2022.11.08.515567
Autor:
John M Murray, Stephen Maher, Talia Mota, Kazuo Suzuki, Anthony D Kelleher, Rob J Center, Damian Purcell
Publikováno v:
PLoS ONE, Vol 12, Iss 2, p e0171572 (2017)
Significant progress has been made in characterizing broadly neutralizing antibodies against the HIV envelope glycoprotein Env, but an effective vaccine has proven elusive. Vaccine development would be facilitated if common features of early founder
Externí odkaz:
https://doaj.org/article/295d8285a3374e9e8e5182501c338768
Publikováno v:
Viruses, Vol 11, Iss 6, p 507 (2019)
A prophylactic vaccine eliciting both broad neutralizing antibodies (bNAbs) to the HIV-1 envelope glycoprotein (Env) and strong T cell responses would be optimal for preventing HIV-1 transmissions. Replication incompetent HIV-1 virus-like particles (
Externí odkaz:
https://doaj.org/article/20913755c99a4caa98484f19f2ca528a
Autor:
Behnaz Heydarchi, Rob J Center, Christopher Gonelli, Brian Muller, Charlene Mackenzie, Georges Khoury, Marit Lichtfuss, Grant Rawlin, Damian F J Purcell
Publikováno v:
PLoS ONE, Vol 11, Iss 6, p e0157353 (2016)
An important feature of a potential vaccine against HIV is the production of broadly neutralising antibodies (BrNAbs) capable of potentially blocking infectivity of a diverse array of HIV strains. BrNAbs naturally arise in some HIV infected individua
Externí odkaz:
https://doaj.org/article/2896f603eac749babe3ca60547b529d6
Autor:
Timothy Donnison, Joey McGregor, Senthil Chinnakannan, Claire Hutchings, Rob J. Center, Pantelis Poumbourios, Paul Klenerman, Heidi E. Drummer, Eleanor Barnes
Publikováno v:
Hepatology (Baltimore, Md.). 76(4)
A prophylactic vaccine targeting multiple HCV genotypes (gt) is urgently required to meet World Health Organization elimination targets. Neutralizing antibodies (nAbs) and CD4We show that vaccinating with ChAd-Gt1-6 and E2Δ123These data are an impor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6534b0dde759e1470b08feddd9bdd9b7
https://pubmed.ncbi.nlm.nih.gov/35503709
https://pubmed.ncbi.nlm.nih.gov/35503709