Zobrazeno 1 - 10
of 280
pro vyhledávání: '"Rob J, de Boer"'
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
We have previously argued that the antigen receptors of T and B lymphocytes evolved to be sufficiently specific to avoid massive deletion of clonotypes by negative selection. Their optimal ‘specificity’ level, i.e., probability of binding any par
Externí odkaz:
https://doaj.org/article/af6df0c92e9e4353bb4807749fa84229
Autor:
Peter C. de Greef, Josien Lanfermeijer, Marion Hendriks, Alper Cevirgel, Martijn Vos, José A. M. Borghans, Debbie van Baarle, Rob J. de Boer
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
T cells recognize pathogens by their highly specific T-cell receptor (TCR), which can bind small fragments of an antigen presented on the Major Histocompatibility Complex (MHC). Antigens that are provided through vaccination cause specific T cells to
Externí odkaz:
https://doaj.org/article/afb7e7e73a364e1094fcc54460087e70
Autor:
Gerdien Mijnheer, Nila Hendrika Servaas, Jing Yao Leong, Arjan Boltjes, Eric Spierings, Phyllis Chen, Liyun Lai, Alessandra Petrelli, Sebastiaan Vastert, Rob J de Boer, Salvatore Albani, Aridaman Pandit, Femke van Wijk
Publikováno v:
eLife, Vol 12 (2023)
Autoimmune inflammation is characterized by tissue infiltration and expansion of antigen-specific T cells. Although this inflammation is often limited to specific target tissues, it remains yet to be explored whether distinct affected sites are infil
Externí odkaz:
https://doaj.org/article/7571fb8d41c545a59ee5ff9879ec1345
Autor:
Bettina Weigelin, Annemieke Th. den Boer, Esther Wagena, Kelly Broen, Harry Dolstra, Rob J. de Boer, Carl G. Figdor, Johannes Textor, Peter Friedl
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Cytotoxic CD8+ T lymphocytes (CTL) often fail to kill tumour cells in one-to-one interactions. Here the authors show that these sublethal interactions from multiple CTL can add up over time and achieve tumour cell killing by additive cytotoxicity.
Externí odkaz:
https://doaj.org/article/62213730d2074330a309addcd60ee54f
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
The fact that T-cell numbers remain relatively stable throughout life, and that T-cell proliferation rates increase during lymphopenia, has led to the consensus that T-cell numbers are regulated in a density-dependent manner. Competition for resource
Externí odkaz:
https://doaj.org/article/111c5e36ba314aba8dacde36516affa5
Autor:
Alessandra Ruggiero, Giuseppe Rubens Pascucci, Nicola Cotugno, Sara Domínguez-Rodríguez, Stefano Rinaldi, Alfredo Tagarro, Pablo Rojo, Caroline Foster, Alasdair Bamford, Anita De Rossi, Eleni Nastouli, Nigel Klein, Elena Morrocchi, Benoit Fatou, Kinga K. Smolen, Al Ozonoff, Michela Di Pastena, Katherine Luzuriaga, Hanno Steen, Carlo Giaquinto, Philip Goulder, Paolo Rossi, Ofer Levy, Savita Pahwa, Paolo Palma, the EPIICAL Consortium, Mark Cotton, Shaun Barnabas, Thanyawee Puthanakit, Louise Kuhn, Andrew Yates, Avy Violari, Kennedy Otwombe, Paula Vaz, Maria Grazia Lain, Tacilta Nampossa, Denise Naniche, Sheila Fernandez-Luis, Elisa Lopez, Holly Peay, Moira Spyer, Vincent Calvez, Anne-Genevieve Marcelin, Maria Angeles Munoz, Annalisa Dalzini, Raffaella Petrara, Kathleen Gartner, Lesley De Armas, Pahwa Rajendra, Suresh Pallikkuth, Deborah Persaud, Nicolas Chomont, Mathias Lichterfeld, Silvia Faggion, Daniel Gomez Pena, Andrea Oletto, Alessandra Nardone, Paola Zangari, Silvia Di Cesare, Chiara Medri, Olga Kolesova, Carla Paganin, William James, Inger Lindfors - Rossi, Shrabon Samiur Hassan, Francesca Mazzetto, Hellen Akisinku, Musakanya Chingandu, Francesca Rocchi, Ilaria Pepponi, Rob J. De Boer, Juliane Schroter, Viviana Giannuzzi, Sinead Morris
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
BackgroundDespite a successful antiretroviral therapy (ART), adolescents living with perinatally acquired HIV (PHIV) experience signs of B-cell hyperactivation with expansion of ‘namely’ atypical B-cell phenotypes, including double negative (CD27
Externí odkaz:
https://doaj.org/article/4c3438cc6e094cf89b7fa756b480c8ba
Autor:
Sara P H van den Berg, Lyanne Y Derksen, Julia Drylewicz, Nening M Nanlohy, Lisa Beckers, Josien Lanfermeijer, Stephanie N Gessel, Martijn Vos, Sigrid A Otto, Rob J de Boer, Kiki Tesselaar, José A M Borghans, Debbie van Baarle
Publikováno v:
PLoS Pathogens, Vol 17, Iss 12, p e1010152 (2021)
Cytomegalovirus (CMV) infection has a major impact on the T-cell pool, which is thought to be associated with ageing of the immune system. The effect on the T-cell pool has been interpreted as an effect of CMV on non-CMV specific T-cells. However, it
Externí odkaz:
https://doaj.org/article/75fa94e444bf43b9ac20d94ea3bccc0d
Autor:
Mario Castro, Rob J de Boer
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 10, p e1009425 (2021)
In their Commentary paper, Villaverde and Massonis (On testing structural identifiability by a simple scaling method: relying on scaling symmetries can be misleading) have commented on our paper in which we proposed a simple scaling method to test st
Externí odkaz:
https://doaj.org/article/c53c1ef088fc474f94fb0cc16d9ffbf1
Autor:
Rob J. De Boer, Andrew J. Yates
Publikováno v:
Annual Review of Immunology. 41:513-532
Many of the pathways that underlie the diversification of naive T cells into effector and memory subsets, and the maintenance of these populations, remain controversial. In recent years a variety of experimental tools have been developed that allow u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b4074c7b0b5b930f56fcb8b5507bc224
https://doi.org/10.1146/annurev-immunol-101721-040924
https://doi.org/10.1146/annurev-immunol-101721-040924
Autor:
Mariona Baliu-Piqué, Vera van Hoeven, Julia Drylewicz, Lotte E van der Wagen, Anke Janssen, Sigrid A Otto, Menno C van Zelm, Rob J de Boer, Jürgen Kuball, Jose AM Borghans, Kiki Tesselaar
Publikováno v:
eLife, Vol 10 (2021)
Lymphocyte numbers need to be quite tightly regulated. It is generally assumed that lymphocyte production and lifespan increase homeostatically when lymphocyte numbers are low and, vice versa, return to normal once cell numbers have normalized. This
Externí odkaz:
https://doaj.org/article/284e6b966f534a63b87407d15f4ffc95