Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Rob Horsefield"'
Autor:
Urszula Kosinska-Eriksson, Maria Fellert, Kristina Hedfalk, Rob Horsefield, Anna Backmark, Urban Johanson, Richard Neutze, Maria Nyblom, Per Kjellbom, Kristina Nordén, Susanna Törnroth-Horsefield, Karin Lindkvist-Petersson
Publikováno v:
Acta Crystallographica Section D Biological Crystallography. 64:1183-1186
This work presents a comparison of the crystal packing of three eukaryotic membrane proteins: human aquaporin 1, human aquaporin 5 and a spinach plasma membrane aquaporin. All were purified from expression constructs both with and without affinity ta
Autor:
Susanna Törnroth-Horsefield, Richard Neutze, Hirotada Mori, Natsuko Yamamoto, Pontus Gourdon, Lars Brive, Arjan Snijder, Rob Horsefield
Publikováno v:
Törnroth-Horsefield, S, Gourdon, P, Horsefield, R, Brive, L, Yamamoto, N, Mori, H, Snijder, A & Neutze, R 2007, ' Crystal structure of AcrB in complex with a single transmembrane subunit reveals another twist ', Structure, vol. 15, no. 12, pp. 1663-73 . https://doi.org/10.1016/j.str.2007.09.023
Bacterial drug resistance is a serious concern for human health. Multidrug efflux pumps export a broad variety of substrates out of the cell and thereby convey resistance to the host. In Escherichia coli, the AcrB:AcrA:TolC efflux complex forms a pri
Autor:
Kazuro Shiomi, Bernadette Byrne, Rob Horsefield, So Iwata, Satoshi Omura, Graham J. Sexton, Victoria Yankovskaya, William Guy Whittingham, Gary Cecchini
Publikováno v:
Journal of Biological Chemistry. 281:7309-7316
The transfer of electrons and protons between membrane-bound respiratory complexes is facilitated by lipid-soluble redox-active quinone molecules (Q). This work presents a structural analysis of the quinone-binding site (Q-site) identified in succina
Publikováno v:
Current Protein and Peptide Science. 5:107-118
The super-macromolecular complex, succinate:quinone oxidoreductase (SQR, Complex II, succinate dehydrogenase) couples the oxidation of succinate in the matrix / cytoplasm to the reduction of quinone in the membrane. This function directly connects th
Autor:
Niek Dekker, Stefan Geschwindner, Patrik Johansson, Rob Horsefield, Clay W Scott, Anna Tigerström, Jeffrey S. Albert
Publikováno v:
Journal of medicinal chemistry. 56(8)
We describe the development of a novel fragment screening methodology employing a plate-based optical biosensor system that can operate in a 384-well format. The method is based on the “inhibition in solution assay” (ISA) approach using an immobi
Autor:
Herman G.P. Swarts, Euan Gordon, Rob Horsefield, Arjan Snijder, Richard Neutze, Jan Joep H.H.M. De Pont
Publikováno v:
Protein expression and purification.
Structural biology is increasingly reliant on elevated throughput methods for protein production. In particular, development of efficient methods of heterologous production of membrane proteins is essential. Here, we describe the heterologous overpro
Autor:
Euan Gordon, Herman G.P. Swarts, Jan Joep H.H.M. De Pont, Richard Neutze, Rob Horsefield, Arjan Snijder
Publikováno v:
Protein Expression and Purification, 62, 1-8
Protein Expression and Purification, 62, 1, pp. 1-8
Protein Expression and Purification, 62, 1, pp. 1-8
Contains fulltext : 70443.pdf (Publisher’s version ) (Closed access) Structural biology is increasingly reliant on elevated throughput methods for protein production. In particular, development of efficient methods of heterologous production of mem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35322f03c957718e6e7200ef9cfa5588
http://hdl.handle.net/2066/70443
http://hdl.handle.net/2066/70443
Autor:
Rob Horsefield, Richard Neutze, Maria Fellert, Kristina Nordén, Jan Kvassman, Per Kjellbom, Anke C. Terwisscha van Scheltinga, Susanna Törnroth-Horsefield, Anna Backmark, Urban Johanson
Publikováno v:
Proceedings of the National Academy of Sciences, 105(36). NATL ACAD SCIENCES
Human aquaporin 5 (HsAQP5) facilitates the transport of water across plasma membranes and has been identified within cells of the stomach, duodenum, pancreas, airways, lungs, salivary glands, sweat glands, eyes, lacrimal glands, and the inner ear. AQ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10f55adb6a924e293940a1fbb7501a74
https://research.rug.nl/en/publications/73801ed4-a396-46e0-9d55-db50eb09e305
https://research.rug.nl/en/publications/73801ed4-a396-46e0-9d55-db50eb09e305
Autor:
Rob, Horsefield, Victoria, Yankovskaya, Graham, Sexton, William, Whittingham, Kazuro, Shiomi, Satoshi, Omura, Bernadette, Byrne, Gary, Cecchini, So, Iwata
Publikováno v:
The Journal of biological chemistry. 281(11)
The transfer of electrons and protons between membrane-bound respiratory complexes is facilitated by lipid-soluble redox-active quinone molecules (Q). This work presents a structural analysis of the quinone-binding site (Q-site) identified in succina
Autor:
Gary Cecchini, So Iwata, Susanna Törnroth, Bernadette Byrne, Rob Horsefield, César Luna-Chavez, Christophe Léger, Victoria Yankovskaya, Hideto Miyoshi
Publikováno v:
Science (New York, N.Y.). 299(5607)
The structure of Escherichia coli succinate dehydrogenase (SQR), analogous to the mitochondrial respiratory complex II, has been determined, revealing the electron transport pathway from the electron donor, succinate, to the terminal electron accepto