Výsledky vyhledávání - "Rob H. Meloen"

Proteasome inhibition and mechanism of resistance to a synthetic, library-based hexapeptide

Autor: Rik J. Scheper, Sue Ellen Verbrugge, Yehuda G. Assaraf, Huib Ovaa, Gerrit Jansen, Robert H. Shoemaker, Godefridus J. Peters, Rob H. Meloen, Ruud Oerlemans, Celia R. Berkers, George L. Scheffer, Jacqueline Cloos, Jerry W. Slootstra, Ben A. C. Dijkmans

Publikováno v: Investigational New Drugs
Oerlemans, R, Berkers, C R, Assaraf, Y G, Scheffer, G L, Peters, G J, Verbrugge, S E, Cloos, J, Slootstra, J, Meloen, R H, Shoemaker, R H, Dijkmans, B A C, Scheper, R J, Ovaa, H & Jansen, G 2018, ' Proteasome inhibition and mechanism of resistance to a synthetic, library-based hexapeptide ', Investigational New Drugs, vol. 36, no. 5, pp. 797-809 . https://doi.org/10.1007/s10637-018-0569-x
Investigational New Drugs, 36(5), 797-809. Kluwer Academic Publishers
Investigational New Drugs, 36(5), 797-809

Summary Background The hexapeptide 4A6 (Ac-Thr(tBu)-His(Bzl)-Thr(Bzl)-Nle-Glu(OtBu)-Gly-Bza) was isolated from a peptide library constructed to identify peptide-based transport inhibitors of multidrug resistance (MDR) efflux pumps including P-glycopr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51de26c79f798655a697b79404426de5
http://www.scopus.com/inward/record.url?scp=85041905364&partnerID=8YFLogxK

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Targeted vaccination against the bevacizumab binding site on VEGF using 3D-structured peptides elicits efficient antitumor activity

Autor: Wouter Cornelis Puijk, Madelon Q. Wentink, Rob H. Meloen, Sebastien P. Tabruyn, Danièle Altschuh, Tilman M. Hackeng, T. Schuurman, Arjan W. Griffioen, Peter Timmerman, Klaus Schwamborn

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, 113(44), 12532-12537. National Academy of Sciences
Proceedings of the National Academy of Sciences of the United States of America, 113(44), 12532-12537
Wentink, M Q, Hackeng, T M, Tabruyn, S P, Puijk, W C, Schwamborn, K, Altschuh, D, Meloen, R H, Schuurman, T, Griffioen, A W & Timmerman, P 2016, ' Targeted vaccination against the bevacizumab binding site on VEGF using 3D-structured peptides elicits efficient antitumor activity ', Proceedings of the National Academy of Sciences of the United States of America, vol. 113, no. 44, pp. 12532-12537 . https://doi.org/10.1073/pnas.1610258113
Proceedings of the National Academy of Sciences of the United States of America 113 (2016) 44

Therapeutic targeting of the VEGF signaling axis by the VEGF-neutralizing monoclonal antibody bevacizumab has clearly demonstrated clinical benefit in cancer patients. To improve this strategy using a polyclonal approach, we developed a vaccine targe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::690d95d73c3ca18fa8be10f00d276863
https://europepmc.org/articles/PMC5098619/

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Binding of CDR-derived peptides is mechanistically different from that of high-affinity parental antibodies

Autor: Rodrigo Barderas, Susana Shochat, Rob H. Meloen, Peter Timmerman, Danièle Altschuh, Johan Desmet, J I Casal

Publikováno v: Journal of Molecular Recognition, 23(6), 559-568. John Wiley and Sons Ltd
Digital.CSIC. Repositorio Institucional del CSIC
instname

10 páginas, 6 figuras, 2 tablas -- PAGS nros. 559-568
We present data that reveal crucial differences between the binding mode of anti-gastrin17 (G17, pyroEGPWLEEEEEAYGWMDF-NH2) monoclonal antibodies (mAbs) and their CDR-derived synthetic binde

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc3d42f03b6b1ad18643b8a86c4d21a6
https://doi.org/10.1002/jmr.1017

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Synthetic peptide vaccines: palmitoylation of peptide antigens by a thioester bond increases immunogenicity

Autor: Jan P. M. Langeveld, N. J. C. M. Beekman, Ronald S. Boshuizen, Kristian Dalsgaard, W.M.M. Schaaper, Godefridus I. Tesser, Rob H. Meloen, Søren Kamstrup

Publikováno v: The Journal of Peptide Research. 50:357-364

Synthetic peptides have frequently been used to immunize animals. However, peptides less than about 20 to 30 amino acids long are poor immunogens. In general, to increase its immunogenicity, the presentation of the peptide should be improved, and mol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ba161ff0dbc71d049a1237652db43f4
https://doi.org/10.1111/j.1399-3011.1997.tb01195.x

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SUMO Assay with Peptide Arrays on Solid Support: Insights into SUMO Target Sites

Autor: Titia K. Sixma, Johannes P. M. Langedijk, Evert Van Dijk, Puck Knipscheer, Willem J. van Dijk, Rob H. Meloen, Klaus Schwamborn

Publikováno v: The Journal of Biochemistry. 144:39-49

The modification of proteins by SUMO (small ubiquitin-like modifier) regulates various cellular processes. Sumoylation often occurs on a specific lysine residue within the consensus motif psiKxE/D. However, little is known about the specificity and s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c700ca75fcbc9677a396e55479a470a2
https://doi.org/10.1093/jb/mvn039

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Characterization of gastrin-cholecystokinin 2 receptor interaction in relation to c-fos induction

Autor: Martine J. Hollestelle, Peter Timmerman, Jo W.M. Höppener, Rob H. Meloen

Publikováno v: Endocrine related cancer, 15(1), 301-309. Society for Endocrinology

The interaction of gastrin with the cholecystokinin 2 (CCK2)/gastrin receptor has been studied extensively in relation to gastric acid secretion. However, not much is known about the contribution of individual amino acids of gastrin interacting with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c194963c60f6b1d9c7e5c5441c19087
https://doi.org/10.1677/erc-07-0206

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Designing antibodies for the inhibition of gastrin activity in tumoral cell lines

Autor: Danièle Altschuh, Peter Timmerman, Jorge L. Martínez-Torrecuadrada, Jo W.M. Höppener, Martine J. Hollestelle, J I Casal, Rodrigo Barderas, Susana Shochat, Rob H. Meloen

Publikováno v: International journal of cancer, 122(10), 2351-2359. Wiley-Liss Inc.
International Journal of Cancer
International Journal of Cancer, Wiley, 2008, epub ahead of print. ⟨10.1002/ijc.23395⟩

Gastrin and its derivatives are becoming important targets for immunotherapy of pancreatic, gastric and colorectal tumors. This study was conducted to design antibodies able to block gastrin binding to the gastrin/cholecystokinin-2 (CCK-2) receptor i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1d174fa48ff5a94c24a34adb8652af0
https://hdl.handle.net/11245/1.294787

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Functional Reconstruction and Synthetic Mimicry of a Conformational Epitope using CLIPS-technology

Autor: Rob H. Meloen, Peter Timmerman, Wouter Cornelis Puijk

Publikováno v: Journal of Molecular Recognition, 20(5), 283-299. John Wiley and Sons Ltd

This paper describes immunization studies with CLIPS-constrained peptides covering only the major part (beta3-loop) of a structurally complex antigenic site on human Follicle Stimulating Hormone beta-subunit (FSH-beta). In cases where linear and SS-c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c80c812a15bf6f4e0b959de142ebce06
https://hdl.handle.net/11245/1.276401

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