Výsledky vyhledávání - "Rob E. Ploemacher"

Addition of treosulfan to a nonmyeloablative conditioning regimen results in enhanced chimerism and immunologic tolerance in an experimental allogeneic bone marrow transplant model

Autor: Julian D. Down, Rob E. Ploemacher, Mary E. White-Scharf, Kevin W. Johnson, Elwin J. C. Rombouts, Joachim Baumgart, Kenol Etienne, G.Robbin Westerhof

Publikováno v: Biology of Blood and Marrow Transplantation. 10:236-245

Treosulfan (l-threitol-1,4-bismethanesulfonate) is an alkylating agent with routine clinical application in the treatment of ovarian cancer. In this murine study we show that this drug also has the ability to deplete primitive hematopoietic stem cell

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5685921832d0126d4bd555fb3db44878
https://doi.org/10.1016/j.bbmt.2003.11.004

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Relation between CXCR-4 expression, Flt3 mutations and unfavourable prognosis of adult acute myeloid leukemia

Autor: Biljana Pavic, Elwin J. C. Rombouts, Bob Löwenberg, Rob E. Ploemacher

Publikováno v: Blood, 104, 550-557. American Society of Hematology

Recently it was shown that, analogous to normal hematopoietic cells, the level of CXC chemokine receptor 4 (CXCR-4) expression on acute myeloid leukemia (AML) cells correlates with stromal cell derived factor-1 alpha (SDF-1)-induced chemotaxis. As we

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::090f65003a63c61aa2be53c02ccd72f8
https://doi.org/10.1182/blood-2004-02-0566

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Embryonal subregion-derived stromal cell lines from novel temperature-sensitive SV40 T antigen transgenic mice support hematopoiesis

Autor: Claudia Orelio, Robert A.J. Oostendorp, Nuray Kusadasi, Kirsty Harvey, Rob E. Ploemacher, Alexander Medvinsky, Katrin Ottersbach, Todd Covey, Elaine Dzierzak, Chris Saris, Naoki Nakayama

Publikováno v: Journal of Cell Science. 115:2099-2108

Throughout life, the hematopoietic system requires a supportive microenvironment that allows for the maintenance and differentiation of hematopoietic stem cells (HSC). To understand the cellular interactions and molecules that provide these functions

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97ee1c83cae552118766e2952d406a34
https://doi.org/10.1242/jcs.115.10.2099

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Stromal cells from mouse aorta-gonad-mesonephros subregions are potent supporters of hematopoietic stem cell activity

Autor: Marella F. T. R. de Bruijn, Alexander Medvinsky, Kirsty Harvey, Robert A.J. Oostendorp, Rob E. Ploemacher, Nuray Kusadasi, Chris Saris, Elaine Dzierzak

Publikováno v: Blood, 99, 1183-1189. American Society of Hematology

The aorta-gonads-mesonephros (AGM) region autonomously generates the first adult repopulating hematopoietic stem cells (HSCs) in the mouse embryo. HSC activity is initially localized to the dorsal aorta and mesenchyme (AM) and vitelline and umbilical

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9b4153974d5c941a4ef6ea8c7098be4
https://hdl.handle.net/1765/57936

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O6-Benzylguanine potentiates BCNU but not busulfan toxicity in hematopoietic stem cells

Autor: Geoffrey P. Margison, Amanda J. Watson, A Boudewijn, Rob E. Ploemacher, Irene Blokland, G.Robbin Westerhof, JD Down, Michelle Wood, Alan T McGown

Publikováno v: Experimental Hematology, 29(5), 633-638. ELSEVIER SCIENCE INC
Experimental Hematology, 29, 633-638. Elsevier Inc.

Objective. Busulfan (BU) is often used in conditioning regimens prior to bone marrow transplantation, but its mechanism of action remains to be resolved. We have examined the possibility that BU may exert part of its toxic effects via DNA alkylation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a84034e7c5fd37c48f6cf8ca10c934b
https://doi.org/10.1016/s0301-472x(01)00631-2

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Connexin-43 gap junctions are involved in multiconnexin-expressing stromal support of hemopoietic progenitors and stem cells

Autor: Rob E. Ploemacher, Angelique E. M. Mayen, Jose A. Cancelas, Alexandra E. de Koning, Wendy Koevoet, Elwin J. C. Rombouts

Publikováno v: Blood. 96:498-505

Gap junctions (GJs) provide for a unique system of intercellular communication (IC) allowing rapid transport of small molecules from cell to cell. GJs are formed by a large family of proteins named connexins (Cxs). Cx43 has been considered as the pre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ef6ef61dc365e2db10dc4ecfbb6649b
https://doi.org/10.1182/blood.v96.2.498

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Gap Junction Intercellular Communication is Likely to be Involved in Regulation of Stroma-dependent Proliferation of Hemopoietic Stem Cells

Autor: Tibor Krenacs, Rob E. Ploemacher, Martin Rosendaal, Angelique E. M. Mayen, Alexandra E. de Koning

Publikováno v: Hematology. 5:133-147

The 80-100 fold increased immunohistological expression of the Gap Junction (GJ) protein Connexin-43 in murine bone marrow during the neonatal period and directly following cytoreductive treatment of adult mice suggests that the regulation of stem ce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15916f3d6e535a3e2b5a5dda59e65015
https://doi.org/10.1080/10245332.2000.11746498

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How useful is thein vitro expansion of fetal CD34+ progenitor cells from maternal blood samples for diagnostic purposes?

Autor: Karin Korver-Hakkennes, Rob E. Ploemacher, Helen Brandenburg, Mieke W. J. C. Jansen, Juriy W. Wladimiroff, Hajo I. J. Wildschut, Dik van Leenen

Publikováno v: Prenatal Diagnosis. 20:725-731

Fetal cells present in the maternal circulation are a potential source of fetal DNA that can be used for the development of a prenatal diagnostic test. Since their numbers are very low, amplification of fetal cells has been discussed for a long time.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::06354bb3a0b25c319b6119df961d08b0
https://doi.org/10.1002/1097-0223(200009)20:9<725::aid-pd913>3.0.co

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Sustained Receptor Activation and Hyperproliferation in Response to Granulocyte Colony-stimulating Factor (G-CSF) in Mice with a Severe Congenital Neutropenia/Acute Myeloid Leukemia–derived Mutation in the G-CSF Receptor Gene

Autor: Angelique E. M. Mayen, Alister C. Ward, Ivo P. Touw, Rob E. Ploemacher, Claudia Antonissen, Mirjam H. A. Hermans

Publikováno v: The Journal of Experimental Medicine
Journal of Experimental Medicine, 189(4), 683-691. Rockefeller University Press

In approximately 20% of cases of severe congenital neutropenia (SCN), mutations are found in the gene encoding the granulocyte colony-stimulating factor receptor (G-CSF–R). These mutations introduce premature stop codons, which result in truncation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8636b17b10e871386d2f3f8d4e8685b2
https://doi.org/10.1084/jem.189.4.683

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