Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Rob A. van der Kammen"'
Autor:
Zhiheng Zhang, Jörg Kleeff, Nadja Maeritz, Susanne Raulefs, Xiaoping Zou, Helmut Friess, Christina Ludwig, Dianbo Yao, Kathleen Schuck, Metello Innocenti, Yamin Zhao, Shanshan Shen, Vivien Tissen, Achim Krüger, Christoph W. Michalski, Jan G. D’Haese, Rob A. van der Kammen, Carsten Jäger, Benjamin Schoeps, Anna Melissa Schlitter, Bo Kong
Background & Aims Oncogenic KrasG12D induces neoplastic transformation of pancreatic acinar cells through acinar-to-ductal metaplasia (ADM), an actin-based morphogenetic process, and drives pancreatic ductal adenocarcinoma (PDAC). mTOR (mechanistic t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba34c09707c2496b2d8d168be927eda2
https://hdl.handle.net/10281/396252
https://hdl.handle.net/10281/396252
Autor:
Metello Innocenti, Claudia Scarponi, Stefania Madonna, Rob A. van der Kammen, Hans Janssen, Iris de Rink, Cristina Albanesi, Ji Ying Song, Wim Brugman
Publikováno v:
Development.
Arp2/3 complex assembles branched actin filaments key to many cellular processes, but its organismal roles remain poorly understood. Here we employed conditional arpc4 knockout mice to study the function of the Arp2/3 complex in the epidermis. We fou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82928e6903f2c8799736a622b4780604
https://doi.org/10.1242/dev.156323
https://doi.org/10.1242/dev.156323
Publikováno v:
Journal of Cell Science. 122:2127-2136
Rac1 and Rac3 are highly homologous regulatory proteins that belong to the small GTPases of the Rho family. Previously, we showed that Rac3 induces cell rounding and prevents neuronal differentiation, in contrast to its close relative Rac1, which sti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b75b07f1fbc166caabb61e89b3abccb
https://doi.org/10.1242/jcs.039958
https://doi.org/10.1242/jcs.039958
Autor:
Katarzyna M. Kedziora, Metello Innocenti, Tadamoto Isogai, Daniela Leyton-Puig, Kees Jalink, Rob A. van der Kammen
Publikováno v:
Journal of cell science. 128(20)
Protrusion of lamellipodia and ruffles requires polymerization of branched actin filaments by Arp2/3 complex. Although regulation of Arp2/3-complex activity has been extensively investigated, the mechanism of initiation of lamellipodia and ruffles re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a66f23d58fa445a5924b8962868dbb27
https://pubmed.ncbi.nlm.nih.gov/26349808
https://pubmed.ncbi.nlm.nih.gov/26349808
Publikováno v:
Scientific Reports
Formin proteins are key regulators of the cytoskeleton involved in developmental and homeostatic programs and human disease. For these reasons, small molecules interfering with Formins’ activity have gained increasing attention. Among them, small m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a6588f891957e1e0f3384ff35de657c
http://europepmc.org/articles/PMC5386218
http://europepmc.org/articles/PMC5386218
Autor:
Rob A. van der Kammen, John G. Collard, Alexander E.E. Mertens, Cristina Olivo, D. Michiel Pegtel, Irene H. L. Hamelers, Arnoud Sonnenberg
Publikováno v:
The Journal of Cell Biology
The Rho-like guanosine triphosphatase Rac1 regulates various signaling pathways, including integrin-mediated adhesion and migration of cells. However, the mechanisms by which integrins signal toward Rac are poorly understood. We show that the Rac-spe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2399135a33e4d4e110154b2e3dd73d61
https://doi.org/10.1083/jcb.200509172
https://doi.org/10.1083/jcb.200509172
Autor:
Alexander E.E. Mertens, Rob A. van der Kammen, Cristina Olivo, John G. Collard, Tomasz P. Rygiel
Publikováno v:
The Journal of Cell Biology
The GTPases Rac and Cdc42 play a pivotal role in the establishment of cell polarity by stimulating biogenesis of tight junctions (TJs). In this study, we show that the Rac-specific guanine nucleotide exchange factor Tiam1 (T-lymphoma invasion and met
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e00a15835a65e0ec5a48b8a99e11df65
https://doi.org/10.1083/jcb.200502129
https://doi.org/10.1083/jcb.200502129
Autor:
Maarten van der Valk, John G. Collard, Angeliki Malliri, Rob A. van der Kammen, Frits Michiels, Kristopher Clark
Publikováno v:
Nature. 417:867-871
Proteins of the Rho family control signalling pathways that regulate the actin cytoskeleton and gene transcription. In vitro studies have implicated Rho-like GTP-hydrolysing enzymes (GTPases) in cell migration, cell-cycle progression, and Ras-induced
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::662b863605f7f7db36c6660c551215dd
https://doi.org/10.1038/nature00848
https://doi.org/10.1038/nature00848
Autor:
John G. Collard, Jean Paul ten Klooster, Gerben C.M. Zondag, Lennert Janssen, Rob A. van der Kammen, Eva E. Evers
Publikováno v:
The Journal of Cell Biology
Proteins of the Rho family regulate cytoskeletal rearrangements in response to receptor stimulation and are involved in the establishment and maintenance of epithelial cell morphology. We recently showed that Rac is able to downregulate Rho activity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c49d76df3b4a1375af8a2aae41ca1859
https://doi.org/10.1083/jcb.149.4.775
https://doi.org/10.1083/jcb.149.4.775
Autor:
Rob A. van der Kammen, Jean Paul ten Klooster, Sanne van Delft, John G. Collard, Eva E. Sander
Publikováno v:
Journal of Cell Biology. 147:1009-1022
Using biochemical assays to determine the activation state of Rho-like GTPases, we show that the guanine nucleotide exchange factor Tiam1 functions as a specific activator of Rac but not Cdc42 or Rho in NIH3T3 fibroblasts. Activation of Rac by Tiam1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e5000258cdb94f0df97905b42d612366
https://doi.org/10.1083/jcb.147.5.1009
https://doi.org/10.1083/jcb.147.5.1009