Zobrazeno 1 - 10
of 101
pro vyhledávání: '"Rob A Gruters"'
Autor:
Henk-Jan van den Ham, Jason D Cooper, Jakub Tomasik, Sabine Bahn, Joeri L Aerts, Albert D M E Osterhaus, Rob A Gruters, Arno C Andeweg, DC-TRN trial investigators
Publikováno v:
PLoS ONE, Vol 13, Iss 2, p e0192278 (2018)
To characterize the host response to dendritic cell-based immunotherapy and subsequent combined antiretroviral therapy (cART) interruption in HIV-1-infected individuals at the plasma protein level.An autologous dendritic cell (DC) therapeutic vaccine
Externí odkaz:
https://doaj.org/article/9ac140f9ad9c47daa1f594d853eb3911
Autor:
Jeroen J A van Kampen, Mariska L Reedijk, Peter C Burgers, Lennard J M Dekker, Nico G Hartwig, Ineke E van der Ende, Ronald de Groot, Albert D M E Osterhaus, David M Burger, Theo M Luider, Rob A Gruters
Publikováno v:
PLoS ONE, Vol 5, Iss 7, p e11409 (2010)
HIV protease inhibitors must penetrate into cells to exert their action. Differences in the intracellular pharmacokinetics of these drugs may explain why some patients fail on therapy or suffer from drug toxicity. Yet, there is no information availab
Externí odkaz:
https://doaj.org/article/754670a0851940d0a990a4d05dd52f35
Autor:
Thessa Laeremans, Sabine den Roover, Cynthia Lungu, Sigrid D’haese, Rob A. Gruters, Sabine D. Allard, Joeri L. Aerts
Publikováno v:
npj Vaccines, Vol 8, Iss 1, Pp 1-13 (2023)
Abstract Although natural killer (NK) cells have been studied in connection with dendritic cell (DC)-based vaccination in the field of cancer immunology, their role has barely been addressed in the context of therapeutic vaccination against HIV-1. In
Externí odkaz:
https://doaj.org/article/8d718e76751947ccbcc26ed725f9a812
Autor:
Jeroen J.A. van Kampen, Hanh Thi Pham, Sunbin Yoo, Ronald J. Overmars, Cynthia Lungu, Rizwan Mahmud, Carolina A.M. Schurink, Sander van Boheemen, Rob A. Gruters, Pieter L.A. Fraaij, David M. Burger, Jolanda J.C. Voermans, Casper Rokx, David A.M.C. van de Vijver, Thibault Mesplède
Publikováno v:
Journal of Global Antimicrobial Resistance, Vol 31, Iss , Pp 323-327 (2022)
ABSTRACT: Objectives: We report a case of incomplete HIV-1 suppression on a dolutegravir, lamivudine, and abacavir single-tablet regimen with the emergence of the H51Y and G118R integrase resistance mutations. Methods: Integrase sequencing was perfor
Externí odkaz:
https://doaj.org/article/0a938eb9f0cb4d779bb3ebd4b1d4ed7e
Autor:
Cynthia Lungu, Ronald J. Overmars, Esmée Grundeken, Patrick H. M. Boers, Marchina E. van der Ende, Thibault Mesplède, Rob A. Gruters
Publikováno v:
Viruses, Vol 15, Iss 11, p 2236 (2023)
Although some individuals with HIV-2 develop severe immunodeficiency and AIDS-related complications, most may never progress to AIDS. Replication-competent HIV-2 isolated from asymptomatic long-term non-progressors (controllers) have lower replicatio
Externí odkaz:
https://doaj.org/article/77e38f7aaf384a6b80059352043cad5b
Autor:
Shringar Rao, Cynthia Lungu, Raquel Crespo, Thijs H. Steijaert, Alicja Gorska, Robert-Jan Palstra, Henrieke A. B. Prins, Wilfred van Ijcken, Yvonne M. Mueller, Jeroen J. A. van Kampen, Annelies Verbon, Peter D. Katsikis, Charles A. B. Boucher, Casper Rokx, Rob A. Gruters, Tokameh Mahmoudi
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-20 (2021)
DEAD-box polypeptide 3 (DDX3) is a host protein belonging to the family of ATP-dependent RNA helicases. Here, the authors demonstrate that DDX3 inhibitors reverse HIV-1 latency and selectively induce cell death in HIV-1-infected cell lines, primary C
Externí odkaz:
https://doaj.org/article/983a234271bf4954b9536cec417f77df
Inducible HIV-1 Reservoir Quantification: Clinical Relevance, Applications and Advancements of TILDA
Publikováno v:
Frontiers in Microbiology, Vol 12 (2021)
The presence of a stable HIV-1 reservoir persisting over time despite effective antiretroviral suppression therapy precludes a cure for HIV-1. Characterizing and quantifying this residual reservoir is considered an essential prerequisite to develop a
Externí odkaz:
https://doaj.org/article/42383371a44d4c09ab5af6a05357b34f
Autor:
Henrieke A. B. Prins, Raquel Crespo, Cynthia Lungu, Shringar Rao, Letao Li, Ronald J. Overmars, Grigorius Papageorgiou, Yvonne M. Mueller, Mateusz Stoszko, Tanvir Hossain, Tsung Wai Kan, Bart J. A. Rijnders, Hannelore I. Bax, Eric C. M. van Gorp, Jan L. Nouwen, Theodora E. M. S. de Vries-Sluijs, Carolina A. M. Schurink, Mariana de Mendonça Melo, Els van Nood, Angela Colbers, David Burger, Robert-Jan Palstra, Jeroen J. A. van Kampen, David A. M. C. van de Vijver, Thibault Mesplède, Peter D. Katsikis, Rob A. Gruters, Birgit C. P. Koch, Annelies Verbon, Tokameh Mahmoudi, Casper Rokx
Publikováno v:
Science Advances, 9
Science Advances, 9, 11
Science advances, 9(11):eade6675. American Association for the Advancement of Science
Science Advances, 9, 11
Science advances, 9(11):eade6675. American Association for the Advancement of Science
Contains fulltext : 291084.pdf (Publisher’s version ) (Open Access) Reactivation of the latent HIV-1 reservoir is a first step toward triggering reservoir decay. Here, we investigated the impact of the BAF complex inhibitor pyrimethamine on the res
Autor:
Lennert W.J. van den Dries, Rob A. Gruters, Sascha B.C. Hövels – van der Borden, Marieke J.H.A. Kruip, Moniek ede Maat, Eric C.M. van Gorp, Marchina E. van der Ende
Publikováno v:
Frontiers in Microbiology, Vol 6 (2015)
BackgroundArterial and venous thrombotic events are more prevalent in HIV infected individuals compared to the general population, even in the era of combination antiretroviral therapy. Although the mechanism is not fully understood, recent evidence
Externí odkaz:
https://doaj.org/article/fca6f61fb949430b8834099c42bb9dd1
Autor:
José Alcamí, Arno C. Andeweg, Patrick Aloy, Lorna Leal, Mireia Arnedo, Francisco Díez-Fuertes, Henk-Jan van den Ham, Rob A. Gruters, Roque Pastor-lbáñez, Felipe García, Csaba Fehér, Montserrat Plana
Publikováno v:
Vaccines
Volume 9
Issue 7
Vaccines, 9(7):799. Multidisciplinary Digital Publishing Institute (MDPI)
Repisalud
Instituto de Salud Carlos III (ISCIII)
Vaccines, Vol 9, Iss 799, p 799 (2021)
Volume 9
Issue 7
Vaccines, 9(7):799. Multidisciplinary Digital Publishing Institute (MDPI)
Repisalud
Instituto de Salud Carlos III (ISCIII)
Vaccines, Vol 9, Iss 799, p 799 (2021)
Systems vaccinology has seldomly been used in therapeutic HIV-1 vaccine research. Our aim was to identify early gene ‘signatures’ that predicted virus load control after analytical therapy interruption (ATI) in participants of a dendritic cell-ba