Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Rob, Winkel"'
Autor:
Erik H. Heijne, Christopher D. Hupp, John W. Cuozzo, Anthony D. Keefe, Rob Winkel, L. Babiss, Wendy van Bruggen, Louis Renzetti, Mark J. Mulvihill, Birgit Zech, Andrew J. McRiner, Johan J. N. Veerman, Eddy Damen, Yorik B. Bruseker, Heather A. Thomson, Julie Liu, Gerhard Müller, Koen F. W. Hekking, Ying Zhang, Peter van Rijnsbergen
Publikováno v:
ACS Medicinal Chemistry Letters. 12:555-562
Herein we report the discovery of 2,4-1H-imidazole carboxamides as novel, biochemically potent, and kinome selective inhibitors of transforming growth factor β-activated kinase 1 (TAK1). The target was subjected to a DNA-encoded chemical library (DE
Autor:
Michael Forster, Rob Winkel, Gerhard Müller, Martin Schröder, Mark Kudolo, Stefan Knapp, Roberta Tesch, Koen F. W. Hekking, Sandra Röhm, Jorg J C Benningshof, Stefan Laufer, Apirat Chaikuad, Benedict-Tilman Berger
Publikováno v:
Journal of Medicinal Chemistry. 62:10757-10782
p38 mitogen-activated protein kinases are key mediators of environmental stress response and are promising targets for treatment of inflammatory diseases and cancer. Numerous efforts have led to the discovery of several potent inhibitors; however, so
Autor:
Johan J N, Veerman, Yorik B, Bruseker, Eddy, Damen, Erik H, Heijne, Wendy, van Bruggen, Koen F W, Hekking, Rob, Winkel, Christopher D, Hupp, Anthony D, Keefe, Julie, Liu, Heather A, Thomson, Ying, Zhang, John W, Cuozzo, Andrew J, McRiner, Mark J, Mulvihill, Peter, van Rijnsbergen, Birgit, Zech, Louis M, Renzetti, Lee, Babiss, Gerhard, Müller
Publikováno v:
ACS Med Chem Lett
[Image: see text] Herein we report the discovery of 2,4-1H-imidazole carboxamides as novel, biochemically potent, and kinome selective inhibitors of transforming growth factor β-activated kinase 1 (TAK1). The target was subjected to a DNA-encoded ch
Autor:
Rob Winkel, Claus Voigt, D.L. Foster, Wolfgang Winkler, Andreas Podias, Richard Smokers, Ludwig Joerissen, Rasmus Friberg, George Tsotridis
Publikováno v:
3rd International Conference on Fuel Cell Science, Engineering and Technology.
FCTESTNET (Fuel Cell Testing and Standardization Network) is an ongoing European network project within framework program 5. It is a three-year project that commenced 2003, with 55 partners from European research centers, universities, and industry,