Does Ortho-Substitution Enhance Cytotoxic Potencies in a Series of 3,5-Bis(benzylidene)-4-piperidones?

Autor: Karki SS; College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, SK S7N 5C9, Canada.; Department of Pharmaceutical Chemistry, KLE College of Pharmacy-Bengaluru (A Constituent Unit of KAHER-Belagavi), Bengaluru 560010, Karnataka, India., Das U; College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, SK S7N 5C9, Canada., Balzarini J; Rega Institute of Medical Research, Katholieke Universiteit Leuven, 3000 Leuven, Belgium., De Clercq E; Rega Institute of Medical Research, Katholieke Universiteit Leuven, 3000 Leuven, Belgium., Sakagami H; Mekei University Research Institute of Odontology (M-RIO), School of Dentistry, Meikai University, Sakado 350-0238, Saitama, Japan., Uesawa Y; Department of Medical Molecular Informatics, Meiji Pharmaceutical University, Tokyo 204-858, Japan., Roayapalley PK; College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, SK S7N 5C9, Canada., Dimmock JR; College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, SK S7N 5C9, Canada.

Publikováno v: Medicines (Basel, Switzerland) [Medicines (Basel)] 2024 Oct 30; Vol. 11 (8). Date of Electronic Publication: 2024 Oct 30.

Anticonvulsant Properties of 1-Diethylamino-3-phenylprop-2-en-1-one.

Autor: Das S; Drug Discovery and Development Research Group, University of Saskatchewan, Saskatoon, SK S7N 5E5, Canada., Roayapalley PK; Drug Discovery and Development Research Group, University of Saskatchewan, Saskatoon, SK S7N 5E5, Canada., Vashishtha SC; Drug Discovery and Development Research Group, University of Saskatchewan, Saskatoon, SK S7N 5E5, Canada., Das U; Drug Discovery and Development Research Group, University of Saskatchewan, Saskatoon, SK S7N 5E5, Canada., Dimmock JR; Drug Discovery and Development Research Group, University of Saskatchewan, Saskatoon, SK S7N 5E5, Canada.

Publikováno v: Medicines (Basel, Switzerland) [Medicines (Basel)] 2023 Sep 08; Vol. 10 (9). Date of Electronic Publication: 2023 Sep 08.

Novel Unsymmetric 3,5-Bis(benzylidene)-4-piperidones That Display Tumor-Selective Toxicity.

Autor: Chhikara A; Department of Chemistry, Dyal Singh College, University of Delhi, New Delhi 110003, India., Roayapalley PK; Drug Discovery and Development Research Cluster, College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, SK S7N 5E5, Canada., Sakagami H; School of Dentistry, Meikai University, Sakado 350-0283, Japan., Amano S; School of Dentistry, Meikai University, Sakado 350-0283, Japan., Satoh K; School of Dentistry, Meikai University, Sakado 350-0283, Japan., Uesawa Y; Department of Medical Molecular Informatics, Meiji Pharmaceutical University, Tokyo 204-8588, Japan., Das U; Drug Discovery and Development Research Cluster, College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, SK S7N 5E5, Canada., Das S; Drug Discovery and Development Research Cluster, College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, SK S7N 5E5, Canada., Borrego EA; Department of Biological Sciences and Border Biomedical Research Center, The University of Texas at El Paso, El Paso, TX 79968-0519, USA., Guerena CD; Department of Biological Sciences and Border Biomedical Research Center, The University of Texas at El Paso, El Paso, TX 79968-0519, USA., Hernandez CR; Department of Biological Sciences and Border Biomedical Research Center, The University of Texas at El Paso, El Paso, TX 79968-0519, USA., Aguilera RJ; Department of Biological Sciences and Border Biomedical Research Center, The University of Texas at El Paso, El Paso, TX 79968-0519, USA., Dimmock JR; Drug Discovery and Development Research Cluster, College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, SK S7N 5E5, Canada.

Publikováno v: Molecules (Basel, Switzerland) [Molecules] 2022 Oct 09; Vol. 27 (19). Date of Electronic Publication: 2022 Oct 09.

Cytotoxic benzylidene hydrazides of terephthalic acid and related compounds.

Autor: Hossain M; School of Sciences, Indiana University Kokomo, Kokomo, USA;, Email: mohoss@iu.edu., Hall SC; School of Sciences, Indiana University Kokomo, Kokomo, USA., Wiggington PJ; School of Sciences, Indiana University Kokomo, Kokomo, USA., Roth SM; School of Sciences, Indiana University Kokomo, Kokomo, USA., Das S; Drug Discovery and Development Research Group, College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, Canada., Das U; Drug Discovery and Development Research Group, College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, Canada., Roayapalley PK; Drug Discovery and Development Research Group, College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, Canada., Dimmock JR; Drug Discovery and Development Research Group, College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, Canada.

Publikováno v: Die Pharmazie [Pharmazie] 2022 Apr 10; Vol. 77 (3), pp. 90-94.

Cytotoxic Tumour-Selective 1,5-Diaryl-3-Oxo-1,4-Pentadienes Mounted on a Piperidine Ring.

Autor: Roayapalley PK; Drug Discovery and Development Research Group, University of Saskatchewan, Saskatoon, SK S7N 5E5, Canada., Sakagami H; School of Dentistry, Meikai University, Sakado, Saitama 350-0283, Japan., Satoh K; School of Dentistry, Meikai University, Sakado, Saitama 350-0283, Japan., Amano S; School of Dentistry, Meikai University, Sakado, Saitama 350-0283, Japan., Bandow K; School of Dentistry, Meikai University, Sakado, Saitama 350-0283, Japan., Aguilera RJ; Department of Biological Sciences and Border Biomedical Research Center, The University of Texas at El Paso, El Paso, TX 79968-0519, USA., Hernandez KGC; Department of Biological Sciences and Border Biomedical Research Center, The University of Texas at El Paso, El Paso, TX 79968-0519, USA., Schiaffino Bustamante AY; Department of Biological Sciences and Border Biomedical Research Center, The University of Texas at El Paso, El Paso, TX 79968-0519, USA., Dimmock SG; Department of Finance, National University of Singapore, Singapore 119245, Singapore., Sharma RK; Department of Pathology and Laboratory Medicine, College of Medicine, University of Saskatchewan, Saskatoon, SK S7N 0W8, Canada., Das U; Drug Discovery and Development Research Group, University of Saskatchewan, Saskatoon, SK S7N 5E5, Canada., Dimmock JR; Drug Discovery and Development Research Group, University of Saskatchewan, Saskatoon, SK S7N 5E5, Canada.

Publikováno v: Medicines (Basel, Switzerland) [Medicines (Basel)] 2021 Dec 16; Vol. 8 (12). Date of Electronic Publication: 2021 Dec 16.