Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Roarke A. Kamber"'
Autor:
S. John Liu, Christopher Zou, Joanna Pak, Alexandra Morse, Dillon Pang, Timothy Casey-Clyde, Ashir A. Borah, David Wu, Kyounghee Seo, Thomas O’Loughlin, Daniel A. Lim, Tomoko Ozawa, Mitchel S. Berger, Roarke A. Kamber, William A. Weiss, David R. Raleigh, Luke A. Gilbert
Publikováno v:
Genome Biology, Vol 25, Iss 1, Pp 1-32 (2024)
Abstract Background Genetic perturbation screens with single-cell readouts have enabled rich phenotyping of gene function and regulatory networks. These approaches have been challenging in vivo, especially in adult disease models such as cancer, whic
Externí odkaz:
https://doaj.org/article/ce15256d82df4ae7a07d376548cbf5c6
Publikováno v:
eLife, Vol 11 (2022)
Autophagy receptor (or adaptor) proteins facilitate lysosomal destruction of various organelles in response to cellular stress, including nutrient deprivation. To what extent membrane-resident autophagy receptors also respond to organelle-restricted
Externí odkaz:
https://doaj.org/article/3a3574a0dde44d9bb79b91762f3e75d5
Autor:
Josh Tycko, Mike V. Van, null Aradhana, Nicole DelRosso, David Yao, Xiaoshu Xu, Connor Ludwig, Kaitlyn Spees, Katherine Liu, Gaelen T Hess, Mingxin Gu, Adi Xiyal Mukund, Peter H. Suzuki, Roarke A. Kamber, Lei S. Qi, Lacramioara Bintu, Michael C. Bassik
Human nuclear proteins contain >1000 transcriptional effector domains that can activate or repress transcription of target genes. We lack a systematic understanding of which effector domains regulate transcription robustly across genomic, cell-type,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8262fb71e21225ffdb58e41a337b2483
https://doi.org/10.1101/2023.05.12.540558
https://doi.org/10.1101/2023.05.12.540558
Publikováno v:
eLife, Vol 6 (2017)
Msp1 is a conserved AAA ATPase in budding yeast localized to mitochondria where it prevents accumulation of mistargeted tail-anchored (TA) proteins, including the peroxisomal TA protein Pex15. Msp1 also resides on peroxisomes but it remains unknown h
Externí odkaz:
https://doaj.org/article/423c5120da494857b5884657a9ad6529
Autor:
Amy Li, Jose A. Seoane, Peter K. Jackson, Micah Olivas, Scott W. Simpkins, Grace R. Anderson, Michael C. Bassik, Kaja Kostyrko, Marcus R. Kelly, Christina Curtis, Monte M. Winslow, Andrew J. Gentles, David Yao, Michael M. Dubreuil, Calvin J. Kuo, Keonil Lee, Michael Wainberg, Kaitlyn Spees, Maryam Yousefi, Anshul Kundaje, Kyuho Han, Alejandro Sweet-Cordero, Sarah E. Pierce, Yuan-Hung Lo, Roarke A. Kamber
Publikováno v:
Nature
Cancer genomics studies have identified thousands of putative cancer driver genes1. Development of high-throughput and accurate models to define the functions of these genes is a major challenge. Here we devised a scalable cancer-spheroid model and p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::814a0e6c24f49fbae32a463f81172744
http://europepmc.org/articles/PMC7368463
http://europepmc.org/articles/PMC7368463
Publikováno v:
eLife. 11
Autophagy receptor (or adaptor) proteins facilitate lysosomal destruction of various organelles in response to cellular stress, including nutrient deprivation. To what extent membrane-resident autophagy receptors also respond to organelle-restricted
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0a22bcefd83e7e6a0bfadf5fd72c941
https://pubmed.ncbi.nlm.nih.gov/35404228
https://pubmed.ncbi.nlm.nih.gov/35404228
Autophagy receptor (or adaptor) proteins facilitate lysosomal destruction of various organelles in response to cellular stress, including nutrient deprivation. To what extent membrane-resident autophagy receptors also respond to organelle-restricted
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e1594600df1f13eb8d98296195ff5cf0
https://doi.org/10.1101/2021.10.06.463364
https://doi.org/10.1101/2021.10.06.463364
Autor:
Livnat Jerby-Arnon, Irving L. Weissman, Amira A. Barkal, Felipe Vences-Catalán, Katherine N. Liu, Julien Sage, Kaitlyn Spees, Yoko Nishiga, Roarke A. Kamber, Daniel Fernández, Mingxin Gu, Allison Banuelos, Jose A. Seoane, Sijie Lin, Bhek Morton, Christina Curtis, David Yao, Michael C. Bassik
Publikováno v:
Nature
Monoclonal antibody therapies targeting tumour antigens drive cancer cell elimination in large part by triggering macrophage phagocytosis of cancer cells1–7. However, cancer cells evade phagocytosis using mechanisms that are incompletely understood
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c24eb41b14f474e0ef2bd0031064bd0
https://pubmed.ncbi.nlm.nih.gov/34497417
https://pubmed.ncbi.nlm.nih.gov/34497417
Autor:
Daniel Hornburg, Lihua Jiang, Anna Shcherbina, Roarke A. Kamber, Nasa Sinnott-Armstrong, Robin M. Meyers, Akshay Balsubramani, Anshul Kundaje, Michael Wainberg, Joanne Chan, Ruiqi Jian, Wouter Meuleman, Michael M. Dubreuil, Michael C. Bassik, Kaitlyn Spees, Mingxin Gu, Michael Snyder
Publikováno v:
Nat Genet
A central question in the post-genomic era is how genes interact to form biological pathways. Measurements of gene dependency across hundreds of cell lines have been used to cluster genes into 'co-essential' pathways, but this approach has been limit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba8eef63731dd351f0cf22c204b97d27
https://pubmed.ncbi.nlm.nih.gov/33859415
https://pubmed.ncbi.nlm.nih.gov/33859415