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Age-dependent impact of the major common genetic risk factor for COVID-19 on severity and mortality.
Autor:
Nakanishi T; Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland.; Department of Human Genetics and.; Centre for Clinical Epidemiology, Department of Medicine, Lady Davis Institute, Jewish General Hospital, McGill University, Montréal, Quebec, Canada.; Kyoto-McGill International Collaborative School in Genomic Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan.; Japan Society for the Promotion of Science, Tokyo, Japan., Pigazzini S; Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland.; University of Milano-Bicocca, Milano, Italy., Degenhardt F; Institute of Clinical Molecular Biology, Christian-Albrechts-University, Kiel, Germany., Cordioli M; Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland., Butler-Laporte G; Centre for Clinical Epidemiology, Department of Medicine, Lady Davis Institute, Jewish General Hospital, McGill University, Montréal, Quebec, Canada.; Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montréal, Quebec, Canada., Maya-Miles D; Digestive Diseases Unit, Virgen del Rocio University Hospital, Institute of Biomedicine of Seville, University of Seville, Seville, Spain.; Centro de Investigación Biomédica en Red en Enfermedades Hepáticas y Digestivas (CIBERehd), Instituto de Salud Carlos III (ISCIII), Madrid, Spain., Bujanda L; Department of Liver and Gastrointestinal Diseases, Biodonostia Health Research Institute, Donostia University Hospital, University of the Basque Country (UPV/EHU), CIBERehd, Ikerbasque, San Sebastian, Spain., Bouysran Y; Centre de Génétique Humaine, Hôpital Erasme, Université Libre de Bruxelles (ULB), Brussels, Belgium., Niemi ME; Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland., Palom A; Liver Unit, Department of Internal Medicine, Hospital Universitari Vall d'Hebron, Vall d'Hebron Barcelona Hospital Campus, Barcelona, Spain.; Departament de Medicina: Bellaterra, Universitat Autònoma de Barcelona, Barcelona, Spain.; Liver Diseases, Vall d'Hebron Institut de Recerca (VHIR), Barcelona, Spain., Ellinghaus D; Institute of Clinical Molecular Biology, Christian-Albrechts-University, Kiel, Germany.; Novo Nordisk Foundation Center for Protein Research, Disease Systems Biology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Khan A; Division of Nephrology, Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York, USA., Martínez-Bueno M; GENYO, Centre for Genomics and Oncological Research: Pfizer/University of Granada/Andalusian Regional Government, Granada, Spain., Rolker S; nstitute of Human Genetics, University Hospital Bonn, Medical Faculty University of Bonn, Bonn, Germany., Amitrano S; Genetica Medica, Azienda Ospedaliero-Universitaria Senese, Siena, Italy., Roade Tato L; Centro de Investigación Biomédica en Red en Enfermedades Hepáticas y Digestivas (CIBERehd), Instituto de Salud Carlos III (ISCIII), Madrid, Spain.; Liver Unit, Department of Internal Medicine, Hospital Universitari Vall d'Hebron, Vall d'Hebron Barcelona Hospital Campus, Barcelona, Spain.; Departament de Medicina: Bellaterra, Universitat Autònoma de Barcelona, Barcelona, Spain., Fava F; Genetica Medica, Azienda Ospedaliero-Universitaria Senese, Siena, Italy.; Medical Genetics and.; Med Biotech Hub and Competence Center, Department of Medical Biotechnologies, University of Siena, Italy., Spinner CD; Technical University of Munich, School of Medicine, University Hospital Rechts der Isar, Department of Internal Medicine II, Munich, Germany., Prati D; Department of Transfusion Medicine and Hematology, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Università degli Studi di Milano, Milano, Italy., Bernardo D; Centro de Investigación Biomédica en Red en Enfermedades Hepáticas y Digestivas (CIBERehd), Instituto de Salud Carlos III (ISCIII), Madrid, Spain.; Mucosal Immunology Lab, Unit of Excellence Institute of Biomedicine and Molecular Genetics (IBGM), University of Valladolid-CSIC, Valladolid, Spain., Garcia F; Hospital Universitario Clinico San Cecilio, Granada, Spain.; Instituto de Investigación Ibs.Granada, Granada, Spain., Darcis G; University of Liege, GIGA-Insitute, Liege, Belgium.; Liege University Hospital (CHU of Liege), Liege, Belgium., Fernández-Cadenas I; Stroke Pharmacogenomics and Genetics Group, Biomedical Research Institute Sant Pau (IIB Sant Pau), Barcelona, Spain., Holter JC; Department of Microbiology, Oslo University Hospital, Oslo, Norway.; Institute of Clinical Medicine, University of Oslo, Oslo, Norway., Banales JM; Department of Liver and Gastrointestinal Diseases, Biodonostia Health Research Institute, Donostia University Hospital, University of the Basque Country (UPV/EHU), CIBERehd, Ikerbasque, San Sebastian, Spain.; Department of Biochemistry and Genetics, School of Sciences, University of Navarra, Pamplona, Spain., Frithiof R; Department of Surgical Sciences, Anaesthesiology and Intensive Care Medicine, Uppsala University, Uppsala, Sweden., Kiryluk K; Division of Nephrology, Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York, USA., Duga S; Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy.; IRCCS Humanitas Clinical and Research Hospital, Rozzano, Milan, Italy., Asselta R; Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy.; IRCCS Humanitas Clinical and Research Hospital, Rozzano, Milan, Italy., Pereira AC; Heart Institute (InCor)/University São Paulo Medical School, São Paulo, Brazil., Romero-Gómez M; Digestive Diseases Unit, Virgen del Rocio University Hospital, Institute of Biomedicine of Seville, University of Seville, Seville, Spain.; Centro de Investigación Biomédica en Red en Enfermedades Hepáticas y Digestivas (CIBERehd), Instituto de Salud Carlos III (ISCIII), Madrid, Spain., Nafría-Jiménez B; Osakidetza Basque Health Service, Donostialdea Integrated Health Organisation, Clinical Biochemistry Department, Sebastian, Spain., Hov JR; Department of Microbiology, Oslo University Hospital, Oslo, Norway.; Norwegian PSC Research Center and Section of Gastroenterology, Department of Transplantation Medicine and.; Research Institute of Internal Medicine, Oslo University Hospital, Oslo, Norway., Migeotte I; Centre de Génétique Humaine, Hôpital Erasme, Université Libre de Bruxelles (ULB), Brussels, Belgium.; Fonds de la Recherche Scientifique (FNRS), Brussels, Belgium., Renieri A; Genetica Medica, Azienda Ospedaliero-Universitaria Senese, Siena, Italy.; Medical Genetics and.; Med Biotech Hub and Competence Center, Department of Medical Biotechnologies, University of Siena, Italy., Planas AM; Institute for Biomedical Research of Barcelona (IIBB), National Spanish Research Council (CSIC), Barcelona, Spain.; Institut d'Investigacions Biomediques August Pi i Sunyer (IDIBAPS), Barcelona, Spain., Ludwig KU; nstitute of Human Genetics, University Hospital Bonn, Medical Faculty University of Bonn, Bonn, Germany., Buti M; Centro de Investigación Biomédica en Red en Enfermedades Hepáticas y Digestivas (CIBERehd), Instituto de Salud Carlos III (ISCIII), Madrid, Spain.; Liver Unit, Department of Internal Medicine, Hospital Universitari Vall d'Hebron, Vall d'Hebron Barcelona Hospital Campus, Barcelona, Spain.; Departament de Medicina: Bellaterra, Universitat Autònoma de Barcelona, Barcelona, Spain., Rahmouni S; Instituto de Investigación Ibs.Granada, Granada, Spain., Alarcón-Riquelme ME; GENYO, Centre for Genomics and Oncological Research: Pfizer/University of Granada/Andalusian Regional Government, Granada, Spain.; Institute for Environmental Medicine, Karolinska Institutet, Solna, Sweden., Schulte EC; Institute of Virology, Technical University of Munich/Helmholtz Zentrum München, Munich, Germany.; Institute of Psychiatric Phenomics and Genomics and.; Department of Psychiatry, University Hospital, LMU Munich University, Munich, Germany., Franke A; Institute of Clinical Molecular Biology, Christian-Albrechts-University, Kiel, Germany.; University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany., Karlsen TH; Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; Norwegian PSC Research Center and Section of Gastroenterology, Department of Transplantation Medicine and.; Research Institute of Internal Medicine, Oslo University Hospital, Oslo, Norway., Valenti L; Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Milano, Italy.; Department of Transfusion Medicine and Hematology, Precision Medicine, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milano, Italy., Zeberg H; Department of Neuroscience, Karolinska Institutet, Sweden.; Max-Planck Institute for Evolutionary Anthropology, Leipzig, Germany., Richards JB; Department of Human Genetics and.; Centre for Clinical Epidemiology, Department of Medicine, Lady Davis Institute, Jewish General Hospital, McGill University, Montréal, Quebec, Canada.; Digestive Diseases Unit, Virgen del Rocio University Hospital, Institute of Biomedicine of Seville, University of Seville, Seville, Spain.; Department of Twin Research, King's College London, London, United Kingdom., Ganna A; Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland.; Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Publikováno v:
The Journal of clinical investigation [J Clin Invest] 2021 Dec 01; Vol. 131 (23).