Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Roach KM"'
Autor:
Allen, RJ, Oldham, JM, Jenkins, DA, Leavy, OC, Guillen-Guio, B, Melbourne, CA, Ma, S-F, Jou, J, Kim, JS, CleanUP-IPF Investigators of the Pulmonary Trials Cooperative, Fahy, WA, Oballa, E, Hubbard, RB, Navaratnam, V, Braybrooke, R, Saini, G, Roach, KM, Tobin, MD, Hirani, N, Whyte, MKB, Kaminski, N, Zhang, Y, Martinez, FJ, Linderholm, AL, Adegunsoye, A, Strek, ME, Maher, TM, Molyneaux, PL, Flores, C, Noth, I, Gisli Jenkins, R, Wain, LV
Publikováno v:
Allen, R, Oldman, J, Jenkins, D A, Leavy, O, Flores, C, Noth, I, Jenkins, R G & Wain, L 2022, ' Longitudinal lung function and gas transfer in individuals with idiopathic pulmonary fibrosis: a genome-wide association study ', The Lancet Respiratory Medicine . https://doi.org/10.1016/S2213-2600(22)00251-X
BACKGROUND: Idiopathic pulmonary fibrosis (IPF) is an incurable lung disease characterised by progressive scarring leading to alveolar stiffness, reduced lung capacity, and impeded gas transfer. We aimed to identify genetic variants associated with d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2939e6a1928745deedb847557a47894
https://pubmed.ncbi.nlm.nih.gov/35985358
https://pubmed.ncbi.nlm.nih.gov/35985358
Autor:
Roach, KM, Castells, E, Dixon, K, Mason, S, Elliott, G, Marshall, H, Poblocka, MA, Macip, S, Richardson, M, Khalfaoui, L, Bradding, P
Publikováno v:
Frontiers in Pharmacology; 10/12/2021, Vol. 12, p1-14, 14p
Publikováno v:
Roach, KM; Feghali-Bostwick, C; Wulff, H; Amrani, Y; & Bradding, P. (2015). Human lung myofibroblast TGFβ1-dependent Smad2/3 signalling is Ca2+-dependent and regulated by KCa3.1 K+ channels. Fibrogenesis and Tissue Repair, 8(1). doi: 10.1186/s13069-015-0022-0. UC Davis: Retrieved from: http://www.escholarship.org/uc/item/42f9m2tr
© Roach et al. Background: Idiopathic pulmonary fibrosis (IPF) is a common and invariably lethal interstitial lung disease with poorly effective therapy. Blockade of the K+ channel KCa3.1 reduces constitutive α-SMA and Smad2/3 nuclear translocation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______325::17b75e4f8deef3af5dd1e829696df124
http://www.escholarship.org/uc/item/42f9m2tr
http://www.escholarship.org/uc/item/42f9m2tr
Publikováno v:
Roach, KM; Wulff, H; Feghali-Bostwick, C; Amrani, Y; & Bradding, P. (2014). Increased constitutive αSMA and Smad2/3 expression in idiopathic pulmonary fibrosis myofibroblasts is KCa3.1-dependent. Respiratory Research, 15(1), 155. doi: 10.1186/s12931-014-0155-5. UC Davis: Retrieved from: http://www.escholarship.org/uc/item/4cb1z533
© 2014 Roach et al.; licensee BioMed Central Ltd. Background: Idiopathic pulmonary fibrosis is a common and invariably fatal disease with limited therapeutic options. Ca2+-activated KCa3.1 potassium channels play a key role in promoting TGFβ1 and b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______325::0fd5939fe4ae43bcbc71943142aef190
http://www.escholarship.org/uc/item/4cb1z533
http://www.escholarship.org/uc/item/4cb1z533
Publikováno v:
PLoS ONE, vol 9, iss 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______325::84f0587212103414dbfc85dae4e42aff
https://escholarship.org/uc/item/75c216d9
https://escholarship.org/uc/item/75c216d9
Publikováno v:
Roach, KM; Duffy, SM; Coward, W; Feghali-Bostwick, C; Wulff, H; & Bradding, P. (2013). The K+channel KCa3.1 as a novel target for idiopathic pulmonary fibrosis. PLoS ONE, 8(12). doi: 10.1371/journal.pone.0085244. UC Davis: Retrieved from: http://www.escholarship.org/uc/item/7hm3t31q
Background: Idiopathic pulmonary fibrosis (IPF) is a common, progressive and invariably lethal interstitial lung disease with no effective therapy. We hypothesised that KCa3.1 K+channel-dependent cell processes contribute to IPF pathophysiology. Meth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______325::7a16f6bc97d3002077efdc3ad5aeafb1
http://www.escholarship.org/uc/item/7hm3t31q
http://www.escholarship.org/uc/item/7hm3t31q
Autor:
Allen RJ; Department of Health Sciences, University of Leicester, Leicester, UK. Electronic address: rja34@leicester.ac.uk., Oldham JM; Division of Pulmonary and Critical Care Medicine, University of Michigan, Ann Arbor, MI, USA., Jenkins DA; Division of Informatics, Imaging & Data Sciences, University of Manchester, Manchester, UK., Leavy OC; Department of Health Sciences, University of Leicester, Leicester, UK., Guillen-Guio B; Department of Health Sciences, University of Leicester, Leicester, UK., Melbourne CA; Department of Health Sciences, University of Leicester, Leicester, UK., Ma SF; Division of Pulmonary & Critical Care Medicine, University of Virginia, Charlottesville, VA, USA., Jou J; Department of Surgery, University of Illinois College of Medicine at Peoria, Peoria, IL, USA., Kim JS; Division of Pulmonary & Critical Care Medicine, University of Virginia, Charlottesville, VA, USA., Fahy WA; Discovery Medicine, GlaxoSmithKline, Stevenage, UK., Oballa E; Discovery Medicine, GlaxoSmithKline, Stevenage, UK., Hubbard RB; Division of Epidemiology and Public Health, University of Nottingham, Nottingham, UK; National Institute for Health Research, Nottingham Biomedical Research Centre, Nottingham University Hospitals NHS Trust, Nottingham, UK., Navaratnam V; Division of Epidemiology and Public Health, University of Nottingham, Nottingham, UK; National Institute for Health Research, Nottingham Biomedical Research Centre, Nottingham University Hospitals NHS Trust, Nottingham, UK; Queensland Lung Transplant Service, The Prince Charles Hospital, Brisbane, QLD, Australia., Braybrooke R; Division of Epidemiology and Public Health, University of Nottingham, Nottingham, UK; National Institute for Health Research, Nottingham Biomedical Research Centre, Nottingham University Hospitals NHS Trust, Nottingham, UK., Saini G; Respiratory Medicine, Nottingham University Hospitals NHS Trust, Nottingham, UK., Roach KM; Department of Respiratory Sciences, University of Leicester, Glenfield Hospital, Leicester, UK., Tobin MD; Department of Health Sciences, University of Leicester, Leicester, UK., Hirani N; Centre for Inflammation Research, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK., Whyte MKB; Centre for Inflammation Research, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK., Kaminski N; Section of Pulmonary, Critical Care and Sleep Medicine, Yale School of Medicine, New Haven, CT, USA., Zhang Y; Division of Pulmonary, Allergy and Critical Care Medicine, The University of Pittsburgh, Pittsburgh, PA, USA., Martinez FJ; Division of Pulmonary and Critical Care Medicine, Weill Cornell Medicine, New York, NY, USA., Linderholm AL; Department of Internal Medicine, University of California Davis, Davis, CA, USA., Adegunsoye A; Section of Pulmonary and Critical Care Medicine, University of Chicago, Chicago, IL, USA., Strek ME; Section of Pulmonary and Critical Care Medicine, University of Chicago, Chicago, IL, USA., Maher TM; National Heart and Lung Institute, Imperial College London, London, UK; Royal Brompton and Harefield Hospitals, London, UK; Division of Pulmonary and Critical Care Medicine, University of Southern California, Los Angeles, CA, USA., Molyneaux PL; National Heart and Lung Institute, Imperial College London, London, UK; Royal Brompton and Harefield Hospitals, London, UK., Flores C; Research Unit, Hospital Universitario Nuestra Señora de Candelaria, Santa Cruz de Tenerife, Spain; CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain; Genomics Division, Instituto Tecnológico y de Energías Renovables, Santa Cruz de Tenerife, Spain., Noth I; Division of Pulmonary & Critical Care Medicine, University of Virginia, Charlottesville, VA, USA., Gisli Jenkins R; National Heart and Lung Institute, Imperial College London, London, UK., Wain LV; Department of Health Sciences, University of Leicester, Leicester, UK; National Institute for Health Research, Leicester Respiratory Biomedical Research Centre, Glenfield Hospital, Leicester, UK.
Publikováno v:
The Lancet. Respiratory medicine [Lancet Respir Med] 2023 Jan; Vol. 11 (1), pp. 65-73. Date of Electronic Publication: 2022 Aug 16.
Autor:
Alzahrani A; Department of Respiratory Sciences, Clinical Sciences, University of Leicester, Glenfield Hospital, Leicester, United Kingdom.; Department of Applied Medical Sciences, Applied College, Albaha University, Albaha, Saudi Arabia., Hakeem J; Department of Respiratory Sciences, Clinical Sciences, University of Leicester, Glenfield Hospital, Leicester, United Kingdom., Biddle M; Department of Respiratory Sciences, Clinical Sciences, University of Leicester, Glenfield Hospital, Leicester, United Kingdom., Alhadian F; Department of Respiratory Sciences, Clinical Sciences, University of Leicester, Glenfield Hospital, Leicester, United Kingdom., Hussain A; Department of Respiratory Sciences, Clinical Sciences, University of Leicester, Glenfield Hospital, Leicester, United Kingdom., Khalfaoui L; Department of Respiratory Sciences, Clinical Sciences, University of Leicester, Glenfield Hospital, Leicester, United Kingdom., Roach KM; Department of Respiratory Sciences, Clinical Sciences, University of Leicester, Glenfield Hospital, Leicester, United Kingdom., Tliba O; Department of Biomedical Sciences, College of Veterinary Medicine, Long Island University, Brookville, NY, United States., Bradding P; Department of Respiratory Sciences, Clinical Sciences, University of Leicester, Glenfield Hospital, Leicester, United Kingdom., Amrani Y; Department of Respiratory Sciences, Clinical Sciences, University of Leicester, Glenfield Hospital, Leicester, United Kingdom.
Publikováno v:
Frontiers in allergy [Front Allergy] 2021 Dec 29; Vol. 2, pp. 785100. Date of Electronic Publication: 2021 Dec 29 (Print Publication: 2021).
Autor:
Virk HS; NIHR Respiratory BRC, Department of Respiratory Sciences, University of Leicester, Leicester, UK., Biddle MS; NIHR Respiratory BRC, Department of Respiratory Sciences, University of Leicester, Leicester, UK., Smallwood DT; School of Allied Health Sciences, De Montfort University, Leicester, UK., Weston CA; NIHR Respiratory BRC, Department of Respiratory Sciences, University of Leicester, Leicester, UK., Castells E; NIHR Respiratory BRC, Department of Respiratory Sciences, University of Leicester, Leicester, UK., Bowman VW; School of Allied Health Sciences, De Montfort University, Leicester, UK., McCarthy J; NIHR Respiratory BRC, Department of Respiratory Sciences, University of Leicester, Leicester, UK., Amrani Y; NIHR Respiratory BRC, Department of Respiratory Sciences, University of Leicester, Leicester, UK., Duffy SM; NIHR Respiratory BRC, Department of Respiratory Sciences, University of Leicester, Leicester, UK., Bradding P; NIHR Respiratory BRC, Department of Respiratory Sciences, University of Leicester, Leicester, UK., Roach KM; NIHR Respiratory BRC, Department of Respiratory Sciences, University of Leicester, Leicester, UK.
Publikováno v:
British journal of pharmacology [Br J Pharmacol] 2021 Aug; Vol. 178 (15), pp. 2948-2962. Date of Electronic Publication: 2021 May 25.
Autor:
Campiani G; Department of Biotechnology, Chemistry and Pharmacy, DoE Department of Excellence 2018-2022, University of Siena, via Aldo Moro 2, 53100 Siena, Italy., Cavella C; Department of Biotechnology, Chemistry and Pharmacy, DoE Department of Excellence 2018-2022, University of Siena, via Aldo Moro 2, 53100 Siena, Italy., Osko JD; Roy and Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6323, United States., Brindisi M; Department of Biotechnology, Chemistry and Pharmacy, DoE Department of Excellence 2018-2022, University of Siena, via Aldo Moro 2, 53100 Siena, Italy., Relitti N; Department of Biotechnology, Chemistry and Pharmacy, DoE Department of Excellence 2018-2022, University of Siena, via Aldo Moro 2, 53100 Siena, Italy., Brogi S; Department of Pharmacy, University of Pisa, via Bonanno 6, 56126 Pisa, Italy., Saraswati AP; Department of Biotechnology, Chemistry and Pharmacy, DoE Department of Excellence 2018-2022, University of Siena, via Aldo Moro 2, 53100 Siena, Italy., Federico S; Department of Biotechnology, Chemistry and Pharmacy, DoE Department of Excellence 2018-2022, University of Siena, via Aldo Moro 2, 53100 Siena, Italy., Chemi G; Department of Biotechnology, Chemistry and Pharmacy, DoE Department of Excellence 2018-2022, University of Siena, via Aldo Moro 2, 53100 Siena, Italy., Maramai S; Department of Biotechnology, Chemistry and Pharmacy, DoE Department of Excellence 2018-2022, University of Siena, via Aldo Moro 2, 53100 Siena, Italy., Carullo G; Department of Biotechnology, Chemistry and Pharmacy, DoE Department of Excellence 2018-2022, University of Siena, via Aldo Moro 2, 53100 Siena, Italy., Jaeger B; Klinik für Pneumologie, Medizinische Hochschule Hannover, Carl-Neuberg-Str. 1, Hannover 30625, Germany., Carleo A; Klinik für Pneumologie, Medizinische Hochschule Hannover, Carl-Neuberg-Str. 1, Hannover 30625, Germany., Benedetti R; Department of Precision Medicine, University of Campania Luigi Vanvitelli, Vico L. de Crecchio 7, 80138 Naples, Italy., Sarno F; Department of Precision Medicine, University of Campania Luigi Vanvitelli, Vico L. de Crecchio 7, 80138 Naples, Italy., Lamponi S; Department of Biotechnology, Chemistry and Pharmacy, DoE Department of Excellence 2018-2022, University of Siena, via Aldo Moro 2, 53100 Siena, Italy., Rottoli P; Specialization School of Respiratory Diseases, Department of Medical Sciences, Surgery and Neurosciences, Centro didattico Le Scotte, University of Siena, 53100 Siena, Italy., Bargagli E; Department of Medical Sciences, Surgery and Neurosciences, Respiratory Diseases Unit, AOUS, Centro didattico Le Scotte, University of Siena, 53100 Siena, Italy., Bertucci C; Department of Pharmacy and Biotechnology, University of Bologna, Via Belmeloro, 6, Bologna 40126, Italy., Tedesco D; Department of Pharmacy and Biotechnology, University of Bologna, Via Belmeloro, 6, Bologna 40126, Italy., Herp D; Institute of Pharmaceutical Sciences, Albert-Ludwigs-Universität Freiburg, Albertstraße 25, 79104 Freiburg, Germany., Senger J; Institute of Pharmaceutical Sciences, Albert-Ludwigs-Universität Freiburg, Albertstraße 25, 79104 Freiburg, Germany., Ruberti G; Institute of Biochemistry and Cell Biology (IBBC), National Research Council (CNR), via E. Ramarini 32, 00015 Monterotondo (Rome), Italy., Saccoccia F; Institute of Biochemistry and Cell Biology (IBBC), National Research Council (CNR), via E. Ramarini 32, 00015 Monterotondo (Rome), Italy., Saponara S; Department of Life Sciences, University of Siena, via Aldo Moro 2, I-53100 Siena, Italy., Gorelli B; Department of Life Sciences, University of Siena, via Aldo Moro 2, I-53100 Siena, Italy., Valoti M; Department of Life Sciences, University of Siena, via Aldo Moro 2, I-53100 Siena, Italy., Kennedy B; UCD School of Biomolecular and Biomedical Science, UCD Conway Institute, University College Dublin, D04 V1W8 Dublin, Ireland., Sundaramurthi H; UCD School of Biomolecular and Biomedical Science, UCD Conway Institute, University College Dublin, D04 V1W8 Dublin, Ireland., Butini S; Department of Biotechnology, Chemistry and Pharmacy, DoE Department of Excellence 2018-2022, University of Siena, via Aldo Moro 2, 53100 Siena, Italy., Jung M; Institute of Pharmaceutical Sciences, Albert-Ludwigs-Universität Freiburg, Albertstraße 25, 79104 Freiburg, Germany., Roach KM; Department of Respiratory Sciences, University of Leicester, UK, Institute of Lung Health and NIHR Leicester BRC-Respiratory, LE5 4PW Leicester, U.K., Altucci L; Department of Precision Medicine, University of Campania Luigi Vanvitelli, Vico L. de Crecchio 7, 80138 Naples, Italy., Bradding P; Department of Respiratory Sciences, University of Leicester, UK, Institute of Lung Health and NIHR Leicester BRC-Respiratory, LE5 4PW Leicester, U.K., Christianson DW; Roy and Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6323, United States., Gemma S; Department of Biotechnology, Chemistry and Pharmacy, DoE Department of Excellence 2018-2022, University of Siena, via Aldo Moro 2, 53100 Siena, Italy., Prasse A; Klinik für Pneumologie, Medizinische Hochschule Hannover, Carl-Neuberg-Str. 1, Hannover 30625, Germany.
Publikováno v:
Journal of medicinal chemistry [J Med Chem] 2021 Jul 22; Vol. 64 (14), pp. 9960-9988. Date of Electronic Publication: 2021 Jul 12.