β-hydroxybutyrate is a metabolic regulator of proteostasis in the aged and Alzheimer disease brain.

Autor: Madhavan SS; Buck Institute for Research on Aging, Novato, CA 94945, USA; Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA 90089, USA; Division of Geriatrics, University of California, San Francisco, San Francisco, CA 94118, USA., Roa Diaz S; Buck Institute for Research on Aging, Novato, CA 94945, USA; Division of Geriatrics, University of California, San Francisco, San Francisco, CA 94118, USA., Peralta S; Buck Institute for Research on Aging, Novato, CA 94945, USA., Nomura M; Buck Institute for Research on Aging, Novato, CA 94945, USA., King CD; Buck Institute for Research on Aging, Novato, CA 94945, USA., Ceyhan KE; Buck Institute for Research on Aging, Novato, CA 94945, USA., Lin A; Buck Institute for Research on Aging, Novato, CA 94945, USA., Bhaumik D; Buck Institute for Research on Aging, Novato, CA 94945, USA., Foulger AC; Buck Institute for Research on Aging, Novato, CA 94945, USA., Shah S; Buck Institute for Research on Aging, Novato, CA 94945, USA., Blade T; Buck Institute for Research on Aging, Novato, CA 94945, USA., Gray W; Buck Institute for Research on Aging, Novato, CA 94945, USA., Chamoli M; Buck Institute for Research on Aging, Novato, CA 94945, USA., Eap B; Buck Institute for Research on Aging, Novato, CA 94945, USA; Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA 90089, USA., Panda O; Buck Institute for Research on Aging, Novato, CA 94945, USA., Diaz D; Buck Institute for Research on Aging, Novato, CA 94945, USA., Garcia TY; Buck Institute for Research on Aging, Novato, CA 94945, USA; Division of Geriatrics, University of California, San Francisco, San Francisco, CA 94118, USA., Stubbs BJ; Buck Institute for Research on Aging, Novato, CA 94945, USA., Ulrich SM; Department of Chemistry, Ithaca College, Ithaca, NY 14850, USA., Lithgow GJ; Buck Institute for Research on Aging, Novato, CA 94945, USA; Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA 90089, USA., Schilling B; Buck Institute for Research on Aging, Novato, CA 94945, USA; Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA 90089, USA., Verdin E; Buck Institute for Research on Aging, Novato, CA 94945, USA; Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA 90089, USA., Chaudhuri AR; Buck Institute for Research on Aging, Novato, CA 94945, USA., Newman JC; Buck Institute for Research on Aging, Novato, CA 94945, USA; Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA 90089, USA; Division of Geriatrics, University of California, San Francisco, San Francisco, CA 94118, USA. Electronic address: jnewman@buckinstitute.org.

Publikováno v: Cell chemical biology [Cell Chem Biol] 2024 Nov 25. Date of Electronic Publication: 2024 Nov 25.

Association of biological aging with frailty and post-transplant outcomes among adults with cirrhosis.

Autor: LaHue SC; Department of Neurology, School of Medicine, University of California, San Francisco, CA, USA. sara.lahue@ucsf.edu.; Department of Neurology, UCSF Weill Institute for Neurosciences, University of California, 505 Parnassus Ave, Box 0114, San Francisco, CA, 94143, USA. sara.lahue@ucsf.edu.; Buck Institute for Research On Aging, Novato, CA, USA. sara.lahue@ucsf.edu., Fuentealba M; Buck Institute for Research On Aging, Novato, CA, USA., Roa Diaz S; Buck Institute for Research On Aging, Novato, CA, USA.; Division of Geriatrics, Department of Medicine, School of Medicine, University of California, San Francisco, CA, USA., Seetharaman S; Division of Gastroenterology and Hepatology, Department of Medicine, University of California-San Francisco, San Francisco, CA, USA., Garcia T; Buck Institute for Research On Aging, Novato, CA, USA.; Division of Geriatrics, Department of Medicine, School of Medicine, University of California, San Francisco, CA, USA., Furman D; Buck Institute for Research On Aging, Novato, CA, USA.; Instituto de Investigaciones en Medicina Traslacional, Universidad Austral, Consejo Nacional de Investigaciones Científicas y Técnicas, 1629, Pilar, Argentina.; Stanford 1000 Immunomes Project, Stanford University School of Medicine, Stanford, CA, USA., Lai JC; Division of Gastroenterology and Hepatology, Department of Medicine, University of California-San Francisco, San Francisco, CA, USA., Newman JC; Buck Institute for Research On Aging, Novato, CA, USA.; Division of Geriatrics, Department of Medicine, School of Medicine, University of California, San Francisco, CA, USA.

Publikováno v: GeroScience [Geroscience] 2024 Jun; Vol. 46 (3), pp. 3287-3295. Date of Electronic Publication: 2024 Jan 21.

A randomized open-label, observational study of the novel ketone ester, bis octanoyl (R)-1,3-butanediol, and its acute effect on ß-hydroxybutyrate and glucose concentrations in healthy older adults.

Autor: Stephens EB; Buck Institute for Research on Aging, Novato, CA, USA., Senadheera C; Buck Institute for Research on Aging, Novato, CA, USA., Roa-Diaz S; Buck Institute for Research on Aging, Novato, CA, USA., Peralta S; Buck Institute for Research on Aging, Novato, CA, USA., Alexander L; Buck Institute for Research on Aging, Novato, CA, USA., Silverman-Martin W; Buck Institute for Research on Aging, Novato, CA, USA., Yukawa M; Veteran's Affairs Medical Center, San Francisco, CA, USA., Morris J; Buck Institute for Research on Aging, Novato, CA, USA.; Veteran's Affairs Medical Center, San Francisco, CA, USA.; Independent Researcher, Greenbrae, CA, USA.; Division of Geriatrics, University of California, San Francisco, CA, USA., Johnson JB; Independent Researcher, Greenbrae, CA, USA., Newman JC; Buck Institute for Research on Aging, Novato, CA, USA.; Division of Geriatrics, University of California, San Francisco, CA, USA., Stubbs BJ; Buck Institute for Research on Aging, Novato, CA, USA.

Publikováno v: MedRxiv : the preprint server for health sciences [medRxiv] 2024 Apr 18. Date of Electronic Publication: 2024 Apr 18.

β-hydroxybutyrate is a metabolic regulator of proteostasis in the aged and Alzheimer disease brain.

Autor: Madhavan SS; Buck Institute for Research on Aging, Novato, CA, USA.; Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA.; Department of Geriatrics, University of California San Francisco, San Francisco, CA, USA., Roa Diaz S; Buck Institute for Research on Aging, Novato, CA, USA.; Department of Geriatrics, University of California San Francisco, San Francisco, CA, USA., Peralta S; Buck Institute for Research on Aging, Novato, CA, USA., Nomura M; Buck Institute for Research on Aging, Novato, CA, USA., King CD; Buck Institute for Research on Aging, Novato, CA, USA., Lin A; Buck Institute for Research on Aging, Novato, CA, USA., Bhaumik D; Buck Institute for Research on Aging, Novato, CA, USA., Shah S; Buck Institute for Research on Aging, Novato, CA, USA., Blade T; Buck Institute for Research on Aging, Novato, CA, USA., Gray W; Buck Institute for Research on Aging, Novato, CA, USA., Chamoli M; Buck Institute for Research on Aging, Novato, CA, USA., Eap B; Buck Institute for Research on Aging, Novato, CA, USA.; Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA., Panda O; Buck Institute for Research on Aging, Novato, CA, USA., Diaz D; Buck Institute for Research on Aging, Novato, CA, USA., Garcia TY; Buck Institute for Research on Aging, Novato, CA, USA.; Department of Geriatrics, University of California San Francisco, San Francisco, CA, USA., Stubbs BJ; Buck Institute for Research on Aging, Novato, CA, USA., Lithgow GJ; Buck Institute for Research on Aging, Novato, CA, USA.; Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA., Schilling B; Buck Institute for Research on Aging, Novato, CA, USA.; Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA., Verdin E; Buck Institute for Research on Aging, Novato, CA, USA.; Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA., Chaudhuri AR; Buck Institute for Research on Aging, Novato, CA, USA., Newman JC; Buck Institute for Research on Aging, Novato, CA, USA.; Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA.; Department of Geriatrics, University of California San Francisco, San Francisco, CA, USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2023 Jul 03. Date of Electronic Publication: 2023 Jul 03.

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