Zobrazeno 1 - 10
of 298
pro vyhledávání: '"Ro15‐4513"'
Autor:
Nisha Singh, Amanda Kiemes, Diana Cash, Gemma Modinos, Anthony C. Vernon, Alba Peris-Yague, Marie-Caroline Cotel
Publikováno v:
European Neuropsychopharmacology. 41:106-117
Post-mortem studies suggest that schizophrenia is associated with abnormal expression of specific GABAA receptor (GABAAR) α subunits, including α5GABAAR. Positron emission tomography (PET) measures of GABAAR availability in schizophrenia, however,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e05d8dab22b9701f57046c1df0d3d4d
https://doi.org/10.1016/j.euroneuro.2020.10.004
https://doi.org/10.1016/j.euroneuro.2020.10.004
Autor:
Matthias J. Koepp, Colm J. McGinnity, Jane de Tisi, Siti N. Yaakub, John S. Duncan, Rainer Hinz, Alexander Hammers, Anne Lingford-Hughes, Charlotte Thyssen, Rolf A. Heckemann, Daniela A. Riaño Barros, Jim Myers, Josemir W. Sander
Publikováno v:
Mcginnity, C J, Riaño Barros, D A, Hinz, R, Myers, J F, Yaakub, S N, Thyssen, C, Heckemann, R A, De Tisi, J, Duncan, J S, Sander, J W, Lingford-hughes, A, Koepp, M J & Hammers, A 2021, ' Αlpha 5 subunit-containing GABAA receptors in temporal lobe epilepsy with normal MRI ', Brain Communications, vol. 3, no. 1, fcaa190 . https://doi.org/10.1093/braincomms/fcaa190
GABAA receptors containing the α5 subunit mediate tonic inhibition and are widely expressed in the limbic system. In animals, activation of α5-containing receptors impairs hippocampus-dependent memory. Temporal lobe epilepsy is associated with memo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c32dd49a21ff91882d56023586a8441b
https://doi.org/10.1093/braincomms/fcaa190
https://doi.org/10.1093/braincomms/fcaa190
Autor:
Sangeetha V. Iyer, Rodrigo eBenavides, Dev eChandra, James M Cook, Sundari eRallapalli, Harry L. June, Gregg E Homanics
Publikováno v:
Frontiers in Pharmacology, Vol 2 (2011)
Alcohol (ethanol) is widely consumed for its desirable effects but unfortunately has strong addiction potential. Some imidazobenzodiazepines such as Ro15-4513 are able to antagonize many ethanol-induced behaviors. Controversial biochemical and pharma
Externí odkaz:
https://doaj.org/article/d11fa9e153f94213a94ba85cfec4c44a
Autor:
Colm J, McGinnity, Daniela A, Riaño Barros, Rainer, Hinz, James F, Myers, Siti N, Yaakub, Charlotte, Thyssen, Rolf A, Heckemann, Jane, de Tisi, John S, Duncan, Josemir W, Sander, Anne, Lingford-Hughes, Matthias J, Koepp, Alexander, Hammers
Publikováno v:
Brain Communications
GABAA receptors containing the α5 subunit mediate tonic inhibition and are widely expressed in the limbic system. In animals, activation of α5-containing receptors impairs hippocampus-dependent memory. Temporal lobe epilepsy is associated with memo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::cd9488230833338ff0564cf830139bc0
https://pubmed.ncbi.nlm.nih.gov/33501420
https://pubmed.ncbi.nlm.nih.gov/33501420
Autor:
Jakob Udby Blicher, Kim V. Hansen, Kim Mouridsen, Arne Møller, Hans C. Lou, David J. Brooks, Kristine Rømer Thomsen
Publikováno v:
Brain and Behavior
Møller, A, Rømer Thomsen, K, Brooks, D J, Mouridsen, K, Blicher, J U, Hansen, K V & Lou, H C 2019, ' Attenuation of dopamine-induced GABA release in problem gamblers ', Brain and Behavior, vol. 9, no. 3, e01239 . https://doi.org/10.1002/brb3.1239
Møller, A, Rømer Thomsen, K, Brooks, D J, Mouridsen, K, Blicher, J U, Hansen, K V & Lou, H C 2019, ' Attenuation of dopamine-induced GABA release in problem gamblers ', Brain and Behavior, vol. 9, no. 3, e01239 . https://doi.org/10.1002/brb3.1239
INTRODUCTION: We have previously shown that an interaction between medial prefrontal and parietal cortices is instrumental in promoting self-awareness via synchronizing oscillations in the gamma range. The synchronization of these oscillations is mod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e93470a1f2c5d1de522933210c04ff2
https://doi.org/10.1002/brb3.1239
https://doi.org/10.1002/brb3.1239
Akademický článek
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Autor:
Amanda Kiemes, Nisha Singh, Diana Cash, Felipe V. Gomes, Anthony A. Grace, Gemma Modinos, Federico Turkheimer
Publikováno v:
Schizophrenia Bulletin
Background Post-mortem studies in schizophrenia patients have repeatedly found abnormalities in the γ-aminobutyric acid (GABA) inhibitory neurotransmission system in the form of parvalbumin (PV)-expressing GABAergic interneuron reduction and aberran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f743152eb1191d7684ecf322f1f3df7
http://europepmc.org/articles/PMC7234682
http://europepmc.org/articles/PMC7234682
Autor:
Amanda Kiemes, Gemma Modinos, Anthony C. Vernon, Alba Peris-Yague, Marie-Caroline Cotel, Nisha Singh, Diana Cash
Publikováno v:
Schizophrenia Bulletin
Background Post-mortem studies in schizophrenia (SZ) have reported abnormalities in the GABAergic system, more specifically, on αGABA-A receptors (αGABA-A R) (Benes, Kwok, Vincent, & Todtenkopf, 1998; Beneyto, Abbott, Hashimoto, & Lewis, 2011). Con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::991de131b4fef569c1fdb4398b48dced
https://doi.org/10.1093/schbul/sbaa029.769
https://doi.org/10.1093/schbul/sbaa029.769
Autor:
Jørgen Scheel-Krüger, Karina H. Vase, Anne M. Landau, Jan Jacobsen, Freja Bertelsen, Arne Møller
Publikováno v:
Bertelsen, F, Landau, A M, Vase, K H, Jacobsen, J, Scheel-Krüger, J & Møller, A 2018, ' Acute in vivo effect of valproic acid on the GABAergic system in rat brain : A [C-11]Ro15-4513 microPET study ', Brain Research, vol. 1680, pp. 110-114 . https://doi.org/10.1016/j.brainres.2017.12.018
γ-Aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the nervous system acting mainly through GABAA receptors. In the presence of high levels of GABA, an allosteric shift in the GABAA receptors can change the affinity of benzodia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1be58d8ccee7acd95f1e4052a2ded520
https://pure.au.dk/portal/da/publications/acute-in-vivo-effect-of-valproic-acid-on-the-gabaergic-system-in-rat-brain(416d9d9b-2ddc-4a35-811a-b0fb70756175).html
https://pure.au.dk/portal/da/publications/acute-in-vivo-effect-of-valproic-acid-on-the-gabaergic-system-in-rat-brain(416d9d9b-2ddc-4a35-811a-b0fb70756175).html
Publikováno v:
Psychopharmacology. 233:715-725
There is an emerging body of evidence that implicates a crucial role of γ-aminobutyric acid subtype A (GABAA) receptors in modulating the rewarding effects of a number of abused drugs. Modulation of GABAA receptors may therefore represent a novel dr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5d35e1dae5dc9e647a8df683132730f
https://doi.org/10.1007/s00213-015-4155-z
https://doi.org/10.1007/s00213-015-4155-z