Zobrazeno 1 - 10
of 75
pro vyhledávání: '"Ro 25-6981"'
Publikováno v:
Pharmaceutics, Vol 13, Iss 9, p 1482 (2021)
The GluN2B subunit of NMDA receptors represents a perspective therapeutic target in various CNS pathologies, including epilepsy. Because of its predominant expression in the immature brain, selective GluN2B antagonists are expected to be more effecti
Externí odkaz:
https://doaj.org/article/e3f59e41c636488aa51e4a0706d95700
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 13, p 4791 (2020)
Clinical and preclinical studies indicate that zinc (Zn) is an essential factor in the development and treatment of major depressive disorder (MDD). Conventional monoamine-based antidepressants mobilize zinc in the blood and brain of depressed patien
Externí odkaz:
https://doaj.org/article/9ddc55bece2545c5a721d7a64bb64933
Publikováno v:
Neurobiology of Disease, Vol 54, Iss , Pp 183-193 (2013)
Impairment of synaptic plasticity such as long-term potentiation (LTP) is a common finding in various animal models of a number of neurodegenerative disorders. While cognitive deficits associated with these models are plausibly attributed to impaired
Externí odkaz:
https://doaj.org/article/01d69dd7f4144dd18a34e27c62335144
Publikováno v:
Pharmaceutics
Volume 13
Issue 9
Pharmaceutics, Vol 13, Iss 1482, p 1482 (2021)
Volume 13
Issue 9
Pharmaceutics, Vol 13, Iss 1482, p 1482 (2021)
The GluN2B subunit of NMDA receptors represents a perspective therapeutic target in various CNS pathologies, including epilepsy. Because of its predominant expression in the immature brain, selective GluN2B antagonists are expected to be more effecti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38b2ef95643eb93a227c76da5343f375
Publikováno v:
Neurobiology of Disease, Vol 14, Iss 3, Pp 404-416 (2003)
Glutamate receptors were studied in the brains of controls and Parkinson's disease (PD) patients, of which 10 of 14 developed motor complications (dyskinesias and/or wearing-off) following levodopa therapy. 125I-RTI binding to the dopamine transporte
Externí odkaz:
https://doaj.org/article/bceb66a6745e4caeb197056dfa4767a1
Publikováno v:
Frontiers in Behavioral Neuroscience, Vol 7 (2013)
Working memory is a type of short-term memory involved in the maintenance and manipulation of information essential for complex cognition. While memory span capacity has been extensively studied in humans as a measure of working memory, it has receiv
Externí odkaz:
https://doaj.org/article/66fcee8c79574354a9e6197b3f86f273
Akademický článek
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Akademický článek
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Publikováno v:
Neurobiology of Disease, Vol 54, Iss, Pp 183-193 (2013)
Impairment of synaptic plasticity such as long-term potentiation (LTP) is a common finding in various animal models of a number of neurodegenerative disorders. While cognitive deficits associated with these models are plausibly attributed to impaired
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00f614e5f78a25402de93af929e1ec97
https://doi.org/10.1016/j.nbd.2012.12.011
https://doi.org/10.1016/j.nbd.2012.12.011
Autor:
Chris G. Parsons, Mariangela Calcagno, Riccardo Viaro, Flora Mela, Andrzej Dekundy, Mirco Budri, Michele Morari, Yves Auberson, Omar S. Mabrouk
Publikováno v:
ACS Chemical Neuroscience. 4:808-816
Dual probe microdialysis was used to investigate whether GluN2A and GluN2B NMDA receptor subunits regulate striatal output pathways under dyskinetic conditions. The preferential GluN2A antagonist NVP-AAM077 perfused in the dopamine-depleted striatum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85ccf8f2ef249575a29806c655f8fc32
https://doi.org/10.1021/cn400016d
https://doi.org/10.1021/cn400016d