Antithrombins Wibble and Wobble (T85M/K): archetypal conformational diseases with in vivo latent-transition, thrombosis, and heparin activation

Autor: Nj, Beauchamp, Rn, Pike, Daly M, Butler L, Makris M, Tim Dafforn, Zhou A, Hl, Fitton, Fe, Preston, Ir, Peake, Rw, Carrell

Publikováno v: Europe PubMed Central

The inherent variability of conformational diseases is demonstrated by two families with different mutations of the same conserved aminoacid in antithrombin. Threonine 85 underlies the opening of the main beta-sheet of the molecule and its replacemen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::e45f4f9696f0ade92045fd5c17e641c6
http://europepmc.org/abstract/med/9763552

Effect of a protease-activated receptor-2 antagonist (GB88) on inflammation-related loss of alveolar bone in periodontal disease.

Autor: Francis N; Department of Veterinary Biosciences, Melbourne Veterinary School, The University of Melbourne, Parkville, Victoria, Australia., Sanaei R; Department of Veterinary Biosciences, Melbourne Veterinary School, The University of Melbourne, Parkville, Victoria, Australia., Ayodele BA; Department of Veterinary Biosciences, Melbourne Veterinary School, The University of Melbourne, Parkville, Victoria, Australia., O'Brien-Simpson NM; Melbourne Dental School and The Bio21 Institute of Molecular Science and Biotechnology, The University of Melbourne, Parkville, Victoria, Australia., Fairlie DP; ARC Centre of Excellence for Innovations in Peptide and Protein Science, Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, 4072, Australia., Wijeyewickrema LC; Department of Biochemistry and Chemistry, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Victoria, Australia., Pike RN; Department of Biochemistry and Chemistry, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Victoria, Australia., Mackie EJ; Department of Veterinary Biosciences, Melbourne Veterinary School, The University of Melbourne, Parkville, Victoria, Australia., Pagel CN; Department of Veterinary Biosciences, Melbourne Veterinary School, The University of Melbourne, Parkville, Victoria, Australia.

Publikováno v: Journal of periodontal research [J Periodontal Res] 2023 Jun; Vol. 58 (3), pp. 544-552. Date of Electronic Publication: 2023 Mar 31.

Twenty years of bioinformatics research for protease-specific substrate and cleavage site prediction: a comprehensive revisit and benchmarking of existing methods.

Autor: Li F; Biomedicine Discovery Institute and Department of Biochemistry & Molecular Biology, Monash University, Melbourne, VIC 3800, Australia., Wang Y; Biomedicine Discovery Institute and Department of Biochemistry & Molecular Biology, Monash University, Melbourne, VIC 3800, Australia.; Institute of Image Processing and Pattern Recognition, Shanghai Jiao Tong University, Shanghai 200240, China., Li C; Biomedicine Discovery Institute and Department of Biochemistry & Molecular Biology, Monash University, Melbourne, VIC 3800, Australia.; Department of Biology, Institute of Molecular Systems Biology,ETH Zürich, Zürich 8093, Switzerland., Marquez-Lago TT; Department of Genetics and Department of Cell, Developmental and Integrative Biology, School of Medicine, University of Alabama at Birmingham, AL, USA., Leier A; Department of Genetics and Department of Cell, Developmental and Integrative Biology, School of Medicine, University of Alabama at Birmingham, AL, USA., Rawlings ND; EMBL European Bioinformatics Institute, Wellcome Trust Genome Campus, Wellcome Trust Genome Campus,Hinxton, Cambridgeshire CB10 1SD, UK., Haffari G; Monash Centre for Data Science, Faculty of Information Technology, Monash University, Melbourne, VIC 3800, Australia., Revote J; Biomedicine Discovery Institute and Department of Biochemistry & Molecular Biology, Monash University, Melbourne, VIC 3800, Australia., Akutsu T; Bioinformatics Center, Institute for Chemical Research, Kyoto University, Kyoto 611-0011, Japan., Chou KC; Gordon Life Science Institute, Boston, MA 02478, USA.; Center for Informational Biology, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 610054, China., Purcell AW; Biomedicine Discovery Institute and Department of Biochemistry & Molecular Biology, Monash University, Melbourne, VIC 3800, Australia., Pike RN; La Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC 3086, Australia.; ARC Centre of Excellence in Advanced Molecular Imaging, Monash University, Melbourne, VIC 3800, Australia., Webb GI; Monash Centre for Data Science, Faculty of Information Technology, Monash University, Melbourne, VIC 3800, Australia., Ian Smith A; Biomedicine Discovery Institute and Department of Biochemistry & Molecular Biology, Monash University, Melbourne, VIC 3800, Australia.; ARC Centre of Excellence in Advanced Molecular Imaging, Monash University, Melbourne, VIC 3800, Australia., Lithgow T; Biomedicine Discovery Institute and Department of Microbiology, Monash University, Melbourne, Victoria 3800, Australia., Daly RJ; Biomedicine Discovery Institute and Department of Biochemistry & Molecular Biology, Monash University, Melbourne, VIC 3800, Australia., Whisstock JC; Biomedicine Discovery Institute and Department of Biochemistry & Molecular Biology, Monash University, Melbourne, VIC 3800, Australia.; ARC Centre of Excellence in Advanced Molecular Imaging, Monash University, Melbourne, VIC 3800, Australia., Song J; Biomedicine Discovery Institute and Department of Biochemistry & Molecular Biology, Monash University, Melbourne, VIC 3800, Australia.; Monash Centre for Data Science, Faculty of Information Technology, Monash University, Melbourne, VIC 3800, Australia.; ARC Centre of Excellence in Advanced Molecular Imaging, Monash University, Melbourne, VIC 3800, Australia.

Publikováno v: Briefings in bioinformatics [Brief Bioinform] 2019 Nov 27; Vol. 20 (6), pp. 2150-2166.

Protease-associated import systems are widespread in Gram-negative bacteria.

Autor: Grinter R; School of Biological Sciences, Monash University, Clayton, Victoria, Australia.; Infection and Immunity Program, Biomedicine Discovery Institute and Department of Microbiology, Monash University, Clayton, Australia.; Institute of Microbiology and Infection, School of Immunity and Infection, University of Birmingham, Birmingham, England, United Kingdom., Leung PM; School of Biological Sciences, Monash University, Clayton, Victoria, Australia., Wijeyewickrema LC; Department of Biochemistry and Genetics, La Trobe Institute of Molecular Sciences, La Trobe University, Melbourne, Victoria, Australia., Littler D; Infection and Immunity Program, Biomedicine Discovery Institute and Department of Microbiology, Monash University, Clayton, Australia., Beckham S; Infection and Immunity Program, Biomedicine Discovery Institute and Department of Microbiology, Monash University, Clayton, Australia.; La Trobe Rural Health School, College of Science, Health and Engineering, La Trobe University, Bendigo, Australia., Pike RN; Department of Biochemistry and Genetics, La Trobe Institute of Molecular Sciences, La Trobe University, Melbourne, Victoria, Australia., Walker D; Institute of Infection, Immunity, and Inflammation, College of Medical, Veterinary, and Life Sciences, University of Glasgow, Glasgow, United Kingdom., Greening C; School of Biological Sciences, Monash University, Clayton, Victoria, Australia., Lithgow T; Infection and Immunity Program, Biomedicine Discovery Institute and Department of Microbiology, Monash University, Clayton, Australia.

Publikováno v: PLoS genetics [PLoS Genet] 2019 Oct 15; Vol. 15 (10), pp. e1008435. Date of Electronic Publication: 2019 Oct 15 (Print Publication: 2019).

Molecular basis for the folding of β-helical autotransporter passenger domains.

Autor: Yuan X; Research School of Biology, Australian National University, Canberra, ACT, 0200, Australia., Johnson MD; Research School of Biology, Australian National University, Canberra, ACT, 0200, Australia., Zhang J; Research School of Biology, Australian National University, Canberra, ACT, 0200, Australia., Lo AW; School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD, 4072, Australia.; Australian Infectious Disease Research Centre, The University of Queensland, Brisbane, QLD, 4072, Australia., Schembri MA; School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD, 4072, Australia.; Australian Infectious Disease Research Centre, The University of Queensland, Brisbane, QLD, 4072, Australia., Wijeyewickrema LC; Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC, 3086, Australia., Pike RN; Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC, 3086, Australia., Huysmans GHM; Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY, 10065, USA., Henderson IR; Institute of Microbiology and Infection, University of Birmingham, Birmingham, B15 2TT, UK., Leyton DL; Research School of Biology, Australian National University, Canberra, ACT, 0200, Australia. denisse.leyton@anu.edu.au.; Medical School, Australian National University, Canberra, ACT, 0200, Australia. denisse.leyton@anu.edu.au.

Publikováno v: Nature communications [Nat Commun] 2018 Apr 11; Vol. 9 (1), pp. 1395. Date of Electronic Publication: 2018 Apr 11.