Enhanced synthesis of stress proteins caused by hypoxia and relation to altered cell growth and metabolism

Autor: CS Heacock, RM Sutherland

Publikováno v: British Journal of Cancer

Cultured cells maintained in very low oxygen levels alter their structure, metabolism and genetic expression. Culture conditions for cells were modified to minimise variation of nutrients and to allow normal survival levels after 24 h of hypoxic expo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7f5bf1476f0a8fac42834932f08eb16
https://pubmed.ncbi.nlm.nih.gov/1696830

Heterogeneity of Glutathione Content in Human Ovarian Cancer

Autor: Fy, Lee, Vessey A, Rofstad E, Dietmar Siemann, Rm, Sutherland

Publikováno v: Scopus-Elsevier
Europe PubMed Central

Intracellular glutathione (GSH) has been shown to be one of the major factors modulating tumor response to a variety of commonly used anti-neoplastic agents. In this study the GSH contents of human ovarian tumors from primary biopsies, nude mouse xen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::3181df223a21080e695ee28201589479
http://www.scopus.com/inward/record.url?eid=2-s2.0-0024432977&partnerID=MN8TOARS

A human colon adenocarcinoma xenograft--radiation response, cellular composition, and tumor disaggregation

Autor: Cm, West, Pc, Keng, Dietmar Siemann, Rm, Sutherland

Publikováno v: Europe PubMed Central

The human colon adenocarcinoma cell line WiDr was xenografted and the tumor characterized. When athymic mice (NCR-nu) were inoculated with 10(6) cells, tumors appeared after 7-14 days with a 93-100% take rate and grew with an initial volume-doubling

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::6ffee30c26be9370ed36474255d2fb4d
http://europepmc.org/abstract/med/3468298

BCL-XL antagonism selectively reduces neutrophil life span within inflamed tissues without causing neutropenia.

Autor: Carrington EM; The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Australia., Louis C; The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Australia., Kratina T; The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia., Hancock M; The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia., Keenan CR; The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Australia., Iannarella N; The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia., Allan RS; The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Australia., Wardak AZ; The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia., Czabotar PE; The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Australia., Herold MJ; The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Australia., Schenk RL; The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Australia., White CA; The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Australia., D'Silva D; The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia., Yang Y; The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia., Wong W; The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia.; Royal Melbourne Hospital, Parkville, Australia., Wong H; The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia., Bryant VL; The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Australia., Huntington ND; Department of Medical Biology, University of Melbourne, Parkville, Australia.; Biomedicine Discovery Institute and the Department of Biochemistry and Molecular Biology, Monash University, Clayton, Australia; and., Rautela J; The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Australia.; Biomedicine Discovery Institute and the Department of Biochemistry and Molecular Biology, Monash University, Clayton, Australia; and., Sutherland RM; The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Australia., Zhan Y; The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Australia., Hansen J; The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia., Nhu D; The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Australia., Lessene G; The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Australia., Wicks IP; The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Australia.; Royal Melbourne Hospital, Parkville, Australia., Lew AM; The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Australia.; Department of Microbiology & Immunology, University of Melbourne, Parkville,Australia.

Publikováno v: Blood advances [Blood Adv] 2021 Jun 08; Vol. 5 (11), pp. 2550-2562.

Repurposed JAK1/JAK2 Inhibitor Reverses Established Autoimmune Insulitis in NOD Mice.

Autor: Trivedi PM; St. Vincent's Institute, Fitzroy, Victoria, Australia.; The University of Melbourne, Department of Medicine, St. Vincent's Hospital, Fitzroy, Victoria, Australia., Graham KL; St. Vincent's Institute, Fitzroy, Victoria, Australia.; The University of Melbourne, Department of Medicine, St. Vincent's Hospital, Fitzroy, Victoria, Australia., Scott NA; St. Vincent's Institute, Fitzroy, Victoria, Australia.; The University of Melbourne, Department of Medicine, St. Vincent's Hospital, Fitzroy, Victoria, Australia., Jenkins MR; Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia.; The Walter and Eliza Hall Institute, Parkville, Victoria, Australia., Majaw S; St. Vincent's Institute, Fitzroy, Victoria, Australia., Sutherland RM; St. Vincent's Institute, Fitzroy, Victoria, Australia.; The Walter and Eliza Hall Institute, Parkville, Victoria, Australia.; Department of Medical Biology, The University of Melbourne, Parkville, Victoria, Australia., Fynch S; St. Vincent's Institute, Fitzroy, Victoria, Australia., Lew AM; The Walter and Eliza Hall Institute, Parkville, Victoria, Australia.; Department of Medical Biology, The University of Melbourne, Parkville, Victoria, Australia., Burns CJ; The Walter and Eliza Hall Institute, Parkville, Victoria, Australia., Krishnamurthy B; St. Vincent's Institute, Fitzroy, Victoria, Australia.; The University of Melbourne, Department of Medicine, St. Vincent's Hospital, Fitzroy, Victoria, Australia., Brodnicki TC; St. Vincent's Institute, Fitzroy, Victoria, Australia.; The University of Melbourne, Department of Medicine, St. Vincent's Hospital, Fitzroy, Victoria, Australia., Mannering SI; St. Vincent's Institute, Fitzroy, Victoria, Australia.; The University of Melbourne, Department of Medicine, St. Vincent's Hospital, Fitzroy, Victoria, Australia., Kay TW; St. Vincent's Institute, Fitzroy, Victoria, Australia.; The University of Melbourne, Department of Medicine, St. Vincent's Hospital, Fitzroy, Victoria, Australia., Thomas HE; St. Vincent's Institute, Fitzroy, Victoria, Australia hthomas@svi.edu.au.; The University of Melbourne, Department of Medicine, St. Vincent's Hospital, Fitzroy, Victoria, Australia.

Publikováno v: Diabetes [Diabetes] 2017 Jun; Vol. 66 (6), pp. 1650-1660. Date of Electronic Publication: 2017 Mar 14.