Inflammatory cytokines provide a third signal for activation of naive CD4+ and CD8+ T cells

Autor: Jm, Curtsinger, Cs, Schmidt, anna mondino, Dc, Lins, Rm, Kedl, Mk, Jenkins, Mf, Mescher

Publikováno v: Europe PubMed Central

The effects of inflammatory cytokines on naive T cells have been studied using MHC protein/peptide complexes on microspheres, thus avoiding the use of APCs whose functions may be affected by the cytokines. IL-1, but not IL-12, increased proliferation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::7247eee7c6b7ce12f7b2d04895a9166f
https://pubmed.ncbi.nlm.nih.gov/10092777

Author Correction: Elective nodal irradiation mitigates local and systemic immunity generated by combination radiation and immunotherapy in head and neck tumors.

Autor: Darragh LB; Department of Radiation Oncology, University of Colorado Denver at Anschutz Medical Campus, Aurora, CO, USA.; Department of Immunology and Microbiology, University of Colorado Denver at Anschutz Medical Campus, Aurora, CO, USA., Gadwa J; Department of Radiation Oncology, University of Colorado Denver at Anschutz Medical Campus, Aurora, CO, USA., Pham TT; Department of Otolaryngology Head and Neck Surgery, University of Colorado Denver at Anschutz Medical Campus, Aurora, CO, USA., Van Court B; Department of Radiation Oncology, University of Colorado Denver at Anschutz Medical Campus, Aurora, CO, USA., Neupert B; Department of Radiation Oncology, University of Colorado Denver at Anschutz Medical Campus, Aurora, CO, USA., Olimpo NA; Department of Radiation Oncology, University of Colorado Denver at Anschutz Medical Campus, Aurora, CO, USA., Nguyen K; Department of Pathology, University of Colorado Denver at Anschutz Medical Campus, Aurora, CO, USA., Nguyen D; Department of Radiation Oncology, University of Colorado Denver at Anschutz Medical Campus, Aurora, CO, USA., Knitz MW; Department of Radiation Oncology, University of Colorado Denver at Anschutz Medical Campus, Aurora, CO, USA., Hoen M; Department of Radiation Oncology, University of Colorado Denver at Anschutz Medical Campus, Aurora, CO, USA., Corbo S; Department of Radiation Oncology, University of Colorado Denver at Anschutz Medical Campus, Aurora, CO, USA., Joshi M; Department of Pharmacology, University of Colorado Denver at Anschutz Medical campus, Aurora, CO, USA., Zhuang Y; Department of Pediatrics, Cancer Center Biostatistics Core, University of Colorado Anschutz Medical campus, Aurora, CO, USA., Amann M; Roche Innovation Center Zurich, Roche Pharmaceutical Research and Early Development (pRED) Schlieren, Zurich, Switzerland., Wang XJ; Department of Pathology and Laboratory Medicine, University of California Davis, School of Medicine, Davis, USA.; Veterans Affairs Medical Center, VA Eastern Colorado Health Care System, Aurora, CO, 80045, USA., Dow S; Department of Radiation Oncology, Colorado State University, Fort Collins, Colorado Campus, Aurora, CO, USA., Kedl RM; Department of Radiation Oncology, University of Colorado Denver at Anschutz Medical Campus, Aurora, CO, USA., Samedi V; Department of Pathology, University of Colorado Denver at Anschutz Medical Campus, Aurora, CO, USA., Boss MK; Department of Radiation Oncology, Colorado State University, Fort Collins, Colorado Campus, Aurora, CO, USA., Karam SD; Department of Radiation Oncology, University of Colorado Denver at Anschutz Medical Campus, Aurora, CO, USA. sana.karam@cuanschutz.edu.; Department of Immunology and Microbiology, University of Colorado Denver at Anschutz Medical Campus, Aurora, CO, USA. sana.karam@cuanschutz.edu.

Publikováno v: Nature communications [Nat Commun] 2024 Oct 10; Vol. 15 (1), pp. 8781. Date of Electronic Publication: 2024 Oct 10.

Antigen experience history directs distinct functional states of CD8+ CAR T cells during the anti-leukemia response.

Autor: DeGolier KR; Department of Immunology, University of Colorado Anschutz Medical Campus; Aurora, CO, USA.; Department of Pediatrics, University of Colorado Anschutz Medical Campus; Aurora, CO, USA., Danis E; Biostatistics and Bioinformatics Shared Resource, University of Colorado Cancer Center, University of Colorado Anschutz Medical Campus; Aurora, CO, USA., D'Antonio M; Department of Immunology, University of Colorado Anschutz Medical Campus; Aurora, CO, USA., Cimons J; Department of Immunology, University of Colorado Anschutz Medical Campus; Aurora, CO, USA.; Department of Pediatrics, University of Colorado Anschutz Medical Campus; Aurora, CO, USA., Yarnell M; Department of Pediatrics, University of Colorado Anschutz Medical Campus; Aurora, CO, USA.; Center for Cancer and Blood Disorders, Children's Hospital Colorado; Aurora, CO, USA., Kedl RM; Department of Immunology, University of Colorado Anschutz Medical Campus; Aurora, CO, USA., Kohler ME; Department of Immunology, University of Colorado Anschutz Medical Campus; Aurora, CO, USA.; Department of Pediatrics, University of Colorado Anschutz Medical Campus; Aurora, CO, USA.; Center for Cancer and Blood Disorders, Children's Hospital Colorado; Aurora, CO, USA., Scott-Browne JP; Department of Immunology, University of Colorado Anschutz Medical Campus; Aurora, CO, USA.; Department of Immunology and Genomic Medicine, National Jewish Health, Denver, CO, USA., Fry TJ; Department of Immunology, University of Colorado Anschutz Medical Campus; Aurora, CO, USA.; Department of Pediatrics, University of Colorado Anschutz Medical Campus; Aurora, CO, USA.; Center for Cancer and Blood Disorders, Children's Hospital Colorado; Aurora, CO, USA.

Publikováno v: Research square [Res Sq] 2023 Dec 21. Date of Electronic Publication: 2023 Dec 21.

Vaccine adjuvant-elicited CD8 ⁺ T cell immunity is co-dependent on T-bet and FOXO1.

Autor: Ivanova DL; Department of Immunology and Microbiology, University of Colorado - Anschutz Medical Campus, Aurora, CO 80045, USA., Thompson SB; Department of Immunology and Microbiology, University of Colorado - Anschutz Medical Campus, Aurora, CO 80045, USA., Klarquist J; Department of Immunology and Microbiology, University of Colorado - Anschutz Medical Campus, Aurora, CO 80045, USA., Harbell MG; Department of Immunology and Microbiology, University of Colorado - Anschutz Medical Campus, Aurora, CO 80045, USA., Kilgore AM; Department of Immunology and Microbiology, University of Colorado - Anschutz Medical Campus, Aurora, CO 80045, USA., Lasda EL; Department of Biochemistry & Molecular Genetics, University of Colorado - Anschutz Medical Campus, Aurora, CO 80045, USA., Hesselberth JR; Department of Biochemistry & Molecular Genetics, University of Colorado - Anschutz Medical Campus, Aurora, CO 80045, USA., Hunter CA; Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Kedl RM; Department of Immunology and Microbiology, University of Colorado - Anschutz Medical Campus, Aurora, CO 80045, USA. Electronic address: ross.kedl@cuanschutz.edu.

Publikováno v: Cell reports [Cell Rep] 2023 Aug 29; Vol. 42 (8), pp. 112911. Date of Electronic Publication: 2023 Jul 29.

Simultaneous targeting of PD-1 and IL-2Rβγ with radiation therapy inhibits pancreatic cancer growth and metastasis.

Autor: Piper M; Department of Radiation Oncology, University of Colorado, Anschutz Medical Campus, Aurora, CO 80045, USA., Hoen M; Department of Radiation Oncology, University of Colorado, Anschutz Medical Campus, Aurora, CO 80045, USA., Darragh LB; Department of Radiation Oncology, University of Colorado, Anschutz Medical Campus, Aurora, CO 80045, USA; Department of Microbiology and Immunology, University of Colorado, Anschutz Medical Campus, Aurora, CO 80045, USA., Knitz MW; Department of Radiation Oncology, University of Colorado, Anschutz Medical Campus, Aurora, CO 80045, USA., Nguyen D; Department of Radiation Oncology, University of Colorado, Anschutz Medical Campus, Aurora, CO 80045, USA., Gadwa J; Department of Radiation Oncology, University of Colorado, Anschutz Medical Campus, Aurora, CO 80045, USA., Durini G; Roche Innovation Center Zurich, Roche Pharma Research and Early Development (pRED), Schlieren, Switzerland., Karakoc I; Roche Innovation Center Zurich, Roche Pharma Research and Early Development (pRED), Schlieren, Switzerland., Grier A; Department of Biochemistry and Molecular Genetics, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO 80045, USA., Neupert B; Department of Radiation Oncology, University of Colorado, Anschutz Medical Campus, Aurora, CO 80045, USA., Van Court B; Department of Radiation Oncology, University of Colorado, Anschutz Medical Campus, Aurora, CO 80045, USA., Abdelazeem KNM; Department of Radiation Oncology, University of Colorado, Anschutz Medical Campus, Aurora, CO 80045, USA., Yu J; Department of Radiation Oncology, University of Colorado, Anschutz Medical Campus, Aurora, CO 80045, USA., Olimpo NA; Department of Radiation Oncology, University of Colorado, Anschutz Medical Campus, Aurora, CO 80045, USA., Corbo S; Department of Radiation Oncology, University of Colorado, Anschutz Medical Campus, Aurora, CO 80045, USA., Ross RB; Department of Radiation Oncology, University of Colorado, Anschutz Medical Campus, Aurora, CO 80045, USA., Pham TT; Department of Radiation Oncology, University of Colorado, Anschutz Medical Campus, Aurora, CO 80045, USA., Joshi M; Department of Pharmacology, University of Colorado, Anschutz Medical Campus, Aurora, CO 80045, USA., Kedl RM; Department of Microbiology and Immunology, University of Colorado, Anschutz Medical Campus, Aurora, CO 80045, USA., Saviola AJ; Department of Biochemistry and Molecular Genetics, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO 80045, USA., Amann M; Roche Innovation Center Zurich, Roche Pharma Research and Early Development (pRED), Schlieren, Switzerland., Umaña P; Roche Innovation Center Zurich, Roche Pharma Research and Early Development (pRED), Schlieren, Switzerland., Codarri Deak L; Roche Innovation Center Zurich, Roche Pharma Research and Early Development (pRED), Schlieren, Switzerland., Klein C; Roche Innovation Center Zurich, Roche Pharma Research and Early Development (pRED), Schlieren, Switzerland., D'Alessandro A; Department of Biochemistry and Molecular Genetics, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO 80045, USA., Karam SD; Department of Radiation Oncology, University of Colorado, Anschutz Medical Campus, Aurora, CO 80045, USA; Department of Microbiology and Immunology, University of Colorado, Anschutz Medical Campus, Aurora, CO 80045, USA. Electronic address: sana.karam@cuanschutz.edu.

Publikováno v: Cancer cell [Cancer Cell] 2023 May 08; Vol. 41 (5), pp. 950-969.e6. Date of Electronic Publication: 2023 Apr 27.