Publisher Correction: Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability.

Autor: Lagou V; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.; Department of Microbiology and Immunology, Laboratory of Adaptive Immunity, KU Leuven, Leuven, Belgium.; VIB-KU Leuven Center for Brain and Disease Research, Leuven, Belgium., Mägi R; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia., Hottenga JJ; Department of Biological Psychology, Vrije Universiteit, Amsterdam, The Netherlands.; Amsterdam Public Health Research Institute, VU University medical center, Amsterdam, The Netherlands., Grallert H; Research Unit of Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München Research Center for Environmental Health, Neuherberg, Germany.; German Center for Diabetes Research (DZD, München-Neuherberg, Germany., Perry JRB; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, UK., Bouatia-Naji N; University of Lille Nord de France, Lille, France.; CNRS UMR8199, Institut Pasteur de Lille, Lille, France.; INSERM U970, Paris Cardiovascular Research Center PARCC, 75006, Paris, France., Marullo L; Department of Life Sciences and Biotechnology, University of Ferrara, Ferrara, Italy., Rybin D; Boston University Data Coordinating Center, Boston, MA, USA., Jansen R; Department of Psychiatry, VU University Medical Center, Amsterdam, The Netherlands., Min JL; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.; Bristol Medical School, University of Bristol, Bristol, UK., Dimas AS; Institute for Bioinnovation, Biomedical Sciences Research Center Al. Fleming, Vari, Greece., Ulrich A; Department of Medicine, Imperial College London, London, UK., Zudina L; Department of Medicine, Imperial College London, London, UK., Gådin JR; Cardiovascular Medicine Unit, Center for Molecular Medicine, Department of Medicine, Karolinska Institutet, Stockholm, Karolinska University Hospital, Solna, Sweden., Jiang L; Department of Medicine, Imperial College London, London, UK.; Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, 4072, Australia., Faggian A; Department of Medicine, Imperial College London, London, UK., Bonnefond A; University of Lille Nord de France, Lille, France.; CNRS UMR8199, Institut Pasteur de Lille, Lille, France.; Department of Medicine, Imperial College London, London, UK., Fadista J; Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark., Stathopoulou MG; Université de Lorraine, IGE-PCV, F-54000, Nancy, France., Isaacs A; Genetic Epidemiology Unit, Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.; CARIM School for Cardiovascular Diseases and Maastricht Centre for Systems Biology (MaCSBio, Maastricht University, Maastricht, The Netherlands.; Department of Physiology, Maastricht University, Maastricht, The Netherlands., Willems SM; Genetic Epidemiology Unit, Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands., Navarro P; MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, UK., Tanaka T; Translational Gerontology Branch, Longitudinal Study Section, National Institute on Aging, Baltimore, MD, USA., Jackson AU; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Montasser ME; Division of Endocrinology, Diabetes, and Nutrition, Department of Medicine, University of Maryland, School of Medicine, Baltimore, MD, USA., O'Connell JR; Division of Endocrinology, Diabetes, and Nutrition, Department of Medicine, University of Maryland, School of Medicine, Baltimore, MD, USA., Bielak LF; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA., Webster RJ; Laboratory for Cancer Medicine, Harry Perkins Institute of Medical Research, University of Western Australia Centre for Medical Research, Nedlands, WA, Australia., Saxena R; Broad Institute of Harvard and Massachusetts Institute of Technology (MIT), Cambridge, MA, USA.; Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA, USA.; Department of Genetics, Harvard Medical School, Boston, MA, USA.; Departmentartment of Anesthesia, Critical Care and Pain Medicine, MGH, Boston, MA, USA., Stafford JM; Department of Biostatistics and Data Science, Division of Public Health Sciences, Wake Forest University School of Medicine, Winston-Salem, NC, USA., Pourcain BS; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.; Bristol Medical School, University of Bristol, Bristol, UK., Timpson NJ; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.; Bristol Medical School, University of Bristol, Bristol, UK., Salo P; Public Health Genomics Unit, Department of Chronic Disease Prevention, Finnish Institute for Health and Welfare, Helsinki, Finland., Shin SY; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, UK., Amin N; Department of Epidemiology Erasmus MC, Rotterdam, the Netherlands., Smith AV; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.; Icelandic Heart Association, Kopavogur, Iceland.; Faculty of Medicine, University of Iceland, Reykjavik, Iceland., Li G; Cardiovascular Health Research Unit, University of Washington, Seattle, WA, USA.; Department of Medicine, University of Washington, Seattle, WA, USA., Verweij N; Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Goel A; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.; Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK., Ford I; Robertson Centre for Biostatistics, University of Glasgow, Glasgow, UK., Johnson PCD; Robertson Centre for Biostatistics, University of Glasgow, Glasgow, UK.; Institute of Biodiversity, Animal Health & Comparative Medicine, University of Glasgow, Glasgow, UK., Johnson T; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.; NIHR Barts Cardiovascular Biomedical Research Unit, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK., Kapur K; Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland., Thorleifsson G; deCODE Genetics, Reykjavik, Iceland., Strawbridge RJ; Cardiovascular Medicine Unit, Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden.; Center for Molecular Medicine, Karolinska University Hospital Solna, Stockholm, Sweden.; Institute of Health and Wellbeing, University of Glasgow, Glasgow, UK., Rasmussen-Torvik LJ; Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Esko T; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia., Mihailov E; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia., Fall T; Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden., Fraser RM; Usher Institute, University of Edinburgh, Edinburgh, UK.; Synpromics Ltd, Roslin Innovation Centre, Easter Bush Campus, Edinburgh, EH25 9RG, UK., Mahajan A; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.; Genentech, 340 Point San Bruno Boulevard, South San Francisco, CA, 94080, USA., Kanoni S; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.; Wellcome Trust Sanger Institute, Hinxton, UK., Giedraitis V; Department of Public Health and Caring Sciences, Uppsala Universitet, Uppsala, Sweden., Kleber ME; Vth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany., Silbernagel G; Division of Angiology, Department of Internal Medicine, Medical University of Graz, Graz, Austria., Meyer J; Institute of Genetic Epidemiology,Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Müller-Nurasyid M; Institute of Genetic Epidemiology,Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; Institute of Medical Informatics, Biometry and Epidemiology, Chair of Epidemiology and Chair of Genetic Epidemiology, Ludwig-Maximilians-Universität, Munich, Germany.; Department of Medicine I, University Hospital Grosshadern, Ludwig-Maximilians-University, Munich, Germany.; Institute of Medical Biostatistics, Epidemiology and Informatics (IMBEI, University Medical Center, Johannes Gutenberg University, 55101, Mainz, Germany., Ganna A; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Sarin AP; Institute for Molecular Medicine Finland, FIMM, University of Helsinki, Helsinki, Finland.; Public Health Genomics Unit, Finnish Institute for Health and Welfare, Helsinki, Finland., Yengo L; University of Lille Nord de France, Lille, France.; CNRS UMR8199, Institut Pasteur de Lille, Lille, France.; Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, 4072, Australia., Shungin D; Department of Public Health & Clinical Medicine, Umeå University, Umeå, Sweden.; Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Skåne University Hospital Malmö, Malmö, Sweden.; Department of Odontology, Umeå University, Umeå, Sweden., Luan J; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, UK., Horikoshi M; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK.; RIKEN, Center for Integrative Medical Sciences, Laboratory for Endocrinology, Metabolism and Kidney Disease, Yokohama, Japan., An P; Division of Statistical Genomics, Washington University School of Medicine, St. Louis, MO, USA., Sanna S; Istituto di Ricerca Genetica e Biomedica, CNR, Monserrato, Italy.; Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands., Boettcher Y; Department of Medicine, University of Leipzig, Leipzig, Germany.; IFB AdiposityDiseases, University of Leipzig, Leipzig, Germany., Rayner NW; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.; Wellcome Trust Sanger Institute, Hinxton, UK.; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK., Nolte IM; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., Zemunik T; Faculty of Medicine, University of Split, Split, Croatia., Iperen EV; Department of Clinical Epidemiology and Biostatistics, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands., Kovacs P; IFB AdiposityDiseases, University of Leipzig, Leipzig, Germany., Hastie ND; MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, UK., Wild SH; Usher Institute, University of Edinburgh, Edinburgh, UK., McLachlan S; Usher Institute, University of Edinburgh, Edinburgh, UK., Campbell S; MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, UK., Polasek O; Faculty of Medicine, University of Split, Split, Croatia., Carlson O; Laboratory of Clinical Investigation, National Institute of Aging, Baltimore, MD, USA., Egan J; Laboratory of Clinical Investigation, National Institute of Aging, Baltimore, MD, USA., Kiess W; IFB AdiposityDiseases, University of Leipzig, Leipzig, Germany.; Pediatric Research Center, Department of Women's & Child Health, University of Leipzig, Leipzig, Germany., Willemsen G; Department of Biological Psychology, Vrije Universiteit, Amsterdam, The Netherlands., Kuusisto J; Department of Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland., Laakso M; Department of Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland., Dimitriou M; Department of Dietetics-Nutrition, Harokopio University, Athens, Greece., Hicks AA; Center for Biomedicine, European Academy Bozen/Bolzano (EURAC) (Affiliated Institute of the University of LübeckLübeckGermany), Bolzano, Italy., Rauramaa R; Kuopio Research Institute of Exercise Medicine, Kuopio, Finland.; Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, Finland., Bandinelli S; Geriatric Unit, Azienda Sanitaria Firenze (ASF), Florence, Italy., Thorand B; German Center for Diabetes Research (DZD, München-Neuherberg, Germany.; Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Liu Y; Department of Epidemiology and Prevention, Division of Public Health Sciences, Wake Forest University School of Medicine, Winston-Salem, NC, USA., Miljkovic I; Department of Epidemiology, Center for Aging and Population Health, University of Pittsburgh, Pittsburgh, PA, USA., Lind L; Department of Medical Sciences, Uppsala University, Akademiska sjukhuset, Uppsala, Sweden., Doney A; Pat McPherson Centre for Pharmacogenetics and Pharmacogenomics, Division of Molecular and Clinical Medicine, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK., Perola M; Public Health Genomics Unit, Department of Chronic Disease Prevention, Finnish Institute for Health and Welfare, Helsinki, Finland.; Institute for Molecular Medicine Finland, FIMM, University of Helsinki, Helsinki, Finland.; Estonian Genome Center, University of Tartu, Tartu, Estonia., Hingorani A; Department of Epidemiology and Public Health, University College London, London, UK., Kivimaki M; Department of Epidemiology and Public Health, University College London, London, UK., Kumari M; Department of Epidemiology and Public Health, University College London, London, UK.; University of Essex, Wivenhoe Park, Colchester, Essex, UK., Bennett AJ; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK., Groves CJ; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK., Herder C; German Center for Diabetes Research (DZD, München-Neuherberg, Germany.; Institute of Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Düsseldorf, Germany.; Division of Endocrinology and Diabetology, Medical Faculty, Heinrich Heine University Düsseldorf, Düsseldorf, Germany., Koistinen HA; Department of Public Health Solutions, Finnish Institute for Health and Welfare, P.O. Box 30, Helsinki, FI-00271, Finland.; Department of Medicine, University of Helsinki and Helsinki University Central Hospital, P.O. Box 340, Haartmaninkatu 4, Helsinki, FI-00029, Finland.; Minerva Foundation Institute for Medical Research, Biomedicum 2U, Tukholmankatu 8, Helsinki, FI-00290, Finland., Kinnunen L; Department of Public Health Solutions, Finnish Institute for Health and Welfare, P.O. Box 30, Helsinki, FI-00271, Finland., Faire U; Division of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden., Bakker SJL; Department of Internal Medicine, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Uusitupa M; Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland., Palmer CNA; Pat McPherson Centre for Pharmacogenetics and Pharmacogenomics, Division of Molecular and Clinical Medicine, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK., Jukema JW; Dept of Cardiology, Leiden University Medical Center, Leiden, The Netherlands.; Netherlands Heart Institute, Utrecht, The Netherlands., Sattar N; Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK., Pouta A; Department of Government Services, Finnish Institute for Health and Welfare, Helsinki, Finland.; PEDEGO Research Unit, Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland., Snieder H; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., Boerwinkle E; IMM Center for Human Genetics, University of Texas Health Science Center at Houston, Houston, TX, USA.; Division of Epidemiology, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USA., Pankow JS; Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MiI, USA., Magnusson PK; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden., Krus U; Department of Clinical Sciences, Diabetes and Endocrinology Research Unit, University Hospital Malmö, Lund University, Malmö, Sweden., Scapoli C; Department of Life Sciences and Biotechnology, University of Ferrara, Ferrara, Italy., de Geus EJCN; Department of Biological Psychology, Vrije Universiteit, Amsterdam, The Netherlands.; Amsterdam Public Health Research Institute, VU University medical center, Amsterdam, The Netherlands., Blüher M; Department of Medicine, University of Leipzig, Leipzig, Germany.; Department of Preventive Medicine, Keck School of Medicine of USC, Los Angeles, CA, USA., Wolffenbuttel BHR; Department of Endocrinology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Province MA; Division of Statistical Genomics, Washington University School of Medicine, St. Louis, MO, USA., Abecasis GR; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Meigs JB; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; General Medicine Division, Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Hovingh GK; Department of Vascular Medicine, Amsterdam UMC, Amsterdam, The Netherlands.; Novo Nordisk A/S, Copenhagen, Denmark., Lindström J; Finnish Institute for Health and Welfare, Diabetes Prevention Unit, Helsinki, Finland., Wilson JF; MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, UK.; Usher Institute, University of Edinburgh, Edinburgh, UK., Wright AF; MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, UK., Dedoussis GV; Department of Dietetics-Nutrition, Harokopio University, Athens, Greece., Bornstein SR; Department of Medicine, Division for Prevention and Care of Diabetes, Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany., Schwarz PEH; Department for Prevention and Care of Diabetes, Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.; Paul Langerhans Institute Dresden of the Helmholtz Center Munich at University Hospital and Faculty of Medicine, TU Dresden, Dresden, Germany.; German Center for Diabetes Research (DZD e.V.), Neuherberg, Germany., Tönjes A; Department of Medicine, University of Leipzig, Leipzig, Germany.; IFB AdiposityDiseases, University of Leipzig, Leipzig, Germany., Winkelmann BR; Cardiology Group, Frankfurt-Sachsenhausen, Germany., Boehm BO; Lee Kong Chian School of Medicine, Nanyang Technological University Singapore and Imperial College London, Singapore, Singapore., März W; Vth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.; Synlab Academy, Synlab Holding Deutschland GmbH, Mannheim, Germany., Metspalu A; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia., Price JF; Usher Institute, University of Edinburgh, Edinburgh, UK., Deloukas P; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.; Wellcome Trust Sanger Institute, Hinxton, UK.; Princess Al-Jawhara Al-Brahim Centre of Excellence in Research of Hereditary Disorders (PACER-HD, King Abdulaziz University, Jeddah, Saudi Arabia., Körner A; IFB AdiposityDiseases, University of Leipzig, Leipzig, Germany.; Diabetes Research Center, Diabetes Unit, Massachusetts General Hospital, Boston, MA, USA., Lakka TA; Kuopio Research Institute of Exercise Medicine, Kuopio, Finland.; Institute of Biomedicine/Physiology, University of Eastern Finland, Kuopio Campus, Kuopio, Finland., Keinanen-Kiukaanniemi SM; Faculty of Medicine, Center for Life Course Health Research, University of Oulu, Oulu, Finland.; Unit of General Practice, Oulu University Hospital, Oulu, Finland., Saaristo TE; Finnish Diabetes Association, Tampere, Finland.; Pirkanmaa Hospital District, Tampere, Finland., Bergman RN; Diabetes and Obesity Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA., Tuomilehto J; Department of Chronic Disease Prevention, Finnish Institute for Health and Welfare, Helsinki, Finland.; Department of Public Health, University of Helsinki, Helsinki, Finland.; Centre for Vascular Prevention, Danube-University Krems, Krems, Austria.; Diabetes Research Group, King Abdulaziz University, Jeddah, Saudi Arabia., Wareham NJ; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, UK., Langenberg C; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, UK., Männistö S; Department of Public Health Solutions, Finnish Institute for Health and Welfare, P.O. Box 30, Helsinki, FI-00271, Finland., Franks PW; Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Skåne University Hospital Malmö, Malmö, Sweden.; Department of Nutrition, Harvard School of Public Health, Boston, MA, USA.; Department of Public Health & Clinical Medicine, Units of Medicine and Nutritional Research, Umeå University, Umeå, Sweden., Hayward C; MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, UK., Vitart V; MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, UK., Kaprio J; Institute for Molecular Medicine Finland, FIMM, University of Helsinki, Helsinki, Finland.; Department of Public Health, University of Helsinki, Helsinki, Finland., Visvikis-Siest S; Université de Lorraine, IGE-PCV, F-54000, Nancy, France., Balkau B; Inserm, CESP Center for Research in Epidemiology and Public Health, U1018, Villejuif, France.; Univ Paris-Saclay, Univ Paris Sud, UVSQ, UMRS 1018, UMRS 1018, Villejuif, France., Altshuler D; Broad Institute of Harvard and Massachusetts Institute of Technology (MIT), Cambridge, MA, USA.; Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Rudan I; Usher Institute, University of Edinburgh, Edinburgh, UK., Stumvoll M; Department of Medicine, University of Leipzig, Leipzig, Germany.; IFB AdiposityDiseases, University of Leipzig, Leipzig, Germany., Campbell H; Usher Institute, University of Edinburgh, Edinburgh, UK., van Duijn CM; Genetic Epidemiology Unit, Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.; Centre for Medical Systems Biology, Leiden, The Netherlands., Gieger C; Research Unit of Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München Research Center for Environmental Health, Neuherberg, Germany.; German Center for Diabetes Research (DZD, München-Neuherberg, Germany.; Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Illig T; Research Unit of Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München Research Center for Environmental Health, Neuherberg, Germany.; Hannover Unified Biobank, Hannover Medical School, Hannover, Germany.; Institute of Human Genetics, Hannover Medical School, Hannover, Germany., Ferrucci L; Clinical Research Branch, National Institute on Aging, Baltimore, MD, USA., Pedersen NL; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden., Pramstaller PP; Center for Biomedicine, European Academy Bozen/Bolzano (EURAC) (Affiliated Institute of the University of LübeckLübeckGermany), Bolzano, Italy.; Department of Neurology, General Central Hospital, Bolzano, Italy.; Department of Neurology, University of Lübeck, Lübeck, Germany., Boehnke M; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Frayling TM; Genetics of Complex Traits, Peninsula Medical School, University of Exeter, Exeter, UK., Shuldiner AR; Division of Endocrinology, Diabetes, and Nutrition, Department of Medicine, University of Maryland, School of Medicine, Baltimore, MD, USA.; The Regeneron Genetics Center, Regeneron Pharmaceuticals, Tarrytown, NY, USA., Peyser PA; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA., Kardia SLR; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA., Palmer LJ; School of Public Health, University of Adelaide, Adelaide, Australia., Penninx BW; Department of Psychiatry, VU University Medical Center, Amsterdam, The Netherlands., Meneton P; U872 Institut National de la Santé et de la Recherche Médicale, Centre de Recherche des Cordeliers, 75006, Paris, France., Harris TB; Geriatric Epidemiology Section, Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, Bethesda, MD, USA., Navis G; Department of Internal Medicine, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Harst PV; Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.; Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands., Smith GD; MRC Integrative Epidemiology Unit (IEU), University of Bristol, Bristol, UK., Forouhi NG; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, UK., Loos RJF; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, UK.; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Salomaa V; Finnish Institute for Health and Welfare, Helsinki, Finland., Soranzo N; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, UK., Boomsma DI; Department of Biological Psychology, Vrije Universiteit, Amsterdam, The Netherlands., Groop L; Institute for Molecular Medicine Finland, FIMM, University of Helsinki, Helsinki, Finland.; Department of Clinical Sciences, Diabetes and Endocrinology Research Unit, University Hospital Malmö, Lund University, Malmö, Sweden., Tuomi T; Institute for Molecular Medicine Finland, FIMM, University of Helsinki, Helsinki, Finland.; Department of Clinical Sciences, Diabetes and Endocrinology Research Unit, University Hospital Malmö, Lund University, Malmö, Sweden.; Endocrinology, Abdominal Centre, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.; Research Program for Clinical and Molecular Metabolism, University of Helsinki and Folkhälsan Research Center, Helsinki, Finland., Hofman A; Department of Epidemiology Erasmus MC, Rotterdam, the Netherlands.; Netherlands Consortium for healthy ageing, the Hague, The Netherlands.; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, USA., Munroe PB; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.; NIHR Barts Cardiovascular Biomedical Research Unit, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK., Gudnason V; Icelandic Heart Association, Kopavogur, Iceland.; Faculty of Medicine University of Iceland, Reykjavik, Iceland., Siscovick DS; Cardiovascular Health Research Unit, University of Washington, Seattle, WA, USA.; Department of Medicine, University of Washington, Seattle, WA, USA.; Department of Epidemiology, University of Washington, Seattle, WA, USA., Watkins H; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.; Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK., Lecoeur C; University of Lille Nord de France, Lille, France.; CNRS UMR8199, Institut Pasteur de Lille, Lille, France., Vollenweider P; Department of Medicine, University Hospital Lausanne, Lausanne, Switzerland., Franco-Cereceda A; Cardiothoracic Surgery Unit, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden., Eriksson P; Cardiovascular Medicine Unit, Center for Molecular Medicine, Department of Medicine, Karolinska Institutet, Stockholm, Karolinska University Hospital, Solna, Sweden., Jarvelin MR; Department of Epidemiology and Biostatistics and HPA-MRC Center, School of Public Health, Imperial College London, London, UK.; Institue of Health Sciences, University of Oulu, Oulu, Finland., Stefansson K; deCODE Genetics, Reykjavik, Iceland.; Faculty of Medicine, University of Iceland, Reykjavík, Iceland., Hamsten A; Cardiovascular Medicine Unit, Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden.; Center for Molecular Medicine, Karolinska University Hospital Solna, Stockholm, Sweden.; Department of Cardiology, Karolinska University Hospital Solna, Stockholm, Sweden., Nicholson G; Department of Statistics, University of Oxford, Oxford, UK., Karpe F; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK.; Oxford National Institute for Health Research Biomedical Research Centre, Churchill Hospital, Oxford, UK., Dermitzakis ET; Department of Genetic Medicine and Development, University of Geneva Medical School, Geneva, Switzerland., Lindgren CM; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.; Broad Institute of Harvard and Massachusetts Institute of Technology (MIT), Cambridge, MA, USA.; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK.; Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford, UK., McCarthy MI; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK.; Oxford National Institute for Health Research Biomedical Research Centre, Churchill Hospital, Oxford, UK.; Genentech, 340 Point San Bruno Boulevard, South San Francisco, CA, 94080, USA., Froguel P; University of Lille Nord de France, Lille, France.; CNRS UMR8199, Institut Pasteur de Lille, Lille, France.; Department of Medicine, Imperial College London, London, UK., Kaakinen MA; Department of Medicine, Imperial College London, London, UK.; School of Biosciences and Medicine, Department of Clinical and Experimental Medicine, University of Surrey, Guildford, UK., Lyssenko V; Department of Clinical Sciences, Diabetes and Endocrinology Research Unit, University Hospital Malmö, Lund University, Malmö, Sweden.; Department of Clinical Science, University of Bergen, Bergen, Norway., Watanabe RM; Department of Preventive Medicine, Keck School of Medicine of USC, Los Angeles, CA, USA.; Department of Physiology & Neuroscience, Keck School of Medicine of USC, Los Angeles, CA, USA.; USC Diabetes and Obesity Research Institute, Los Angeles, CA, USA., Ingelsson E; Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden.; Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, USA.; Stanford Cardiovascular Institute, Stanford University, Stanford, CA, 94305, USA., Florez JC; Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA, USA.; Diabetes Research Center, Diabetes Unit, Massachusetts General Hospital, Boston, MA, USA., Dupuis J; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA., Barroso I; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, UK.; University of Cambridge Metabolic Research Laboratories and NIHR Cambridge Biomedical Research Centre, Wellcome Trust-MRC Institute of Metabolic Science, Cambridge, UK.; Exeter Centre of ExcEllence in Diabetes (ExCEED), University of Exeter Medical School, Exeter, UK., Morris AP; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.; Estonian Genome Center, University of Tartu, Tartu, Estonia.; Department of Biostatistics, University of Liverpool, Liverpool, UK.; Centre for Genetics and Genomics Versus Arthritis, Centre for Musculoskeletal Research, The University of Manchester, Manchester, UK., Prokopenko I; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK. i.prokopenko@surrey.ac.uk.; Department of Medicine, Imperial College London, London, UK. i.prokopenko@surrey.ac.uk.; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK. i.prokopenko@surrey.ac.uk.; School of Biosciences and Medicine, Department of Clinical and Experimental Medicine, University of Surrey, Guildford, UK. i.prokopenko@surrey.ac.uk.; Institute of Biochemistry and Genetics, Ufa Federal Research Centre Russian Academy of Sciences, Ufa, Russian Federation. i.prokopenko@surrey.ac.uk.

Publikováno v: Nature communications [Nat Commun] 2021 Feb 08; Vol. 12 (1), pp. 995. Date of Electronic Publication: 2021 Feb 08.

A genetic chronology for the Indian Subcontinent points to heavily sex-biased dispersals.

Autor: Silva M; Department of Biological Sciences, School of Applied Sciences, University of Huddersfield, Queensgate, Huddersfield, HD1 3DH, UK., Oliveira M; i3S (Instituto de Investigação e Inovação em Saúde, Universidade do Porto), R. Alfredo Allen 208, 4200-135, Porto, Portugal.; IPATIMUP (Instituto de Patologia e Imunologia Molecular da Universidade do Porto), Rua Júlio Amaral de Carvalho 45, 4200-135, Porto, Portugal., Vieira D; Department of Informatics, University of Minho, Campus de Gualtar, 4710-057, Braga, Portugal.; CBMA (Centre of Molecular and Environmental Biology), Department of Biology, University of Minho, Campus de Gualtar, 4710-057, Braga, Portugal., Brandão A; i3S (Instituto de Investigação e Inovação em Saúde, Universidade do Porto), R. Alfredo Allen 208, 4200-135, Porto, Portugal.; IPATIMUP (Instituto de Patologia e Imunologia Molecular da Universidade do Porto), Rua Júlio Amaral de Carvalho 45, 4200-135, Porto, Portugal., Rito T; i3S (Instituto de Investigação e Inovação em Saúde, Universidade do Porto), R. Alfredo Allen 208, 4200-135, Porto, Portugal.; Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Campus de Gualtar, 4710-057, Braga, Portugal.; ICVS/3B's-PT Government Associate Laboratory, Braga/Guimarães, Portugal., Pereira JB; i3S (Instituto de Investigação e Inovação em Saúde, Universidade do Porto), R. Alfredo Allen 208, 4200-135, Porto, Portugal.; IPATIMUP (Instituto de Patologia e Imunologia Molecular da Universidade do Porto), Rua Júlio Amaral de Carvalho 45, 4200-135, Porto, Portugal., Fraser RM; Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland, UK.; Synpromics Ltd, Nine Edinburgh Bioquarter, Edinburgh, EH16 4UX, UK., Hudson B; Archaeology Department, University of Sydney, Sydney, NSW, 2006, Australia., Gandini F; Department of Biological Sciences, School of Applied Sciences, University of Huddersfield, Queensgate, Huddersfield, HD1 3DH, UK., Edwards C; Department of Biological Sciences, School of Applied Sciences, University of Huddersfield, Queensgate, Huddersfield, HD1 3DH, UK., Pala M; Department of Biological Sciences, School of Applied Sciences, University of Huddersfield, Queensgate, Huddersfield, HD1 3DH, UK., Koch J; University of Wales Centre for Advanced Welsh and Celtic Studies, National Library of Wales, Aberystwyth, SY23 3HH, Wales, UK., Wilson JF; Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland, UK.; MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, EH4 2XU, Scotland, UK., Pereira L; i3S (Instituto de Investigação e Inovação em Saúde, Universidade do Porto), R. Alfredo Allen 208, 4200-135, Porto, Portugal.; IPATIMUP (Instituto de Patologia e Imunologia Molecular da Universidade do Porto), Rua Júlio Amaral de Carvalho 45, 4200-135, Porto, Portugal., Richards MB; Department of Biological Sciences, School of Applied Sciences, University of Huddersfield, Queensgate, Huddersfield, HD1 3DH, UK. m.b.richards@hud.ac.uk., Soares P; IPATIMUP (Instituto de Patologia e Imunologia Molecular da Universidade do Porto), Rua Júlio Amaral de Carvalho 45, 4200-135, Porto, Portugal. pedrosoares@bio.uminho.pt.; CBMA (Centre of Molecular and Environmental Biology), Department of Biology, University of Minho, Campus de Gualtar, 4710-057, Braga, Portugal. pedrosoares@bio.uminho.pt.

Publikováno v: BMC evolutionary biology [BMC Evol Biol] 2017 Mar 23; Vol. 17 (1), pp. 88. Date of Electronic Publication: 2017 Mar 23.

The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals.

Autor: Ehret GB; Center for Complex Disease Genomics, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.; Cardiology, Department of Medicine, Geneva University Hospital, Rue Gabrielle-Perret-Gentil 4, 1211 Geneva 14, Switzerland., Ferreira T; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK., Chasman DI; Division of Preventive Medicine, Brigham and Women's Hospital, 900 Commonwealth Ave. East, Boston, MA 02215, USA.; Harvard Medical School, Boston, MA 02115, USA., Jackson AU; Department of Biostatistics, University of Michigan, Ann Arbor, MI 48109, USA.; Center for Statistical Genetics, University of Michigan, Ann Arbor, MI 48109, USA., Schmidt EM; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA., Johnson T; Clinical Pharmacology, William Harvey Research Institute, Queen Mary University of London, London, EC1M 6BQ, UK.; GlaxoSmithKline, Gunnels Wood Road, Stevenage SG1 2NY, UK., Thorleifsson G; deCODE Genetics/Amgen, Inc., Reykjavik, Iceland., Luan J; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK., Donnelly LA; Medical Research Institute, University of Dundee, Ninewells Hospital and Medical School, Dundee, DD1 9SY, UK., Kanoni S; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK., Petersen AK; Institute of Genetic Epidemiology, Helmholtz Zentrum München, Neuherberg 85764, Germany., Pihur V; Center for Complex Disease Genomics, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA., Strawbridge RJ; Cardiovascular Research Unit, Center for Molecular Medicine L8:03, Department of Medicine, Karolinska Institutet, 171 76 Stockholm, Sweden.; Center for Molecular Medicine, Karolinska University Hospital Solna, Stockholm, Sweden., Shungin D; Department of Public Health and Clinical Medicine, Umeå University, Sweden.; Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Skåne University Hospital Malmö, SE-205 02 Malmö, Sweden.; Department of Odontology, Umeå University, Sweden., Hughes MF; Centre of Excellence for Public Health, Queens University Belfast, Grosvenor Road, Belfast BT126JP, UK., Meirelles O; Laboratory of Genetics, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USA., Kaakinen M; Department of Genomics of Common Disease, School of Public Health, Imperial College London, Hammersmith Hospital, London, UK., Bouatia-Naji N; INSERM UMR970, Paris Cardiovascular Research Center PARCC, 56 rue Leblanc, 75015 Paris, France.; University Paris-Descartes, Sorbonne Paris Cité, 12 rue de l'Ecole de medicine, F-75006 Paris, France., Kristiansson K; National Institute for Health and Welfare, FI-00271 Helsinki, Finland.; Institute for Molecular Medicine Finland FIMM, University of Helsinki, 00290 Helsinki, Finland., Shah S; Genetic Epidemiology Group, Dept. Epidemiology and Public Health, UCL, London, WC1E 6BT, UK., Kleber ME; Vth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Theodor-Kutzer-Ufer 1-3, 68167 Mannheim, Germany., Guo X; Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, 1124 W. Carson Street, Torrance, CA 90502, USA., Lyytikäinen LP; Department of Clinical Chemistry, Fimlab Laboratories, Tampere 33520, Finland.; Department of Clinical Chemistry, University of Tampere School of Medicine, Tampere 33014, Finland., Fava C; University of Lund, Dept Internal Medicine, Malmo, SE 20502, Sweden.; University of Verona, Dept of Internal Medicine, Verona, Italy 37134., Eriksson N; Uppsala University, Uppsala Clinical Research Center, SE-75185 Uppsala, Sweden., Nolte IM; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands., Magnusson PK; Dept of Medical Epidemiology and Biostatistics, Karolinska Institutet, Box 281, SE-171 77 Stockholm, Sweden., Salfati EL; Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA., Rallidis LS; Second Department of Cardiology, Attikon Hospital, School of Medicine, University of Athens, Athens, Greece., Theusch E; Children's Hospital Oakland Research Institute, Oakland, CA 94609, USA., Smith AJP; Department of Cardiovascular Genetics, Institute of Cardiovascular Sciences, University College London, London WC1E 6JF, UK., Folkersen L; Cardiovascular Research Unit, Center for Molecular Medicine L8:03, Department of Medicine, Karolinska Institutet, 171 76 Stockholm, Sweden., Witkowska K; Clinical Pharmacology, William Harvey Research Institute, Queen Mary University of London, London, EC1M 6BQ, UK.; NIHR Barts Cardiovascular Biomedical Research Unit, Queen Mary University of London, London, EC1M 6BQ, UK., Pers TH; Division of Endocrinology, Boston Children's Hospital, Boston, MA 02115, USA.; Center for Basic and Translational Obesity Research, Boston Children's Hospital, Boston, MA 02115, USA.; Program in Medical and Population Genetics, Broad Institute, 7 Cambridge Center, Cambridge, MA 02142, USA.; Novo Nordisk Foundation Centre for Basic Metabolic Research, Section of Metabolic, Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 2100, Denmark.; Department of Epidemiology Research, Statens Serum Institut, 2300, Copenhagen, Denmark., Joehanes R; National Heart, Lung and Blood Institute's Framingham Heart Study, Framingham, MA 01702, USA., Kim SK; Dept. Dev. Bio. And Genetics, Stanford University Medical Center, Stanford, CA 94305, USA., Lataniotis L; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK., Jansen R; Department of Psychiatry, VU University Medical Center, Amsterdam, The Netherlands., Johnson AD; National Heart, Lung and Blood Institute's Framingham Heart Study, Framingham, MA 01702, USA.; National Heart, Lung and Blood Institute, Cardiovascular Epidemiology and Human Genomics Branch, Bethesda, MD 20814, USA., Warren H; Clinical Pharmacology, William Harvey Research Institute, Queen Mary University of London, London, EC1M 6BQ, UK.; NIHR Barts Cardiovascular Biomedical Research Unit, Queen Mary University of London, London, EC1M 6BQ, UK., Kim YJ; Center for Genome Science, National Institute of Health, Osong Health Technology Administration Complex, Chungcheongbuk-do, Republic of Korea., Zhao W; Division of Translational Medicine and Human Genetics, Department of Medicine, University of Pennyslvania, USA., Wu Y; Department of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA., Tayo BO; Department of Preventive Medicine and Epidemiology, Loyola University Chicago Stritch School of Medicine, Maywood, IL, 60153, USA., Bochud M; Institute of Social and Preventive Medicine (IUMSP), Centre Hospitalier Universitaire Vaudois and University of Lausanne, Route de la Corniche 10, 1010 Lausanne, Switzerland., Absher D; HudsonAlpha Institute for Biotechnology, Huntsville, AL 35086, USA., Adair LS; Department of Nutrition, University of North Carolina, Chapel Hill, NC 27599, USA., Amin N; Genetic Epidemiology Unit, Department of Epidemiology, Erasmus MC, Rotterdam, 3015CN, The Netherlands., Arking DE; Center for Complex Disease Genomics, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA., Axelsson T; Uppsala University, Department of Medical Sciences, SE-75185 Uppsala, Sweden., Baldassarre D; Dipartimento di Scienze Farmacologiche e Biomolecolari, Università di Milano, Milan, Italy.; Centro Cardiologico Monzino, IRCCS, Milan, Italy., Balkau B; INSERM Centre for Research in Epidemiology and Population Health, U1018, Villejuif, France University Paris-Sud, URMS 1018, Villejuif, France., Bandinelli S; Geriatric Unit, Azienda Sanitaria Firenze (ASF), Florence, Italy., Barnes MR; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.; NIHR Barts Cardiovascular Biomedical Research Unit, Queen Mary University of London, London, EC1M 6BQ, UK., Barroso I; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, CB10 1SA, Hinxton, UK.; University of Cambridge Metabolic Research Laboratories, Level 4, Institute of Metabolic Science Box 289 Addenbrookes Hospital Cambridge CB2 OQQ, UK.; NIHR Cambridge Biomedical Research Centre, Level 4, Institute of Metabolic Science Box 289 Addenbrookes Hospital Cambridge CB2 OQQ, UK., Bevan S; School of Life Science, University of Lincoln, Joseph Banks Laboratories, Lincoln LN6 7DL, UK., Bis JC; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA 98101, USA., Bjornsdottir G; deCODE Genetics/Amgen, Inc., Reykjavik, Iceland., Boehnke M; Department of Biostatistics, University of Michigan, Ann Arbor, MI 48109, USA.; Center for Statistical Genetics, University of Michigan, Ann Arbor, MI 48109, USA., Boerwinkle E; Human Genetics Center, School of Public Health, University of Texas Health Science Center at Houston, 1200 Pressler St., Suite 453E, Houston, TX 77030, USA., Bonnycastle LL; Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, MD 20892, USA., Boomsma DI; Department of Biological Psychology, VU University, Amsterdam, The Netherlands., Bornstein SR; Dept of Medicine III, University of Dresden, Medical Faculty Carl Gustav Carus, Fetscherstrasse 74, 01307 Dresden, Germany., Brown MJ; The Barts Heart Centre, William Harvey Research Institute, Queen Mary University of London, London EC1M 6BQ, UK., Burnier M; Nephrology, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Bugnon 17, 1005 Lausanne, Switzerland., Cabrera CP; Clinical Pharmacology, William Harvey Research Institute, Queen Mary University of London, London, EC1M 6BQ, UK.; NIHR Barts Cardiovascular Biomedical Research Unit, Queen Mary University of London, London, EC1M 6BQ, UK., Chambers JC; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, Norfolk Place, London W2 1PG, UK.; Department of Cardiology, Ealing Hospital NHS Trust, Uxbridge Road, Southall, Middlesex UB1 3EU, UK.; Imperial College Healthcare NHS Trust, London, UK., Chang IS; National Institute of Cancer Research, National Health Research Institutes. 35 Keyan Rd., Zhunan Town, Miaoli County 350, Taiwan., Cheng CY; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore 168751, Singapore.; Duke-NUS Graduate Medical School Singapore, Singapore 169857, Singapore.; Department of Ophthalmology, National University of Singapore and National University Health System, Singapore 119228., Chines PS; Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, MD 20892, USA., Chung RH; Division of Biostatistics and Bioinformatics, Institute of Population Health Sciences, National Health Research Institutes. 35 Keyan Rd., Zhunan Town, Miaoli County 350, Taiwan., Collins FS; Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, MD 20892, USA., Connell JM; University of Dundee, Ninewells Hospital and Medical School, Dundee, DD1 9SY, UK., Döring A; Institute of Epidemiology I, Helmholtz Zentrum München, Neuherberg 85764, Germany.; Institute of Epidemiology II, Helmholtz Zentrum München, Neuherberg 85764, Germany., Dallongeville J; UMR744 Inserm-Lille2-Institut Pasteur Lille, France., Danesh J; Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK.; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, CB10 1SA, Hinxton, UK.; NIHR Blood and Transplant Research Unit in Donor Health and Genomics, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK., de Faire U; Division of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden., Delgado G; Vth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Theodor-Kutzer-Ufer 1-3, 68167 Mannheim, Germany., Dominiczak AF; BHF Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, University of Glasgow, 126 University Place, Glasgow, G12 8QT, UK., Doney ASF; Medical Research Institute, University of Dundee, Ninewells Hospital and Medical School, Dundee, DD1 9SY, UK., Drenos F; Department of Cardiovascular Genetics, Institute of Cardiovascular Sciences, University College London, London WC1E 6JF, UK., Edkins S; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, CB10 1SA, Hinxton, UK., Eicher JD; National Heart, Lung and Blood Institute's Framingham Heart Study, Framingham, MA 01702, USA.; National Heart, Lung and Blood Institute, Cardiovascular Epidemiology and Human Genomics Branch, Bethesda, MD 20814, USA., Elosua R; Cardiovascular Epidemiology and Genetics. IMIM (Institut Hospital del Mar d'Investigacions Mèdiques), Barcelona, Spain., Enroth S; Department of Immunology, Genetics and Pathology, University of Uppsala, Box 815, Biomerical center, 751 08 Uppsala, Sweden.; Science for Life Laboratory, University of Uppsala, Box 815, Biomerical center, 751 08 Uppsala, Sweden., Erdmann J; Institut für Integrative und Experimentelle Genomik, Universiät zu Lübeck, RatzeburgerAllee 160, 23538 Lübeck, Germany.; Deutsches Zentrum für Herz-Kreislauf-Forschung (DZHK), partner site Hamburg, Kiel, Lübeck, Universität zu Lübeck, Lübeck, Germany., Eriksson P; Cardiovascular Research Unit, Center for Molecular Medicine L8:03, Department of Medicine, Karolinska Institutet, 171 76 Stockholm, Sweden., Esko T; Estonian Genome Center, University of Tartu, Tartu, 51010, Estonia.; Divisions of Endocrinology/Children's Hospital, Boston, MA 02115, USA.; Broad Institute of Harvard and MIT, Cambridge, MA 02139 USA., Evangelou E; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, Norfolk Place, London W2 1PG, UK.; Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, 45110, Greece., Evans A; Centre of Excellence for Public Health, Queens University Belfast, Grosvenor Road, Belfast BT126JP, UK., Fall T; Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden., Farrall M; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK.; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 9DU, UK., Felix JF; Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, P.O.Box 2040, 3000 CA Rotterdam, The Netherlands., Ferrières J; Toulouse University School of Medicine, Rangueil University Hospital, INSERM UMR1027, Toulouse, France., Ferrucci L; Translational Gerontology Branch, National Institute on Aging, Baltimore MD, USA., Fornage M; Institute of Molecular Medicine, University of Texas Health Science Center at Houston, TX, USA., Forrester T; Tropical Metabolism Research Unit, Tropical Medicine Research Institute, University of the West Indies, Mona, Kingston 7, Jamaica., Franceschini N; Department of Epidemiology, University of North Carolina, Chapel Hill, NC 27599, USA., Duran OHF; Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, P.O.Box 2040, 3000 CA Rotterdam, The Netherlands., Franco-Cereceda A; Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, 45110, Greece., Fraser RM; Institute for Population Health Sciences and Informatics, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland.; Synpromics Ltd, 9 Bioquarter, Little France Road, Edinburgh, EH16 4UX, Scotland., Ganesh SK; University of Michigan Medical School, 7220 MSRB III, Ann Arbor MI 48109, USA., Gao H; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, Norfolk Place, London W2 1PG, UK., Gertow K; Cardiovascular Research Unit, Center for Molecular Medicine L8:03, Department of Medicine, Karolinska Institutet, 171 76 Stockholm, Sweden.; Center for Molecular Medicine, Karolinska University Hospital Solna, Stockholm, Sweden., Gianfagna F; EPIMED Research Centre - Epidemiology and Preventive Medicine, Department of Clinical and Experimental Medicine, University of Insubria, Varese, Italy.; Department of Epidemiology and Prevention, IRCCS Istituto Neurologico Mediterraneo NEUROMED, 86077 Pozzilli, Italy., Gigante B; Division of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden., Giulianini F; Division of Preventive Medicine, Brigham and Women's Hospital, 900 Commonwealth Ave. East, Boston, MA 02215, USA., Goel A; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK.; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 9DU, UK., Goodall AH; Department of Cardiovascular Sciences, University of Leicester, Glenfield Hospital, Leicester LE3 9QP, UK.; National Institute for Health Research Leicester Cardiovascular Biomedical Research Unit, Glenfield Hospital, Leicester LE3 9QP, UK., Goodarzi MO; Division of Endocrinology, Diabetes and Metabolism, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA., Gorski M; Department of Genetic Epidemiology, Institute of Epidemiology and Preventive Medicine, University of Regensburg, Franz-Josef-Strauss-Allee 11, 93053 Regensburg, Germany.; Department of Nephrology, University Hospital Regensburg, Franz-Josef-Strauss-Allee 11, 93053 Regensburg, Germany., Gräßler J; Department of Medicine III, Division Pathobiochemistry, Technische Universität Dresden, Dresden, Germany., Groves C; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK., Gudnason V; Icelandic Heart Association, Kopavogur, Iceland.; Faculty of Medicine, University of Iceland, Reykjavik, Iceland., Gyllensten U; Department of Immunology, Genetics and Pathology, University of Uppsala, Box 815, Biomerical center, 751 08 Uppsala, Sweden.; Science for Life Laboratory, University of Uppsala, Box 815, Biomerical center, 751 08 Uppsala, Sweden., Hallmans G; Department of Public Health and Clinical Medicine, Umeå University, Sweden., Hartikainen AL; Institute of Clinical Medicine/Obstetrics and Gynaecology, University of Oulu, Oulu, Finland.; Medical Research Center, Oulu University Hospital, Oulu, Finland., Hassinen M; Kuopio Research Institute of Exercise Medicine, Kuopio, Finland., Havulinna AS; National Institute for Health and Welfare, FI-00271 Helsinki, Finland., Hayward C; Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, EH4 2XU Scotland, UK., Hercberg S; UREN, INSERM U557, INRA U1125, CNAM, SMBH, Sorbonne Paris Cité, Université Paris 13, Bobigny, France., Herzig KH; Institute of Biomedicine, University of Oulu, Medical Research Center Oulu and Oulu University Hospital, Finland.; Biocenter Oulu, P.O.Box 5000, Aapistie 5A, FI-90014 University of Oulu, Finland.; Department of Gastroenterology and Metabolism, Poznan University of Medical Sciences, Poznan, Poland., Hicks AA; Center for Biomedicine, European Academy Bozen/Bolzano (EURAC), Bolzano, 39100, Italy - affiliated institute of the University of Lübeck, Germany., Hingorani AD; Genetic Epidemiology Group, Dept. Epidemiology and Public Health, UCL, London, WC1E 6BT, UK., Hirschhorn JN; Division of Endocrinology, Boston Children's Hospital, Boston, MA 02115, USA.; Center for Basic and Translational Obesity Research, Boston Children's Hospital, Boston, MA 02115, USA.; Program in Medical and Population Genetics, Broad Institute, 7 Cambridge Center, Cambridge, MA 02142, USA.; Department of Genetics, Harvard Medical School, Boston, 02115, USA., Hofman A; Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, P.O.Box 2040, 3000 CA Rotterdam, The Netherlands.; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA., Holmen J; HUNT Research Centre, Department of Public Health and General Practice, Norwegian University of Science and Technology, 7600 Levanger, Norway., Holmen OL; HUNT Research Centre, Department of Public Health and General Practice, Norwegian University of Science and Technology, 7600 Levanger, Norway.; St. Olav Hospital, Trondheim University Hospital, Trondheim, Norway., Hottenga JJ; Department of Biological Psychology, VU University, Amsterdam, The Netherlands., Howard P; Department of Cardiovascular Genetics, Institute of Cardiovascular Sciences, University College London, London WC1E 6JF, UK., Hsiung CA; Division of Biostatistics and Bioinformatics, Institute of Population Health Sciences, National Health Research Institutes. 35 Keyan Rd., Zhunan Town, Miaoli County 350, Taiwan., Hunt SC; Cardiovascular Genetics Division, University of Utah School of Medicine, Salt Lake City, Utah, USA.; Department of Genetic Medicine, Weill Cornell Medical College Qatar, Doha, Qatar., Ikram MA; Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, P.O.Box 2040, 3000 CA Rotterdam, The Netherlands.; Department of Radiology, Erasmus MC, The Netherlands.; Department of Neurology, Erasmus MC, University Medical Center Rotterdam, P.O.Box 2040, 3000 CA Rotterdam, The Netherlands., Illig T; Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, Neuherberg 85764, Germany.; Hannover Unified Biobank, Hannover Medical School, Hannover 30625, Germany.; Hannover Medical School, Institute for Human Genetics, Carl-Neuberg-Strasse 1, 30625 Hanover, Germany., Iribarren C; Kaiser Permanente, Division of Research, Oakland, CA 94612, USA., Jensen RA; Human Genetics Center, School of Public Health, University of Texas Health Science Center at Houston, 1200 Pressler St., Suite 453E, Houston, TX 77030, USA.; Department of Medicine, University of Washington, Seattle, Washington 98101, USA., Kähönen M; Department of Clinical Physiology, Tampere University Hospital, Tampere 33521, Finland., Kang H; Department of Biostatistics, University of Michigan, Ann Arbor, MI 48109, USA.; Center for Statistical Genetics, University of Michigan, Ann Arbor, MI 48109, USA., Kathiresan S; Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA 02114, USA.; Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA 02114, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Program in Medical and Population Genetics, Broad Institute, 7 Cambridge Center, Cambridge, MA 02142, USA.; Cardiology Division, Department of Medicine, Massachusetts General Hospital., Keating BJ; Division of Transplantation, Department of Surgery, University of Pennsylvania, PA 19104 USA.; Department of Pediatrics, University of Pennsylvania, Philadelphia, PA, USA., Khaw KT; Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Cambridge CB2 2SR, UK., Kim YK; Center for Genome Science, National Institute of Health, Osong Health Technology Administration Complex, Chungcheongbuk-do, Republic of Korea., Kim E; Institute for Translational Genomics and Population Sciences, Department of Pediatrics, LABioMed at Harbor-UCLA Medical Center, 1124 W. Carson Street, Torrance, CA 90502, USA., Kivimaki M; Genetic Epidemiology Group, Dept. Epidemiology and Public Health, UCL, London, WC1E 6BT, UK., Klopp N; Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, Neuherberg 85764, Germany.; Hannover Unified Biobank, Hannover Medical School, Hannover 30625, Germany., Kolovou G; 1st Cardiology Department, Onassis Cardiac Surgery Center 356, Sygrou Ave, Athens, Greece., Komulainen P; Kuopio Research Institute of Exercise Medicine, Kuopio, Finland., Kooner JS; National Heart and Lung Institute, Imperial College London, Hammersmith Hospital Campus, Ducane Road, London W12 0NN, UK.; Department of Cardiology, Ealing Hospital NHS Trust, Uxbridge Road, Southall, Middlesex UB1 3EU, UK.; Imperial College Healthcare NHS Trust, London, UK., Kosova G; Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA 02114, USA.; Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA 02114, USA.; Broad Institute of Harvard and MIT, Cambridge, MA 02139 USA., Krauss RM; Department of Medicine, Children's Hospital Oakland Research Institute, Oakland, CA 94609, USA., Kuh D; MRC Unit for Lifelong Health and Ageing at UCL, London, WC1B 5JU, UK., Kutalik Z; Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland.; Swiss Institute of Bioinformatics, Lausanne, Switzerland., Kuusisto J; Department of Medicine, University of Eastern Finland and Kuopio University Hospital, 70210 Kuopio, Finland., Kvaløy K; HUNT Research Centre, Department of Public Health and General Practice, Norwegian University of Science and Technology, 7600 Levanger, Norway., Lakka TA; Institute of Biomedicine/Physiology, University of Eastern Finland, Kuopio Campus, Finland.; Kuopio Research Institute of Exercise Medicine, Kuopio, Finland.; Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, Finland., Lee NR; Office of Population Studies Foundation Inc., Talamban, Cebu City, 6000, Philippines.; Department of Anthropology, Sociology, and History, University of San Carlos, Talamban, Cebu City, 6000, Philippines., Lee IT; Division of Endocrine and Metabolism, Department of Internal Medicine, Chichung Veterans General Hospital, Taichung 40705, Taiwan.; School of Medicine, National Yang-Ming University, Taipei, Taiwan., Lee WJ; Department of Medical Research, Taichung Veterans General Hospital, Taichung 407, Taiwan., Levy D; National Heart, Lung and Blood Institute's Framingham Heart Study, Framingham, MA 01702, USA.; Population Sciences Branch, National Heart Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA., Li X; Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, 1124 W. Carson Street, Torrance, CA 90502, USA., Liang KW; Cardiovascular Center, Taichung Veterans General Hospital, Taichung, 40705, Taiwan.; Institute of Clinical Medicine, National Yang Ming University School of Medicine, Taipei 112, Taiwan., Lin H; Section of Computational Biomedicine, Department of Medicine, Boston University School of Medicine, Boston, 02446 MA, USA.; National Heart, Lung and Blood Institute's Framingham Heart Study, Framingham, MA 01702, USA., Lin L; Cardiology, Department of Medicine, Geneva University Hospital, Rue Gabrielle-Perret-Gentil 4, 1211 Geneva 14, Switzerland., Lindström J; National Institute for Health and Welfare, FI-00271 Helsinki, Finland., Lobbens S; European Genomic Institute for Diabetes (EGID), FR 3508 Lille, France.; Centre National de la Recherche Scientifique (CNRS) UMR 8199, Lille Pasteur Institute, 1 rue du Prof Calmette, 59019 Lille Cedex, France.; Lille 2 University, Lille, France., Männistö S; National Institute for Health and Welfare, FI-00271 Helsinki, Finland., Müller G; Center for Evidence-based Healthcare, University of Dresden, Medical Faculty Carl Gustav Carus, Fetscherstrasse 74, 01307 Dresden, Germany., Müller-Nurasyid M; Institute of Genetic Epidemiology, Helmholtz Zentrum München, Neuherberg 85764, Germany.; Department of Medicine I, University Hospital Grosshadern, Ludwig-Maximilians University, Munich, Germany.; Institute of Medical Informatics, Biometry and Epidemiology, Chair of Epidemiology, Ludwig-Maximilians-Universität, München 81377, Germany., Mach F; Cardiology, Department of Medicine, Geneva University Hospital, Rue Gabrielle-Perret-Gentil 4, 1211 Geneva 14, Switzerland., Markus HS; Neurology Unit, University of Cambridge, R3, Box 83, Cambridge Biomedical Campus, Cambridge, Cb2 0QQ, UK., Marouli E; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.; Department of Dietetics-Nutrition, Harokopio University, 70 El. Venizelou Str, Athens, Greece., McCarthy MI; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK., McKenzie CA; Tropical Metabolism Research Unit, Tropical Medicine Research Institute, University of the West Indies, Mona, Kingston 7, Jamaica., Meneton P; INSERM U1142 LIMICS, UMR_S 1142 Sorbonne Universités, UPMC Université Paris 06, Université Paris 13, Paris, France., Menni C; Department of Twin Research and Genetic Epidemiology, King's College London, London, UK., Metspalu A; Estonian Genome Center, University of Tartu, Tartu, 51010, Estonia., Mijatovic V; Department of Life and Reproduction Sciences, University of Verona, Strada le Grazie 8, 37134 Verona, Italy., Moilanen L; Department of Medicine, Kuopio University Hospital, Kuopio, Finland.; Unit of General Practice, Oulu University Hospital, Oulu, Finland., Montasser ME; Department of Medicine, Program for Personalized and Genomic Medicine, University of Maryland, School of Medicine, Baltimore, Maryland 21201, USA., Morris AD; Medical Research Institute, University of Dundee, Ninewells Hospital and Medical School, Dundee, DD1 9SY, UK., Morrison AC; Department of Epidemiology, Human Genetics and Environmental Sciences, School of Public Health, University of Texas Health Science Center at Houston, 1200 Pressler St., Suite 453E, Houston, TX 77030, USA., Mulas A; Istituto di Ricerca Genetica e Biomedica (IRGB), Consiglio Nazionale delle Ricerche, c/o Cittadella Universitaria di Monseratto, Monserrato, Cagliari 09042, Italy., Nagaraja R; Laboratory of Genetics, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USA., Narisu N; Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, MD 20892, USA., Nikus K; Department of Cardiology, School of Medicine, University of Tampere, Tampere 33014, Finland.; School of Medicine, University of Tampere, Tampere 33014, Finland., O'Donnell CJ; National Heart, Lung and Blood Institute, Division of Intramural Research, Bethesda, MD, USA.; National Heart, Lung and Blood Institute's Framingham Heart Study, Framingham, MA 01702, USA.; Cardiology Division, Department of Medicine, Massachusetts General Hospital., O'Reilly PF; Institute of Psychiatry, Psychology and Neuroscience, King's College London, London SE5 8AF, UK., Ong KK; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK., Paccaud F; Institute of Social and Preventive Medicine (IUMSP), Centre Hospitalier Universitaire Vaudois and University of Lausanne, Route de la Corniche 10, 1010 Lausanne, Switzerland., Palmer CD; Divisions of Endocrinology, Children's Hospital Boston, Massachusetts 02115, USA.; Genetics and Program in Genomics, Children's Hospital Boston, Massachusetts 02115, USA.; Program in Medical and Population Genetics, Broad Institute, 7 Cambridge Center, Cambridge, MA 02142, USA., Parsa A; Department of Medicine, Program for Personalized and Genomic Medicine, University of Maryland, School of Medicine, Baltimore, Maryland 21201, USA., Pedersen NL; Dept of Medical Epidemiology and Biostatistics, Karolinska Institutet, Box 281, SE-171 77 Stockholm, Sweden., Penninx BW; Department of Psychiatry, EMGO Institute, Neuroscience Campus, VU University Medical Centre, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands.; Department of Psychiatry, University of Groningen, University Medical Center Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands.; Department of Psychiatry, Leiden University Medical Centre, P.O. Box 9600, 2300 RC Leiden, The Netherlands., Perola M; National Institute for Health and Welfare, FI-00271 Helsinki, Finland.; Institute for Molecular Medicine Finland FIMM, University of Helsinki, 00290 Helsinki, Finland.; Estonian Genome Center, University of Tartu, Tartu, 51010, Estonia., Peters A; Institute of Epidemiology II, Helmholtz Zentrum München, Neuherberg 85764, Germany., Poulter N; International Centre for Circulatory Health, Imperial College London, W2 1PG, UK., Pramstaller PP; Center for Biomedicine, European Academy Bozen/Bolzano (EURAC), Bolzano, 39100, Italy - affiliated institute of the University of Lübeck, Germany.; Department of Neurology, General Central Hospital, Bolzano, 39100, Italy.; Department of Neurology, University of Lübeck, Lübeck, Germany., Psaty BM; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA 98101, USA.; Department of Epidemiology, University of Washington, Seattle, WA, USA.; Department of Health Services, University of Washington, Seattle, WA.; Group Health Research Institute, Group Health Cooperative, Seattle, WA., Quertermous T; Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA., Rao DC; Division of Biostatistics, Washington University School of Medicine, Saint Louis, MO, 63110, USA., Rasheed A; Center for Non-Communicable Diseases, Karachi, Pakistan., Rayner NWNWR; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK.; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK.; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, CB10 1SA, Hinxton, UK., Renström F; Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Skåne University Hospital Malmö, SE-205 02 Malmö, Sweden.; Department of Nutrition, Harvard School of Public Health, Boston, MA, USA.; Department of Public Health and Clinical Medicine, Umeå University, Sweden., Rettig R; Institute of Physiology, University Medicine Greifswald, Greifswald, Germany., Rice KM; Department of Biostatistics, University of Washington, Seattle, WA, USA., Roberts R; University of Ottawa Heart Institute, Cardiovascular Research Methods Centre Ontario, Canada.; Ruddy Canadian Cardiovascular Genetics Centre, Ontario, Canada., Rose LM; Division of Preventive Medicine, Brigham and Women's Hospital, 900 Commonwealth Ave. East, Boston, MA 02215, USA., Rossouw J; National Heart, Lung, and Blood Institute, 6701 Rockledge Ave., Bethesda, MD 20892, USA., Samani NJ; Department of Cardiovascular Sciences, University of Leicester, Glenfield Hospital, Leicester LE3 9QP, UK.; Leicester NIHR Biomedical Research Unit in Cardiovascular Disease, Glenfield Hospital, Leicester LE3 9QP, UK., Sanna S; Istituto di Ricerca Genetica e Biomedica (IRGB), Consiglio Nazionale delle Ricerche, c/o Cittadella Universitaria di Monseratto, Monserrato, Cagliari 09042, Italy., Saramies J; South Karelia Central Hospital, Lappeenranta, Finland., Schunkert H; Deutsches Herzzentrum München, Germany.; Technische Universität München, Germany.; Deutsches Zentrum für Herz-Kreislauf-Forschung (DZHK), München, Germany.; Munich Heart Alliance, Germany., Sebert S; Center For Life-course Health Research, P.O.Box 5000, FI-90014 University of Oulu, Finland.; Biocenter Oulu, P.O.Box 5000, Aapistie 5A, FI-90014 University of Oulu, Finland.; Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, Finland., Sheu WH; Division of Endocrine and Metabolism, Department of Internal Medicine, Chichung Veterans General Hospital, Taichung 40705, Taiwan.; School of Medicine, National Yang-Ming University, Taipei, Taiwan.; College of Medicine, National Defense Medical Center, Taipei, Taiwan., Shin YA; Center for Genome Science, National Institute of Health, Osong Health Technology Administration Complex, Chungcheongbuk-do, Republic of Korea., Sim X; Department of Biostatistics, University of Michigan, Ann Arbor, MI 48109, USA.; Center for Statistical Genetics, University of Michigan, Ann Arbor, MI 48109, USA.; Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore 117597., Smit JH; Department of Psychiatry, EMGO Institute, Neuroscience Campus, VU University Medical Centre, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands., Smith AV; Icelandic Heart Association, Kopavogur, Iceland.; Faculty of Medicine, University of Iceland, Reykjavik, Iceland., Sosa MX; Center for Complex Disease Genomics, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA., Spector TD; Department of Twin Research and Genetic Epidemiology, King's College London, London, UK., Stančáková A; University of Eastern Finland and Kuopio University Hospital, 70210 Kuopio, Finland., Stanton A; Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin 4, Ireland., Stirrups KE; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.; Department of Haematology, University of Cambridge, Cambridge, UK., Stringham HM; Department of Biostatistics, University of Michigan, Ann Arbor, MI 48109, USA.; Center for Statistical Genetics, University of Michigan, Ann Arbor, MI 48109, USA., Sundstrom J; Uppsala University, Department of Medical Sciences, SE-75185 Uppsala, Sweden., Swift AJ; Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, MD 20892, USA., Syvänen AC; Uppsala University, Department of Medical Sciences, SE-75185 Uppsala, Sweden., Tai ES; Department of Medicine, National University of Singapore and National University Health System, Singapore 119228, Singapore.; Duke-NUS Graduate Medical School Singapore, Singapore 169857, Singapore.; Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore 117597., Tanaka T; Translational Gerontology Branch, National Institute on Aging, Baltimore MD, USA., Tarasov KV; Laboratory of Cardiovascular Science, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, 21224, USA., Teumer A; Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany., Thorsteinsdottir U; deCODE Genetics/Amgen, Inc., Reykjavik, Iceland.; Faculty of Medicine, University of Iceland, Reykjavik, Iceland., Tobin MD; Department of Health Sciences, University of Leicester, University Rd, Leicester LE1 7RH, UK., Tremoli E; Dipartimento di Scienze Farmacologiche e Biomolecolari, Università di Milano, Milan, Italy.; Centro Cardiologico Monzino, IRCCS, Milan, Italy., Uitterlinden AG; Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, P.O.Box 2040, 3000 CA Rotterdam, The Netherlands.; Department of internal medicine, Erasmus MC, Rotterdam, 3000CA, The Netherlands., Uusitupa M; Department of Public Health and Clinical Nutrition, University of Eastern Finland, Finland.; Research Unit, Kuopio University Hospital, Kuopio, Finland., Vaez A; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands.; Research Institute for Primordial Prevention of Non-communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran., Vaidya D; Johns Hopkins Medical Institutions, 1830 East Monument St., Baltimore, MD 21287, USA., van Duijn CM; Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, P.O.Box 2040, 3000 CA Rotterdam, The Netherlands.; Centre of Medical Systems Biology (CMSB 1-2), NGI Erasmus Medical Center, Rotterdam, The Netherlands., van Iperen EPA; Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Academic Medical Center, Amsterdam, The Netherlands.; Durrer Center for Cardiogenetic Research, ICIN-Netherlands Heart Institute, Utrecht, The Netherlands., Vasan RS; National Heart, Lung and Blood Institute's Framingham Heart Study, Framingham, MA 01702, USA.; Section of Preventive medicine, Department of Medicine, Boston University School of Medicine, Boston, 02446 MA, USA.; Cardiology, Department of Medicine, Boston University School of Medicine, Boston, 02446 MA, USA., Verwoert GC; Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, P.O.Box 2040, 3000 CA Rotterdam, The Netherlands., Virtamo J; National Institute for Health and Welfare, FI-00271 Helsinki, Finland., Vitart V; Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, EH4 2XU Scotland, UK., Voight BF; Program in Medical and Population Genetics, Broad Institute, 7 Cambridge Center, Cambridge, MA 02142, USA.; Department of Pharmacology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA., Vollenweider P; Department of Internal medicine, University Hospital Lausanne, Lausanne, Switzerland., Wagner A; Department of Epidemiology and Public Health, EA3430, University of Strasbourg, Strasbourg, France., Wain LV; Department of Health Sciences, University of Leicester, University Rd, Leicester LE1 7RH, UK., Wareham NJ; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK., Watkins H; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK.; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 9DU, UK., Weder AB; Division of Cardiovascular Medicine, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA., Westra HJ; University Medical Center Groningen, University of Groningen, Groningen, 9700RB, The Netherlands., Wilks R; Epidemiology Research Unit, Tropical Medicine Research Institute, University of the West Indies, Mona, Kingston 7, Jamaica., Wilsgaard T; Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, Tromsø, Norway.; Department of Clinical Medicine, Faculty of Health Sciences, University of Tromsø, Tromsø, Norway., Wilson JF; Institute for Population Health Sciences and Informatics, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland.; Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, EH4 2XU Scotland, UK., Wong TY; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore 168751, Singapore.; Duke-NUS Graduate Medical School Singapore, Singapore 169857, Singapore.; Department of Ophthalmology, National University of Singapore and National University Health System, Singapore 119228., Yang TP; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.; MRC Cancer Unit, University of Cambridge, Cambridge, UK., Yao J; Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, 1124 W. Carson Street, Torrance, CA 90502, USA., Yengo L; European Genomic Institute for Diabetes (EGID), FR 3508 Lille, France.; Centre National de la Recherche Scientifique (CNRS) UMR 8199, Lille Pasteur Institute, 1 rue du Prof Calmette, 59019 Lille Cedex, France.; Lille 2 University, Lille, France., Zhang W; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, Norfolk Place, London W2 1PG, UK.; Department of Cardiology, Ealing Hospital NHS Trust, Uxbridge Road, Southall, Middlesex UB1 3EU, UK., Zhao JH; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK., Zhu X; Department of Epidemiology and Biostatistics, School of Medicine, Case Western Reserve University, Cleveland, OH, 44106, USA., Bovet P; Ministry of Health, Victoria, Republic of Seychelles.; Institute of Social and Preventive Medicine (IUMSP), Centre Hospitalier Universitaire Vaudois and University of Lausanne, Route de la Corniche 10, 1010 Lausanne, Switzerland., Cooper RS; Department of Preventive Medicine and Epidemiology, Loyola University Chicago Stritch School of Medicine, Maywood, IL, 60153, USA., Mohlke KL; Department of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA., Saleheen D; Department of Biostatistics and Epidemiology, University of Pennsylvania, USA.; Center for Non-Communicable Diseases, Karachi, Pakistan., Lee JY; Center for Genome Science, National Institute of Health, Osong Health Technology Administration Complex, Chungcheongbuk-do, Republic of Korea., Elliott P; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, Norfolk Place, London W2 1PG, UK.; MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, Norfolk Place, London W2 1PG, UK., Gierman HJ; Dept. Dev. Bio. And Genetics, Stanford University Medical Center, Stanford, CA 94305, USA.; Enterprise Informatics, Illumina Inc., Santa Clara CA, 95050, USA., Willer CJ; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA.; Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, MI 48109, USA.; Department of Human Genetics, University of Michigan, Ann Arbor, Michigan, USA., Franke L; Department of Genetics, University of Groningen, University Medical Centre Groningen, Groningen, 9711, The Netherlands., Hovingh GK; Dept Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands., Taylor KD; Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, 1124 W. Carson Street, Torrance, CA 90502, USA., Dedoussis G; Department of Dietetics-Nutrition, Harokopio University, 70 El. Venizelou Str, Athens, Greece., Sever P; International Centre for Circulatory Health, Imperial College London, W2 1PG, UK., Wong A; MRC Unit for Lifelong Health and Ageing at UCL, London, WC1B 5JU, UK., Lind L; Uppsala University, Department of Medical Sciences, SE-75185 Uppsala, Sweden., Assimes TL; Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA., Njølstad I; Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, Tromsø, Norway.; Department of Clinical Medicine, Faculty of Health Sciences, University of Tromsø, Tromsø, Norway., Schwarz PE; Dept of Medicine III, University of Dresden, Medical Faculty Carl Gustav Carus, Fetscherstrasse 74, 01307 Dresden, Germany., Langenberg C; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK., Snieder H; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands., Caulfield MJ; Clinical Pharmacology, William Harvey Research Institute, Queen Mary University of London, London, EC1M 6BQ, UK.; NIHR Barts Cardiovascular Biomedical Research Unit, Queen Mary University of London, London, EC1M 6BQ, UK., Melander O; University of Lund, Dept Internal Medicine, Malmo, SE 20502, Sweden., Laakso M; Department of Medicine, University of Eastern Finland and Kuopio University Hospital, 70210 Kuopio, Finland., Saltevo J; Department of Medicine, Central Finland Health Care District, Jyväskylä, Finland., Rauramaa R; Kuopio Research Institute of Exercise Medicine, Kuopio, Finland.; Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, Finland., Tuomilehto J; National Institute for Health and Welfare, FI-00271 Helsinki, Finland.; Dasman Diabetes Institute, Dasman, 15462 Kuwait.; Saudi Diabetes Research Group, King Abdulaziz University, 21589 Jeddah, Saudi Arabia.; Centre for Vascular Prevention, Danube-University Krems, 3500 Krems, Austria., Ingelsson E; Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden.; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK., Lehtimäki T; Department of Clinical Chemistry, Fimlab Laboratories, Tampere 33520, Finland.; Department of Clinical Chemistry, University of Tampere School of Medicine, Tampere 33014, Finland., Hveem K; HUNT Research Centre, Department of Public Health and General Practice, Norwegian University of Science and Technology, 7600 Levanger, Norway., Palmas W; Department of Medicine, Columbia University, 622 West 168th St., New York, NY 10032, USA., März W; Synlab Academy, Synlab Services GmbH, P5, 7, 68161 Mannheim, Germany.; Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, 8036 Graz, Austria., Kumari M; Genetic Epidemiology Group, Dept. Epidemiology and Public Health, UCL, London, WC1E 6BT, UK., Salomaa V; National Institute for Health and Welfare, FI-00271 Helsinki, Finland., Chen YI; Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, 1124 W. Carson Street, Torrance, CA 90502, USA., Rotter JI; Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, 1124 W. Carson Street, Torrance, CA 90502, USA., Froguel P; European Genomic Institute for Diabetes (EGID), FR 3508 Lille, France.; Centre National de la Recherche Scientifique (CNRS) UMR 8199, Lille Pasteur Institute, 1 rue du Prof Calmette, 59019 Lille Cedex, France.; Lille 2 University, Lille, France.; Department of Genomics of Common Disease, School of Public Health, Imperial College London, Hammersmith Hospital, London, UK., Jarvelin MR; Center For Life-course Health Research, P.O.Box 5000, FI-90014 University of Oulu, Finland.; Biocenter Oulu, P.O.Box 5000, Aapistie 5A, FI-90014 University of Oulu, Finland.; Unit of Primary Care, Oulu University Hospital, Kajaanintie 50, P.O.Box 20, FI-90220 Oulu, 90029 OYS, Finland.; MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, Norfolk Place, London W2 1PG, UK., Lakatta EG; Laboratory of Cardiovascular Science, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, 21224, USA., Kuulasmaa K; National Institute for Health and Welfare, FI-00271 Helsinki, Finland., Franks PW; Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Skåne University Hospital Malmö, SE-205 02 Malmö, Sweden.; Department of Nutrition, Harvard School of Public Health, Boston, MA, USA.; Department of Public Health and Clinical Medicine, Umeå University, Sweden., Hamsten A; Cardiovascular Research Unit, Center for Molecular Medicine L8:03, Department of Medicine, Karolinska Institutet, 171 76 Stockholm, Sweden.; Center for Molecular Medicine, Karolinska University Hospital Solna, Stockholm, Sweden., Wichmann HE; Institute of Epidemiology I, Helmholtz Zentrum München, Neuherberg 85764, Germany.; Institute of Medical Informatics, Biometry and Epidemiology, Chair of Epidemiology, Ludwig-Maximilians-Universität, München 81377, Germany.; Grosshadern, Klinikum, München 81377, Germany., Palmer CNA; Medical Research Institute, University of Dundee, Ninewells Hospital and Medical School, Dundee, DD1 9SY, UK., Stefansson K; deCODE Genetics/Amgen, Inc., Reykjavik, Iceland.; Faculty of Medicine, University of Iceland, Reykjavik, Iceland., Ridker PM; Division of Preventive Medicine, Brigham and Women's Hospital, 900 Commonwealth Ave. East, Boston, MA 02215, USA.; Harvard Medical School, Boston, MA 02115, USA., Loos RJF; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK.; The Charles Bronfman Institute for Personalized Medicine, The Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; Mindich Child health Development Institute, The Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Chakravarti A; Center for Complex Disease Genomics, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA., Deloukas P; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.; Princess Al-Jawhara Al-Brahim Centre of Excellence in Research of Hereditary Disorders (PACER-HD), King Abdulaziz University, Jeddah 21589, Saudi Arabia., Morris AP; Department of Biostatistics, University of Liverpool, Liverpool L69 3GA, UK.; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK., Newton-Cheh C; Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA 02114, USA.; Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA 02114, USA.; Program in Medical and Population Genetics, Broad Institute, 7 Cambridge Center, Cambridge, MA 02142, USA.; Broad Institute of Harvard and MIT, Cambridge, MA 02139 USA., Munroe PB; Clinical Pharmacology, William Harvey Research Institute, Queen Mary University of London, London, EC1M 6BQ, UK.; NIHR Barts Cardiovascular Biomedical Research Unit, Queen Mary University of London, London, EC1M 6BQ, UK.

Publikováno v: Nature genetics [Nat Genet] 2016 Oct; Vol. 48 (10), pp. 1171-1184. Date of Electronic Publication: 2016 Sep 12.

Homozygous loss-of-function variants in European cosmopolitan and isolate populations.

Autor: Kaiser VB; MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine and vera.kaiser@igmm.ed.ac.uk., Svinti V; MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine and., Prendergast JG; The Roslin Institute, The University of Edinburgh, Easter Bush, Midlothian EH25 9RG, UK., Chau YY; MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine and., Campbell A; Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK., Patarcic I; Medical School, University of Split, Soltanska 2, Split 21000, Croatia., Barroso I; Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK., Joshi PK; Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Teviot Place, Edinburgh EH8 9AG, UK., Hastie ND; MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine and., Miljkovic A; Medical School, University of Split, Soltanska 2, Split 21000, Croatia., Taylor MS; MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine and., Enroth S; Department of Immunology, Genetics, and Pathology, Biomedical Center, SciLifeLab Uppsala, Uppsala University, Uppsala SE-75108, Sweden and., Memari Y; Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK., Kolb-Kokocinski A; Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK., Wright AF; MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine and., Gyllensten U; Department of Immunology, Genetics, and Pathology, Biomedical Center, SciLifeLab Uppsala, Uppsala University, Uppsala SE-75108, Sweden and., Durbin R; Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK., Rudan I; Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Teviot Place, Edinburgh EH8 9AG, UK., Campbell H; Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Teviot Place, Edinburgh EH8 9AG, UK., Polašek O; Medical School, University of Split, Soltanska 2, Split 21000, Croatia, Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Teviot Place, Edinburgh EH8 9AG, UK., Johansson Å; Department of Immunology, Genetics, and Pathology, Biomedical Center, SciLifeLab Uppsala, Uppsala University, Uppsala SE-75108, Sweden and., Sauer S; Max-Planck-Institute for Molecular Genetics, Otto-Warburg-Laboratory, Berlin, Germany., Porteous DJ; Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK., Fraser RM; Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Teviot Place, Edinburgh EH8 9AG, UK., Drake C; MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine and., Vitart V; MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine and., Hayward C; MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine and., Semple CA; MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine and., Wilson JF; MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine and Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Teviot Place, Edinburgh EH8 9AG, UK.

Publikováno v: Human molecular genetics [Hum Mol Genet] 2015 Oct 01; Vol. 24 (19), pp. 5464-74. Date of Electronic Publication: 2015 Jul 14.

Genetic studies of body mass index yield new insights for obesity biology.

Autor: Locke AE; Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan 48109, USA., Kahali B; Department of Internal Medicine, Division of Gastroenterology, and Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan 48109, USA., Berndt SI; Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA., Justice AE; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA., Pers TH; Divisions of Endocrinology and Genetics and Center for Basic and Translational Obesity Research, Boston Children's Hospital, Boston, Massachusetts 02115, USA.; Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts 02142, USA.; Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA.; Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, Lyngby 2800, Denmark., Day FR; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK., Powell C; Department of Internal Medicine, Division of Gastroenterology, and Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan 48109, USA., Vedantam S; Divisions of Endocrinology and Genetics and Center for Basic and Translational Obesity Research, Boston Children's Hospital, Boston, Massachusetts 02115, USA.; Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts 02142, USA., Buchkovich ML; Department of Genetics, University of North Carolina, Chapel Hill, North Carolina 27599, USA., Yang J; Queensland Brain Institute, The University of Queensland, Brisbane 4072, Australia.; The University of Queensland Diamantina Institute, The Translation Research Institute, Brisbane 4012, Australia., Croteau-Chonka DC; Department of Genetics, University of North Carolina, Chapel Hill, North Carolina 27599, USA.; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA., Esko T; Divisions of Endocrinology and Genetics and Center for Basic and Translational Obesity Research, Boston Children's Hospital, Boston, Massachusetts 02115, USA.; Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts 02142, USA.; Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA.; Estonian Genome Center, University of Tartu, Tartu 51010, Estonia., Fall T; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 17177, Sweden.; Science for Life Laboratory, Uppsala University, Uppsala 75185, Sweden.; Department of Medical Sciences, Molecular Epidemiology, Uppsala University, Uppsala 75185, Sweden., Ferreira T; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK., Gustafsson S; Science for Life Laboratory, Uppsala University, Uppsala 75185, Sweden.; Department of Medical Sciences, Molecular Epidemiology, Uppsala University, Uppsala 75185, Sweden., Kutalik Z; Institute of Social and Preventive Medicine (IUMSP), Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne 1010, Switzerland.; Swiss Institute of Bioinformatics, Lausanne 1015, Switzerland.; Department of Medical Genetics, University of Lausanne, Lausanne 1005, Switzerland., Luan J; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK., Mägi R; Estonian Genome Center, University of Tartu, Tartu 51010, Estonia.; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK., Randall JC; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.; Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK., Winkler TW; Department of Genetic Epidemiology, Institute of Epidemiology and Preventive Medicine, University of Regensburg, D-93053 Regensburg, Germany., Wood AR; Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter EX1 2LU, UK., Workalemahu T; Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA., Faul JD; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, Michigan 48104, USA., Smith JA; Department of Epidemiology, University of Michigan, Ann Arbor, Michigan 48109, USA., Zhao JH; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK., Zhao W; Department of Epidemiology, University of Michigan, Ann Arbor, Michigan 48109, USA., Chen J; Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA., Fehrmann R; Department of Genetics, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands., Hedman ÅK; Science for Life Laboratory, Uppsala University, Uppsala 75185, Sweden.; Department of Medical Sciences, Molecular Epidemiology, Uppsala University, Uppsala 75185, Sweden.; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK., Karjalainen J; Department of Genetics, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands., Schmidt EM; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan 48109, USA., Absher D; HudsonAlpha Institute for Biotechnology, Huntsville, Alabama 35806, USA., Amin N; Genetic Epidemiology Unit, Department of Epidemiology, Erasmus MC University Medical Center, 3015 GE Rotterdam, The Netherlands., Anderson D; Telethon Institute for Child Health Research, Centre for Child Health Research, The University of Western Australia, Perth, Western Australia 6008, Australia., Beekman M; Netherlands Consortium for Healthy Aging (NCHA), Leiden University Medical Center, Leiden 2300 RC, The Netherlands.; Department of Molecular Epidemiology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands., Bolton JL; Centre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh EH8 9AG, UK., Bragg-Gresham JL; Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan 48109, USA.; Kidney Epidemiology and Cost Center, University of Michigan, Ann Arbor, Michigan 48109, USA., Buyske S; Department of Statistics & Biostatistics, Rutgers University, Piscataway, New Jersey 08854, USA.; Department of Genetics, Rutgers University, Piscataway, New Jersey 08854, USA., Demirkan A; Genetic Epidemiology Unit, Department of Epidemiology, Erasmus MC University Medical Center, 3015 GE Rotterdam, The Netherlands.; Department of Human Genetics, Leiden University Medical Center, 2333 ZC Leiden, The Netherlands., Deng G; Ealing Hospital NHS Trust, Middlesex UB1 3HW, UK.; Department of Gastroenterology and Hepatology, Imperial College London, London W2 1PG, UK.; Institute of infectious Diseases, Southwest Hospital, Third Military Medical University, Chongqing, China., Ehret GB; Center for Complex Disease Genomics, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.; Cardiology, Department of Specialties of Internal Medicine, Geneva University Hospital, Geneva 1211, Switzerland., Feenstra B; Department of Epidemiology Research, Statens Serum Institut, Copenhagen DK-2300, Denmark., Feitosa MF; Department of Genetics, Washington University School of Medicine, St Louis, Missouri 63110, USA., Fischer K; Estonian Genome Center, University of Tartu, Tartu 51010, Estonia., Goel A; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.; Division of Cardiovacular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 9DU, UK., Gong J; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA., Jackson AU; Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan 48109, USA., Kanoni S; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK., Kleber ME; Vth Department of Medicine (Nephrology, Hypertensiology, Endocrinology, Diabetology, Rheumatology), Medical Faculty of Mannheim, University of Heidelberg, D-68187 Mannheim, Germany.; Department of Internal Medicine II, Ulm University Medical Centre, D-89081 Ulm, Germany., Kristiansson K; National Institute for Health and Welfare, FI-00271 Helsinki, Finland., Lim U; Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii 96813, USA., Lotay V; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA., Mangino M; Department of Twin Research and Genetic Epidemiology, King's College London, London SE1 7EH, UK., Leach IM; Department of Cardiology, University Medical Center Groningen, University of Groningen, 9700RB Groningen, The Netherlands., Medina-Gomez C; Netherlands Consortium for Healthy Aging (NCHA), 3015GE Rotterdam, The Netherlands.; Department of Epidemiology, Erasmus MC University Medical Center, 3015GE Rotterdam, The Netherlands.; Department of Internal Medicine, Erasmus MC University Medical Center, 3015GE Rotterdam, The Netherlands., Medland SE; QIMR Berghofer Medical Research Institute, Brisbane, Queensland 4006, Australia., Nalls MA; Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892, USA., Palmer CD; Divisions of Endocrinology and Genetics and Center for Basic and Translational Obesity Research, Boston Children's Hospital, Boston, Massachusetts 02115, USA.; Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts 02142, USA., Pasko D; Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter EX1 2LU, UK., Pechlivanis S; Institute for Medical Informatics, Biometry and Epidemiology (IMIBE), University Hospital Essen, 45147 Essen, Germany., Peters MJ; Netherlands Consortium for Healthy Aging (NCHA), 3015GE Rotterdam, The Netherlands.; Department of Internal Medicine, Erasmus MC University Medical Center, 3015GE Rotterdam, The Netherlands., Prokopenko I; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford OX3 7LJ, UK.; Department of Genomics of Common Disease, School of Public Health, Imperial College London, Hammersmith Hospital, London W12 0NN, UK., Shungin D; Department of Clinical Sciences, Genetic & Molecular Epidemiology Unit, Lund University Diabetes Center, Skåne University Hosptial, Malmö 205 02, Sweden.; Department of Public Health and Clinical Medicine, Unit of Medicine, Umeå University, Umeå 901 87, Sweden.; Department of Odontology, Umeå University, Umeå 901 85, Sweden., Stančáková A; University of Eastern Finland, FI-70210 Kuopio, Finland., Strawbridge RJ; Atherosclerosis Research Unit, Center for Molecular Medicine, Department of Medicine, Karolinska Institutet, Stockholm 17176, Sweden., Sung YJ; Division of Biostatistics, Washington University School of Medicine, St Louis, Missouri 63110, USA., Tanaka T; Translational Gerontology Branch, National Institute on Aging, Baltimore, Maryland 21225, USA., Teumer A; Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, D-17475 Greifswald, Germany., Trompet S; Department of Cardiology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands.; Department of Gerontology and Geriatrics, Leiden University Medical Center, 2300 RC Leiden, The Netherlands., van der Laan SW; Experimental Cardiology Laboratory, Division Heart and Lungs, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands., van Setten J; Department of Medical Genetics, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands., Van Vliet-Ostaptchouk JV; Department of Endocrinology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands., Wang Z; Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.; Core Genotyping Facility, SAIC-Frederick, Inc., NCI-Frederick, Frederick, Maryland 21702, USA., Yengo L; CNRS UMR 8199, F-59019 Lille, France.; European Genomic Institute for Diabetes, F-59000 Lille, France.; Université de Lille 2, F-59000 Lille, France., Zhang W; Ealing Hospital NHS Trust, Middlesex UB1 3HW, UK.; Department of Epidemiology and Biostatistics, Imperial College London, London W2 1PG, UK., Isaacs A; Genetic Epidemiology Unit, Department of Epidemiology, Erasmus MC University Medical Center, 3015 GE Rotterdam, The Netherlands.; Center for Medical Sytems Biology, 2300 RC Leiden, The Netherlands., Albrecht E; Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, D-85764 Neuherberg, Germany., Ärnlöv J; Science for Life Laboratory, Uppsala University, Uppsala 75185, Sweden.; Department of Medical Sciences, Molecular Epidemiology, Uppsala University, Uppsala 75185, Sweden.; School of Health and Social Studies, Dalarna University, SE-791 88 Falun, Sweden., Arscott GM; PathWest Laboratory Medicine of Western Australia, Nedlands, Western Australia 6009, Australia., Attwood AP; Department of Haematology, University of Cambridge, Cambridge CB2 0PT, UK.; NHS Blood and Transplant, Cambridge CB2 0PT, UK., Bandinelli S; Geriatric Unit, Azienda Sanitaria Firenze (ASF), 50125 Florence, Italy., Barrett A; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford OX3 7LJ, UK., Bas IN; USC-Office of Population Studies Foundation, Inc., University of San Carlos, Cebu City 6000, Philippines., Bellis C; Department of Genetics, Texas Biomedical Research Institute, San Antonio, Texas 78227, USA.; Genomics Research Centre, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland 4001, Australia., Bennett AJ; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford OX3 7LJ, UK., Berne C; Department of Medical Sciences, Endocrinology, Diabetes and Metabolism, Uppsala University, Uppsala 75185, Sweden., Blagieva R; Division of Endocrinology, Diabetes and Metabolism, Ulm University Medical Centre, D-89081 Ulm, Germany., Blüher M; Integrated Research and Treatment Center (IFB) Adiposity Diseases, University of Leipzig, D-04103 Leipzig, Germany.; Department of Medicine, University of Leipzig, D-04103 Leipzig, Germany., Böhringer S; Netherlands Consortium for Healthy Aging (NCHA), Leiden University Medical Center, Leiden 2300 RC, The Netherlands.; Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, 2300 RC Leiden, The Netherlands., Bonnycastle LL; Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, Maryland 20892, USA., Böttcher Y; Integrated Research and Treatment Center (IFB) Adiposity Diseases, University of Leipzig, D-04103 Leipzig, Germany., Boyd HA; Department of Epidemiology Research, Statens Serum Institut, Copenhagen DK-2300, Denmark., Bruinenberg M; LifeLines Cohort Study, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands., Caspersen IH; Department of Biology, Norwegian University of Science and Technology, 7491 Trondheim, Norway., Chen YI; Department of Pediatrics, University of California Los Angeles, Torrance, California 90502, USA.; Transgenomics Institute, Los Angeles Biomedical Research Institute, Torrance, California 90502, USA., Clarke R; Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford OX3 7LF, UK., Daw EW; Department of Genetics, Washington University School of Medicine, St Louis, Missouri 63110, USA., de Craen AJM; Department of Gerontology and Geriatrics, Leiden University Medical Center, 2300 RC Leiden, The Netherlands., Delgado G; Vth Department of Medicine (Nephrology, Hypertensiology, Endocrinology, Diabetology, Rheumatology), Medical Faculty of Mannheim, University of Heidelberg, D-68187 Mannheim, Germany., Dimitriou M; Department of Dietetics-Nutrition, Harokopio University, 17671 Athens, Greece., Doney ASF; Medical Research Institute, University of Dundee, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK., Eklund N; National Institute for Health and Welfare, FI-00271 Helsinki, Finland.; Institute for Molecular Medicine, University of Helsinki, FI-00014 Helsinki, Finland., Estrada K; Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts 02142, USA.; Department of Internal Medicine, Erasmus MC University Medical Center, 3015GE Rotterdam, The Netherlands.; Analytic and Translational Genetics Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA., Eury E; CNRS UMR 8199, F-59019 Lille, France.; European Genomic Institute for Diabetes, F-59000 Lille, France.; Université de Lille 2, F-59000 Lille, France., Folkersen L; Atherosclerosis Research Unit, Center for Molecular Medicine, Department of Medicine, Karolinska Institutet, Stockholm 17176, Sweden., Fraser RM; Centre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh EH8 9AG, UK., Garcia ME; Laboratory of Epidemiology and Population Sciences, National Institute on Aging, NIH, Bethesda, Maryland 20892, USA., Geller F; Department of Epidemiology Research, Statens Serum Institut, Copenhagen DK-2300, Denmark., Giedraitis V; Department of Public Health and Caring Sciences, Geriatrics, Uppsala University, Uppsala 75185, Sweden., Gigante B; Division of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden, Stockholm 17177, Sweden., Go AS; Kaiser Permanente, Division of Research, Oakland, California 94612, USA., Golay A; Service of Therapeutic Education for Diabetes, Obesity and Chronic Diseases, Geneva University Hospital, Geneva CH-1211, Switzerland., Goodall AH; Department of Cardiovascular Sciences, University of Leicester, Glenfield Hospital, Leicester LE3 9QP, UK.; National Institute for Health Research (NIHR) Leicester Cardiovascular Biomedical Research Unit, Glenfield Hospital, Leicester LE3 9QP, UK., Gordon SD; QIMR Berghofer Medical Research Institute, Brisbane, Queensland 4006, Australia., Gorski M; Department of Genetic Epidemiology, Institute of Epidemiology and Preventive Medicine, University of Regensburg, D-93053 Regensburg, Germany.; Department of Nephrology, University Hospital Regensburg, D-93053 Regensburg, Germany., Grabe HJ; Department of Psychiatry and Psychotherapy, University Medicine Greifswald, HELIOS-Hospital Stralsund, D-17475 Greifswald, Germany.; German Center for Neurodegenerative Diseases (DZNE), Rostock, Greifswald, D-17475 Greifswald, Germany., Grallert H; Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, D-85764 Neuherberg, Germany.; Research Unit of Molecular Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, D-85764 Neuherberg, Germany.; German Center for Diabetes Research (DZD), 85764 Neuherberg, Germany., Grammer TB; Vth Department of Medicine (Nephrology, Hypertensiology, Endocrinology, Diabetology, Rheumatology), Medical Faculty of Mannheim, University of Heidelberg, D-68187 Mannheim, Germany., Gräßler J; Department of Medicine III, University Hospital Carl Gustav Carus, Technische Universität Dresden, D-01307 Dresden, Germany., Grönberg H; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 17177, Sweden., Groves CJ; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford OX3 7LJ, UK., Gusto G; Institut inter Régional pour la Santé, Synergies, F-37520 La Riche, France., Haessler J; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA., Hall P; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 17177, Sweden., Haller T; Estonian Genome Center, University of Tartu, Tartu 51010, Estonia., Hallmans G; Department of Public Health and Clinical Medicine, Unit of Nutritional Research, Umeå University, Umeå 90187, Sweden., Hartman CA; Department of Psychiatry, University of Groningen, University Medical Center Groningen, 9700RB Groningen, The Netherlands., Hassinen M; Kuopio Research Institute of Exercise Medicine, 70100 Kuopio, Finland., Hayward C; MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU, UK., Heard-Costa NL; National Heart, Lung, and Blood Institute, the Framingham Heart Study, Framingham, Massachusetts 01702, USA.; Department of Neurology, Boston University School of Medicine, Boston, Massachusetts 02118, USA., Helmer Q; Netherlands Consortium for Healthy Aging (NCHA), Leiden University Medical Center, Leiden 2300 RC, The Netherlands.; Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, 2300 RC Leiden, The Netherlands.; Faculty of Psychology and Education, VU University Amsterdam, 1081BT Amsterdam, The Netherlands., Hengstenberg C; Deutsches Forschungszentrum für Herz-Kreislauferkrankungen (DZHK) (German Research Centre for Cardiovascular Research), Munich Heart Alliance, D-80636 Munich, Germany.; Deutsches Herzzentrum München, Technische Universität München, D-80636 Munich, Germany., Holmen O; Department of Public Health and General Practice, Norwegian University of Science and Technology, Trondheim 7489, Norway., Hottenga JJ; Biological Psychology, VU University Amsterdam, 1081BT Amsterdam, The Netherlands., James AL; Department of Pulmonary Physiology and Sleep Medicine, Nedlands, Western Australia 6009, Australia.; School of Medicine and Pharmacology, University of Western Australia, Crawley 6009, Australia., Jeff JM; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA., Johansson Å; Uppsala University, Department of Immunology, Genetics, Pathology, SciLifeLab, Rudbeck Laboratory, SE-751 85 Uppsala, Sweden., Jolley J; Department of Haematology, University of Cambridge, Cambridge CB2 0PT, UK.; NHS Blood and Transplant, Cambridge CB2 0PT, UK., Juliusdottir T; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK., Kinnunen L; National Institute for Health and Welfare, FI-00271 Helsinki, Finland., Koenig W; Department of Internal Medicine II, Ulm University Medical Centre, D-89081 Ulm, Germany., Koskenvuo M; Hjelt Institute Department of Public Health, University of Helsinki, FI-00014 Helsinki, Finland., Kratzer W; Department of Internal Medicine I, Ulm University Medical Centre, D-89081 Ulm, Germany., Laitinen J; Finnish Institute of Occupational Health, FI-90100 Oulu, Finland., Lamina C; Division of Genetic Epidemiology, Department of Medical Genetics, Molecular and Clinical Pharmacology, Innsbruck Medical University, 6020 Innsbruck, Austria., Leander K; Division of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden, Stockholm 17177, Sweden., Lee NR; USC-Office of Population Studies Foundation, Inc., University of San Carlos, Cebu City 6000, Philippines., Lichtner P; Institute of Human Genetics, Helmholtz Zentrum München - German Research Center for Environmental Health, D-85764 Neuherberg, Germany., Lind L; Department of Medical Sciences, Cardiovascular Epidemiology, Uppsala University, Uppsala 75185, Sweden., Lindström J; National Institute for Health and Welfare, FI-00271 Helsinki, Finland., Lo KS; Montreal Heart Institute, Montreal, Quebec H1T 1C8, Canada., Lobbens S; CNRS UMR 8199, F-59019 Lille, France.; European Genomic Institute for Diabetes, F-59000 Lille, France.; Université de Lille 2, F-59000 Lille, France., Lorbeer R; Institute for Community Medicine, University Medicine Greifswald, D-17475 Greifswald, Germany., Lu Y; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.; The Genetics of Obesity and Related Metabolic Traits Program, The Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA., Mach F; Cardiology, Department of Specialties of Internal Medicine, Geneva University Hospital, Geneva 1211, Switzerland., Magnusson PKE; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 17177, Sweden., Mahajan A; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK., McArdle WL; School of Social and Community Medicine, University of Bristol, Bristol BS8 2BN, UK., McLachlan S; Centre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh EH8 9AG, UK., Menni C; Department of Twin Research and Genetic Epidemiology, King's College London, London SE1 7EH, UK., Merger S; Division of Endocrinology, Diabetes and Metabolism, Ulm University Medical Centre, D-89081 Ulm, Germany., Mihailov E; Estonian Genome Center, University of Tartu, Tartu 51010, Estonia.; Institute of Molecular and Cell Biology, University of Tartu, Tartu 51010, Estonia., Milani L; Estonian Genome Center, University of Tartu, Tartu 51010, Estonia., Moayyeri A; Department of Twin Research and Genetic Epidemiology, King's College London, London SE1 7EH, UK.; Farr Institute of Health Informatics Research, University College London, London NW1 2DA, UK., Monda KL; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.; The Center for Observational Research, Amgen, Inc., Thousand Oaks, California 91320, USA., Morken MA; Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, Maryland 20892, USA., Mulas A; Istituto di Ricerca Genetica e Biomedica (IRGB), Consiglio Nazionale delle Ricerche, Cagliari, Sardinia 09042, Italy., Müller G; Center for Evidence-based Healthcare, University Hospital Carl Gustav Carus, Technische Universität Dresden, D-01307 Dresden, Germany., Müller-Nurasyid M; Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, D-85764 Neuherberg, Germany.; Deutsches Forschungszentrum für Herz-Kreislauferkrankungen (DZHK) (German Research Centre for Cardiovascular Research), Munich Heart Alliance, D-80636 Munich, Germany.; Department of Medicine I, University Hospital Grosshadern, Ludwig-Maximilians-Universität, D-81377 Munich, Germany.; Institute of Medical Informatics, Biometry and Epidemiology, Chair of Genetic Epidemiology, Ludwig-Maximilians-Universität, D-81377 Munich, Germany., Musk AW; Department of Respiratory Medicine, Sir Charles Gairdner Hospital, Nedlands, Western Australia 6009, Australia., Nagaraja R; Laboratory of Genetics, National Institute on Aging, Baltimore, Maryland 21224, USA., Nöthen MM; Department of Genomics, Life & Brain Center, University of Bonn, 53127 Bonn, Germany.; Institute of Human Genetics, University of Bonn, 53127 Bonn, Germany., Nolte IM; Department of Epidemiology, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands., Pilz S; Department of Epidemiology and Biostatistics, Institute for Research in Extramural Medicine, Institute for Health and Care Research, VU University Medical Center, 1081BT Amsterdam, The Netherlands.; Department of Internal Medicine, Division of Endocrinology and Metabolism, Medical University of Graz, 8036 Graz, Austria., Rayner NW; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.; Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK.; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford OX3 7LJ, UK., Renstrom F; Department of Clinical Sciences, Genetic & Molecular Epidemiology Unit, Lund University Diabetes Center, Skåne University Hosptial, Malmö 205 02, Sweden., Rettig R; Institute of Physiology, University Medicine Greifswald, D-17495 Karlsburg, Germany., Ried JS; Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, D-85764 Neuherberg, Germany., Ripke S; Analytic and Translational Genetics Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA., Robertson NR; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford OX3 7LJ, UK., Rose LM; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02215, USA., Sanna S; Istituto di Ricerca Genetica e Biomedica (IRGB), Consiglio Nazionale delle Ricerche, Cagliari, Sardinia 09042, Italy., Scharnagl H; Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz 8036, Austria., Scholtens S; LifeLines Cohort Study, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands., Schumacher FR; Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA., Scott WR; Ealing Hospital NHS Trust, Middlesex UB1 3HW, UK.; Department of Epidemiology and Biostatistics, Imperial College London, London W2 1PG, UK., Seufferlein T; Department of Internal Medicine I, Ulm University Medical Centre, D-89081 Ulm, Germany., Shi J; National Cancer Institute, Bethesda, Maryland 20892, USA., Smith AV; Icelandic Heart Association, Kopavogur 201, Iceland.; University of Iceland, Reykjavik 101, Iceland., Smolonska J; Department of Genetics, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands.; Department of Epidemiology, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands., Stanton AV; Molecular & Cellular Therapeutics, Royal College of Surgeons in Ireland, 123 St Stephen's Green, Dublin 2, Ireland., Steinthorsdottir V; deCODE Genetics, Amgen Inc., Reykjavik 101, Iceland., Stirrups K; Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK.; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK., Stringham HM; Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan 48109, USA., Sundström J; Department of Medical Sciences, Cardiovascular Epidemiology, Uppsala University, Uppsala 75185, Sweden., Swertz MA; Department of Genetics, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands., Swift AJ; Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, Maryland 20892, USA., Syvänen AC; Science for Life Laboratory, Uppsala University, Uppsala 75185, Sweden.; Department of Medical Sciences, Molecular Medicine, Uppsala University, Uppsala 75144, Sweden., Tan ST; Ealing Hospital NHS Trust, Middlesex UB1 3HW, UK.; National Heart and Lung Institute, Imperial College London, London SW3 6LY, UK., Tayo BO; Department of Public Health Sciences, Stritch School of Medicine, Loyola University of Chicago, Maywood, Illinois 61053, USA., Thorand B; German Center for Diabetes Research (DZD), 85764 Neuherberg, Germany.; Institute of Epidemiology II, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany, D-85764 Neuherberg, Germany., Thorleifsson G; deCODE Genetics, Amgen Inc., Reykjavik 101, Iceland., Tyrer JP; Department of Oncology, University of Cambridge, Cambridge CB2 0QQ, UK., Uh HW; Netherlands Consortium for Healthy Aging (NCHA), Leiden University Medical Center, Leiden 2300 RC, The Netherlands.; Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, 2300 RC Leiden, The Netherlands., Vandenput L; Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg 413 45, Sweden., Verhulst FC; Department of Child and Adolescent Psychiatry/Psychology, Erasmus MC University Medical Centre, 3000 CB Rotterdam, The Netherlands., Vermeulen SH; Department for Health Evidence, Radboud University Medical Centre, 6500 HB Nijmegen, The Netherlands.; Department of Genetics, Radboud University Medical Centre, 6500 HB Nijmegen, The Netherlands., Verweij N; Department of Cardiology, University Medical Center Groningen, University of Groningen, 9700RB Groningen, The Netherlands., Vonk JM; Department of Epidemiology, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands., Waite LL; HudsonAlpha Institute for Biotechnology, Huntsville, Alabama 35806, USA., Warren HR; Department of Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK., Waterworth D; Genetics, GlaxoSmithKline, King of Prussia, Pennsylvania 19406, USA., Weedon MN; Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter EX1 2LU, UK., Wilkens LR; Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii 96813, USA., Willenborg C; German Center for Cardiovascular Research, partner site Hamburg/Lubeck/Kiel, 23562 Lubeck, Germany.; Institut für Integrative und Experimentelle Genomik, Universität zu Lübeck, D-23562 Lübeck, Germany., Wilsgaard T; Department of Community Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway, 9037 Tromsø, Norway., Wojczynski MK; Department of Genetics, Washington University School of Medicine, St Louis, Missouri 63110, USA., Wong A; MRC Unit for Lifelong Health and Ageing at University College London, London WC1B 5JU, UK., Wright AF; MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU, UK., Zhang Q; Department of Genetics, Washington University School of Medicine, St Louis, Missouri 63110, USA., Brennan EP; Diabetes Complications Research Centre, Conway Institute, School of Medicine and Medical Sciences, University College Dublin, Dublin 4, Ireland., Choi M; Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Korea., Dastani Z; Lady Davis Institute, Departments of Human Genetics, Epidemiology and Biostatistics, McGill University, Montréal, Québec H3T1E2, Canada., Drong AW; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK., Eriksson P; Atherosclerosis Research Unit, Center for Molecular Medicine, Department of Medicine, Karolinska Institutet, Stockholm 17176, Sweden., Franco-Cereceda A; Cardiothoracic Surgery Unit, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm 17176, Sweden., Gådin JR; Atherosclerosis Research Unit, Center for Molecular Medicine, Department of Medicine, Karolinska Institutet, Stockholm 17176, Sweden., Gharavi AG; Department of Medicine, Columbia University College of Physicians and Surgeons, New York 10032, USA., Goddard ME; Biosciences Research Division, Department of Primary Industries, Victoria 3083, Australia.; Department of Food and Agricultural Systems, University of Melbourne, Victoria 3010, Australia., Handsaker RE; Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts 02142, USA.; Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA., Huang J; Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA.; State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, Rui Jin Hospital Affiliated with Shanghai Jiao Tong University School of Medicine, Shanghai, China., Karpe F; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford OX3 7LJ, UK.; NIHR Oxford Biomedical Research Centre, OUH Trust, Oxford OX3 7LE, UK., Kathiresan S; Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts 02142, USA.; Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA., Keildson S; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK., Kiryluk K; Department of Medicine, Columbia University College of Physicians and Surgeons, New York 10032, USA., Kubo M; Laboratory for Genotyping Development, RIKEN Center for Integrative Medical Sciences, Yokohama 230-0045, Japan., Lee JY; Center for Genome Science, National Institute of Health, Chungcheongbuk-do, Chungbuk 363-951, Republic of Korea., Liang L; Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA.; Harvard School of Public Health, Department of Biostatistics, Harvard University, Boston, Massachusetts 2115, USA., Lifton RP; Department of Genetics, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, New Haven, Connecticut 06520, USA., Ma B; Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA.; College of Information Science and Technology, Dalian Maritime University, Dalian, Liaoning 116026, China., McCarroll SA; Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts 02142, USA.; Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA., McKnight AJ; Nephrology Research, Centre for Public Health, Queen's University of Belfast, Belfast, County Down BT9 7AB, UK., Min JL; School of Social and Community Medicine, University of Bristol, Bristol BS8 2BN, UK., Moffatt MF; National Heart and Lung Institute, Imperial College London, London SW3 6LY, UK., Montgomery GW; QIMR Berghofer Medical Research Institute, Brisbane, Queensland 4006, Australia., Murabito JM; National Heart, Lung, and Blood Institute, the Framingham Heart Study, Framingham, Massachusetts 01702, USA.; Section of General Internal Medicine, Boston University School of Medicine, Boston, Massachusetts 02118, USA., Nicholson G; Department of Statistics, University of Oxford, 1 South Parks Road, Oxford OX1 3TG, UK.; MRC Harwell, Harwell Science and Innovation Campus, Harwell OX11 0QG, UK., Nyholt DR; QIMR Berghofer Medical Research Institute, Brisbane, Queensland 4006, Australia.; Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland 4059, Australia., Okada Y; Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama 230-0045, Japan.; Department of Human Genetics and Disease Diversity, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 113-8510 Tokyo, Japan., Perry JRB; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.; Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter EX1 2LU, UK.; Department of Twin Research and Genetic Epidemiology, King's College London, London SE1 7EH, UK., Dorajoo R; Genome Institute of Singapore, Agency for Science, Technology and Research, 138672 Singapore., Reinmaa E; Estonian Genome Center, University of Tartu, Tartu 51010, Estonia., Salem RM; Divisions of Endocrinology and Genetics and Center for Basic and Translational Obesity Research, Boston Children's Hospital, Boston, Massachusetts 02115, USA.; Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts 02142, USA.; Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA., Sandholm N; Department of Biomedical Engineering and Computational Science, Aalto University School of Science, Helsinki FI-00076, Finland.; Department of Medicine, Division of Nephrology, Helsinki University Central Hospital, FI-00290 Helsinki, Finland.; Folkhälsan Institute of Genetics, Folkhälsan Research Center, FI-00290 Helsinki, Finland., Scott RA; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK., Stolk L; Netherlands Consortium for Healthy Aging (NCHA), Leiden University Medical Center, Leiden 2300 RC, The Netherlands.; Department of Internal Medicine, Erasmus MC University Medical Center, 3015GE Rotterdam, The Netherlands., Takahashi A; Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama 230-0045, Japan., Tanaka T; Department of Human Genetics and Disease Diversity, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 113-8510 Tokyo, Japan.; Laboratory for Cardiovascular Diseases, RIKEN Center for Integrative Medical Sciences, Yokohama 230-0045, Japan.; Division of Disease Diversity, Bioresource Research Center, Tokyo Medical and Dental University, 113-8510 Tokyo, Japan., van 't Hooft FM; Atherosclerosis Research Unit, Center for Molecular Medicine, Department of Medicine, Karolinska Institutet, Stockholm 17176, Sweden., Vinkhuyzen AAE; Queensland Brain Institute, The University of Queensland, Brisbane 4072, Australia., Westra HJ; Department of Genetics, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands., Zheng W; Division of Epidemiology, Department of Medicine; Vanderbilt Epidemiology Center; and Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee 37075, USA., Zondervan KT; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.; Nuffield Department of Obstetrics & Gynaecology, University of Oxford, Oxford OX3 7BN, UK., Heath AC; Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, USA., Arveiler D; Department of Epidemiology and Public Health, EA3430, University of Strasbourg, Faculty of Medicine, Strasbourg, France., Bakker SJL; Department of Internal Medicine, University Medical Center Groningen, University of Groningen, 9700RB Groningen, The Netherlands., Beilby J; PathWest Laboratory Medicine of Western Australia, Nedlands, Western Australia 6009, Australia.; Pathology and Laboratory Medicine, The University of Western Australia, Perth, Western Australia 6009, Australia., Bergman RN; Cedars-Sinai Diabetes and Obesity Research Institute, Los Angeles, California 90048, USA., Blangero J; Department of Genetics, Texas Biomedical Research Institute, San Antonio, Texas 78227, USA., Bovet P; Institute of Social and Preventive Medicine (IUMSP), Centre Hospitalier Universitaire Vaudois and University of Lausanne, 1010 Lausanne, Switzerland.; Ministry of Health, Victoria, Republic of Seychelles., Campbell H; Centre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh EH8 9AG, UK., Caulfield MJ; Department of Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK., Cesana G; University of Milano, Bicocca, 20126, Italy., Chakravarti A; Center for Complex Disease Genomics, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA., Chasman DI; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02215, USA.; Harvard Medical School, Boston, Massachusetts 02115, USA., Chines PS; Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, Maryland 20892, USA., Collins FS; Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, Maryland 20892, USA., Crawford DC; Center for Human Genetics Research, Vanderbilt University Medical Center, Nashville, Tennessee 37203, USA.; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee 37232, USA., Cupples LA; National Heart, Lung, and Blood Institute, the Framingham Heart Study, Framingham, Massachusetts 01702, USA.; Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts 02118, USA., Cusi D; Department of Health Sciences, University of Milano, I 20142, Italy.; Fondazione Filarete, Milano I 20139, Italy., Danesh J; Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK., de Faire U; Division of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden, Stockholm 17177, Sweden., den Ruijter HM; Experimental Cardiology Laboratory, Division Heart and Lungs, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands.; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands., Dominiczak AF; Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8TA, UK., Erbel R; Clinic of Cardiology, West-German Heart Centre, University Hospital Essen, 45147 Essen, Germany., Erdmann J; German Center for Cardiovascular Research, partner site Hamburg/Lubeck/Kiel, 23562 Lubeck, Germany.; Institut für Integrative und Experimentelle Genomik, Universität zu Lübeck, D-23562 Lübeck, Germany., Eriksson JG; National Institute for Health and Welfare, FI-00271 Helsinki, Finland.; Department of General Practice and Primary Health Care, University of Helsinki, FI-00290 Helsinki, Finland.; Unit of General Practice, Helsinki University Central Hospital, Helsinki 00290, Finland., Farrall M; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.; Division of Cardiovacular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 9DU, UK., Felix SB; Department of Internal Medicine B, University Medicine Greifswald, D-17475 Greifswald, Germany.; DZHK (Deutsches Zentrum für Herz-Kreislaufforschung - German Centre for Cardiovascular Research), partner site Greifswald, D-17475 Greifswald, Germany., Ferrannini E; Department of Internal Medicine, University of Pisa, 56100 Pisa, Italy.; National Research Council Institute of Clinical Physiology, University of Pisa, 56124 Pisa, Italy., Ferrières J; Department of Cardiology, Toulouse University School of Medicine, Rangueil Hospital, 31400 Toulouse, France., Ford I; Robertson Center for Biostatistics, University of Glasgow, Glasgow G12 8QQ, UK., Forouhi NG; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK., Forrester T; UWI Solutions for Developing Countries, The University of the West Indies, Mona, Kingston 7, Jamaica., Franco OH; Netherlands Consortium for Healthy Aging (NCHA), 3015GE Rotterdam, The Netherlands.; Department of Epidemiology, Erasmus MC University Medical Center, 3015GE Rotterdam, The Netherlands., Gansevoort RT; Department of Internal Medicine, University Medical Center Groningen, University of Groningen, 9700RB Groningen, The Netherlands., Gejman PV; NorthShore University HealthSystem, Evanston, IL 60201, University of Chicago, Chicago, Illinois, USA., Gieger C; Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, D-85764 Neuherberg, Germany., Gottesman O; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA., Gudnason V; Icelandic Heart Association, Kopavogur 201, Iceland.; University of Iceland, Reykjavik 101, Iceland., Gyllensten U; Uppsala University, Department of Immunology, Genetics, Pathology, SciLifeLab, Rudbeck Laboratory, SE-751 85 Uppsala, Sweden., Hall AS; Leeds MRC Medical Bioinformatics Centre, University of Leeds, Leeds LS2 9LU, UK., Harris TB; Laboratory of Epidemiology and Population Sciences, National Institute on Aging, NIH, Bethesda, Maryland 20892, USA., Hattersley AT; Institute of Biomedical & Clinical Science, University of Exeter, Barrack Road, Exeter EX2 5DW, UK., Hicks AA; Center for Biomedicine, European Academy Bozen, Bolzano (EURAC), Bolzano 39100, Italy (affiliated institute of the University of Lübeck, D-23562 Lübeck, Germany)., Hindorff LA; Division of Genomic Medicine, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA., Hingorani AD; Institute of Cardiovascular Science, University College London, London WC1E 6BT, UK., Hofman A; Netherlands Consortium for Healthy Aging (NCHA), 3015GE Rotterdam, The Netherlands.; Department of Epidemiology, Erasmus MC University Medical Center, 3015GE Rotterdam, The Netherlands., Homuth G; Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, D-17475 Greifswald, Germany., Hovingh GK; Department of Vascular Medicine, Academic Medical Center, 1105 AZ Amsterdam, The Netherlands., Humphries SE; Centre for Cardiovascular Genetics, Institute Cardiovascular Sciences, University College London, London WC1E 6JJ, UK., Hunt SC; Cardiovascular Genetics Division, Department of Internal Medicine, University of Utah, Salt Lake City, Utah 84108, USA., Hyppönen E; Sansom Institute for Health Research, University of South Australia, Adelaide 5000, South Australia, Australia.; School of Population Health, University of South Australia, Adelaide 5000, South Australia, Australia.; South Australian Health and Medical Research Institute, Adelaide, South Australia 5000, Australia.; Population, Policy, and Practice, University College London Institute of Child Health, London WC1N 1EH, UK., Illig T; Research Unit of Molecular Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, D-85764 Neuherberg, Germany.; Hannover Unified Biobank, Hannover Medical School, Hannover, D-30625 Hannover, Germany., Jacobs KB; Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.; Core Genotyping Facility, SAIC-Frederick, Inc., NCI-Frederick, Frederick, Maryland 21702, USA., Jarvelin MR; Department of Epidemiology and Biostatistics, Imperial College London, London W2 1PG, UK.; National Institute for Health and Welfare, FI-90101 Oulu, Finland.; MRC Health Protection Agency (HPA) Centre for Environment and Health, School of Public Health, Imperial College London, London W2 1PG, UK.; Unit of Primary Care, Oulu University Hospital, FI-90220 Oulu, Finland.; Institute of Health Sciences, University of Oulu, FI-90014 Oulu, Finland.; Institute of Health Sciences, University of Oulu, FI-90014 Oulu, Finland., Jöckel KH; Institute for Medical Informatics, Biometry and Epidemiology (IMIBE), University Hospital Essen, 45147 Essen, Germany., Johansen B; Department of Biology, Norwegian University of Science and Technology, 7491 Trondheim, Norway., Jousilahti P; National Institute for Health and Welfare, FI-00271 Helsinki, Finland., Jukema JW; Department of Cardiology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands.; Durrer Center for Cardiogenetic Research, Interuniversity Cardiology Institute Netherlands (ICIN), 3501 DG Utrecht, The Netherlands.; Interuniversity Cardiology Institute of the Netherlands (ICIN), 3501 DG Utrecht, The Netherlands., Jula AM; National Institute for Health and Welfare, FI-00271 Helsinki, Finland., Kaprio J; National Institute for Health and Welfare, FI-00271 Helsinki, Finland.; Institute for Molecular Medicine, University of Helsinki, FI-00014 Helsinki, Finland.; Hjelt Institute Department of Public Health, University of Helsinki, FI-00014 Helsinki, Finland., Kastelein JJP; Department of Vascular Medicine, Academic Medical Center, 1105 AZ Amsterdam, The Netherlands., Keinanen-Kiukaanniemi SM; Institute of Health Sciences, University of Oulu, FI-90014 Oulu, Finland.; Unit of Primary Health Care/General Practice, Oulu University Hospital, FI-90220 Oulu, Finland., Kiemeney LA; Department for Health Evidence, Radboud University Medical Centre, 6500 HB Nijmegen, The Netherlands.; Department of Urology, Radboud University Medical Centre, 6500 HB Nijmegen, The Netherlands., Knekt P; National Institute for Health and Welfare, FI-00271 Helsinki, Finland., Kooner JS; Ealing Hospital NHS Trust, Middlesex UB1 3HW, UK.; National Heart and Lung Institute, Imperial College London, London SW3 6LY, UK.; Imperial College Healthcare NHS Trust, London W12 0HS, UK., Kooperberg C; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA., Kovacs P; Integrated Research and Treatment Center (IFB) Adiposity Diseases, University of Leipzig, D-04103 Leipzig, Germany.; Department of Medicine, University of Leipzig, D-04103 Leipzig, Germany., Kraja AT; Department of Genetics, Washington University School of Medicine, St Louis, Missouri 63110, USA., Kumari M; Department of Epidemiology and Public Health, University College London, London WC1E 6BT, UK.; Department of Biological and Social Epidemiology, University of Essex, Wivenhoe Park, Colchester, Essex CO4 3SQ, UK., Kuusisto J; Department of Medicine, Kuopio University Hospital and University of Eastern Finland, FI-70210 Kuopio, Finland., Lakka TA; Kuopio Research Institute of Exercise Medicine, 70100 Kuopio, Finland.; Department of Physiology, Institute of Biomedicine, University of Eastern Finland, Kuopio Campus, FI-70211 Kuopio, Finland.; Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital and University of Eastern Finland, FI-70210 Kuopio, Finland., Langenberg C; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK.; Department of Epidemiology and Public Health, University College London, London WC1E 6BT, UK., Marchand LL; Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii 96813, USA., Lehtimäki T; Department of Clinical Chemistry, Fimlab Laboratories and School of Medicine University of Tampere, FI-33520 Tampere, Finland., Lyssenko V; Steno Diabetes Center A/S, Gentofte DK-2820, Denmark.; Lund University Diabetes Centre and Department of Clinical Science, Diabetes & Endocrinology Unit, Lund University, Malmö 221 00, Sweden., Männistö S; National Institute for Health and Welfare, FI-00271 Helsinki, Finland., Marette A; Institut Universitaire de Cardiologie et de Pneumologie de Québec, Faculty of Medicine, Laval University, Quebec, QC G1V 0A6, Canada.; Institute of Nutrition and Functional Foods, Laval University, Quebec, QC G1V 0A6, Canada., Matise TC; Department of Genetics, Rutgers University, Piscataway, New Jersey 08854, USA., McKenzie CA; UWI Solutions for Developing Countries, The University of the West Indies, Mona, Kingston 7, Jamaica., McKnight B; Department of Biostatistics, University of Washington, Seattle, Washington 98195, USA., Moll FL; Department of Surgery, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands., Morris AD; Medical Research Institute, University of Dundee, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK., Morris AP; Estonian Genome Center, University of Tartu, Tartu 51010, Estonia.; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.; Department of Biostatistics, University of Liverpool, Liverpool L69 3GA, UK., Murray JC; Department of Pediatrics, University of Iowa, Iowa City, Iowa 52242, USA., Nelis M; Estonian Genome Center, University of Tartu, Tartu 51010, Estonia., Ohlsson C; Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg 413 45, Sweden., Oldehinkel AJ; Department of Psychiatry, University of Groningen, University Medical Center Groningen, 9700RB Groningen, The Netherlands., Ong KK; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK.; MRC Unit for Lifelong Health and Ageing at University College London, London WC1B 5JU, UK., Madden PAF; Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, USA., Pasterkamp G; Experimental Cardiology Laboratory, Division Heart and Lungs, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands., Peden JF; Illumina, Inc, Little Chesterford, Cambridge CB10 1XL, UK., Peters A; Research Unit of Molecular Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, D-85764 Neuherberg, Germany.; Deutsches Forschungszentrum für Herz-Kreislauferkrankungen (DZHK) (German Research Centre for Cardiovascular Research), Munich Heart Alliance, D-80636 Munich, Germany.; Institute of Epidemiology II, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany, D-85764 Neuherberg, Germany., Postma DS; University of Groningen, University Medical Center Groningen, Department of Pulmonary Medicine and Tuberculosis, Groningen, The Netherlands., Pramstaller PP; Center for Biomedicine, European Academy Bozen, Bolzano (EURAC), Bolzano 39100, Italy (affiliated institute of the University of Lübeck, D-23562 Lübeck, Germany).; Department of Neurology, General Central Hospital, Bolzano 39100, Italy., Price JF; Centre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh EH8 9AG, UK., Qi L; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA.; Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA., Raitakari OT; Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, FI-20521 Turku, Finland.; Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, FI-20521 Turku, Finland., Rankinen T; Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, Louisiana 70808, USA., Rao DC; Department of Genetics, Washington University School of Medicine, St Louis, Missouri 63110, USA.; Division of Biostatistics, Washington University School of Medicine, St Louis, Missouri 63110, USA.; Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, USA., Rice TK; Division of Biostatistics, Washington University School of Medicine, St Louis, Missouri 63110, USA.; Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, USA., Ridker PM; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02215, USA.; Harvard Medical School, Boston, Massachusetts 02115, USA., Rioux JD; Montreal Heart Institute, Montreal, Quebec H1T 1C8, Canada.; Université de Montréal, Montreal, Quebec H1T 1C8, Canada., Ritchie MD; Center for Systems Genomics, The Pennsylvania State University, University Park, Pennsylvania 16802, USA., Rudan I; Centre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh EH8 9AG, UK.; Croatian Centre for Global Health, Faculty of Medicine, University of Split, 21000 Split, Croatia., Salomaa V; National Institute for Health and Welfare, FI-00271 Helsinki, Finland., Samani NJ; Department of Cardiovascular Sciences, University of Leicester, Glenfield Hospital, Leicester LE3 9QP, UK.; National Institute for Health Research (NIHR) Leicester Cardiovascular Biomedical Research Unit, Glenfield Hospital, Leicester LE3 9QP, UK., Saramies J; South Carelia Central Hospital, 53130 Lappeenranta, Finland., Sarzynski MA; Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, Louisiana 70808, USA., Schunkert H; Deutsches Forschungszentrum für Herz-Kreislauferkrankungen (DZHK) (German Research Centre for Cardiovascular Research), Munich Heart Alliance, D-80636 Munich, Germany.; Deutsches Herzzentrum München, Technische Universität München, D-80636 Munich, Germany., Schwarz PEH; Department of Medicine III, University Hospital Carl Gustav Carus, Technische Universität Dresden, D-01307 Dresden, Germany.; Paul Langerhans Institute Dresden, German Center for Diabetes Research (DZD), 01307 Dresden, Germany., Sever P; International Centre for Circulatory Health, Imperial College London, London W2 1PG, UK., Shuldiner AR; Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA.; Program for Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA.; Geriatric Research and Education Clinical Center, Vetrans Administration Medical Center, Baltimore, Maryland 21201, USA., Sinisalo J; Helsinki University Central Hospital Heart and Lung Center, Department of Medicine, Helsinki University Central Hospital, FI-00290 Helsinki, Finland., Stolk RP; Department of Epidemiology, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands., Strauch K; Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, D-85764 Neuherberg, Germany.; Institute of Medical Informatics, Biometry and Epidemiology, Chair of Genetic Epidemiology, Ludwig-Maximilians-Universität, D-81377 Munich, Germany., Tönjes A; Integrated Research and Treatment Center (IFB) Adiposity Diseases, University of Leipzig, D-04103 Leipzig, Germany.; Department of Medicine, University of Leipzig, D-04103 Leipzig, Germany., Trégouët DA; Sorbonne Universités, UPMC Univ Paris 06, UMR S 1166, F-75013 Paris, France.; INSERM, UMR S 1166, Team Genomics and Physiopathology of Cardiovascular Diseases, F-75013 Paris, France.; Institute for Cardiometabolism And Nutrition (ICAN), F-75013 Paris, France., Tremblay A; Department of Kinesiology, Laval University, Quebec QC G1V 0A6, Canada., Tremoli E; Dipartimento di Scienze Farmacologiche e Biomolecolari, Università di Milano & Centro Cardiologico Monzino, Instituto di Ricovero e Cura a Carattere Scientifico, Milan 20133, Italy., Virtamo J; National Institute for Health and Welfare, FI-00271 Helsinki, Finland., Vohl MC; Institute of Nutrition and Functional Foods, Laval University, Quebec, QC G1V 0A6, Canada.; Department of Food Science and Nutrition, Laval University, Quebec QC G1V 0A6, Canada., Völker U; Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, D-17475 Greifswald, Germany.; DZHK (Deutsches Zentrum für Herz-Kreislaufforschung - German Centre for Cardiovascular Research), partner site Greifswald, D-17475 Greifswald, Germany., Waeber G; Department of Internal Medicine, University Hospital (CHUV) and University of Lausanne, Lausanne 1011, Switzerland., Willemsen G; Biological Psychology, VU University Amsterdam, 1081BT Amsterdam, The Netherlands., Witteman JC; Department of Epidemiology, Erasmus MC University Medical Center, 3015GE Rotterdam, The Netherlands., Zillikens MC; Netherlands Consortium for Healthy Aging (NCHA), 3015GE Rotterdam, The Netherlands.; Department of Internal Medicine, Erasmus MC University Medical Center, 3015GE Rotterdam, The Netherlands., Adair LS; Department of Nutrition, University of North Carolina, Chapel Hill, North Carolina 27599, USA., Amouyel P; Institut Pasteur de Lille; INSERM, U744; Université de Lille 2; F-59000 Lille, France., Asselbergs FW; Institute of Cardiovascular Science, University College London, London WC1E 6BT, UK.; Durrer Center for Cardiogenetic Research, Interuniversity Cardiology Institute Netherlands (ICIN), 3501 DG Utrecht, The Netherlands.; Department of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands., Assimes TL; Department of Medicine, Stanford University School of Medicine, Palo Alto, California 94304, USA., Bochud M; Institute of Social and Preventive Medicine (IUMSP), Centre Hospitalier Universitaire Vaudois and University of Lausanne, 1010 Lausanne, Switzerland.; Ministry of Health, Victoria, Republic of Seychelles., Boehm BO; Lee Kong Chian School of Medicine, Imperial College London and Nanyang Technological University, Singapore, 637553 Singapore, Singapore.; Department of Internal Medicine I, Ulm University Medical Centre, D-89081 Ulm, Germany., Boerwinkle E; Health Science Center at Houston, University of Texas, Houston, Texas 77030, USA., Bornstein SR; Department of Medicine III, University Hospital Carl Gustav Carus, Technische Universität Dresden, D-01307 Dresden, Germany., Bottinger EP; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA., Bouchard C; Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, Louisiana 70808, USA., Cauchi S; CNRS UMR 8199, F-59019 Lille, France.; European Genomic Institute for Diabetes, F-59000 Lille, France.; Université de Lille 2, F-59000 Lille, France., Chambers JC; Ealing Hospital NHS Trust, Middlesex UB1 3HW, UK.; Department of Epidemiology and Biostatistics, Imperial College London, London W2 1PG, UK.; Imperial College Healthcare NHS Trust, London W12 0HS, UK., Chanock SJ; Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA., Cooper RS; Department of Public Health Sciences, Stritch School of Medicine, Loyola University of Chicago, Maywood, Illinois 61053, USA., de Bakker PIW; Department of Medical Genetics, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands.; Department of Medicine, Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.; Department of Epidemiology, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands., Dedoussis G; Department of Dietetics-Nutrition, Harokopio University, 17671 Athens, Greece., Ferrucci L; Translational Gerontology Branch, National Institute on Aging, Baltimore, Maryland 21225, USA., Franks PW; Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA.; Department of Clinical Sciences, Genetic & Molecular Epidemiology Unit, Lund University Diabetes Center, Skåne University Hosptial, Malmö 205 02, Sweden.; Department of Public Health and Clinical Medicine, Unit of Medicine, Umeå University, Umeå 901 87, Sweden., Froguel P; Department of Genomics of Common Disease, School of Public Health, Imperial College London, Hammersmith Hospital, London W12 0NN, UK.; CNRS UMR 8199, F-59019 Lille, France.; European Genomic Institute for Diabetes, F-59000 Lille, France.; Université de Lille 2, F-59000 Lille, France., Groop LC; Institute for Molecular Medicine, University of Helsinki, FI-00014 Helsinki, Finland.; Lund University Diabetes Centre and Department of Clinical Science, Diabetes & Endocrinology Unit, Lund University, Malmö 221 00, Sweden., Haiman CA; Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA., Hamsten A; Atherosclerosis Research Unit, Center for Molecular Medicine, Department of Medicine, Karolinska Institutet, Stockholm 17176, Sweden., Hui J; PathWest Laboratory Medicine of Western Australia, Nedlands, Western Australia 6009, Australia.; Pathology and Laboratory Medicine, The University of Western Australia, Perth, Western Australia 6009, Australia.; School of Population Health, The University of Western Australia, Nedlands, Western Australia 6009, Australia., Hunter DJ; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA.; Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA.; Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA., Hveem K; Department of Public Health and General Practice, Norwegian University of Science and Technology, Trondheim 7489, Norway., Kaplan RC; Albert Einstein College of Medicine, Department of Epidemiology and Population Health, Belfer 1306, New York 10461, USA., Kivimaki M; Department of Epidemiology and Public Health, University College London, London WC1E 6BT, UK., Kuh D; MRC Unit for Lifelong Health and Ageing at University College London, London WC1B 5JU, UK., Laakso M; Department of Medicine, Kuopio University Hospital and University of Eastern Finland, FI-70210 Kuopio, Finland., Liu Y; Center for Human Genetics, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina 27157, USA., Martin NG; QIMR Berghofer Medical Research Institute, Brisbane, Queensland 4006, Australia., März W; Vth Department of Medicine (Nephrology, Hypertensiology, Endocrinology, Diabetology, Rheumatology), Medical Faculty of Mannheim, University of Heidelberg, D-68187 Mannheim, Germany.; Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz 8036, Austria.; Synlab Academy, Synlab Services GmbH, 68163 Mannheim, Germany., Melbye M; Department of Medicine, Stanford University School of Medicine, Palo Alto, California 94304, USA.; Department of Clinical Medicine, Copenhagen University, 2200 Copenhagen, Denmark., Metspalu A; Estonian Genome Center, University of Tartu, Tartu 51010, Estonia.; Institute of Molecular and Cell Biology, University of Tartu, Tartu 51010, Estonia., Moebus S; Institute for Medical Informatics, Biometry and Epidemiology (IMIBE), University Hospital Essen, 45147 Essen, Germany., Munroe PB; Department of Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK., Njølstad I; Department of Community Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway, 9037 Tromsø, Norway., Oostra BA; Genetic Epidemiology Unit, Department of Epidemiology, Erasmus MC University Medical Center, 3015 GE Rotterdam, The Netherlands.; Center for Medical Sytems Biology, 2300 RC Leiden, The Netherlands.; Department of Clinical Genetics, Erasmus MC University Medical Center, 3000 CA Rotterdam, The Netherlands., Palmer CNA; Medical Research Institute, University of Dundee, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK., Pedersen NL; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 17177, Sweden., Perola M; Estonian Genome Center, University of Tartu, Tartu 51010, Estonia.; National Institute for Health and Welfare, FI-00271 Helsinki, Finland.; Institute for Molecular Medicine, University of Helsinki, FI-00014 Helsinki, Finland., Pérusse L; Institute of Nutrition and Functional Foods, Laval University, Quebec, QC G1V 0A6, Canada.; Department of Kinesiology, Laval University, Quebec QC G1V 0A6, Canada., Peters U; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA., Power C; Population, Policy, and Practice, University College London Institute of Child Health, London WC1N 1EH, UK., Quertermous T; Department of Medicine, Stanford University School of Medicine, Palo Alto, California 94304, USA., Rauramaa R; Kuopio Research Institute of Exercise Medicine, 70100 Kuopio, Finland.; Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital and University of Eastern Finland, FI-70210 Kuopio, Finland., Rivadeneira F; Netherlands Consortium for Healthy Aging (NCHA), 3015GE Rotterdam, The Netherlands.; Department of Epidemiology, Erasmus MC University Medical Center, 3015GE Rotterdam, The Netherlands.; Department of Internal Medicine, Erasmus MC University Medical Center, 3015GE Rotterdam, The Netherlands., Saaristo TE; Finnish Diabetes Association, Kirjoniementie 15, FI-33680 Tampere, Finland.; Pirkanmaa Hospital District, FI-33521 Tampere, Finland., Saleheen D; Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK.; Center for Non-Communicable Diseases, Karatchi, Pakistan.; Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA., Sattar N; BHF Glasgow Cardiovascular Research Centre, Division of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow G12 8TA, UK., Schadt EE; Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, New York 10580, USA., Schlessinger D; Laboratory of Genetics, National Institute on Aging, Baltimore, Maryland 21224, USA., Slagboom PE; Netherlands Consortium for Healthy Aging (NCHA), Leiden University Medical Center, Leiden 2300 RC, The Netherlands.; Department of Molecular Epidemiology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands., Snieder H; Department of Epidemiology, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands., Spector TD; Department of Twin Research and Genetic Epidemiology, King's College London, London SE1 7EH, UK., Thorsteinsdottir U; deCODE Genetics, Amgen Inc., Reykjavik 101, Iceland.; Faculty of Medicine, University of Iceland, Reykjavik 101, Iceland., Stumvoll M; Integrated Research and Treatment Center (IFB) Adiposity Diseases, University of Leipzig, D-04103 Leipzig, Germany.; Department of Medicine, University of Leipzig, D-04103 Leipzig, Germany., Tuomilehto J; National Institute for Health and Welfare, FI-00271 Helsinki, Finland.; Institute for Health Research, University Hospital of La Paz (IdiPaz), 28046 Madrid, Spain.; Diabetes Research Group, King Abdulaziz University, 21589 Jeddah, Saudi Arabia.; Centre for Vascular Prevention, Danube-University Krems, 3500 Krems, Austria., Uitterlinden AG; Netherlands Consortium for Healthy Aging (NCHA), 3015GE Rotterdam, The Netherlands.; Department of Epidemiology, Erasmus MC University Medical Center, 3015GE Rotterdam, The Netherlands.; Department of Internal Medicine, Erasmus MC University Medical Center, 3015GE Rotterdam, The Netherlands., Uusitupa M; Department of Public Health and Clinical Nutrition, University of Eastern Finland, Finland.; Research Unit, Kuopio University Hospital, FI-70210 Kuopio, Finland., van der Harst P; Department of Genetics, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands.; Department of Cardiology, University Medical Center Groningen, University of Groningen, 9700RB Groningen, The Netherlands.; Durrer Center for Cardiogenetic Research, Interuniversity Cardiology Institute Netherlands (ICIN), 3501 DG Utrecht, The Netherlands., Walker M; Institute of Cellular Medicine, Newcastle University, Newcastle NE1 7RU, UK., Wallaschofski H; DZHK (Deutsches Zentrum für Herz-Kreislaufforschung - German Centre for Cardiovascular Research), partner site Greifswald, D-17475 Greifswald, Germany.; Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, D-17475 Greifswald, Germany., Wareham NJ; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK., Watkins H; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.; Division of Cardiovacular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 9DU, UK., Weir DR; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, Michigan 48104, USA., Wichmann HE; Institute of Medical Informatics, Biometry and Epidemiology, Chair of Epidemiology, Ludwig-Maximilians-Universität, D-85764 Munich, Germany.; Klinikum Grosshadern, D-81377 Munich, Germany.; Institute of Epidemiology I, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany, D-85764 Neuherberg, Germany., Wilson JF; Centre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh EH8 9AG, UK., Zanen P; Department of Pulmonology, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands., Borecki IB; Department of Genetics, Washington University School of Medicine, St Louis, Missouri 63110, USA., Deloukas P; Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK.; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK.; Princess Al-Jawhara Al-Brahim Centre of Excellence in Research of Hereditary Disorders (PACER-HD), King Abdulaziz University, 21589 Jeddah, Saudi Arabia., Fox CS; National Heart, Lung, and Blood Institute, the Framingham Heart Study, Framingham, Massachusetts 01702, USA., Heid IM; Department of Genetic Epidemiology, Institute of Epidemiology and Preventive Medicine, University of Regensburg, D-93053 Regensburg, Germany.; Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, D-85764 Neuherberg, Germany., O'Connell JR; Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA.; Program for Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA., Strachan DP; Division of Population Health Sciences & Education, St George's, University of London, London SW17 0RE, UK., Stefansson K; deCODE Genetics, Amgen Inc., Reykjavik 101, Iceland.; Faculty of Medicine, University of Iceland, Reykjavik 101, Iceland., van Duijn CM; Genetic Epidemiology Unit, Department of Epidemiology, Erasmus MC University Medical Center, 3015 GE Rotterdam, The Netherlands.; Netherlands Consortium for Healthy Aging (NCHA), 3015GE Rotterdam, The Netherlands.; Department of Epidemiology, Erasmus MC University Medical Center, 3015GE Rotterdam, The Netherlands.; Center for Medical Sytems Biology, 2300 RC Leiden, The Netherlands., Abecasis GR; Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan 48109, USA., Franke L; Department of Genetics, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands., Frayling TM; Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter EX1 2LU, UK., McCarthy MI; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford OX3 7LJ, UK.; Oxford NIHR Biomedical Research Centre, Oxford University Hospitals NHS Trust, Oxford OX3 7LJ, UK., Visscher PM; Queensland Brain Institute, The University of Queensland, Brisbane 4072, Australia.; The University of Queensland Diamantina Institute, The Translation Research Institute, Brisbane 4012, Australia., Scherag A; Institute for Medical Informatics, Biometry and Epidemiology (IMIBE), University Hospital Essen, 45147 Essen, Germany.; Clinical Epidemiology, Integrated Research and Treatment Center, Center for Sepsis Control and Care (CSCC), Jena University Hospital, 07743 Jena, Germany., Willer CJ; Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA.; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan 48109, USA.; Department of Human Genetics, University of Michigan, Ann Arbor, Michigan 48109, USA., Boehnke M; Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan 48109, USA., Mohlke KL; Department of Genetics, University of North Carolina, Chapel Hill, North Carolina 27599, USA., Lindgren CM; Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts 02142, USA.; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK., Beckmann JS; Swiss Institute of Bioinformatics, Lausanne 1015, Switzerland.; Department of Medical Genetics, University of Lausanne, Lausanne 1005, Switzerland.; Service of Medical Genetics, CHUV University Hospital, 1011 Lausanne, Switzerland., Barroso I; Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK.; University of Cambridge Metabolic Research Laboratories, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge CB2 OQQ, UK.; NIHR Cambridge Biomedical Research Centre, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge CB2 OQQ, UK., North KE; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.; Carolina Center for Genome Sciences, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA., Ingelsson E; Science for Life Laboratory, Uppsala University, Uppsala 75185, Sweden.; Department of Medical Sciences, Molecular Epidemiology, Uppsala University, Uppsala 75185, Sweden.; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK., Hirschhorn JN; Divisions of Endocrinology and Genetics and Center for Basic and Translational Obesity Research, Boston Children's Hospital, Boston, Massachusetts 02115, USA.; Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts 02142, USA.; Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA., Loos RJF; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK.; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.; The Genetics of Obesity and Related Metabolic Traits Program, The Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.; The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA., Speliotes EK; Department of Internal Medicine, Division of Gastroenterology, and Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan 48109, USA.

Publikováno v: Nature [Nature] 2015 Feb 12; Vol. 518 (7538), pp. 197-206.