Zobrazeno 1 - 10 of 371 pro vyhledávání: '"Rm, Bertina"'
1
CLINICAL APPLICATION OF PLASMA PROTEIN C DETERMINATION
Autor: RM Bertina, George Zhu, AW Broekmans
Publikováno v: Universal Journal of Pharmaceutical Research.
Objective: Protein C, a vitamin K-dependent coagulation factor, is involved in blood coagulation. Activated protein C inactivates Va and VIIIa and stimulates fibrinolysis. In this process, protein S serve as an important factor for activated protein
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6265a0faa717a38ad74fc2f724886d81
https://doi.org/10.22270/ujpr.v5i6.509
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2
Heerlen polymorphism of protein S, an immunologic polymorphism due to dimorphism of residue 460
Autor: RM Bertina, HK Ploos van Amstel, A van Wijngaarden, J Coenen, MP Leemhuis, PP Deutz-Terlouw, IK van der Linden, PH Reitsma
Publikováno v: Blood. 76:538-548
We recently developed an enzyme-linked immunosorbent assay (ELISA) for total protein S (PS) antigen using the monoclonal antibody S-12. During the screening of thrombophilic patients we identified a patient, who was using marcoumar, with 0% PS by mon
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ae5959fa63527ebc8bf44573b2abd198
https://doi.org/10.1182/blood.v76.3.538.bloodjournal763538
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3
Venous thrombotic risk in family members of unselected individuals with factor V Leiden
Autor: Rp, Lensen, Rm, Bertina, de Ronde H, Jan P Vandenbroucke, Fr, Rosendaal
Publikováno v: Europe PubMed Central
The factor V Leiden mutation (FVL) leads to a seven-fold increased risk of venous thromboembolism (VTE). In thrombophilic families. 25% of carriers have experienced thrombosis before the age of 40 years. Aim of our study was to assess the association
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::cdcc31768eeede5fa90c3532cb6506e7
https://pubmed.ncbi.nlm.nih.gov/10896231
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4
Increased levels of factor VIII and fibrinogen in patients with venous thrombosis are not caused by acute phase reactions
Autor: Pw, Kamphuisen, Jeroen Eikenboom, Hl, Vos, Pablo R, Sturk A, Rm, Bertina, Fr, Rosendaal
Publikováno v: Europe PubMed Central
Factor VIII activity (factor VIII:C) levelsor =150 IU/dl are associated with a 5- to 6-fold increased risk of venous thrombosis compared to levels100 IU/dl, and fibrinogen levelsor =5.0 g/l increase the thrombosis risk 4-fold. These high levels are p
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::f3b7336d4332fe11c035edae530edf37
https://pubmed.ncbi.nlm.nih.gov/11057882
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5
Hemostatic effects of oral contraceptives in women who developed deep-vein thrombosis while using oral contraceptives
Autor: Kw, Bloemenkamp, Fr, Rosendaal, Fm, Helmerhorst, Koster T, Rm, Bertina, Jan P Vandenbroucke
Publikováno v: Europe PubMed Central
Comparison of the effect of oral contraceptives on hemostatic variables in venous thrombosis patients (thrombosis while using oral contraceptives) with the effect in healthy control subjects. Our aim was to assess whether some of these effects were m
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::4f5e3f9557c35b1bd154194a09bbffb5
https://pubmed.ncbi.nlm.nih.gov/9759614
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6
Familial clustering of factor VIII and von Willebrand factor levels
Autor: Pw, Kamphuisen, Jeanine Houwing-Duistermaat, Hc, Houwelingen, Jc, Eikenboom, Rm, Bertina, Fr, Rosendaal
Publikováno v: Europe PubMed Central
Recently, we found that high levels of clotting factor VIII (150 IU/dl) are common and make an important contribution to thrombotic risk. The determinants of high factor VIII:C are unclear and might be partly genetic. Therefore, we tested the influen
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::7972438a7d332c295b46efec9290d5d6
https://pubmed.ncbi.nlm.nih.gov/9493584
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8
Apparent different thrombotic tendency in patients with factor V Leiden and protein C deficiency due to selection of patients
Autor: Rp, Lensen, Fr, Rosendaal, Koster T, Cf, Allaart, de Ronde H, Jan P Vandenbroucke, Ph, Reitsma, Rm, Bertina
Publikováno v: Europe PubMed Central
Both activated protein C (APC) resistance and protein C deficiency are associated with an increased risk for venous thrombosis. To assess their tendencies to venous thrombosis, we compared the median age of first venous thromboembolism in patients wi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5fdaf7fd01ada0e42a719becb2c47c7
https://pubmed.ncbi.nlm.nih.gov/8943855
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9
Resistance to activated protein C and factor V Leiden as risk factors for venous thrombosis
Autor: Rm, Bertina, Ph, Reitsma, Fr, Rosendaal, Jan P Vandenbroucke
Publikováno v: Europe PubMed Central
The recent discovery of the factor V Leiden mutation as the molecular defect in the large majority of APC-resistant individuals, has drastically changed our view on familial thrombophilia and it has contributed to a better understanding of the intera
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::869ffc506698bbc137f0dbd2392976ab
https://pubmed.ncbi.nlm.nih.gov/8578504
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10
Construction and characterization of thrombin-resistant variants of recombinant human protein S
Autor: Gt, Chang, Aaldering L, Tilman Hackeng, Ph, Reitsma, Rm, Bertina, Bn, Bouma
Publikováno v: Europe PubMed Central
Protein S is a vitamin K-dependent plasma protein that functions as a cofactor of activated protein C (APC) in the inactivation of coagulation factors Va and VIIIa. Protein S, migrates as a doublet on reduced SDS polyacrylamide gel electrophoresis. T
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::f7f70b7a66fd725373989fb6d38cedcf
https://pubmed.ncbi.nlm.nih.gov/7900076
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