Zobrazeno 1 - 10
of 58
pro vyhledávání: '"Rk, Narla"'
Publikováno v:
Europe PubMed Central
The compound bis(4,7-dimethyl-1,10-phenanthroline) sulfatooxovanadium(IV) (METVAN [VO(SO4)(Me2-Phen)2]), exhibits potent cytotoxicity against human cancer cells at low micromolar concentrations. At concentrationsor = 1 microM, METVAN treatment was as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::9b65893d3ef8029bdcbd8d3bae07da38
https://pubmed.ncbi.nlm.nih.gov/11448932
https://pubmed.ncbi.nlm.nih.gov/11448932
Publikováno v:
Europe PubMed Central
We have examined the in vitro anticancer activity of METVAN [bis(4,7-dimethyl-1,10 phenanthroline) sulfatooxovanadium(IV); VO(SO(4))(Me(2)-Phen)(2)] against acute lymphoblastic leukemia (ALL; NALM-6 and MOLT-3), acute myeloid leukemia (AML; HL-60), H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::7c6977554e9ad529b538f99dc46bb440
https://pubmed.ncbi.nlm.nih.gov/11309362
https://pubmed.ncbi.nlm.nih.gov/11309362
Publikováno v:
Europe PubMed Central
Agents that either promote or inhibit tubulin polymerization exhibit anticancer activity by disrupting normal mitotic spindle assembly and cell division as well as inducing apoptosis. Recently identified novel agents that target tubulin include synth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::ad78b878789b71808274cad7d45a62a5
https://pubmed.ncbi.nlm.nih.gov/11249582
https://pubmed.ncbi.nlm.nih.gov/11249582
Publikováno v:
Europe PubMed Central
In a systematic effort to design inhibitors of the epidermal growth factor receptor (EGFR) family protein tyrosine kinases (PTK) as anti-cancer agents, we have constructed a three-dimensional homology model of the EGFR kinase domain and used molecula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::c155a052a688e61c689616ef894ce4ca
http://europepmc.org/abstract/med/10766295
http://europepmc.org/abstract/med/10766295
Autor:
Fatih M. Uckun, Rk, Narla, Jun X, Zeren T, Venkatachalam T, Kg, Waddick, Rostostev A, Myers DE
Publikováno v:
Europe PubMed Central
The receptor (R) for epidermal growth factor (EGF) is expressed at high levels on human breast cancer cells and associates with ErbB2, ErbB3, and Src proto-oncogene family protein tyrosine kinases (PTKs) to form membrane-associated PTK complexes with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::0cd15b494aad992e71be21e3576e6ac7
http://europepmc.org/abstract/med/9563884
http://europepmc.org/abstract/med/9563884
Autor:
Fatih M. Uckun, Rk, Narla, Zeren T, Yanishevski Y, Myers DE, Waurzyniak B, Ek O, Schneider E, Messinger Y, Lm, Chelstrom, Gunther R, Evans W
Publikováno v:
Europe PubMed Central
Epidermal growth factor receptor (EGFR)-associated protein tyrosine kinase (PTK) complexes have vital anti-apoptotic functions in human breast cancer cells. We have shown previously that targeting the naturally occurring PTK inhibitor genistein to th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::4937d65ba08f2ebd258780974479aafd
http://europepmc.org/abstract/med/9607569
http://europepmc.org/abstract/med/9607569
Publikováno v:
Europe PubMed Central
A novel homology model of the kinase domain of Janus kinase (JAK) 3 was used for the structure-based design of dimethoxyquinazoline compounds with potent and specific inhibitory activity against JAK3. The active site of JAK3 in this homology model me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::a0db693861e5326e34bd83fd834ef304
http://europepmc.org/abstract/med/10389946
http://europepmc.org/abstract/med/10389946
Publikováno v:
Europe PubMed Central
Epidermal growth factor receptor (EGF-R) tyrosine kinase is known to be overexpressed in several malignancies and is an important target for anticancer drug design. We constructed a homology model to represent the structure of EGF-R and propose that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::67ee69b721a97b1cbeff47dad21e891c
http://europepmc.org/abstract/med/9829728
http://europepmc.org/abstract/med/9829728
Publikováno v:
Europe PubMed Central
We have evaluated the cytotoxicities of the combinations of calcium mobilizers and PKC inhibitors against human acute lymphoblastic leukemia (ALL) cells. Here we report that calcium mobilizers alone or PKC inhibitors alone do not induce apoptosis in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::3432ceb4b2d158da91d9261c8a2131be
http://europepmc.org/abstract/med/10037185
http://europepmc.org/abstract/med/10037185
Publikováno v:
Europe PubMed Central
Glioblastoma multiforme is a highly invasive primary brain tumor with a disappointingly high local recurrence rate and mortality despite intensive multimodality treatment programs. Therefore, new agents that are capable of inhibiting the infiltration
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::9d409159559397d253ef23c51fabb66a
http://europepmc.org/abstract/med/9796979
http://europepmc.org/abstract/med/9796979