Zobrazeno 1 - 10
of 298
pro vyhledávání: '"Rk, Humphries"'
Publikováno v:
Leukemia. 19:636-643
Hox genes have been identified in chromosomal translocations involving the nucleoporin gene NUP98. Though the resulting chimeric proteins directly participate in the development of leukemia, the long latency and monoclonal nature of the disease suppo
Publikováno v:
Leukemia. 13:687-698
To explore the possibility that deregulated HOX gene expression might commonly occur during leukemic hematopoiesis, we compared the relative levels of expression of these and related genes in phenotypically and functionally defined subpopulations of
Publikováno v:
Scopus-Elsevier
Recent assessment of the long-term repopulating activity of defined subsets of hematopoietic cells has offered new insights into the characteristics of the transplantable stem cells of this system; however, as yet, there is very little known about me
Autor:
M Lu, Corey Largman, Wei-Fang Shen, C P Chang, H J Lawrence, Michael L. Cleary, RK Humphries, S Rozenfeld, Guy Sauvageau
Publikováno v:
Nucleic Acids Research. 24:898-906
Eight of the nine homeobox genes of the Hoxb locus encode proteins which contain a conserved hexapeptide motif upstream from the homeodomain. All eight proteins (Hoxb-1-Hoxb-8) bind to a target oligonucleotide in the presence of Pbx1a under condition
Publikováno v:
Scopus-Elsevier
We have investigated the use of a cell surface antigen as a dominant selectable marker to facilitate the detection and selection of retrovirally infected target cells. The small coding region of the human cell surface antigen CD24 (approximately 240
Publikováno v:
Blood. 83:128-136
Normal murine bone marrow (BM) cells were sorted on the basis of low forward and orthogonal light scatter properties, Sca-1 expression (Sca-1+), lack of staining with a cocktail of mature hematopoietic lineage markers (Lin-), and binding of wheat ger
Publikováno v:
Proceedings of the National Academy of Sciences. 89:1968-1972
Marrow cells from male mice pretreated with 5-fluorouracil were infected with helper-free neomycin-resistant (neor) recombinant retrovirus and then used to initiate long-term cultures (LTC) on irradiated adherent marrow feeder layers. Four weeks late
Autor:
J. D. Cashman, P. L. Lansdorp, T Otsuka, Allen C. Eaves, Heather J. Sutherland, RK Humphries, Donna E. Hogge, Connie J. Eaves
Publikováno v:
Annals of the New York Academy of Sciences. 628:298-306
Cells at two distinct early stages in the development of mature human blood cells from primitive totipotent hematopoietic stem cells can now be defined and quantitated by separate in vitro assays. Current evidence suggests that most, if not all, colo
Publikováno v:
Blood. 77:493-499
The ability of granulocyte-macrophage colony-stimulating factor (GM- CSF) and G-CSF to influence hematopoiesis in long-term cultures (LTC) of human marrow was studied by cocultivating light density normal human marrow cells with human marrow fibrobla
Autor:
JD Shepherd, GL Phillips, RK Humphries, Ali G. Turhan, DK Kalousek, Michael J. Barnett, Connie J. Eaves, DE Reece, Hans G. Klingemann, PL Lansdorp
Publikováno v:
Europe PubMed Central
Philadelphia (Ph1) chromosome-positive clonogenic progenitors usually disappear within 4 to 6 weeks in long-term cultures established from the marrow of patients with chronic myeloid leukemia (CML). In contrast, coexisting chromosomally normal hemato