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The cholecystokinin CCK2 receptor antagonist, JNJ-26070109, inhibits gastric acid secretion and prevents omeprazole-induced acid rebound in the rat.

Autor: Barrett, TD, Lagaud, G, Wagaman, P, Freedman, JM, Yan, W, Andries, L, Rizzolio, MC, Morton, MF, Shankley, NP

Publikováno v: British Journal of Pharmacology; Jul2012, Vol. 166 Issue 5, p1684-1693, 10p

Discovery of a Gut-Restricted JAK Inhibitor for the Treatment of Inflammatory Bowel Disease.

Autor: Leonard KA; Janssen Research and Development, 1400 McKean Road, Spring House, Pennsylvania 19477, United States., Madge LA; Janssen Research and Development, 1400 McKean Road, Spring House, Pennsylvania 19477, United States., Krawczuk PJ; Janssen Research and Development, 1400 McKean Road, Spring House, Pennsylvania 19477, United States., Wang A; Janssen Research and Development, 1400 McKean Road, Spring House, Pennsylvania 19477, United States., Kreutter KD; Janssen Research and Development, 1400 McKean Road, Spring House, Pennsylvania 19477, United States., Bacani GM; Janssen Research and Development, 3210 Merryfield Row, San Diego, California 92121, United States., Chai W; Janssen Research and Development, 3210 Merryfield Row, San Diego, California 92121, United States., Smith RC; Janssen Research and Development, 3210 Merryfield Row, San Diego, California 92121, United States., Tichenor MS; Janssen Research and Development, 3210 Merryfield Row, San Diego, California 92121, United States., Harris MC; Janssen Research and Development, 1400 McKean Road, Spring House, Pennsylvania 19477, United States., Malaviya R; Janssen Research and Development, 1400 McKean Road, Spring House, Pennsylvania 19477, United States., Seierstad M; Janssen Research and Development, 3210 Merryfield Row, San Diego, California 92121, United States., Johnson ME; Janssen Research and Development, 1400 McKean Road, Spring House, Pennsylvania 19477, United States., Venable JD; Janssen Research and Development, 3210 Merryfield Row, San Diego, California 92121, United States., Kim S; Janssen Research and Development, 3210 Merryfield Row, San Diego, California 92121, United States., Hirst GC; Janssen Research and Development, 3210 Merryfield Row, San Diego, California 92121, United States., Mathur AS; Janssen Research and Development, 1400 McKean Road, Spring House, Pennsylvania 19477, United States., Rao TS; Janssen Research and Development, 3210 Merryfield Row, San Diego, California 92121, United States., Edwards JP; Janssen Research and Development, 1400 McKean Road, Spring House, Pennsylvania 19477, United States., Rizzolio MC; Janssen Research and Development, 3210 Merryfield Row, San Diego, California 92121, United States., Koudriakova T; Janssen Research and Development, 3210 Merryfield Row, San Diego, California 92121, United States.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2020 Mar 26; Vol. 63 (6), pp. 2915-2929. Date of Electronic Publication: 2020 Mar 16.

Pharmacological characterization of 1-(5-chloro-6-(trifluoromethoxy)-1H-benzoimidazol-2-yl)-1H-pyrazole-4-carboxylic acid (JNJ-42041935), a potent and selective hypoxia-inducible factor prolyl hydroxylase inhibitor.

Autor: Barrett TD; Cardiovascular Metabolic Research, Johnson and Johnson Pharmaceutical Research and Development LLC, 3210 Merryfield Row, San Diego, CA 92121, USA. tbarret1@its.jnj.com, Palomino HL, Brondstetter TI, Kanelakis KC, Wu X, Haug PV, Yan W, Young A, Hua H, Hart JC, Tran DT, Venkatesan H, Rosen MD, Peltier HM, Sepassi K, Rizzolio MC, Bembenek SD, Mirzadegan T, Rabinowitz MH, Shankley NP

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Identification and optimization of anthranilic sulfonamides as novel, selective cholecystokinin-2 receptor antagonists.

Autor: Allison BD; Johnson and Johnson Pharmaceutical Research and Development, LLC, 3210 Merryfield Row, San Diego, California 92121, USA., Phuong VK, McAtee LC, Rosen M, Morton M, Prendergast C, Barrett T, Lagaud G, Freedman J, Li L, Wu X, Venkatesan H, Pippel M, Woods C, Rizzolio MC, Hack M, Hoey K, Deng X, King C, Shankley NP, Rabinowitz MH

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2006 Oct 19; Vol. 49 (21), pp. 6371-90.