Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Rizaldy P. Scott"'
Autor:
Michael D. Donnan, Rizaldy P. Scott, Tuncer Onay, Antoine Tarjus, Ummiye Venus Onay, Susan E. Quaggin
Publikováno v:
Frontiers in Medicine, Vol 6 (2019)
Nephrotic syndrome is one of the most common glomerular diseases in children and can be classified on the basis of steroid responsiveness. While multiple genetic causes have been discovered for steroid resistant nephrotic syndrome, the genetics of st
Externí odkaz:
https://doaj.org/article/a276fb3894f74d96aea9b9f2619ceb60
Autor:
Michael D. Donnan, Dilip K. Deb, Tuncer Onay, Rizaldy P. Scott, Eric Ni, Yalu Zhou, Susan E. Quaggin
Publikováno v:
American Journal of Physiology-Renal Physiology. 324:F91-F105
Targeting VEGFR-3 in kidney lymphatics has been proposed as a method to treat kidney disease. However, expression of VEGFR-3 is not lymphatic-specific. We demonstrated developmental expression of VEGFR-3 in glomerular endothelial cells, with loss of
Autor:
Christopher M. Schafer, Silvia Martin-Almedina, Katarzyna Kurylowicz, Neil Dufton, Lourdes Osuna-Almagro, Meng-Ling Wu, Charmain F. Johnson, Aarti V. Shah, Dorian O. Haskard, Andrianna Buxton, Erika Willis, Kate Wheeler, Sean Turner, Magdalena Chlebicz, Rizaldy P. Scott, Susan Kovats, Audrey Cleuren, Graeme M. Birdsey, Anna M. Randi, Courtney T. Griffin
Publikováno v:
bioRxiv
BackgroundDuring infectious diseases, pro-inflammatory cytokines transiently destabilize interactions between adjacent vascular endothelial cells (ECs) to facilitate the passage of immune molecules and cells into tissues. However, in the lung the res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::526ae34af15f04eccb276895f65dccd1
https://doi.org/10.1101/2023.02.08.527788
https://doi.org/10.1101/2023.02.08.527788
Autor:
Jeffrey R. Gulcher, Nicholas A. Cilfone, Carmen J. Booth, Heino Velazquez, Nicolas Ricard, Susan E. Quaggin, Michael Simons, Rizaldy P. Scott, Thomas Chittenden, Javier L. Baylon
Publikováno v:
The Journal of Experimental Medicine
Suppression of endothelial ERK1/1 pathways results in multi-organ failure, similar to what is observed in patients treated with anti-VEGF therapies.
The mechanism of maintaining vascular endothelial identity and integrity is largely unknown. In
The mechanism of maintaining vascular endothelial identity and integrity is largely unknown. In
Autor:
Yashpal S. Kanwar, Monika L Wnuk, Isabel Anna Carota, Christina S. Bartlett, Rizaldy P. Scott, Jeffrey H. Miner, Susan E. Quaggin
Publikováno v:
American Journal of Physiology-Renal Physiology. 313:F1232-F1242
Proteinuria has been reported in cancer patients receiving agents that target the transmembrane receptor neuropilin-1 (Nrp1) suggesting potential adverse effects on glomerular function. Here we show that Nrp1 is highly expressed by mesangial cells an
Publikováno v:
Frontiers in Medicine
Frontiers in Medicine, Vol 6 (2019)
Frontiers in Medicine, Vol 6 (2019)
Nephrotic syndrome is one of the most common glomerular diseases in children and can be classified on the basis of steroid responsiveness. While multiple genetic causes have been discovered for steroid resistant nephrotic syndrome, the genetics of st
Autor:
Gregory Farber, Romulo Hurtado, Sarah Loh, Rizaldy P. Scott, Susan E. Quaggin, Raphael Kopan, James Mtui, Catherine Meyer-Schwesinger, Sebastien Monette, Doris Herzlinger, Carl P. Blobel
The principal function of glomeruli is to filter blood through a highly-specialized filtration barrier consisting of a fenestrated endothelium, the glomerular basement membrane and podocyte foot processes. Previous studies have uncovered a crucial ro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::247b7cf09bba1899d36a1cbccfd84031
https://europepmc.org/articles/PMC5878725/
https://europepmc.org/articles/PMC5878725/
Autor:
Vera Eremina, Yael Kenig-Kozlovsky, Tomokazu Souma, Veronica Ramirez, Susan E. Quaggin, Christine E. Tanna, Tuncer Onay, Rizaldy P. Scott, Yanyang Li, Sunday S. Oladipupo, Matthew D. Breyer, Antoine Tarjus, Dietmar Vestweber, Daniele Procissi, Isabel Anna Carota, Shinji Yamaguchi, Christina S. Bartlett, Chengjin Li, Benjamin R. Thomson
Publikováno v:
The Journal of Experimental Medicine
Diabetic nephropathy is a leading cause of kidney failure. VE-PTP phosphatase expression is increased in the endothelium of rodents with diabetes and hypertension. Genetic deletion of VE-PTP reduces kidney injury in diabetic mice, suggesting it may b
Autor:
Minghao Ye, Shintaro Ide, Minoru Takemoto, Chengjin Li, Yusuke Baba, Gal Finer, Tuncer Onay, Yoshihiro Akimoto, Susan E. Quaggin, Yoshiro Maezawa, Jing Jin, Kana Ide, Tomokazu Souma, Takuya Minamizuka, Koutaro Yokote, Xiangmin Zhao, Rizaldy P. Scott
Publikováno v:
Journal of the American Society of Nephrology : JASN. 29(12)
Background The mammalian kidney develops through reciprocal inductive signals between the metanephric mesenchyme and ureteric bud. Transcription factor 21 (Tcf21) is highly expressed in the metanephric mesenchyme, including Six2-expressing cap mesenc
Autor:
Rizaldy P. Scott, Susan E. Quaggin
Publikováno v:
Journal of Cell Biology. 209:199-210
The function of the kidney, filtering blood and concentrating metabolic waste into urine, takes place in an intricate and functionally elegant structure called the renal glomerulus. Normal glomerular function retains circulating cells and valuable ma