Zobrazeno 1 - 10
of 453
pro vyhledávání: '"Riza M"'
Autor:
Florence M. Chardon, Troy A. McDiarmid, Nicholas F. Page, Riza M. Daza, Beth K. Martin, Silvia Domcke, Samuel G. Regalado, Jean-Benoît Lalanne, Diego Calderon, Xiaoyi Li, Lea M. Starita, Stephan J. Sanders, Nadav Ahituv, Jay Shendure
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract CRISPR-based gene activation (CRISPRa) is a strategy for upregulating gene expression by targeting promoters or enhancers in a tissue/cell-type specific manner. Here, we describe an experimental framework that combines highly multiplexed per
Externí odkaz:
https://doaj.org/article/9bd7fc937a4c4d249a6334bbcbf59eb9
Autor:
David F. Read, Gregory T. Booth, Riza M. Daza, Dana L. Jackson, Rula Green Gladden, Sanjay R. Srivatsan, Brent Ewing, Jennifer M. Franks, Cailyn H. Spurrell, Anne Roshella Gomes, Diana O’Day, Aishwarya A. Gogate, Beth K. Martin, Haleigh Larson, Christian Pfleger, Lea Starita, Yiing Lin, Jay Shendure, Shin Lin, Cole Trapnell
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-14 (2024)
Abstract Sex differences and age-related changes in the human heart at the tissue, cell, and molecular level have been well-documented and many may be relevant for cardiovascular disease. However, how molecular programs within individual cell types v
Externí odkaz:
https://doaj.org/article/c78d59de759c46328c8bc8b520ab680e
Autor:
Gregory T. Booth, Riza M. Daza, Sanjay R. Srivatsan, José L. McFaline-Figueroa, Rula Green Gladden, Andrew C. Mullen, Scott N. Furlan, Jay Shendure, Cole Trapnell
Publikováno v:
BMC Genomics, Vol 24, Iss 1, Pp 1-23 (2023)
Abstract Single-cell chromatin accessibility has emerged as a powerful means of understanding the epigenetic landscape of diverse tissues and cell types, but profiling cells from many independent specimens is challenging and costly. Here we describe
Externí odkaz:
https://doaj.org/article/11167b29a9ec4b1fa5f656373a3275ff
Autor:
Mohammad Lotfollahi, Anna Klimovskaia Susmelj, Carlo De Donno, Leon Hetzel, Yuge Ji, Ignacio L Ibarra, Sanjay R Srivatsan, Mohsen Naghipourfar, Riza M Daza, Beth Martin, Jay Shendure, Jose L McFaline‐Figueroa, Pierre Boyeau, F Alexander Wolf, Nafissa Yakubova, Stephan Günnemann, Cole Trapnell, David Lopez‐Paz, Fabian J Theis
Publikováno v:
Molecular Systems Biology, Vol 19, Iss 6, Pp 1-19 (2023)
Abstract Recent advances in multiplexed single‐cell transcriptomics experiments facilitate the high‐throughput study of drug and genetic perturbations. However, an exhaustive exploration of the combinatorial perturbation space is experimentally u
Externí odkaz:
https://doaj.org/article/418ea36376f0413cb228551ff196f2db
Autor:
Vivek Rai, Daniel X. Quang, Michael R. Erdos, Darren A. Cusanovich, Riza M. Daza, Narisu Narisu, Luli S. Zou, John P. Didion, Yuanfang Guan, Jay Shendure, Stephen C.J. Parker, Francis S. Collins
Publikováno v:
Molecular Metabolism, Vol 32, Iss , Pp 109-121 (2020)
Objective: Type 2 diabetes (T2D) is a complex disease characterized by pancreatic islet dysfunction, insulin resistance, and disruption of blood glucose levels. Genome-wide association studies (GWAS) have identified > 400 independent signals that enc
Externí odkaz:
https://doaj.org/article/0652de6a60844aac846ea57777b9e833
Autor:
Jie Liu, John T. Halloran, Jeffrey A. Bilmes, Riza M. Daza, Choli Lee, Elisabeth M. Mahen, Donna Prunkard, Chaozhong Song, Sibel Blau, Michael O. Dorschner, Vijayakrishna K. Gadi, Jay Shendure, C. Anthony Blau, William S. Noble
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
Abstract A comprehensive characterization of tumor genetic heterogeneity is critical for understanding how cancers evolve and escape treatment. Although many algorithms have been developed for capturing tumor heterogeneity, they are designed for anal
Externí odkaz:
https://doaj.org/article/c58b18b457184aafaf83bba3e97a5fdf
Autor:
Li, Xiaoyi, Chen, Wei, Martin, Beth K., Calderon, Diego, Lee, Choli, Choi, Junhong, Chardon, Florence M., McDiarmid, Troy A., Daza, Riza M., Kim, Haedong, Lalanne, Jean-Benoît, Nathans, Jenny F., Lee, David S., Shendure, Jay
Publikováno v:
In Cell 9 May 2024 187(10):2411-2427
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Akademický článek
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