Telomere elongation through hTERT immortalization leads to chromosome repositioning in control cells and genomic instability in Hutchinson-Gilford progeria syndrome fibroblasts, expressing a novel SUN1 isoform

Autor: Bikkul, Mehmet U, Faragher, Richard G A, Worthington, Gemma, Meinke, Peter, Kerr, Alastair R W, Sammy, Aakila, Riyahi, Kumars, Horton, Daniel, Schirmer, Eric C, Hubank, Michael, Kill, Ian R, Anderson, Rhona M, Slijepcevic, Predrag, Makarov, Evgeny, Bridger, Joanna M

Publikováno v: Bikkul, M U, Faragher, R G A, Worthington, G, Meinke, P, Kerr, A R W, Sammy, A, Riyahi, K, Horton, D, Schirmer, E C, Hubank, M, Kill, I R, Anderson, R M, Slijepcevic, P, Makarov, E & Bridger, J M 2019, ' Telomere elongation through hTERT immortalization leads to chromosome repositioning in control cells and genomic instability in Hutchinson-Gilford progeria syndrome fibroblasts, expressing a novel SUN1 isoform ', Genes, Chromosomes and Cancer, vol. 58, no. 6, pp. 341-356 . https://doi.org/10.1002/gcc.22711

Immortalizing primary cells with human telomerase reverse transcriptase (hTERT) has been common practice to enable primary cells to be of extended use in the laboratory because they avoid replicative senescence. Studying exogenously expressed hTERT i

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https://bura.brunel.ac.uk/handle/2438/17178

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The effects of exogenous antioxidants on lifespan and oxidative stress resistance in Drosophila melanogaster

Autor: Magwere, Tapiwanashe¹, West, Melanie¹, Riyahi, Kumars¹, Murphy, Michael P.², Smith, Robin A.J.³, Partridge, Linda¹ l.partridge@ucl.ac.uk

Publikováno v: Mechanisms of Ageing & Development. Apr2006, Vol. 127 Issue 4, p356-370. 15p.