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Akademický článek

A new histone deacetylase inhibitor remodels the tumor microenvironment by deletion of polymorphonuclear myeloid-derived suppressor cells and sensitizes prostate cancer to immunotherapy

Autor: Zude Chen, Xiaoshuang Yang, Zugen Chen, Minzhao Li, Wei Wang, Riwei Yang, Zuomin Wang, Yuxiang Ma, Yulong Xu, Shan Ao, Leqi Liang, Chao Cai, Changning Wang, Tuo Deng, Di Gu, Hongqing Zhou, Guohua Zeng

Publikováno v: BMC Medicine, Vol 21, Iss 1, Pp 1-14 (2023)

Abstract Background Prostate cancer (PCa) is the most common malignancy diagnosed in men. Immune checkpoint blockade (ICB) alone showed disappointing results in PCa. It is partly due to the formation of immunosuppressive tumor microenvironment (TME)

Externí odkaz: https://doaj.org/article/8172630b3a68414aab193319f3c377d9

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Akademický článek

COVID-19 inhibits spermatogenesis in the testes by inducing cellular senescence

Autor: Zuomin Wang, Yuxiang Ma, Zude Chen, Riwei Yang, Qinwei Liu, Jinyou Pan, Jiamin Wang, Yangzhou Liu, Mingda Zhou, Yihan Zhang, Yuhao Zhou, Shuxin Yang, Bangyu Zou, Jingwei Lin, Yingxin Cai, Zheng Jiang, Zhen Zhou, Zhigang Zhao

Publikováno v: Frontiers in Genetics, Vol 13 (2023)

Introduction: COVID-19 (SARS-CoV-2) has been linked to organ damage in humans since its worldwide outbreak. It can also induce severe sperm damage, according to research conducted at numerous clinical institutions. However, the exact mechanism of dam

Externí odkaz: https://doaj.org/article/11ddb5b35a85440f895c808183b044b9

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Akademický článek

Distinct immune and inflammatory response patterns contribute to the identification of poor prognosis and advanced clinical characters in bladder cancer patients

Autor: Zhenglin Chang, Rongqi Li, Jinhu Zhang, Lingyue An, Gaoxiang Zhou, Min Lei, Jiwang Deng, Riwei Yang, Zhenfeng Song, Wen Zhong, Defeng Qi, Xiaolu Duan, Shujue Li, Baoqing Sun, Wenqi Wu

Publikováno v: Frontiers in Immunology, Vol 13 (2022)

Due to the molecular heterogeneity, most bladder cancer (BLCA) patients show no pathological responses to immunotherapy and chemotherapy yet suffer from their toxicity. This study identified and validated three distinct and stable molecular clusters

Externí odkaz: https://doaj.org/article/e793c3f461104d5599ea650a03e649bd

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PET Imaging of Bromodomain and Extra-Terminal Domain Inhibitors for the Noninvasive Assessment of Metabolic Changes in the Liver and Brain of Early-Stage Alcoholic Liver Disease

Autor: Zude Chen, Riwei Yang, Yulong Xu, Leqi Liang, Shan Ao, Zuomin Wang, Ping Bai, Di Gu, Xiaolu Duan, Yongda Liu, Wen Zhong, Peng Xu, Tuo Deng, Guohua Zeng, Changning Wang

Publikováno v: Molecular pharmaceutics. 19(7)

Alcoholic liver disease (ALD) has a significant impact on human health and is one of the leading causes of liver disease mortality. The early and exact diagnosis of ALD is very important since the early stage of disease progression can be reversible.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be4282db1f4c4c9cc09b4189c484d6f8
https://pubmed.ncbi.nlm.nih.gov/35604773

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Fc Fragment of IgE Receptor Ig (FCER1G) acts as a key gene involved in cancer immune infiltration and tumour microenvironment

Autor: Riwei Yang, Zude Chen, Leqi Liang, Shan Ao, Jinhu Zhang, Zhenglin Chang, Zuomin Wang, Yuhao Zhou, Xiaolu Duan, Tuo Deng

Publikováno v: ImmunologyREFERENCES.

Although recent studies have revealed the relationship between Fc Fragment of IgE Receptor Ig (FCER1G) and human tumours, there is still a lack of a more comprehensive pan-cancer analysis of FCER1G as an immune-related gene. In this study, we investi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44b650ef78d8484eabfcab6a8f8368c2
https://pubmed.ncbi.nlm.nih.gov/36054819

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