Výsledky vyhledávání - "Rivka Melamed"

Deleterious synergistic effects of distress and surgery on cancer metastasis: Abolishment through an integrated perioperative immune-stimulating stress-inflammatory-reducing intervention

Autor: Hagar Lavon, Shamgar Ben-Eliyahu, Rivka Melamed, Yosi Azan, Lee Shaashua, Elad Sandbank, Ella Rosenne, L. Sorski, R. Haldar, Pini Matzner, Amit Benbenishty

Publikováno v: Brain, Behavior, and Immunity. 80:170-178

The perioperative period holds disproportionate impact on long-term cancer outcomes. Nevertheless, perioperative interventions to improve long-term cancer outcomes are not clinical routines, including perioperative stress-reducing or immune-stimulati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::420cc2ab0170a12b584cf1f4471fd7b5
https://doi.org/10.1016/j.bbi.2019.03.005

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Prevention of liver metastases through perioperative acute CpG-C immune stimulation

Autor: Rivka Melamed, Ella Rosenne, Elad Sandbank, L. Sorski, Lee Shaashua, Shamgar Ben-Eliyahu, Pini Matzner, I. Ricon, Hagar Lavon, B. Levi, Amit Benbenishty

Publikováno v: Cancer Immunol Immunother

Following excision of colorectal tumors, metastatic disease is prevalent, primarily occurs in the liver, and is highly predictive of poor prognosis. The perioperative period is now recognized as critical in determining the incidence of postoperative

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a1ec10eb18a905fb0862ce06d0b6abf
https://pubmed.ncbi.nlm.nih.gov/32405793

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Reducing liver metastases of colon cancer in the context of extensive and minor surgeries through β-adrenoceptors blockade and COX2 inhibition

Autor: Hagar Lavon, Rivka Melamed, L. Sorski, Shamgar Ben-Eliyahu, Ella Rosenne, Lee Shaashua, Pini Matzner

Publikováno v: Brain, Behavior, and Immunity. 58:91-98

Liver metastases are a major cause of colorectal cancer death, and the perioperative period is believed to critically affect the metastatic process. Here we tested whether blocking excess release of catecholamines and prostaglandins during surgical p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20a5ceced38605f56ab1a7918b332513
https://doi.org/10.1016/j.bbi.2016.05.017

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Perioperative treatment with the new synthetic TLR-4 agonist GLA-SE reduces cancer metastasis without adverse effects

Autor: Hagar Lavon, Rivka Melamed, L. Sorski, Amit Benbenishty, Pini Matzner, Ely Elbaz, Shamgar Ben-Eliyahu, Neta Gotlieb, Lee Shaashua, Ella Rosenne, Steve Reed

Publikováno v: International Journal of Cancer. 138:1754-1764

The use of TLR agonists as an anti-cancer treatment is gaining momentum given their capacity to activate various host cellular responses through the secretion of inflammatory cytokines and type-I interferons. It is now also recognized that the periop

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8cf913056960db65ff44ecabafb9720f
https://doi.org/10.1002/ijc.29885

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Maintaining unperturbed cerebral blood flow is key in the study of brain metastasis and its interactions with stress and inflammatory responses

Autor: Amit Benbenishty, Pablo Blinder, Lee Shaashua, Niva Segev-Amzaleg, Shamgar Ben-Eliyahu, Rivka Melamed

Blood-borne brain metastases are associated with poor prognosis, but little is known about the interplay between cerebral blood flow, surgical stress responses, and the metastatic process. The intra-carotid inoculation approach, traditionally used in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46141ad25ed1f7afb749791b9d293314
https://europepmc.org/articles/PMC5420452/

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Selective Harvesting of Marginating-hepatic Leukocytes

Autor: Shamgar Ben-Eliyahu, Rivka Melamed, Pini Matzner, Lee Shaashua, L. Sorski

Publikováno v: Journal of Visualized Experiments.

Marginating-hepatic (MH) leukocytes (leukocytes adhering to the sinusoids of the liver), were shown to exhibit unique composition and characteristics compared to leukocytes of other immune compartments. Specifically, evidence suggests a distinct pro-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c1591d6a2d584248f74fae6aafda6d1
https://doi.org/10.3791/53918-v

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Stress impairs the efficacy of immune stimulation by CpG-C: Potential neuroendocrine mediating mechanisms and significance to tumor metastasis and the perioperative period

Autor: Yael Goldfarb, Rivka Melamed, L. Sorski, B. Levi, Ella Rosenne, Shamgar Ben-Eliyahu, Gayle G. Page, Pini Matzner, Lee Shaashua

We recently reported that immune stimulation can be compromised if animals are simultaneously subjected to stressful conditions. To test the generalizability of these findings, and to elucidate neuroendocrine mediating mechanisms, we herein employed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83a6ecb2c2b6ada21e0669aef0c93cd9
https://europepmc.org/articles/PMC4917466/

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Continuous stress disrupts immunostimulatory effects of IL-12

Autor: Rivka Melamed, Marganit Benish, B. Levi, L. Sorski, Yael Goldfarb, Ella Rosenne, Shamgar Ben-Eliyahu

Publikováno v: Brain, Behavior, and Immunity. 25:727-735

Immune stimulation by biological response modifiers is a common approach in tumor immunotherapy. IL-12 was found effective in various animal studies, but clinical trials showed limited success. However, among other differences, animal models do not s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05d9122b975e53c337cec4b16927eb12
https://doi.org/10.1016/j.bbi.2011.01.014

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