Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Rivka Ishai-Michaeli"'
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 13, Iss 5, Pp 445-452 (2011)
Development of compounds that target both heparanase and selectins is emerging as a promising approach for cancer therapy. Selectins are vascular cell adhesion molecules that mediate tumor cell interactions with platelets, leukocytes, and the vascula
Externí odkaz:
https://doaj.org/article/b3e7cb6dbb2745d3af42e40515005006
Autor:
Ariel Rubinstein, Israel Vlodavsky, Immanuel Lerner, Amichay Meirovitz, Ruth Atzmon, Raanan Bulvik, Yoav Sherman, Eyal Zcharia, Michael Elkin, Esther Hermano, Tamar Peretz, Dina Rodkin, Rivka Ishai-Michaeli, Victoria Doviner
Publikováno v:
Journal of Clinical Investigation. 121:1709-1721
Ulcerative colitis (UC) is a chronic inflammatory bowel disease that is closely associated with colon cancer. Expression of the enzyme heparanase is clearly linked to colon carcinoma progression, but its role in UC is unknown. Here we demonstrate for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e84b6a8f36ec455b9adb945f1e3381fe
https://doi.org/10.1172/jci43792
https://doi.org/10.1172/jci43792
Publikováno v:
Journal of Cellular Physiology. 192:276-285
A series of nine synthetic polyaromatic compounds were synthesized by polymerization of aromatic ring monomers with formaldehyde, which yield substantially ordered backbones with different functional anionic groups (hydroxyl and carboxyl) on the phen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c1473120ca388bd91e7a768382eebeb
https://doi.org/10.1002/jcp.10136
https://doi.org/10.1002/jcp.10136
Autor:
Olga Kovalchuk, Abraham J. Domb, Alfonso Bentolila, Israel Vlodavsky, Rivka Ishai-Michaeli, Christine Haloun
Publikováno v:
Journal of Medicinal Chemistry. 43:2591-2600
Poly(N-acryl amino acids) bearing side groups with a lipophilic character or having charged functional groups (i.e. -NH(2), -COOH, -SH, -OH, and phenols) were synthesized from the radical polymerization of N-acryl amino acid monomers. Monomers were p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cad760769e73a49e90fab034ae8c2b3
https://doi.org/10.1021/jm000089j
https://doi.org/10.1021/jm000089j
Autor:
Israel Vlodavsky, Tamar Lang, Olga Ostrovsky, Bluma Berman, Meir Shlissel, David G. Regan, Dina Ron, Rivka Ishai-Michaeli
Publikováno v:
Journal of Biological Chemistry. 274:36132-36138
The keratinocyte growth factor (KGF or FGF-7) is unique among its family members both in its target cell specificity and its inhibition by the addition of heparin and the native heparan-sulfate proteoglycan (HSPG), glypican-1 in cells expressing endo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::007e02307740de362228ee234b3744a9
https://doi.org/10.1074/jbc.274.51.36132
https://doi.org/10.1074/jbc.274.51.36132
Autor:
Elena Aingorn, Cy A. Stein, Rivka Ishai-Michaeli, Michael Elkin, Hua Quan Miao, Israel Vlodavsky
Publikováno v:
International Journal of Cancer. 83:424-431
Heparanase activity correlates with the metastatic potential of tumor cells. Moreover, the anti-metastatic effect of non-anti-coagulant species of heparin and certain sulfated polysaccharides was attributed to their heparanase-inhibiting activity. We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb5a43f5b0a9755c4f001714e3e413dc
https://doi.org/10.1002/(sici)1097-0215(19991029)83:3<424::aid-ijc20>3.0.co
https://doi.org/10.1002/(sici)1097-0215(19991029)83:3<424::aid-ijc20>3.0.co
Autor:
Menachem Bitan, Tuvia Peretz, Yael Friedmann, Iris Pecker, Rivka Ishai-Michaeli, Michael Elkin, Israel Michal, Ruth Atzmon, Israel Vlodavsky, Helena Aingorn, Orit Pappo, Larissa Spector
Publikováno v:
Nature Medicine. 5:793-802
Heparan sulfate proteoglycans interact with many extracellular matrix constituents, growth factors and enzymes. Degradation of heparan sulfate by endoglycosidic heparanase cleavage affects a variety of biological processes. We have purified a 50-kDa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1e5ab14d4e6050bb69d4f1ed40dc6df
https://doi.org/10.1038/10518
https://doi.org/10.1038/10518
Autor:
Israel Vlodavsky, Benjamin Medalion, Arnon Nagler, Helena Aingorn, Hua Quan Miao, Amir Elami, Gideon Merin, Rivka Ishai-Michaeli
Publikováno v:
Circulation. 95:1853-1862
Background Proliferation of smooth muscle cells (SMCs) of the arterial wall in response to local injury is an important factor in vascular proliferative disorders. Among the growth factors that promote SMC proliferation is basic fibroblast growth fac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67d23bd5c8ef047c2b016c247291ad14
https://doi.org/10.1161/01.cir.95.7.1853
https://doi.org/10.1161/01.cir.95.7.1853
Autor:
Ehud Levy, Israel Vlodavsky, Abraham Hochberg, Ran Goshen, Michael Elkin, Gill Korner, Nathan de Groot, Rivka Ishai-Michaeli
Publikováno v:
Molecular Human Reproduction. 2:679-684
The role of different extracellular matrix (ECM)-degrading enzymes in the normal functioning of the placenta is well documented. Heparan sulphate proteoglycan (HSPG) is an integral constituent of the placental and decidual ECM. Because this proteogly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52675738362b91f6e018f8fcf7c77ecc
https://doi.org/10.1093/molehr/2.9.679
https://doi.org/10.1093/molehr/2.9.679