Mutant APC reshapes Wnt signaling plasma membrane nanodomains by altering cholesterol levels via oncogenic β-catenin.

Autor: Erazo-Oliveras A; Program in Integrative Nutrition and Complex Diseases, Texas A&M University, College Station, TX, 77843, USA.; Department of Nutrition, Texas A&M University, College Station, TX, 77843, USA.; CPRIT Regional Center of Excellence in Cancer Research, Texas A&M University, College Station, TX, 77843, USA., Muñoz-Vega M; Program in Integrative Nutrition and Complex Diseases, Texas A&M University, College Station, TX, 77843, USA.; Department of Nutrition, Texas A&M University, College Station, TX, 77843, USA.; CPRIT Regional Center of Excellence in Cancer Research, Texas A&M University, College Station, TX, 77843, USA., Mlih M; Department of Cell Biology and Genetics, Texas A&M University, School of Medicine, Bryan, TX, 77807, USA., Thiriveedi V; Department of Medicine, Division of Gastroenterology, Duke University School of Medicine, Durham, NC, 27710, USA.; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC, 27710, USA.; Department of Cell Biology, Duke University School of Medicine, Durham, NC, 27710, USA., Salinas ML; Program in Integrative Nutrition and Complex Diseases, Texas A&M University, College Station, TX, 77843, USA.; Department of Nutrition, Texas A&M University, College Station, TX, 77843, USA.; CPRIT Regional Center of Excellence in Cancer Research, Texas A&M University, College Station, TX, 77843, USA., Rivera-Rodríguez JM; Program in Integrative Nutrition and Complex Diseases, Texas A&M University, College Station, TX, 77843, USA.; Department of Nutrition, Texas A&M University, College Station, TX, 77843, USA.; CPRIT Regional Center of Excellence in Cancer Research, Texas A&M University, College Station, TX, 77843, USA., Kim E; Division of Pulmonary Sciences and Critical Care Medicine, School of Medicine, University of Colorado Anschutz Medical Campus, Denver, CO, 80045, USA., Wright RC; Program in Integrative Nutrition and Complex Diseases, Texas A&M University, College Station, TX, 77843, USA.; Department of Nutrition, Texas A&M University, College Station, TX, 77843, USA., Wang X; Program in Integrative Nutrition and Complex Diseases, Texas A&M University, College Station, TX, 77843, USA.; Department of Nutrition, Texas A&M University, College Station, TX, 77843, USA., Landrock KK; Program in Integrative Nutrition and Complex Diseases, Texas A&M University, College Station, TX, 77843, USA.; Department of Nutrition, Texas A&M University, College Station, TX, 77843, USA., Goldsby JS; Program in Integrative Nutrition and Complex Diseases, Texas A&M University, College Station, TX, 77843, USA.; Department of Nutrition, Texas A&M University, College Station, TX, 77843, USA.; CPRIT Regional Center of Excellence in Cancer Research, Texas A&M University, College Station, TX, 77843, USA., Mullens DA; Program in Integrative Nutrition and Complex Diseases, Texas A&M University, College Station, TX, 77843, USA.; Department of Nutrition, Texas A&M University, College Station, TX, 77843, USA.; CPRIT Regional Center of Excellence in Cancer Research, Texas A&M University, College Station, TX, 77843, USA., Roper J; Department of Medicine, Division of Gastroenterology, Duke University School of Medicine, Durham, NC, 27710, USA.; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC, 27710, USA.; Department of Cell Biology, Duke University School of Medicine, Durham, NC, 27710, USA., Karpac J; Department of Cell Biology and Genetics, Texas A&M University, School of Medicine, Bryan, TX, 77807, USA., Chapkin RS; Program in Integrative Nutrition and Complex Diseases, Texas A&M University, College Station, TX, 77843, USA. r-chapkin@tamu.edu.; Department of Nutrition, Texas A&M University, College Station, TX, 77843, USA. r-chapkin@tamu.edu.; CPRIT Regional Center of Excellence in Cancer Research, Texas A&M University, College Station, TX, 77843, USA. r-chapkin@tamu.edu.; Center for Environmental Health Research, Texas A&M University, College Station, TX, 77843, USA. r-chapkin@tamu.edu.

Publikováno v: Nature communications [Nat Commun] 2023 Jul 19; Vol. 14 (1), pp. 4342. Date of Electronic Publication: 2023 Jul 19.