Type-I-interferon-responsive microglia shape cortical development and behavior.

Autor: Escoubas CC; Departments of Psychiatry and Behavioral Sciences/Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94158, USA., Dorman LC; Departments of Psychiatry and Behavioral Sciences/Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94158, USA; Neuroscience Graduate Program, University of California, San Francisco, San Francisco, CA 94158, USA., Nguyen PT; Departments of Psychiatry and Behavioral Sciences/Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94158, USA; Biomedical Sciences Graduate Program, University of California, San Francisco, San Francisco, CA 94158, USA., Lagares-Linares C; Departments of Psychiatry and Behavioral Sciences/Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94158, USA., Nakajo H; Departments of Psychiatry and Behavioral Sciences/Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94158, USA., Anderson SR; Departments of Psychiatry and Behavioral Sciences/Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94158, USA., Barron JJ; Departments of Psychiatry and Behavioral Sciences/Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94158, USA; Biomedical Sciences Graduate Program, University of California, San Francisco, San Francisco, CA 94158, USA., Wade SD; Departments of Psychiatry and Behavioral Sciences/Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94158, USA; Neuroscience Graduate Program, University of California, San Francisco, San Francisco, CA 94158, USA., Cuevas B; Departments of Psychiatry and Behavioral Sciences/Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94158, USA; Neuroscience Graduate Program, University of California, San Francisco, San Francisco, CA 94158, USA., Vainchtein ID; Departments of Psychiatry and Behavioral Sciences/Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94158, USA., Silva NJ; Departments of Psychiatry and Behavioral Sciences/Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94158, USA., Guajardo R; Departments of Psychiatry and Behavioral Sciences/Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94158, USA; Neuroscience Graduate Program, University of California, San Francisco, San Francisco, CA 94158, USA; Medical Scientist Training Program, University of California, San Francisco, San Francisco, CA 94158, USA., Xiao Y; Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA 94158, USA., Lidsky PV; Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA 94158, USA., Wang EY; Departments of Psychiatry and Behavioral Sciences/Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94158, USA; UCSF SRTP program, University of California, San Francisco, San Francisco, CA 94158, USA., Rivera BM; Institute for Neurodegenerative Diseases/Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94158, USA., Taloma SE; Departments of Psychiatry and Behavioral Sciences/Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94158, USA; Neuroscience Graduate Program, University of California, San Francisco, San Francisco, CA 94158, USA., Kim DK; Departments of Psychiatry and Behavioral Sciences/Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94158, USA., Kaminskaya E; Departments of Psychiatry and Behavioral Sciences/Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94158, USA., Nakao-Inoue H; Departments of Psychiatry and Behavioral Sciences/Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94158, USA., Schwer B; Departments of Psychiatry and Behavioral Sciences/Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94158, USA; Kavli Institute for Fundamental Neuroscience, University of California, San Francisco, San Francisco, CA 94158, USA; Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA 94158, USA; Eli and Edythe Broad Center for Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA; Bakar Aging Research Institute, University of California, San Francisco, San Francisco, CA 94158, USA., Arnold TD; Department of Pediatrics, University of California, San Francisco, San Francisco, CA 94158, USA., Molofsky AB; Department of Laboratory Medicine, University of California, San Francisco, San Francisco, CA 94158, USA., Condello C; Institute for Neurodegenerative Diseases/Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94158, USA; Department of Neurology, University of California, San Francisco, San Francisco, CA 94158, USA., Andino R; Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA 94158, USA., Nowakowski TJ; Departments of Psychiatry and Behavioral Sciences/Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94158, USA; Kavli Institute for Fundamental Neuroscience, University of California, San Francisco, San Francisco, CA 94158, USA; Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA 94158, USA; Eli and Edythe Broad Center for Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA 94158, USA; Department of Anatomy, University of California, San Francisco, San Francisco, CA 94158, USA; Chan-Zuckerberg Biohub, San Francisco, CA 94158, USA., Molofsky AV; Departments of Psychiatry and Behavioral Sciences/Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94158, USA; Kavli Institute for Fundamental Neuroscience, University of California, San Francisco, San Francisco, CA 94158, USA; Eli and Edythe Broad Center for Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA 94158, USA. Electronic address: anna.molofsky@ucsf.edu.

Publikováno v: Cell [Cell] 2024 Apr 11; Vol. 187 (8), pp. 1936-1954.e24. Date of Electronic Publication: 2024 Mar 14.

Guam ALS-PDC is a distinct double-prion disorder featuring both tau and Aβ prions.

Autor: Condello C; Institute for Neurodegenerative Diseases, Weill Institute for Neurosciences, University of California, San Francisco, CA 94158.; Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, CA 94158., Ayers JI; Institute for Neurodegenerative Diseases, Weill Institute for Neurosciences, University of California, San Francisco, CA 94158.; Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, CA 94158., Dalgard CL; Department of Anatomy, Physiology, and Genetics, Uniformed Services University of the Health Sciences, F. Edward Hébert School of Medicine, Bethesda, MD 20814.; The American Genome Center, Uniformed Services University of the Health Sciences, Bethesda, MD 20814., Garcia Garcia MM; Institute for Neurodegenerative Diseases, Weill Institute for Neurosciences, University of California, San Francisco, CA 94158., Rivera BM; Institute for Neurodegenerative Diseases, Weill Institute for Neurosciences, University of California, San Francisco, CA 94158., Seeley WW; Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, CA 94158.; Department of Pathology, University of California, San Francisco, CA 94143., Perl DP; Department of Pathology (Neuropathology), Uniformed Services University of the Health Sciences, F. Edward Hébert School of Medicine, Bethesda, MD 20814., Prusiner SB; Institute for Neurodegenerative Diseases, Weill Institute for Neurosciences, University of California, San Francisco, CA 94158.; Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, CA 94158.; Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94158.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2023 Mar 28; Vol. 120 (13), pp. e2220984120. Date of Electronic Publication: 2023 Mar 23.

Emergence of distinct and heterogeneous strains of amyloid beta with advanced Alzheimer's disease pathology in Down syndrome.

Autor: Maxwell AM; Department of Pharmaceutical Chemistry, Cardiovascular Research Institute, University of California, San Francisco, CA, 94158, USA., Yuan P; Institute for Neurodegenerative Diseases, Weill Institute for Neurosciences, University of California, San Francisco, CA, 94158, USA., Rivera BM; Institute for Neurodegenerative Diseases, Weill Institute for Neurosciences, University of California, San Francisco, CA, 94158, USA., Schaaf W; Department of Physics and Astronomy, San Francisco State University, San Francisco, CA, 94132, USA., Mladinov M; Memory and Aging Center, Weill Institute for Neurosciences, University of California, San Francisco, CA, 94158, USA., Prasher VP; South Birmingham Community NHS Trust, Birmingham, UK.; Liverpool John Moores University, Liverpool, UK., Robinson AC; Division of Neuroscience and Experimental Psychology, Faculty of Biology, Medicine and Health, School of Biological Sciences, The University of Manchester, Salford Royal Hospital, Salford, UK., DeGrado WF; Department of Pharmaceutical Chemistry, Cardiovascular Research Institute, University of California, San Francisco, CA, 94158, USA., Condello C; Institute for Neurodegenerative Diseases, Weill Institute for Neurosciences, University of California, San Francisco, CA, 94158, USA. carlo.condello@ucsf.edu.; Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, CA, 94158, USA. carlo.condello@ucsf.edu.

Publikováno v: Acta neuropathologica communications [Acta Neuropathol Commun] 2021 Dec 27; Vol. 9 (1), pp. 201. Date of Electronic Publication: 2021 Dec 27.

A Viral Protein Restricts Drosophila RNAi Immunity by Regulating Argonaute Activity and Stability.

Autor: Nayak A; Department of Microbiology and Immunology, University of California San Francisco, San Francisco, CA 94158, USA; Department of Biology and Genetics, Stanford University, Stanford, CA 94305, USA., Kim DY; Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, CA 94158, USA; College of Pharmacy, Yeungnam University, Gyeongsan, Gyeongbuk 38541, South Korea., Trnka MJ; Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, CA 94158, USA., Kerr CH; Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, BC V6T 1Z3, Canada., Lidsky PV; Department of Microbiology and Immunology, University of California San Francisco, San Francisco, CA 94158, USA., Stanley DJ; Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, CA 94158, USA., Rivera BM; Department of Microbiology and Immunology, University of California San Francisco, San Francisco, CA 94158, USA., Li KH; Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, CA 94158, USA., Burlingame AL; Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, CA 94158, USA., Jan E; Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, BC V6T 1Z3, Canada., Frydman J; Department of Biology and Genetics, Stanford University, Stanford, CA 94305, USA., Gross JD; Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, CA 94158, USA., Andino R; Department of Microbiology and Immunology, University of California San Francisco, San Francisco, CA 94158, USA. Electronic address: raul.andino@ucsf.edu.

Publikováno v: Cell host & microbe [Cell Host Microbe] 2018 Oct 10; Vol. 24 (4), pp. 542-557.e9.

Cutting edge: T cells trigger CD40-dependent platelet activation and granular RANTES release: a novel pathway for immune response amplification.

Autor: Danese S; Division of Gastroenterology, University Hospitals of Cleveland, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA., de la Motte C, Reyes BM, Sans M, Levine AD, Fiocchi C

Publikováno v: Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2004 Feb 15; Vol. 172 (4), pp. 2011-5.