Zobrazeno 1 - 10
of 68
pro vyhledávání: '"Rive Sarfstein"'
Publikováno v:
Cells, Vol 11, Iss 20, p 3260 (2022)
The growth hormone (GH)–insulin-like growth factor-1 (IGF1) signaling pathway plays a major role in orchestrating cellular interactions, metabolism, growth and aging. Studies from worms to mice showed that downregulated activity of the GH/IGF1 path
Externí odkaz:
https://doaj.org/article/26c96e13378b490baa8aab386580619a
Autor:
Laris Achlaug, Lina Somri-Gannam, Shilhav Meisel-Sharon, Rive Sarfstein, Manisha Dixit, Shoshana Yakar, Mordechai Hallak, Zvi Laron, Haim Werner, Ilan Bruchim
Publikováno v:
Frontiers in Endocrinology, Vol 12 (2021)
The insulin-like growth factors (IGF) are important players in the development of gynecological malignancies, including epithelial ovarian cancer (EOC). The identification of biomarkers that can help in the diagnosis and scoring of EOC patients is of
Externí odkaz:
https://doaj.org/article/1afbe2b029f3461694ba8b14108ce8cf
Identification of UDP-Glucuronosyltransferase 2B15 (UGT2B15) as a Target for IGF1 and Insulin Action
Autor:
Rive Sarfstein, Karthik Nagaraj, Shivang Parikh, Carmit Levy, Zvi Laron, Dafna Benayahu, Haim Werner
Publikováno v:
Cells, Vol 11, Iss 10, p 1627 (2022)
Normal growth and development in mammals are tightly controlled by numerous genetic factors and metabolic conditions. The growth hormone (GH)-insulin-like growth factor-1 (IGF1) hormonal axis is a key player in the regulation of these processes. Dysr
Externí odkaz:
https://doaj.org/article/849f6f5318a646e0bf37f3ee2029a558
Publikováno v:
Frontiers in Endocrinology, Vol 11 (2020)
Insulin and insulin-like growth factor-1 (IGF1), acting respectively via the insulin (INSR) and IGF1 (IGF1R) receptors, play key developmental and metabolic roles throughout life. In addition, both signaling pathways fulfill important roles in cancer
Externí odkaz:
https://doaj.org/article/2649fdf8246445f0b41a26908d4eff1c
Autor:
Danielle Yaron-Saminsky, Karthik Nagaraj, Rive Sarfstein, Zvi Laron, Metsada Pasmanik-Chor, Haim Werner
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 21, p 11861 (2021)
The growth hormone (GH)–insulin-like growth factor-1 (IGF1) endocrine axis is a central player in normal growth and metabolism as well as in a number of pathologies, including cancer. The GH–IGF1 hormonal system, in addition, has emerged as a maj
Externí odkaz:
https://doaj.org/article/eeb9cb2ea6f449418f83d63753f81694
Autor:
Rand Shibel, Rive Sarfstein, Karthik Nagaraj, Lena Lapkina-Gendler, Zvi Laron, Manisha Dixit, Shoshana Yakar, Haim Werner
Publikováno v:
Cells, Vol 10, Iss 6, p 1483 (2021)
Endometrial cancer is the most common gynecologic malignancy in Western countries. The insulin-like growth factor-1 (IGF1) axis has an important role in endometrial cancer biology and emerged as a promising therapeutic target in oncology. However, th
Externí odkaz:
https://doaj.org/article/3d5acbacd8e84b5ebeb88f5e8d8ed1f4
Publikováno v:
Biomolecules, Vol 11, Iss 4, p 531 (2021)
Insulin (InsR) and insulin-like growth factor-1 (IGF1R) receptors mediate the metabolic and growth-promoting actions of insulin and IGF1/IGF2, respectively. Evidence accumulated in recent years indicates that, in addition to their typical cell-surfac
Externí odkaz:
https://doaj.org/article/55521504018a41069bcfa9f8c2169fde
Publikováno v:
Cells, Vol 9, Iss 11, p 2446 (2020)
Laron syndrome (LS) is a rare genetic endocrinopathy that results from mutation of the growth hormone receptor (GH-R) gene and is typically associated with dwarfism and obesity. LS is the best characterized entity under the spectrum of the congenital
Externí odkaz:
https://doaj.org/article/561d2f0885e34536830dcc34d7cb3aa8
Publikováno v:
Frontiers in Endocrinology, Vol 9 (2018)
Insulin analogs were developed to improve diabetes therapy. However, certain modifications introduced into the insulin molecule were shown to enhance their affinity to the insulin-like growth factor-1 receptor (IGF1R). Most tumors, including endometr
Externí odkaz:
https://doaj.org/article/6ad62ae1395e4ee7b89d40f6b80f3a58
Publikováno v:
PLoS ONE, Vol 12, Iss 9, p e0185164 (2017)
The insulin-like growth factor-1 receptor (IGF1R) mediates the biological actions of IGF1 and IGF2. The IGF1R is involved in both physiological and pathological activities and is usually overexpressed in most types of cancer. In addition to its class
Externí odkaz:
https://doaj.org/article/c17fce082abc46979eaacdc489fe4ec8