Zobrazeno 1 - 10
of 83
pro vyhledávání: '"Ritva Heljasvaara"'
Autor:
Raman Devarajan, Valerio Izzi, Hellevi Peltoketo, Gunilla Rask, Saila Kauppila, Marja-Riitta Väisänen, Heli Ruotsalainen, Guillermo Martínez-Nieto, Sanna-Maria Karppinen, Timo Väisänen, Inderjeet Kaur, Jussi Koivunen, Takako Sasaki, Robert Winqvist, Aki Manninen, Fredrik Wärnberg, Malin Sund, Taina Pihlajaniemi, Ritva Heljasvaara
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 18 (2023)
The tumor extracellular matrix (ECM) critically regulates cancer progression and treatment response. Expression of the basement membrane component collagen XVIII (ColXVIII) is induced in solid tumors, but its involvement in tumorigenesis has remained
Externí odkaz:
https://doaj.org/article/e957e170320b4816a30b9afccd36d3ca
Autor:
Guillermo A. Martínez-Nieto, Hanna-Riikka Teppo, Noora Petrelius, Valerio Izzi, Raman Devarajan, Tiina Petäistö, Hengshuo Liu, Kris S. Kim, Sanna-Maria Karppinen, Heli Ruotsalainen, Jarkko Koivunen, Joni M. Mäki, Gilbert C. Walker, Taina Pihlajaniemi, Donald Gullberg, Ritva Heljasvaara
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Integrin α11β1 is a collagen-binding integrin that is needed to induce and maintain the myofibroblast phenotype in fibrotic tissues and during wound healing. The expression of the α11 is upregulated in cancer-associated fibroblasts (CAFs) in vario
Externí odkaz:
https://doaj.org/article/a42f98c2b506481b89f70daf56c95400
Autor:
Iida Jääskeläinen, Tiina Petäistö, Elahe Mirzarazi Dahagi, Mahdokht Mahmoodi, Taina Pihlajaniemi, Mari T. Kaartinen, Ritva Heljasvaara
Publikováno v:
Biomedicines, Vol 11, Iss 5, p 1412 (2023)
The globally increasing prevalence of obesity is associated with the development of metabolic diseases such as type 2 diabetes, dyslipidemia, and fatty liver. Excess adipose tissue (AT) often leads to its malfunction and to a systemic metabolic dysfu
Externí odkaz:
https://doaj.org/article/8def20d19ee748549177ab050ddad63a
Autor:
Valerio Izzi, Juho Lakkala, Raman Devarajan, Eeva-Riitta Savolainen, Pirjo Koistinen, Ritva Heljasvaara, Taina Pihlajaniemi
Publikováno v:
Leukemia Research Reports, Vol 9, Iss , Pp 9-13 (2018)
Relapse of acute myeloid leukemia (AML) is still dramatically frequent, imposing the need for early markers to quantify such risk. Recent evidence point to a prominent role for extracellular matrix (ECM) in AML, but its prognostic value has not yet b
Externí odkaz:
https://doaj.org/article/9859af782f3b48f3aa892fb6e672708a
Autor:
Guillermo Martínez-Nieto, Ritva Heljasvaara, Anne Heikkinen, Hanne-Kaisa Kaski, Raman Devarajan, Otto Rinne, Charlotta Henriksson, Emmi Thomson, Camilla von Hertzen, Ilkka Miinalainen, Heli Ruotsalainen, Taina Pihlajaniemi, Sanna-Maria Karppinen
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 18, p 9978 (2021)
Basement membrane (BM) zone-associated collagen XV (ColXV) has been shown to suppress the malignancy of tumour cells, and its restin domain can inhibit angiogenesis. In human breast cancer, as well as in many other human carcinomas, ColXV is lost fro
Externí odkaz:
https://doaj.org/article/ed07102488da46b6bfacad73bf12acf6
Publikováno v:
F1000Research, Vol 8 (2019)
The efficient healing of skin wounds is crucial for securing the vital barrier function of the skin, but pathological wound healing and scar formation are major medical problems causing both physiological and psychological challenges for patients. A
Externí odkaz:
https://doaj.org/article/6d52ab089a3b4bcf925a2e7d602e9547
Autor:
Valerio Izzi, Juho Lakkala, Raman Devarajan, Anni Kääriäinen, Jarkko Koivunen, Ritva Heljasvaara, Taina Pihlajaniemi
Publikováno v:
Matrix Biology Plus, Vol 1, Iss , Pp - (2019)
The microenvironment plays a central role in cancer, and neoplastic cells actively shape it to their needs by complex arrays of extracellular matrix (ECM) proteins, enzymes, cytokines and growth factors collectively referred to as the matrisome. Stud
Externí odkaz:
https://doaj.org/article/fe32c318bc4f4fda961b345e4f936469
Autor:
Hanne-Kaisa Honkanen, Valerio Izzi, Tiina Petäistö, Tanja Holopainen, Vanessa Harjunen, Taina Pihlajaniemi, Kari Alitalo, Ritva Heljasvaara
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 18, Iss 7, Pp 436-446 (2016)
Vascular endothelial growth factor D (VEGF-D) promotes the lymph node metastasis of cancer by inducing the growth of lymphatic vasculature, but its specific roles in tumorigenesis have not been elucidated. We monitored the effects of VEGF-D in cutane
Externí odkaz:
https://doaj.org/article/ec513bc2ec444e008219bfc5775cf02e
Publikováno v:
Haematologica, Vol 102, Iss 11 (2017)
Externí odkaz:
https://doaj.org/article/f79a9ae70c4342bbbb201745358c0e82
Autor:
Valerio Izzi, Juho Lakkala, Raman Devarajan, Heli Ruotsalainen, Eeva-Riitta Savolainen, Pirjo Koistinen, Ritva Heljasvaara, Taina Pihlajaniemi
Publikováno v:
Haematologica, Vol 102, Iss 7 (2017)
Externí odkaz:
https://doaj.org/article/7a1a814c3d1e464c97a5dbae3a554f67