Výsledky vyhledávání - "Rituparna Ganguly"

Akademický článek

lncRNA DRAIR is downregulated in diabetic monocytes and modulates the inflammatory phenotype via epigenetic mechanisms

Autor: Marpadga A. Reddy, Vishnu Amaram, Sadhan Das, Vinay Singh Tanwar, Rituparna Ganguly, Mei Wang, Linda Lanting, Lingxiao Zhang, Maryam Abdollahi, Zhuo Chen, Xiwei Wu, Sridevi Devaraj, Rama Natarajan

Publikováno v: JCI Insight, Vol 6, Iss 11 (2021)

Long noncoding RNAs (lncRNAs) are increasingly implicated in the pathology of diabetic complications. Here, we examined the role of lncRNAs in monocyte dysfunction and inflammation associated with human type 2 diabetes mellitus (T2D). RNA sequencing

Externí odkaz: https://doaj.org/article/5f467a5642364bdc98a43bb2b160a7be

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Akademický článek

Angiotensin II-Induced Long Non-Coding RNA Alivec Regulates Chondrogenesis in Vascular Smooth Muscle Cells

Autor: Vishnu Amaram Samara, Sadhan Das, Marpadga A. Reddy, Vinay Singh Tanwar, Kenneth Stapleton, Amy Leung, Maryam Abdollahi, Rituparna Ganguly, Linda Lanting, Rama Natarajan

Publikováno v: Cells, Vol 10, Iss 10, p 2696 (2021)

Long non-coding RNAs (lncRNAs) play key roles in Angiotensin II (AngII) signaling but their role in chondrogenic transformation of vascular smooth muscle cells (VSMCs) is unknown. We describe a novel AngII-induced lncRNA Alivec (Angiotensin II-induce

Externí odkaz: https://doaj.org/article/bf30d0f40d4f4e429a491aaf3b6ff8e0

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Akademický článek

Regulation of angiotensin II actions by enhancers and super-enhancers in vascular smooth muscle cells

Autor: Sadhan Das, Parijat Senapati, Zhuo Chen, Marpadga A. Reddy, Rituparna Ganguly, Linda Lanting, Varun Mandi, Anita Bansal, Amy Leung, Selena Zhang, Ye Jia, Xiwei Wu, Dustin E. Schones, Rama Natarajan

Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-19 (2017)

The repertoire of tissue-specific distal regulators of gene transcription enhancers defines homeostasis or disease. Here, the authors reveal the enhancer and super-enhancer signature of vascular smooth muscle cells under normal and angiotensin II sti

Externí odkaz: https://doaj.org/article/c12c799c38c64e36a32adeb8061e24ec

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Palmitic Acid–Induced Long Noncoding RNA PARAIL Regulates Inflammation via Interaction With RNA-Binding Protein ELAVL1 (ELAV Like RNA-Binding Protein 1) in Monocytes and Macrophages

Autor: Vinay Singh Tanwar, Marpadga A. Reddy, Sadhan Das, Vishnu Amaram Samara, Maryam Abdollahi, Suchismita Dey, Vajir Malek, Rituparna Ganguly, Kenneth Stapleton, Linda Lanting, Patrick Pirrotte, Rama Natarajan

Publikováno v: Arteriosclerosis, Thrombosis, and Vascular Biology.

Background: Obesity and diabetes are associated with elevated free fatty acids like palmitic acid (PA), which promote chronic inflammation and impaired inflammation resolution associated with cardiometabolic disorders. Long noncoding RNAs (lncRNAs) a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b55a55e54878fd9a453bf14c2d9e1da6
https://doi.org/10.1161/atvbaha.122.318536

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451-P: Palmitic Acid–Induced lncRNA PARAIL Regulates Inflammation via Restricting HuR Localization to Cytoplasm in Human Monocytes and Macrophages

Autor: VINAY S. TANWAR, MARPADGA A. REDDY, SADHAN DAS, VISHNU AMARAM SAMARA, MARYAM ABDOLLAHI, SUCHISMITA DEY, RITUPARNA GANGULY, LINDA L. LANTING, KENNETH STAPLETON, RAMA NATARAJAN

Publikováno v: Diabetes. 71

Obesity and diabetes are associated with chronic inflammation induced by the elevated circulating levels of Palmitic acid (PA) and also result from impaired resolution of inflammation in macrophages. Here, we examined the role of PA-induced long non-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f37b6f6560a56dce47d62a1431000640
https://doi.org/10.2337/db22-451-p

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TSP-1 (Thrombospondin-1) Deficiency Protects ApoE −/− Mice Against Leptin-Induced Atherosclerosis

Autor: Rituparna Ganguly, Sujay Datta, Jason Lallo, Aakaash Patel, Shreya Gupta, Priya Raman, Saugat Khanal, Amy Mathias, Vahagn Ohanyan, Kyle Storm, Soumyadip Sahu

Publikováno v: Arteriosclerosis, Thrombosis, and Vascular Biology. 41

Objective: Hyperleptinemia, hallmark of obesity, is a putative pathophysiologic trigger for atherosclerosis. We previously reported a stimulatory effect of leptin on TSP-1 (thrombospondin-1) expression, a proatherogenic matricellular protein implicat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::26330476126dd417f2fd8e7350c15a93
https://doi.org/10.1161/atvbaha.120.314962

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TSP-1 (Thrombospondin-1) Deficiency Protects ApoE

Autor: Rituparna, Ganguly, Saugat, Khanal, Amy, Mathias, Shreya, Gupta, Jason, Lallo, Soumyadip, Sahu, Vahagn, Ohanyan, Aakaash, Patel, Kyle, Storm, Sujay, Datta, Priya, Raman

Publikováno v: Arterioscler Thromb Vasc Biol

OBJECTIVE –: Hyperleptinemia, hallmark of obesity, is a putative pathophysiologic trigger for atherosclerosis. We previously reported a stimulatory effect of leptin on thrombospondin-1 (TSP-1) expression, a proatherogenic matricellular protein impl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::77a6bcc0b7c4bce9532f8a2959ae5df8
https://pubmed.ncbi.nlm.nih.gov/33327743

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