Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Ritu M Ramamurthy"'
Autor:
Martin Rodriguez, Brady Trevisan, Ritu M. Ramamurthy, Sunil K. George, Jonathan Diaz, Jordan Alexander, Diane Meares, Denise J. Schwahn, David R. Quilici, Jorge Figueroa, Michael Gautreaux, Andrew Farland, Anthony Atala, Christopher B. Doering, H. Trent Spencer, Christopher D. Porada, Graça Almeida-Porada
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Hemophilia A is the most common X-linked bleeding disorder affecting more than half-a-million individuals worldwide. Persons with severe hemophilia A have coagulation FVIII levels 3 years post-treatment. Cells engraft in major organs, and no
Externí odkaz:
https://doaj.org/article/85e8ab404d0141858837af84107b16bc
Autor:
Ritu M. Ramamurthy, Martin Rodriguez, Hannah C. Ainsworth, Jordan Shields, Diane Meares, Colin Bishop, Andrew Farland, Carl D. Langefeld, Anthony Atala, Christopher B. Doering, H. Trent Spencer, Christopher D. Porada, Graça Almeida-Porada
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
IntroductionPlacenta-derived mesenchymal cells (PLCs) endogenously produce FVIII, which makes them ideally suited for cell-based fVIII gene delivery. We have previously reported that human PLCs can be efficiently modified with a lentiviral vector enc
Externí odkaz:
https://doaj.org/article/2efcac3f576d49ef8ba1813b06b80b44
Autor:
Christopher Stem, Christopher Rodman, Ritu M. Ramamurthy, Sunil George, Diane Meares, Andrew Farland, Anthony Atala, Christopher B. Doering, H. Trent Spencer, Christopher D. Porada, Graça Almeida-Porada
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Patients with the severe form of hemophilia A (HA) present with a severe phenotype, and can suffer from life-threatening, spontaneous hemorrhaging. While prophylactic FVIII infusions have revolutionized the clinical management of HA, this treatment i
Externí odkaz:
https://doaj.org/article/a1e62b40fe0c43a7bf116f6fe432c45e
Autor:
Andrew M. Farland, Sunil George, Christopher D. Porada, Martin Rodriguez, Andrew Rabah, Anthony Atala, Alshaimaa Morsi, Brady Trevisan, H. Trent Spencer, Jordan E Shields, Graça Almeida-Porada, Diane Meares, Nadia El-Akabawy, Ritu M Ramamurthy, Christopher B. Doering
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 17, Iss, Pp 465-477 (2020)
Molecular Therapy. Methods & Clinical Development
Molecular Therapy. Methods & Clinical Development
The delivery of factor VIII (FVIII) through gene and/or cellular platforms has emerged as a promising hemophilia A treatment. Herein, we investigated the suitability of human placental cells (PLCs) as delivery vehicles for FVIII and determined an opt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ccba4872bb8941c61b49d8ccfcacd05
http://www.sciencedirect.com/science/article/pii/S2329050120300310
http://www.sciencedirect.com/science/article/pii/S2329050120300310
Autor:
Sunil George, Graça Almeida-Porada, Christopher B. Doering, Christopher Stem, Andrew M. Farland, Anthony Atala, Diane Meares, Ritu M Ramamurthy, Christopher Rodman, H. Trent Spencer, Christopher D. Porada
Publikováno v:
Frontiers in Cell and Developmental Biology
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Patients with the severe form of hemophilia A (HA) present with a severe phenotype, and can suffer from life-threatening, spontaneous hemorrhaging. While prophylactic FVIII infusions have revolutionized the clinical management of HA, this treatment i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00fedaf78e6772c4ee0d6baa5cf24a6b
http://europepmc.org/articles/PMC8383113
http://europepmc.org/articles/PMC8383113
Autor:
Baisong Lu, Meimei Wan, Anthony Atala, Ritu M Ramamurthy, Christopher D. Porada, Colin E. Bishop, M. Graca Almeida-Porada, Wen Ting Zheng, Sunil George, Yu Zhou
Publikováno v:
Blood. 138:2938-2938
Clinical trials employing AAV vectors for hemophilia A have been hindered by unanticipated immunological and/or inflammatory responses in some of the patients. Also, these trials have often yielded lower levels of transgene expression than were expec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::33eb93d54bcf1bab6463e11ede88e572
https://doi.org/10.1182/blood-2021-147917
https://doi.org/10.1182/blood-2021-147917
Autor:
Andrew Rabah, Brady Trevisan, H. Trent Spencer, Diane Meares, Sunil George, Michael D. Gautreaux, Jorge P. Figueroa, Martin Rodriguez, Denise J. Schwahn, Christopher D. Porada, Ritu M Ramamurthy, Anthony Atala, M. Graca Almeida-Porada, Jordan E Shields, Christopher B. Doering, John Owen
Publikováno v:
Blood. 136:1-2
The treatment of hemophilia A (HA) patients by prenatal transplantation (PNT) is a feasible, yet underestimated and unexplored clinical approach. The procedure, similar to that of an amniocentesis, poses minimal risk to both the fetus and the mother.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9f3cfe8b3bc14e060d9fdd619401dbe4
https://doi.org/10.1182/blood-2020-140845
https://doi.org/10.1182/blood-2020-140845
Autor:
Sunil George, Anthony Atala, Christopher D. Porada, Martin Rodriguez, M. Graca Almeida-Porada, H. Trent Spencer, Jorge P. Figueroa, Christopher B. Doering, Ritu M Ramamurthy, Quan Dm Pham
Publikováno v:
Blood. 136:32-32
Prenatal transplantation (PNT) using stem/progenitor cells has been performed in more than 50 patients using an ultrasound-guided approach, proving that this procedure poses minimal risk to both the fetus and the mother. Since 75% of hemophilia A (HA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::18fc82267e4f8318b5aabe2f43d9cf43
https://doi.org/10.1182/blood-2020-140883
https://doi.org/10.1182/blood-2020-140883