NHE isoform switching and KChIP2 upregulation in aging porcine atria.

Autor: Ritu Kant, Zhaoyang Hu, Jaideep K Malhotra, Trine Krogh-Madsen, David J Christini, Paul M Heerdt, Geoffrey W Abbott

Publikováno v: PLoS ONE, Vol 8, Iss 12, p e82951 (2013)

Aging increases the risk of cardiac pathologies including atrial fibrillation and can alter myocardial responsiveness to therapeutic agents. Here, seeking molecular correlates of myocardial aging processes, we performed global "whole transcript" anal

Externí odkaz: https://doaj.org/article/f402597591de49fbb3bba7b484b83cbb

Synthesis and biological evaluation of 18F-Norfallypride in the rodent brain using PET imaging

Autor: Robert Coleman, Suresh K. Pandey, Neema Pithia, Jogeshwar Mukherjee, Neal Gulati, Ritu Kant

Publikováno v: Nuclear Medicine and Biology. 40:697-704

Norfallypride ( N -[(2-pyrolidinyl)methyl]-2,3-dimethoxy-5-(3'-fluoropropyl)benzamide), an analog of fallypride, has been synthesized and evaluated as a potential PET imaging agent for dopamine receptors with increased subtype selectivity. In order t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8fff6569d4707c65c942100ac2feb64
https://doi.org/10.1016/j.nucmedbio.2013.02.011

Kcne2 deletion causes early-onset nonalcoholic fatty liver disease via iron deficiency anemia

Autor: Torsten K. Roepke, Clemens Köhncke, Ulrike Lisewski, Dara Nguyen, Zhaoyang Hu, Marie Anand, Ritu Kant, Soo Min Lee, Geoffrey W. Abbott

Publikováno v: Lee, SM; Nguyen, D; Anand, M; Kant, R; Koehncke, C; Lisewski, U; et al.(2016). Kcne2 deletion causes early-onset nonalcoholic fatty liver disease via iron deficiency anemia. SCIENTIFIC REPORTS, 6. doi: 10.1038/srep23118. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/98s5z494
Scientific Reports
Scientific reports, vol 6, iss 1

Nonalcoholic fatty liver disease (NAFLD) is an increasing health problem worldwide, with genetic, epigenetic and environmental components. Here, we describe the first example of NAFLD caused by genetic disruption of a mammalian potassium channel subu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17f0e96535b6029ad0a8c002f67b1b85
http://www.escholarship.org/uc/item/98s5z494

Abstract 161: Kcne2 Gene Deletion Combines With A Western Diet To Cause Early-onset Diabetes Mellitus And Atherosclerosis In Mice

Autor: Soo-Min Lee, Ritu Kant, Geoffrey W Abbott

Publikováno v: Circulation Research. 115

The KCNE2 single transmembrane domain protein regulates multiple types of cardiac voltage-gated potassium (Kv) channel in vivo and its disruption causes the ventricular arrhythmia, Long QT Syndrome. Interestingly, a SNP near the human KCNE2 locus was

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3b4e935e01437679eba7c239b5a33b06
https://doi.org/10.1161/res.115.suppl_1.161

Abstract 106: Kcne2 Gene Deletion Predisposes To Sudden Cardiac Death

Autor: Zhaoyang Hu, Ritu Kant, Marie Anand, Elizabeth King, Trine Krogh-Madsen, David Christini, Geoffrey Abbott

Publikováno v: Circulation Research. 113

Sudden cardiac death (SCD) accounts for an estimated 1000 deaths per day in the United States alone. SCD typically involves an ischemic substrate and culminates in a lethal ventricular arrhythmia. KCNE2 potassium channel subunit gene variants are ass

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e402f502ef7c807a989137b9dca2865d
https://doi.org/10.1161/res.113.suppl_1.a106