Preparation, Characterization, and Biological Evaluation of a Hydrophilic Peptide Loaded on PEG-PLGA Nanoparticles

Autor: Marinelli, Lisa, Ciulla, Michele, Ritsema, Jeffrey A S, van Nostrum, Cornelus F, Cacciatore, Ivana, Dimmito, Marilisa Pia, Palmerio, Ferdinando, Orlando, Giustino, Robuffo, Iole, Grande, Rossella, Puca, Valentina, Di Stefano, Antonio, Sub Drug delivery, Sub General Pharmaceutics, Afd Pharmaceutics, Pharmaceutics

Publikováno v: Pharmaceutics, 14(9). American Chemical Society
Pharmaceutics; Volume 14; Issue 9; Pages: 1821

The encapsulation of peptides and proteins in nanosystems has been extensively investigated for masking unfavorable biopharmaceutical properties, including short half-life and poor permeation through biological membranes. Therefore, the aim of this w

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Preparation, Characterization, and Biological Evaluation of a Hydrophilic Peptide Loaded on PEG-PLGA Nanoparticles.

Autor: Marinelli L; Department of Pharmacy, University 'G. d'Annunzio' of Chieti-Pescara, 66100 Chieti, Italy., Ciulla M; Department of Pharmacy, University 'G. d'Annunzio' of Chieti-Pescara, 66100 Chieti, Italy., Ritsema JAS; Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences (UIPS), Utrecht University, Universiteitsweg 99, P.O. Box 80082, 3508 TB Utrecht, The Netherlands., van Nostrum CF; Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences (UIPS), Utrecht University, Universiteitsweg 99, P.O. Box 80082, 3508 TB Utrecht, The Netherlands., Cacciatore I; Department of Pharmacy, University 'G. d'Annunzio' of Chieti-Pescara, 66100 Chieti, Italy., Dimmito MP; Department of Pharmacy, University 'G. d'Annunzio' of Chieti-Pescara, 66100 Chieti, Italy., Palmerio F; Department of Pharmacy, University 'G. d'Annunzio' of Chieti-Pescara, 66100 Chieti, Italy., Orlando G; Department of Pharmacy, University 'G. d'Annunzio' of Chieti-Pescara, 66100 Chieti, Italy., Robuffo I; Institute of Molecular Genetics, National Research Council, Section of Chieti, 66100 Chieti, Italy., Grande R; Department of Pharmacy, University 'G. d'Annunzio' of Chieti-Pescara, 66100 Chieti, Italy.; Center for Advanced Studies and Technology (CAST), University 'G. d'Annunzio' of Chieti-Pescara, 66100 Chieti, Italy., Puca V; Department of Pharmacy, University 'G. d'Annunzio' of Chieti-Pescara, 66100 Chieti, Italy.; Center for Advanced Studies and Technology (CAST), University 'G. d'Annunzio' of Chieti-Pescara, 66100 Chieti, Italy., Di Stefano A; Department of Pharmacy, University 'G. d'Annunzio' of Chieti-Pescara, 66100 Chieti, Italy.

Publikováno v: Pharmaceutics [Pharmaceutics] 2022 Aug 29; Vol. 14 (9). Date of Electronic Publication: 2022 Aug 29.