Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Ritobrita Chakraborty"'
Autor:
Ritobrita Chakraborty, Sandip Dey, Pallabi Sil, Simanta Sarani Paul, Dipita Bhattacharyya, Anirban Bhunia, Jayati Sengupta, Krishnananda Chattopadhyay
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
Chakraborty et al. present biophysical and structural insights into fibril-forming oligomers of alpha-synuclein stabilized by heme. They show that heme targets the His50 residue of the oligomers and locks the protein into a different conformation whi
Externí odkaz:
https://doaj.org/article/25742eb9b9d54e619cd7385d8ac904d4
Autor:
Jayati Sengupta, Ritobrita Chakraborty, Simanta Sarani Paul, Sandip Dey, Dipita Bhattacharyya, Krishnananda Chattopadhyay, Anirban Bhunia, Pallabi Sil
Publikováno v:
Communications Biology
Communications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
Communications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
The fibrillation pathway of alpha-Synuclein, the causative protein of Parkinson’s disease, encompasses transient, heterogeneous oligomeric forms whose structural understanding and link to toxicity are not yet understood. We report that the addition
Autor:
Suvendra N. Bhattacharyya, Bandopadhyay D, Kamalika Mukherjee, Basu S, Saikat Chakrabarti, Ishita Mukherjee, Krishnananda Chattopadhyay, Partha Chakrabarti, Ritobrita Chakraborty
miR-122 is a liver specific miRNA that plays an important role in controlling metabolic homeostasis in mammalian liver cells. Interestingly, miR-122 on exposure to lipotoxic stress is reduced in liver cells. To fight stress, miRNA processor Dicer1 is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7a476ae599c0c254b2947144ef4c80ac
https://doi.org/10.1101/2020.11.30.405449
https://doi.org/10.1101/2020.11.30.405449
Autor:
Ritobrita Chakraborty, Sumanta Ghosh, Bikash Chandra Swain, Umakanta Tripathy, Krishnananda Chattopadhyay, Sakshi
Publikováno v:
ACS chemical neuroscience. 11(11)
The accumulation of an inherently disordered protein α-synuclein (α-syn) aggregates in brain tissue play a pivotal role in the pathology and etiology of Parkinson's disease. Aggregation of α-syn has been found to be complex and heterogeneous, occu
Autor:
Simanta S. Paul, Ritobrita Chakraborty, Pallabi Sil, Sandip Dey, Jayati Sengupta, Krishnananda Chattopadhyay
Aggregation of the intrinsically disordered protein alpha-Synuclein (α-Syn) into insoluble fibrils with a cross-β sheet amyloid structure plays a key role in the neuronal pathology of Parkinson’s disease (PD). The fibrillation pathway of α-Syn e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6373fc801080f007b93202bdbc5d026d
Autor:
Krishnananda Chattopadhyay, Sumit Sahoo, Harapriya Rath, Nyancy Halder, Ritobrita Chakraborty
Publikováno v:
ACS chemical neuroscience. 10(1)
A water-soluble meso-carboxy aryl substituted [18] heteroannulene (porphyrin) and its Zn-complex have been found to be viable in targeting α-Syn aggregation at all its key microevents, namely, primary nucleation, fibril elongation, and secondary nuc
Publikováno v:
ACS Chemical Neuroscience. 10:1135-1136
Recent expeditious advances in the determination of the 3-D structure of fibrils of alpha-synuclein, the intrinsically disordered protein associated with the neurodegenerative Parkinson's disease (PD), have identified amino acid contacts that form th
Autor:
Simanta Sarani Paul, Krishnananda Chattopadhyay, Pallabi Sil, Ritobrita Chakraborty, Shubhasis Haldar
Publikováno v:
Biochemistry. 55(16)
To understand how a protein folds and behaves inside living cells, the effects of synthetic crowding media on protein folding, function, stability, and association have been studied in detail. Because the effect of excluded volume is more prominent i