Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Riti Sharan"'
Publikováno v:
Cells, Vol 12, Iss 18, p 2295 (2023)
Tuberculosis (TB) and Human Immunodeficiency Virus (HIV) co-infection continues to pose a significant healthcare burden. HIV co-infection during TB predisposes the host to the reactivation of latent TB infection (LTBI), worsening disease conditions a
Externí odkaz:
https://doaj.org/article/a50eea363a1e4a54b1ad50c7b1e93f6f
Autor:
Bindu Singh, Chivonne Moodley, Dhiraj K. Singh, Ruby A. Escobedo, Riti Sharan, Garima Arora, Shashank R. Ganatra, Vinay Shivanna, Olga Gonzalez, Shannan Hall-Ursone, Edward J. Dick Jr., Deepak Kaushal, Xavier Alvarez, Smriti Mehra
Publikováno v:
JCI Insight, Vol 8, Iss 2 (2023)
The expression of indoleamine 2,3-dioxygenase (IDO), a robust immunosuppressant, is significantly induced in macaque tuberculosis (TB) granulomas, where it is expressed on IFN-responsive macrophages and myeloid-derived suppressor cells. IDO expressio
Externí odkaz:
https://doaj.org/article/59e3a53626764aa2a1294a8cc4c559ab
Autor:
Riti Sharan, Shashank R. Ganatra, Dhiraj K. Singh, Journey Cole, Taylor W. Foreman, Rajesh Thippeshappa, Charles A. Peloquin, Vinay Shivanna, Olga Gonzalez, Cheryl L. Day, Neel R. Gandhi, Edward J. Dick Jr., Shannan Hall-Ursone, Smriti Mehra, Larry S. Schlesinger, Jyothi Rengarajan, Deepak Kaushal
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 18 (2022)
A once-weekly oral dose of isoniazid and rifapentine for 3 months (3HP) is recommended by the CDC for treatment of latent tuberculosis infection (LTBI). The aim of this study is to assess 3HP-mediated clearance of M. tuberculosis bacteria in macaques
Externí odkaz:
https://doaj.org/article/659732e8266a421b8e6775d23db444b0
Autor:
Riti Sharan, Shashank R. Ganatra, Allison N. Bucsan, Journey Cole, Dhiraj K. Singh, Xavier Alvarez, Maya Gough, Cynthia Alvarez, Alyssa Blakley, Justin Ferdin, Rajesh Thippeshappa, Bindu Singh, Ruby Escobedo, Vinay Shivanna, Edward J. Dick Jr., Shannan Hall-Ursone, Shabaana A. Khader, Smriti Mehra, Jyothi Rengarajan, Deepak Kaushal
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 3 (2022)
Studies using the nonhuman primate model of Mycobacterium tuberculosis/simian immunodeficiency virus coinfection have revealed protective CD4+ T cell–independent immune responses that suppress latent tuberculosis infection (LTBI) reactivation. In p
Externí odkaz:
https://doaj.org/article/3b5a3287ec7841488006eb98b7de9d18
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), remains a leading infectious disease killer worldwide with 1.4 million TB deaths in 2019. While the majority of infected population maintain an active control of the bacteria, a subset de
Externí odkaz:
https://doaj.org/article/c4bec74930224ceb91f810bcce493b18
Autor:
Muriel Pichavant, Riti Sharan, Olivier Le Rouzic, Cécile Olivier, Florence Hennegrave, Gaëlle Rémy, Magdiel Pérez-Cruz, Bachirou Koné, Pierre Gosset, Nicolas Just, Philippe Gosset
Publikováno v:
EBioMedicine, Vol 2, Iss 11, Pp 1686-1696 (2015)
Progression of chronic obstructive pulmonary disease (COPD) is linked to episodes of exacerbations caused by bacterial infections due to Streptococcus pneumoniae. Our objective was to identify during COPD, factors of susceptibility to bacterial infec
Externí odkaz:
https://doaj.org/article/52f709952e9f4033a0b929a472ed7ca8
Autor:
Lori T Maddox, Jesse Cahill, Jeffrey D. Cirillo, Cody Martin, Ashley Holt, Jolene Ramsey, Chandler O’Leary, Ry Young, Russell Moreland, Preeti Sule, Riti Sharan, Thushara Galbadage
Publikováno v:
J Bacteriol
Most phages of Gram-negative bacteria hosts encode spanins for disruption of the outer membrane, which is the last step in host lysis. However, bioinformatic analysis indicates that ∼15% of these phages lack a spanin gene, suggesting they have an a
Publikováno v:
Frontiers in Immunology
Frontiers in Immunology, Vol 12 (2021)
Frontiers in Immunology, Vol 12 (2021)
Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), remains a leading infectious disease killer worldwide with 1.4 million TB deaths in 2019. While the majority of infected population maintain an active control of the bacteria, a subset de
Autor:
Justin Ferdin, Vida L. Hodara, Dhiraj Kumar Singh, Shalini Gautam, Shabaana A. Khader, Shannan Hall-Ursone, Shashank Ganatra, Yenny Goez-Gazi, Tae-Hyung Lee, Benjamin Klaffke, Riti Sharan, Elizabeth Clemmons, Cynthia Alvarez, Olga Gonzalez, Christopher H. Chen, Kathleen M. Brasky, Laura M. Parodi, Kendra J. Alfson, Rajesh Thippeshappa, Alyssa Schami, Joanne Turner, Richard Copin, Andra K. Voges, Angélica Olmo-Fontánez, Makedonka Mitreva, Michal Gazi, Amanda Mannino, Patrice A. Frost, Ruby Escobedo, Alyssa Blakley, Deepak Kaushal, Edward J. Dick, Julia M. Scordo, Dharani Ajithdoss, John Dutton, Journey Cole, Hilary M. Staples, Christos A. Kyratsous, Priscilla Escareno, Luis D. Giavedoni, Ricardo Carrion, Bruce A. Rosa, Maya Gough, Luis Martinez-Sobrido, Mushtaq Ahmed, Bindu Singh, Roy N. Platt, Cory R. A. Hallam, Ken Sayers, Jessica Callery, Jordi B. Torrelles, Adelekan Oyejide, Jean L. Patterson, Andreu G. Vilanova, Carmen Bartley, Tim J. Anderson, Xavier Alvarez, Anna Goodroe, Larry S. Schlesinger, Corinna N. Ross, Alina Baum, Ayan Chatterjee
Publikováno v:
Nature Microbiology
Non-human primate models will expedite therapeutics and vaccines for coronavirus disease 2019 (COVID-19) to clinical trials. Here, we compare acute severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in young and old rhesus macaque
Autor:
Deepak Kaushal, Riti Sharan
Publikováno v:
NPJ Vaccines
npj Vaccines, Vol 5, Iss 1, Pp 1-10 (2020)
npj Vaccines, Vol 5, Iss 1, Pp 1-10 (2020)
One-third of world’s population is predicted to be infected with tuberculosis (TB). The resurgence of this deadly disease has been inflamed by comorbidity with human immunodeficiency virus (HIV). The risk of TB in people living with HIV (PLWH) is 1