Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Rithy Meas"'
Autor:
Rithy Meas, Joanne Nititham, Kimberly E. Taylor, Stephen Maher, Kaylyn Clairmont, Kelly E. W. Carufe, Michael Kashgarian, Timothy Nottoli, Ana Cheong, Zachary D. Nagel, Patrick M. Gaffney, Lindsey A. Criswell, Joann B. Sweasy
Publikováno v:
ACR Open Rheumatology, Vol 4, Iss 9, Pp 760-770 (2022)
Objective To determine if single‐nucleotide polymorphisms (SNPs) in DNA repair genes are enriched in individuals with systemic lupus erythematosus (SLE) and if they are sufficient to confer a disease phenotype in a mouse model. Methods Human exome
Externí odkaz:
https://doaj.org/article/97dbb8d80fed4e8691a4b02bf4ca46c8
Autor:
Tania Rahim, Madison A Levinson, Kelly E W Carufe, Matthew Burak, Rithy Meas, Stephen Maher, Alfred L M Bothwell, Naomi Gades, Joann B Sweasy
Publikováno v:
PLoS ONE, Vol 17, Iss 4, p e0267913 (2022)
Systemic lupus erythematosus is a chronic disease characterized by autoantibodies, renal and cutaneous disease, and immune complex formation. Emerging evidence suggests that aberrant DNA repair is an underlying mechanism of lupus development. We prev
Externí odkaz:
https://doaj.org/article/89a3a8278fd4466b8bc82a4e6f4224b0
Autor:
Baozhi Lin, Zhifei Liu, Meixun Zhao, Penjai Sompongchaiyakul, Hailong Zhang, Thomas M. Blattmann, Shuo Feng, Martin G. Wiesner, Khanh Phon Le, Rithy Meas, Edlic Sathiamurthy
Publikováno v:
Geochimica et Cosmochimica Acta. 351:32-44
Autor:
Baozhi Lin, Zhifei Liu, Meixun Zhao, Penjai Sompongchaiyakul, Hailong Zhang, Thomas Blattmann, Shuo Feng, Martin Wiesner, Khanh Phon Le, Rithy Meas, Edlic Sathiamurthy
Publikováno v:
Goldschmidt2022 abstracts.
Publikováno v:
Lithos. :106795
Differential immunomodulatory effect of PARP inhibition in BRCA1 deficient and competent tumor cells
Autor:
Yu Shyr, Yong Kong, Shuangge Ma, Hailey Wyatt, Kaylyn Clairmont, Victoria Quintana, Shilin Zhao, Kurt A. Schalper, Zachary D. Nagel, Rithy Meas, Patricia LoRusso, Sebastian Oeck, Isabel Alvarado-Cruz, Angelo Porciuncula, Ying Zhu, Daniel J. Laverty, Michael Krauthammer, Mariam M. Mahmoud, Joann B. Sweasy, Mohammed Khan
Publikováno v:
Biochem Pharmacol
Poly-ADP-ribose polymerase (PARP) inhibitors are active against cells and tumors with defects in homology-directed repair as a result of synthetic lethality. PARP inhibitors (PARPi) have been suggested to act by either catalytic inhibition or by PARP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7be385c651532db58837877fc5a7fae6
https://www.ncbi.nlm.nih.gov/pubmed/33285109
https://www.ncbi.nlm.nih.gov/pubmed/33285109
Autor:
Tania Rahim, R. Stephen Lloyd, Joann B. Sweasy, Melis Kant, Alireza G. Senejani, Madison Levinson, Stephen E. Maher, Miral Dizdaroglu, Caroline J. Zeiss, Rithy Meas, Marina Cardó-Vila, Sesha L. A. Paluri, Kaylyn Clairmont, Michael Kashgarian, Isabel Alvarado-Cruz, Pawel Jaruga, Alfred L. M. Bothwell, Erdem Coskun, Matthew J. Burak
Publikováno v:
DNA Repair (Amst)
The Polb gene encodes DNA polymerase beta (Pol β), a DNA polymerase that functions in base excision repair (BER) and microhomology-mediated end-joining. The Pol β-Y265C protein exhibits low catalytic activity and fidelity, and is also deficient in
Autor:
Rithy Meas, Daniel J. Laverty, Kaylyn Clairmont, Victoria Quintana, Isabel Alvarado-Cruz, Patricia LoRusso, Sebastian Oeck, Hailey Wyatt, Kurt A. Schalper, Mariam M. Mahmoud, Angelo Porciuncula, Ying Zhu, Joann B. Sweasy, Mohammed Khan, Yu Shyr, Yong Kong, Zachary D. Nagel, Shuangge Ma, Shilin Zhao, Michael Krauthammer
Poly-ADP-ribose polymerase (PARP) inhibitors are active against cells and tumors with defects in homology-directed repair as a result of synthetic lethality. PARP inhibitors have been suggested to act by either catalytic inhibition or by PARP localiz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b249682be3db497cd9f36a1bfda2780
https://doi.org/10.1101/2020.03.08.982785
https://doi.org/10.1101/2020.03.08.982785
Publikováno v:
Mutation research. Reviews in mutation research. 780
Chromatin is a significant barrier to many DNA damage response (DDR) factors, such as DNA repair enzymes, that process DNA lesions to reduce mutations and prevent cell death; yet, paradoxically, chromatin also has a critical role in many signaling pa
Autor:
Joann B. Sweasy, Mohammed Khan, Isabel Alvarado-Cruz, Sesha L. A. Paluri, Kelly Estelle Wheeler Carufe, Rithy Meas
Publikováno v:
Mutagenesis
Defects in DNA repair have been linked to the accumulation of somatic mutations in tumours. These mutations can promote oncogenesis; however, recent developments have indicated that they may also lead to a targeted immune response against the tumour.