Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Ritesh P. Bhole"'
Publikováno v:
IBRO Neuroscience Reports, Vol 16, Iss , Pp 8-42 (2024)
Alzheimer's disease (AD), a progressive degenerative disorder first identified by Alois Alzheimer in 1907, poses a significant public health challenge. Despite its prevalence and impact, there is currently no definitive ante mortem diagnosis for AD p
Externí odkaz:
https://doaj.org/article/4a46eb517c71452f81e5a18dde8cc2d1
Publikováno v:
Results in Chemistry, Vol 8, Iss , Pp 101615- (2024)
Drug discovery involving covalent drugs has a rich history dating back to the 20th century. Despite their longevity, concerns about safety have relegated covalent drug development to the periphery of research focus. The emergence of the groundbreakin
Externí odkaz:
https://doaj.org/article/06c76f669c1b4a84b33f3d950e581f7f
Publikováno v:
Results in Chemistry, Vol 6, Iss , Pp 101143- (2023)
To alleviate metastatic castration-resistant prostate cancer (mCRPC), enzalutamide, a non-steroidal antiandrogen, is employed. Following androgen deprivation therapy or anti-androgen treatment, compensatory mechanisms in prostate cancer have been ide
Externí odkaz:
https://doaj.org/article/cd1153ef29644d74bc44a72a90050d7e
Autor:
Shraddha S. Ambade, Vivek Kumar Gupta, Ritesh P. Bhole, Pramod B. Khedekar, Rupesh V. Chikhale
Publikováno v:
Molecules, Vol 28, Iss 20, p 7008 (2023)
Staphylococcus aureus is a common human pathogen. Methicillin-resistant Staphylococcus aureus (MRSA) infections pose significant and challenging therapeutic difficulties. MRSA often acquires the non-native gene PBP2a, which results in reduced suscept
Externí odkaz:
https://doaj.org/article/236ccf561ae74b698be19b98e59ee628
Autor:
Ritesh P. Bhole, Rupesh V. Chikhale, Ravindra D. Wavhale, Fatmah Ali Asmary, Tahani Mazyad Almutairi, Hassna Mohammed Alhajri, Chandrakant G. Bonde
Publikováno v:
Heliyon, Vol 7, Iss 3, Pp e06227- (2021)
The androgen receptor inhibitor, Enzalutamide, proved effective against castration resistance prostate cancer, has demonstrated clinical benefits and increased survival rate in men. However, AR mutation (F876L) converts Enzalutamide from antagonist t
Externí odkaz:
https://doaj.org/article/be101058e45849fbbeb073cac46c7aa2
Publikováno v:
Data in Brief, Vol 14, Iss C, Pp 469-473 (2017)
Fragment based Quantitative structure activity relationship (QSAR) analysis on reported 25 2-(2-(4-aryloxybenzylidene) hydrazinyl) benzothiazole dataset as antitubercular agents were carried out. Molecules in the current dataset were fragmented into
Externí odkaz:
https://doaj.org/article/d37cef3eb7244279bbe07eddcebf2f43
Effective potential studies for some new hybrid molecules for their activity against prostate cancer
Publikováno v:
Ars Pharmaceutica, Vol 59, Iss 3, Pp 133-144
ABSTRACT Objective: The present work aimed at developing novel hybrid molecules for targeting the prostate cancer. It is observed that two human shock proteins Hsp70 and Hsp90 are over-expressed in prostate cancer making them one of the important dru
Externí odkaz:
https://doaj.org/article/74c49a7a2b7b4e28936c5039cf24878a
Publikováno v:
Bulletin of the Karaganda University. "Chemistry" series. 101:27-52
Cancer is a chronic disease which can cause death. In traditional chemotherapycytotoxic drugs are used to kill proliferating cancer cells. The cytotoxic agent exhibits less specificity, less biological activity, causes sys-temic toxicity and undesira
Publikováno v:
Current Diabetes Reviews. 17:136-142
Diabetes is a chronic metabolic disorder of the endocrine system characterized by an increase in blood glucose level. Several factors, such as pancreatic damage, oxidative stress, infection, genetic factor, obesity, liver dysfunction, play a vital ro
Publikováno v:
Bioorganic chemistry. 115
Enoyl acyl carrier protein reductase (InhA) is a key enzyme involved in fatty acid synthesis mainly mycolic acid biosynthesis that is a part of NADH dependent acyl carrier protein reductase family. The aim of the present literature is to underline th