Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Ritchie, Williamson"'
Autor:
Villo Muha, Ritchie Williamson, Rachel Hills, Alison D. McNeilly, Thomas G. McWilliams, Jana Alonso, Marianne Schimpl, Aneika C. Leney, Albert J. R. Heck, Calum Sutherland, Kevin D. Read, Rory J. McCrimmon, Simon P. Brooks, Daan M. F. van Aalten
Publikováno v:
Open Biology, Vol 9, Iss 11 (2019)
O-GlcNAcylation is an abundant post-translational modification in the nervous system, linked to both neurodevelopmental and neurodegenerative disease. However, the mechanistic links between these phenotypes and site-specific O-GlcNAcylation remain la
Externí odkaz:
https://doaj.org/article/9e64e5af2f29476f9e4eeb84d52a4cc3
Autor:
Laura Grasso, Olga Suska, Lindsay Davidson, Thomas Gonatopoulos-Pournatzis, Ritchie Williamson, Lize Wasmus, Simone Wiedlich, Mark Peggie, Marios P. Stavridis, Victoria H. Cowling
Publikováno v:
Cell Reports, Vol 16, Iss 5, Pp 1352-1365 (2016)
The mRNA cap recruits factors essential for transcript processing and translation initiation. We report that regulated mRNA cap methylation is a feature of embryonic stem cell (ESC) differentiation. Expression of the mRNA cap methyltransferase activa
Externí odkaz:
https://doaj.org/article/7c9280d710e449b4a47eba3aaf8090c7
Autor:
Kirsten Riches-Suman, Mahmoud Loubani, Israel Olapeju Bolanle, Timothy M. Palmer, Ritchie Williamson
Publikováno v:
Nutrition, Metabolism and Cardiovascular Diseases. 31:1349-1356
Aim Coronary artery bypass graft (CABG) using autologous saphenous vein continues to be a gold standard procedure to restore the supply of oxygen-rich blood to the heart muscles in coronary artery disease (CAD) patients with or without type 2 diabete
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a817fd312f1143d42faae71393f79055
https://doi.org/10.1016/j.numecd.2021.01.017
https://doi.org/10.1016/j.numecd.2021.01.017
Publikováno v:
Cancer Research. 83:348-348
Background: SUMOylation is a post-translational modification where small ubiquitin-like modifier (SUMO) proteins are conjugated to lysine residues of target proteins. SUMO proteins exist in all eukaryotes and participate in a catalytic cycle, which i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ba14db4c24fdcbb88dfb4b1142b23477
https://doi.org/10.1158/1538-7445.am2023-348
https://doi.org/10.1158/1538-7445.am2023-348
Publikováno v:
Neurochemical Research
Hicks, D, Cross, L, Williamson, R & Rattray, M 2019, ' Endoplasmic Reticulum Stress Signalling Induces Casein Kinase 1-Dependent Formation of Cytosolic TDP-43 Inclusions in Motor Neuron-Like Cells. ', Neurochemical research . https://doi.org/10.1007/s11064-019-02832-2
Hicks, D, Cross, L, Williamson, R & Rattray, M 2019, ' Endoplasmic Reticulum Stress Signalling Induces Casein Kinase 1-Dependent Formation of Cytosolic TDP-43 Inclusions in Motor Neuron-Like Cells. ', Neurochemical research . https://doi.org/10.1007/s11064-019-02832-2
Motor neuron disease (MND) is a progressive neurodegenerative disease with no effective treatment. One of the principal pathological hallmarks is the deposition of TAR DNA binding protein 43 (TDP-43) in cytoplasmic inclusions. TDP-43 aggregation occu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85ec3e4011d416b0c3ca529912f31675
https://doi.org/10.1007/s11064-019-02832-2
https://doi.org/10.1007/s11064-019-02832-2
Publikováno v:
Pharmacological research. 165
Cardiovascular diseases (CVDs) are the leading cause of death globally. While the major focus of pharmacological and non-pharmacological interventions has been on targeting disease pathophysiology and limiting predisposing factors, our understanding
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a526d5fd45a4dc6ac1513a74d25f5ff1
https://pubmed.ncbi.nlm.nih.gov/33515704
https://pubmed.ncbi.nlm.nih.gov/33515704
Autor:
Andrew D. Randall, Julia M. Vlachaki Walker, Craig Beall, Josephine L. Robb, John K. Chilton, Paul G. Weightman Potter, Kate L. J. Ellacott, Ritchie Williamson
Publikováno v:
Diabetologia
Aims/hypothesis Hypoglycaemia is a major barrier to good glucose control in type 1 diabetes. Frequent hypoglycaemic episodes impair awareness of subsequent hypoglycaemic bouts. Neural changes underpinning awareness of hypoglycaemia are poorly defined
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de9f515f41de860cc60f7c877fd70409
http://europepmc.org/articles/PMC6290858
http://europepmc.org/articles/PMC6290858
Autor:
Daniel Mariappa, Andrew T. Ferenbach, Daan M. F. van Aalten, Tonia Aristotelous, Matthias Trost, Nithya Selvan, Ritchie Williamson, David G. Campbell, Robert Gourlay, Iva Hopkins-Navratilova
Publikováno v:
Nat Chem Biol
Protein O-GlcNAcylation is a reversible post-translational modification of serines and threonines on nucleocytoplasmic proteins. It is cycled by the enzymes O-GlcNAc transferase (OGT) and O-GlcNAc hydrolase (O-GlcNAcase or OGA). Genetic approaches in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5a8ac9501ca7a6a6f7f659903e6ce82
https://doi.org/10.1038/nchembio.2404
https://doi.org/10.1038/nchembio.2404
Autor:
Andrew D. Randall, Julia M. Vlachaki Walker, Craig Beall, Josephine L. Robb, John K. Chilton, Kate L. J. Ellacott, Ritchie Williamson, Paul G. Weightman Potter
Hypoglycemia is a major barrier to good glucose control in type 1 diabetes and frequent exposure to hypoglycemia can impair awareness to subsequent bouts of hypoglycemia. The neural changes that occur to reduce a person’s awareness of hypoglycemia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dab5304576310022982944c6a16b8a48
https://doi.org/10.1101/271981
https://doi.org/10.1101/271981
Publikováno v:
Biochemical Pharmacology. 84:737-745
Life expectancy is rising however with more people living longer there is a concomitant rise in the incidence of dementia. In addition to age-related cognitive decline there is a higher risk of going on to develop vascular dementia and Alzheimer's di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9df7055cf47b7fa8353c2623e7d10dd
https://doi.org/10.1016/j.bcp.2012.05.007
https://doi.org/10.1016/j.bcp.2012.05.007