Effect of Ritanserin and Duloxetine on the Gene Expression of Primary Aniridia and Healthy Human Limbal Stromal Cells, In Vitro

Autor: Zhen Li, Nóra Szentmáry, Fabian N. Fries, Shweta Suiwal, Ning Chai, Berthold Seitz, Lei Shi, Maryam Amini, Tanja Stachon

Publikováno v: Ophthalmology and Therapy, Vol 13, Iss 11, Pp 2931-2950 (2024)

Abstract Introduction In congenital aniridia caused by mutations in paired box 6 (PAX6), PAX6 influences the migration and differentiation of limbal epithelial cells (LECs), thereby playing a pivotal role in aniridia-associated keratopathy. The antid

Externí odkaz: https://doaj.org/article/64256a9171dd45b691c6e6300fb75b93

Ritanserin suppresses acute myeloid leukemia by inhibiting DGKα to downregulate phospholipase D and the Jak-Stat/MAPK pathway

Autor: Jinshui Tan, Mengya Zhong, Yanyan Hu, Guangchao Pan, Jingwei Yao, Yuanfang Tang, Hongpeng Duan, Yuelong Jiang, Weihang Shan, Jiaqi Lin, Yating Liu, Jiewen Huang, Huijian Zheng, Yong Zhou, Guo Fu, Zhifeng Li, Bing Xu, Jie Zha

Publikováno v: Discover Oncology, Vol 14, Iss 1, Pp 1-15 (2023)

Abstract Refractory or relapsed (R/R) AML is the most challenging form of AML to treat. Due to frequent genetic mutations, therapy alternatives are limited. Here, we identified the role of ritanserin and its target DGKα in AML. Several AML cell line

Externí odkaz: https://doaj.org/article/ed795b3fcb3644ed9cb15069fa02179c

Ritanserin blocks Ca V 1.2 channels in rat artery smooth muscles: electrophysiological, functional, and computational studies.

Autor: Fusi F; Dipartimento di Biotecnologie, Chimica e Farmacia, Università degli Studi di Siena, via A. Moro 2, 53100, Siena, Italy., Trezza A; Dipartimento di Biotecnologie, Chimica e Farmacia, Università degli Studi di Siena, via A. Moro 2, 53100, Siena, Italy., Sgaragli G; Dipartimento di Scienze della Vita, Università degli Studi di Siena, via A. Moro 2, 53100, Siena, Italy., Spiga O; Dipartimento di Biotecnologie, Chimica e Farmacia, Università degli Studi di Siena, via A. Moro 2, 53100, Siena, Italy., Saponara S; Dipartimento di Scienze della Vita, Università degli Studi di Siena, via A. Moro 2, 53100, Siena, Italy. simona.saponara@unisi.it., Bova S; Dipartimento di Scienze del Farmaco, Università degli Studi di Padova, via Marzolo 5, 35131, Padova, Italy.

Publikováno v: Acta pharmacologica Sinica [Acta Pharmacol Sin] 2020 Sep; Vol. 41 (9), pp. 1158-1166. Date of Electronic Publication: 2020 Mar 04.

Ritanserin, a potent serotonin 2A receptor antagonist, represses MEK/ERK signalling pathway to restore PAX6 production and function in aniridia-like cellular model.

Autor: Oved K; Blavatnik Center for Drug Discovery, Tel Aviv University, Tel Aviv, 6997801, Israel., Zennaro L; INSERM UMRS 1138, Team 17, From physiopathology of ocular diseases to clinical development, Centre de Recherche des Cordeliers, Paris, France; Université de Paris, France., Dorot O; Blavatnik Center for Drug Discovery, Tel Aviv University, Tel Aviv, 6997801, Israel., Zerbib J; Université de Paris, France; INSERM U976, Hôpital St-Louis, Paris, France., Frank E; Université de Paris, France; INSERM U976, Hôpital St-Louis, Paris, France., Roux LN; Université de Paris, France; INSERM U976, Hôpital St-Louis, Paris, France., Bremond-Gignac D; INSERM UMRS 1138, Team 17, From physiopathology of ocular diseases to clinical development, Centre de Recherche des Cordeliers, Paris, France; INSERM U976, Hôpital St-Louis, Paris, France; Ophthalmology Department, University Hospital Necker-Enfants malades, AP-HP, Paris, France., Pichinuk E; Blavatnik Center for Drug Discovery, Tel Aviv University, Tel Aviv, 6997801, Israel. Electronic address: eddypichinuk@gmail.com., Aberdam D; INSERM UMRS 1138, Team 17, From physiopathology of ocular diseases to clinical development, Centre de Recherche des Cordeliers, Paris, France; Université de Paris, France; INSERM U976, Hôpital St-Louis, Paris, France. Electronic address: daniel.aberdam@inserm.fr.

Publikováno v: Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2021 Dec 10; Vol. 582, pp. 100-104. Date of Electronic Publication: 2021 Oct 16.

The role of α1- and α2-adrenoceptor subtypes in the vasopressor responses induced by dihydroergotamine in ritanserin-pretreated pithed rats

Autor: Eduardo Rivera-Mancilla, Victor H. Avilés-Rosas, Guadalupe Manrique-Maldonado, Alain H. Altamirano-Espinoza, Belinda Villanueva-Castillo, Antoinette MaassenVanDenBrink, Carlos M. Villalón

Publikováno v: The Journal of Headache and Pain, Vol 18, Iss 1, Pp 1-12 (2017)

Abstract Background Dihydroergotamine (DHE) is an acute antimigraine agent that displays affinity for dopamine D2-like receptors, serotonin 5-HT1/2 receptors and α1/α2-adrenoceptors. Since activation of vascular α1/α2-adrenoceptors results in sys

Externí odkaz: https://doaj.org/article/4d842091c6ed4def9ddb5e122c8662c1