Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Rita Wechter"'
Autor:
Françoise Haeseleer, Rita Wechter, Ning Li, Mark J. Pettenati, Nagesh Rao, Wolfgang Baehr, Izabela Sokal, Darin Bronson, Krzysztof Palczewski
Publikováno v:
Journal of Biological Chemistry. 274:6526-6535
The mammalian retina contains at least two guanylyl cyclases (GC1 and GC2) and two guanylyl cyclase-activating proteins (GCAP1 and GCAP2). Here we present evidence of the presence of a new photoreceptor-specific GCAP, termed GCAP3, which is closely r
Publikováno v:
International Journal of Cancer. 76:563-570
Our experiments were designed to test the cooperativity between the polyamine pathway and HER-2neu in inducing transformation of human mammary epithelial cells in culture. Using the MCF-10A breast epithelial cell line, we observed that induction of o
Autor:
Andrea Manni, Susan K. Gilmour, Rita Wechter, Laurence M. Demers, David T. Mauger, Michael F. Verderame
Publikováno v:
International Journal of Cancer. 70:175-182
In these experiments we tested the hypothesis that constitutive activation of polyamine(PA) biosynthesis may contribute to mammary carcinogenesis. Spontaneously immortalized normal human MCF-10A breast epithelial cells were infected with the retrovir
Publikováno v:
Biochemical Journal. 290:115-121
We have previously reported that prolonged chronic exposure to the S-adenosyl-L-methionine decarboxylase (AdoMetDC) inhibitor, 5′-([(Z)-4-amino-2-butenyl]methylamino)-5′-deoxy-adenosine (MDL 73811, AbeAdo), leads to cytostasis of L1210 cells [Bye
Publikováno v:
Journal of Biological Chemistry. 266:6142-6151
Hypoosmotic stress is a potent inducer of ornithine decarboxylase (ODC) activity in a variety of mammalian cells, but the physiological relevance of this response has not been determined. To test whether an increased putrescine content confers a grow
Autor:
Anthony Rossini, Rita Wechter, Laurence M. Demers, Betty Badger, Andrea Manni, Susan J. Kunselman
Publikováno v:
International journal of cancer. 62(4)
CGP 48664 [4-aminoindanon-1-(2′-amidino)hydrazone dihydrochloride monohydrate] is a newly introduced inhibitor of S-adenosyltnethionine decarboxylase (SAMDC) with increased selectivity of action and reduced toxichy. We analyzed the biochemical and
Publikováno v:
Journal of cellular physiology. 163(1)
Polyamines (PA) have been shown to be critical mediators of estradiol-induced breast cancer cell proliferation. This finding suggests that constitutive activation of the PA pathway may promote tumor progression, possibly leading to hormone independen
Publikováno v:
Breast cancer research and treatment. 34(1)
To determine the direct influence of the polyamine (PA) pathway on breast cancer phenotype, we employed a transfection approach to induce overexpression of the PA biosynthetic enzyme ornithine decarboxylase (ODC) in the hormone-responsive MCF-7 breas
Publikováno v:
The Biochemical journal. 303
The regulation of polyamine transport and the roles of polyamine transport and synthesis in cell growth were investigated using cultured Chinese hamster ovary (CHO) cells and CHOMG cells which are mutants lacking polyamine-transport activity. Metabol
Publikováno v:
Biochemistry. 25:379-384
Decarboxylated S-adenosylmethionine was found to be a substrate for the nuclear acetyltransferases that act on polyamines and on histones. The rate of acetylation of decarboxylated S-adenosylmethionine was more than twice that of spermidine at satura