Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Rita Tommasi"'
Autor:
Katherine Griffiths, Uli Binder, William McDowell, Rita Tommasi, Mark Frigerio, William G. Darby, Chris G. Hosking, Lionel Renaud, Matthias Machacek, Peter Lloyd, Arne Skerra, Michael Foley
Publikováno v:
mAbs, Vol 11, Iss 7, Pp 1331-1340 (2019)
Single domain antibodies that combine antigen specificity with high tissue penetration are an attractive alternative to conventional antibodies. However, rapid clearance from the bloodstream owing to their small size can be a limitation of therapeuti
Externí odkaz:
https://doaj.org/article/7654a6ff13a34f68ab979ca90ac88158
Autor:
Michael Foley, Rita Tommasi, Katherine Merne Griffiths, Mark Frigerio, Matthias Machacek, Lionel Renaud, Arne Skerra, Uli Binder, William G. Darby, William McDowell, Christopher G. Hosking, Peter Lloyd
Publikováno v:
mAbs
Single domain antibodies that combine antigen specificity with high tissue penetration are an attractive alternative to conventional antibodies. However, rapid clearance from the bloodstream owing to their small size can be a limitation of therapeuti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f974fbe950bbe3e9022c25191b4ea958
http://europepmc.org/articles/PMC6748587
http://europepmc.org/articles/PMC6748587
Publikováno v:
Chemical Science. 10:427-439
Site-selective conjugation generally requires both (i) molecular engineering of the protein of interest to introduce a conjugation site at a defined location and (ii) a site-specific conjugation technology. Three N-terminal interferon α2-a (IFN) var
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e60a7ce4fb403fa280d0ed7157e5591f
https://doi.org/10.1039/c8sc03355b
https://doi.org/10.1039/c8sc03355b
Autor:
William McDowell, Julia Swierkosz, George Badescu, Andrew F. Kyle, Mark Frigerio, Amrita Abhilash, Ji-Won Choi, Estera Jamieson, Matthew P. Baker, XiaoBo Sheng, Matthew Bird, Penny Bryant, Ruslan Grygorash, Katarzyna Kozakowska, Korinna Henseleit, Rita Tommasi, Vimal Parekh, Kosma Jurlewicz, Karolina Peciak, Emmanuelle Laurine, Martin Pabst, Nicolas Camper, Antony Godwin, Anaïs Manin, Jeff Edwards, David Morris
Publikováno v:
Molecular Pharmaceutics. 12:1872-1879
The conjugation of monomethyl auristatin E (MMAE) to trastuzumab using a reduction bis-alkylation approach that is capable of rebridging reduced (native) antibody interchain disulfide bonds has been previously shown to produce a homogeneous and stabl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bdafeb6a27047bdb000238cba2a009a
https://doi.org/10.1021/acs.molpharmaceut.5b00116
https://doi.org/10.1021/acs.molpharmaceut.5b00116
Publikováno v:
Protein Expression and Purification. 99:18-26
Protein production can be improved if methods for soluble protein expression are developed. Interferon consensus (IFN-con) is used to treat hepatitis C. IFN-con has superior activity compared to other clinically used interferon α subtypes. However I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1df9e8a725fe1624d2b1b147a08a785
https://doi.org/10.1016/j.pep.2014.03.009
https://doi.org/10.1016/j.pep.2014.03.009
Autor:
Korinna Henseleit, Mark Frigerio, Antony Godwin, Jeff Edwards, XiaoBo Sheng, Matthew Bird, Martin Fisher, Kosma Jurlewicz, George Badescu, Amrita Abhilash, Penny Bryant, Estera Pawlisz, Ruslan Grygorash, Julia Swierkosz, Andrew F. Kyle, Monika Farys, Nicolas Camper, Vimal Parekh, Rita Tommasi
Publikováno v:
Bioconjugate Chemistry. 25:1124-1136
To improve both the homogeneity and the stability of ADCs, we have developed site-specific drug-conjugating reagents that covalently rebridge reduced disulfide bonds. The new reagents comprise a drug, a linker, and a bis-reactive conjugating moiety t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d2e41ca810ded9c08bfb53bf05fccd1
https://doi.org/10.1021/bc500148x
https://doi.org/10.1021/bc500148x
Autor:
Renos Savva, Chrisostomos Prodromou, Rita Tommasi, Emmanuelle Laurine, Laurence H. Pearl, Paul C. Driscoll, Kate Maclagan, Stefanie Reich
Publikováno v:
Future Medicinal Chemistry. 3:271-282
Background: Successful structural investigations of protein–protein interactions can be facilitated by studying only the core interacting regions of the constituent proteins. However, attempting the discovery of stable core complexes using informed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d731e1e82f0551bd679f37279d6e07f
https://doi.org/10.4155/fmc.10.289
https://doi.org/10.4155/fmc.10.289
Autor:
Stefano Cesco, Nicola Tomasi, Luisa Dalla Costa, Rita Tommasi, Elisa Savoia, Roberto Terzano, Stefano Gottardi, Francesco Iacuzzo, Giovanni Cortella, Roberto Pinton
Publikováno v:
Journal of the Science of Food and Agriculture. 91:344-354
BACKGROUND: Unbalanced nutrient availability causes disequilibrated plant growth, which can result in a worsening of harvested product quality, such as high nitrate content in edible tissues. To cope with this problem, improved knowledge of the mecha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::58f72680c743f2c3e8f4baf41e563b34
https://doi.org/10.1002/jsfa.4192
https://doi.org/10.1002/jsfa.4192
Autor:
Teresa Odorisio, Rita Tommasi, Giovanna Zambruno, M. Papi, Francesca Cianfarani, G. Annessi, M. T. Viviano, Cristina Maria Failla
Publikováno v:
British Journal of Dermatology. 154:34-41
Summary Background Granulocyte/macrophage colony-stimulating factor (GM-CSF), a cytokine with pleiotropic functions, has been successfully employed in the treatment of chronic skin ulcers. The biological effects underlying GM-CSF action in impaired w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7ebec6fee1c9b3464f0a28f32af3ae4c
https://doi.org/10.1111/j.1365-2133.2005.06925.x
https://doi.org/10.1111/j.1365-2133.2005.06925.x
Autor:
Antony Godwin, Emmanuelle Laurine, Yuehua Cong, Penny Bryant, Matthew Bird, Julia Swierkosz, Ji-Won Choi, Karolina Peciak, Sitara Dubey, Jeff Edwards, Mire Zloh, Ian Hodgson, Rita Tommasi, Sibylle Heidelberger, Farzad Khayrzad, Ruchi Singh, Amrita Sivasankar, Charles Heise, Estera Pawlisz, George Badescu, John Liddell, Sibu Balan, Keith Powell, Monika Farys, Maurizio Muroni, Satyanarayana Somavarapu, Steve Brocchini
Publikováno v:
Bioconjugate chemistry. 23(2)
The efficacy of protein-based medicines can be compromised by their rapid clearance from the blood circulatory system. Achieving optimal pharmacokinetics is a key requirement for the successful development of safe protein-based medicines. Protein PEG
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c695e99fa036e035a072d2a6876250f8
https://pubmed.ncbi.nlm.nih.gov/22243664
https://pubmed.ncbi.nlm.nih.gov/22243664