Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Rita Striberni"'
Publikováno v:
European Journal of Drug Metabolism and Pharmacokinetics, Vol. 17, No 2 (1992) pp. 115-20
The O-demethylation of codeine (methylmorphine) into morphine is mediated by the polymorphic cytochrome P450 DB1 (P450 IID6). By means of in vitro screening in human liver microsomes we have studied the effect on codeine bioactivation of several drug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e721e9c9b2d28d6dd2accfde922c4b54
https://pubmed.ncbi.nlm.nih.gov/1425809
https://pubmed.ncbi.nlm.nih.gov/1425809
Publikováno v:
Clinical Pharmacology and Therapeutics. 45:34-40
Liver dextromethorphan O-demethylation to dextrorphan is associated with the debrisoquin type of oxidation phenotype in humans. We studied dextromethorphan oxidation in vitro using human liver microsomes to investigate the kinetics of the polymorphic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1999465d5a69f9569b021b1cf598e0a1
https://doi.org/10.1038/clpt.1989.6
https://doi.org/10.1038/clpt.1989.6
Publikováno v:
Biochemical and Biophysical Research Communications, Vol. 152, No 1 (1988) pp. 411-6
Codeine O-demethylation to its active moiety morphine was investigated in human liver microsomes from 1 poor and 5 extensive metabolizer subjects (debrisoquine-type of oxidation polymorphism). Apparent Km of the reaction in one extensive metabolizer'
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::568f5861538f6b01dfe33bdda1781733
https://archive-ouverte.unige.ch/unige:92728
https://archive-ouverte.unige.ch/unige:92728
