Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Rita Schröter"'
Autor:
Martin Steinbüchel, Johannes Menne, Rita Schröter, Ute Neugebauer, Eberhard Schlatter, Giuliano Ciarimboli
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 18, p 14051 (2023)
Endogenous positively charged organic substances, including neurotransmitters and cationic uremic toxins, as well as exogenous organic cations such as the anti-diabetic medication metformin, serve as substrates for organic cation transporters (OCTs)
Externí odkaz:
https://doaj.org/article/facb88ec70244bd8895ae80d02b0d295
Autor:
Anna Hucke, Rita Schröter, Cecilia Ceresa, Alessia Chiorazzi, Annalisa Canta, Sara Semperboni, Paola Marmiroli, Guido Cavaletti, Burkhard Gess, Giuliano Ciarimboli
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 14, p 11486 (2023)
Cisplatin (CDDP) is an efficient chemotherapeutic agent broadly used to treat solid cancers. Chemotherapy with CDDP can cause significant unwanted side effects such as renal toxicity and peripheral neurotoxicity. CDDP is a substrate of organic cation
Externí odkaz:
https://doaj.org/article/a6fe39dfd8d34ed4bfe87cbbee541130
Autor:
Simona Mareike Lüttgenau, Christin Emming, Thomas Wagner, Julia Harms, Justine Guske, Katrin Weber, Ute Neugebauer, Rita Schröter, Olga Panichkina, Zoltán Pethő, Florian Weber, Albrecht Schwab, Anja Kathrin Wege, Pavel Nedvetsky, Michael P. Krahn
Publikováno v:
Molecular Cancer, Vol 20, Iss 1, Pp 1-7 (2021)
Abstract Loss of apical-basal polarity and downregulation of cell-cell contacts is a critical step during the pathogenesis of cancer. Both processes are regulated by the scaffolding protein Pals1, however, it is unclear whether the expression of Pals
Externí odkaz:
https://doaj.org/article/2474a5be80114ad884671a3f42dd5a01
Autor:
Marie-Kristin Kroll, Sebastian Schloer, Peynaz Candan, Nadia Korthals, Christoph Wenzel, Hannah Ihle, Kevin Gilhaus, Kim Rouven Liedtke, Michael Schöfbänker, Beate Surmann, Rita Schröter, Ute Neugebauer, Gita Mall, Stefan Oswald, Stephan Ludwig, Ursula Rescher, Beate Vollenbröker, Giuliano Ciarimboli
Publikováno v:
Biomolecules, Vol 13, Iss 3, p 472 (2023)
In late 2019, the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) as the causative agent of coronavirus disease 2019 (COVID-19) emerged in China and spread rapidly around the world, causing an ongoing pandemic of global concern. CO
Externí odkaz:
https://doaj.org/article/e71fdfe8fe194d379460a457b03f96f0
Autor:
Saliha Harrach, Jasmin Haag, Martin Steinbüchel, Rita Schröter, Ute Neugebauer, Jessica Bertrand, Giuliano Ciarimboli
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 22, p 14189 (2022)
Tyrosine kinase inhibitors (TKI) such as Masitinib were reported to be useful as therapeutic options in malignant disorders and nonmalignant diseases, like coronavirus disease 2019 (COVID-19). Most kinases must be translocated into targeted cells by
Externí odkaz:
https://doaj.org/article/e3347118d39340f48ce8445fc9933cb7
Autor:
Sandra Schorn, Ann-Kristin Dicke, Ute Neugebauer, Rita Schröter, Maren Friedrich, Stefan Reuter, Giuliano Ciarimboli
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Organic cation transporters (OCT) play an important role in mediating cellular uptake of several pharmaceuticals, such as the antidiabetic drug metformin and the platinum-derived chemotherapeutics. Since these drugs can also affect the pancreas, here
Externí odkaz:
https://doaj.org/article/5f8c9424a5cc4e6c88f66b5a6533bfa1
Autor:
Tim N. Koepp, Alexander Tokaj, Pavel I. Nedvetsky, Ana Carolina Conchon Costa, Beatrice Snieder, Rita Schröter, Giuliano Ciarimboli
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 17, p 9658 (2021)
The renal secretory clearance for organic cations (neurotransmitters, metabolism products and drugs) is mediated by transporters specifically expressed in the basolateral and apical plasma membrane domains of proximal tubule cells. Here, human organi
Externí odkaz:
https://doaj.org/article/8bf560cb34be459ab31fda24e4581acc
Autor:
Stefan Oswald, Janett Müller, Ute Neugebauer, Rita Schröter, Edwin Herrmann, Hermann Pavenstädt, Giuliano Ciarimboli
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 21, p 5303 (2019)
Renal drug transporters such as the organic cation transporters (OCTs), organic anion transporters (OATs) and multidrug resistance proteins (MRPs) play an important role in the tubular secretion of many drugs influencing their efficacy and safety. Ho
Externí odkaz:
https://doaj.org/article/f6beec496d31468080d63d5ef005b7d1
Autor:
Dominik Frenzel, Christina Köppen, Oliver Bolle Bauer, Uwe Karst, Rita Schröter, Mladen V. Tzvetkov, Giuliano Ciarimboli
Publikováno v:
Biomolecules, Vol 9, Iss 10, p 578 (2019)
The human organic cation transporter 2 (hOCT2) is highly expressed in proximal tubules of the kidneys, where it plays an important role in the secretion of organic cations. Since many drugs are organic cations, hOCT2 has relevant pharmacological impl
Externí odkaz:
https://doaj.org/article/9b0ec03de8d54c9e91e6e8224a8df51b
Autor:
Anna Hucke, Ga Young Park, Oliver B. Bauer, Georg Beyer, Christina Köppen, Dorothea Zeeh, Christoph A. Wehe, Michael Sperling, Rita Schröter, Marta Kantauskaitè, Yohannes Hagos, Uwe Karst, Stephen J. Lippard, Giuliano Ciarimboli
Publikováno v:
Frontiers in Chemistry, Vol 6 (2018)
Cancer treatment with platinum compounds is an important achievement of modern chemotherapy. However, despite the beneficial effects, the clinical impact of these agents is hampered by the development of drug resistance as well as dose-limiting side
Externí odkaz:
https://doaj.org/article/a08b11d276134b76b82f7a8c9f729f2d