Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Rita S. Cha"'
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-11 (2021)
Waskiewicz et al. identify functionally important and evolutionarily conserved residues of ATM/ATR via data mining and a functional genetic analysis, finding that loss of the intrinsic kinase activity occurs infrequently in carcinogenesis. This study
Externí odkaz:
https://doaj.org/article/a3ab37abd19345cbb306b4a4b5e50121
Publikováno v:
Microbial Cell, Vol 6, Iss 6, Pp 286-294 (2019)
Ribonucleotide reductase (RNR) is an essential holoenzyme required for de novo synthesis of dNTPs. The Saccharomyces cerevisiae genome encodes for two catalytic subunits, Rnr1 and Rnr3. While Rnr1 is required for DNA replication and DNA damage repair
Externí odkaz:
https://doaj.org/article/ae93b009a3c14805bceb4ce2e6c9a37f
Publikováno v:
Biology Open, Vol 4, Iss 12, Pp 1739-1743 (2015)
Inactivation of Mec1, the budding yeast ATR, results in a permanent S phase arrest followed by chromosome breakage and cell death during G2/M. The S phase arrest is proposed to stem from a defect in Mec1-mediated degradation of Sml1, a conserved inhi
Externí odkaz:
https://doaj.org/article/8d91a02359ab4df6b3e3f909010b498c
Publikováno v:
Microbial Cell, Vol 6, Iss 6, Pp 286-294 (2019)
Microbial Cell
Microbial Cell (Graz, Austria)
Microbial Cell (Graz, Austria), 2019, 6 (6), pp.286--294. ⟨10.15698/mic2019.06.680⟩
Microbial Cell
Microbial Cell (Graz, Austria)
Microbial Cell (Graz, Austria), 2019, 6 (6), pp.286--294. ⟨10.15698/mic2019.06.680⟩
International audience; Ribonucleotide reductase (RNR) is an essential holoenzyme required for de novo synthesis of dNTPs. The Saccharomyces cerevisiae genome encodes for two catalytic subunits, Rnr1 and Rnr3. While Rnr1 is required for DNA replicati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fddf6849d688a4f83bf5a49ac57fdda
http://microbialcell.com/researcharticles/2019a-corcoles-saez-microbial-cell/
http://microbialcell.com/researcharticles/2019a-corcoles-saez-microbial-cell/
Publikováno v:
Current Genetics. 65:657-661
The ataxia-telangiectasia mutated/ATM and Rad3-related (ATM/ATR) family proteins are evolutionarily conserved serine/threonine kinases best known for their roles in mediating the DNA damage response. Upon activation, ATM/ATR phosphorylate numerous ta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c7de3e3c55f2ac3207a6a096616c8817
https://doi.org/10.1007/s00294-018-0920-y
https://doi.org/10.1007/s00294-018-0920-y
Publikováno v:
Current Genetics
The ataxia-telangiectasia mutated/ATM and Rad3-related (ATM/ATR) family proteins are evolutionarily conserved serine/threonine kinases best known for their roles in mediating the DNA damage response. Upon activation, ATM/ATR phosphorylate numerous ta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::28214c898f545624d5f4acc71ad8658d
https://pubmed.ncbi.nlm.nih.gov/30610294
https://pubmed.ncbi.nlm.nih.gov/30610294
Autor:
Charles Boone, Anastasia Baryshnikova, Chad L. Myers, Michael Costanzo, Rita S. Cha, Benjamin VanderSluis, Brenda J. Andrews
Publikováno v:
G3: Genes|Genomes|Genetics
Synthetic genetic array (SGA) analysis automates yeast genetics, enabling high-throughput construction of ordered arrays of double mutants. Quantitative colony sizes derived from SGA analysis can be used to measure cellular fitness and score for gene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24f67e78e0f377ac26ff78ffa6080fa1
https://doi.org/10.1534/g3.113.007377
https://doi.org/10.1534/g3.113.007377
Autor:
Ana Penedos, Anthony L. Johnson, Emily Strong, Alastair S. Goldman, Jesús A. Carballo, Rita S. Cha
Publikováno v:
PLoS ONE, Vol 11, Iss 4, p e0154170 (2016)
PLoS ONE
PLoS ONE
A hallmark of the conserved ATM/ATR signalling is its ability to mediate a wide range of functions utilizing only a limited number of adaptors and effector kinases. During meiosis, Tel1 and Mec1, the budding yeast ATM and ATR, respectively, rely on a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::545518afdd9761e7a6eaf2e537b216a3
http://europepmc.org/articles/PMC4835094?pdf=render
http://europepmc.org/articles/PMC4835094?pdf=render
Publikováno v:
Journal of Cell Science. 124:181-185
Fragile sites are specific loci within the genome that exhibit increased tendencies for chromosome breakage. They are conserved among mammals and are also found in lower eukaryotes including yeast and fly. Many conditions, including mutations and exo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86e625d803a1e0323dafeb4c4c8ab28a
https://doi.org/10.1242/jcs.077313
https://doi.org/10.1242/jcs.077313
Autor:
Erik Waskiewicz, Michael Costanzo, Charles Boone, Isaac Corcoles-Saez, Rita S. Cha, Anthony L. Johnson, Kangzhen Dong
Publikováno v:
Developmental Cell. 46:495-503.e2
Unlike most checkpoint proteins, Mec1, an ATM/ATR kinase, is essential. We utilized mec1-4, a missense allele (E2130K) that confers diminished kinase activity, to interrogate the question. Unbiased screen for genetic interactors of mec1-4 identified
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb5d6c64e328db1741aac863bea89ef0
https://doi.org/10.1016/j.devcel.2018.07.011
https://doi.org/10.1016/j.devcel.2018.07.011