Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Rita O'Rourke"'
Autor:
Harriet M. Jackson, Kate E. Foley, Rita O’Rourke, Timothy M. Stearns, Dina Fathalla, B. Paul Morgan, Gareth R. Howell
Publikováno v:
BMC Genetics, Vol 21, Iss 1, Pp 1-16 (2020)
Abstract Background The complement cascade is increasingly implicated in development of a variety of diseases with strong immune contributions such as Alzheimer’s disease and Systemic Lupus Erythematosus. Mouse models have been used to determine fu
Externí odkaz:
https://doaj.org/article/614e55b302c34685b237b64274f950f7
Autor:
Kevin P. Kotredes, Adrian Oblak, Ravi S. Pandey, Peter Bor-Chian Lin, Dylan Garceau, Harriet Williams, Asli Uyar, Rita O'Rourke, Sarah O'Rourke, Cynthia Ingraham, Daria Bednarczyk, Melisa Belanger, Zackary Cope, Kate E. Foley, Benjamin A. Logsdon, Lara M. Mangravite, Stacey J. Sukoff Rizzo, Paul R. Territo, Gregory W. Carter, Michael Sasner, Bruce T. Lamb, Gareth R. Howell
Publikováno v:
Frontiers in Aging Neuroscience, Vol 14 (2022)
Externí odkaz:
https://doaj.org/article/e82314194efb4e0cb333030d27dfb73d
Autor:
Kevin P. Kotredes, Adrian Oblak, Ravi S. Pandey, Peter Bor-Chian Lin, Dylan Garceau, Harriet Williams, Asli Uyar, Rita O’Rourke, Sarah O’Rourke, Cynthia Ingraham, Daria Bednarczyk, Melisa Belanger, Zackary Cope, Kate E. Foley, Benjamin A. Logsdon, Lara M. Mangravite, Stacey J. Sukoff Rizzo, Paul R. Territo, Gregory W. Carter, Michael Sasner, Bruce T. Lamb, Gareth R. Howell
Publikováno v:
Frontiers in Aging Neuroscience, Vol 13 (2021)
Late-onset Alzheimer’s disease (AD; LOAD) is the most common human neurodegenerative disease, however, the availability and efficacy of disease-modifying interventions is severely lacking. Despite exceptional efforts to understand disease progressi
Externí odkaz:
https://doaj.org/article/73c95daef488457a898befbeee08ddc2
Autor:
Adrian L. Oblak, Peter B. Lin, Kevin P. Kotredes, Ravi S. Pandey, Dylan Garceau, Harriet M. Williams, Asli Uyar, Rita O’Rourke, Sarah O’Rourke, Cynthia Ingraham, Daria Bednarczyk, Melisa Belanger, Zackary A. Cope, Gabriela J. Little, Sean-Paul G. Williams, Carl Ash, Adam Bleckert, Tim Ragan, Benjamin A. Logsdon, Lara M. Mangravite, Stacey J. Sukoff Rizzo, Paul R. Territo, Gregory W. Carter, Gareth R. Howell, Michael Sasner, Bruce T. Lamb
Publikováno v:
Frontiers in Aging Neuroscience, Vol 13 (2021)
The ability to investigate therapeutic interventions in animal models of neurodegenerative diseases depends on extensive characterization of the model(s) being used. There are numerous models that have been generated to study Alzheimer’s disease (A
Externí odkaz:
https://doaj.org/article/cf05bc2f1a3744e1a9a02450444608bd
Autor:
Kristen D Onos, Asli Uyar, Kelly J Keezer, Harriet M Jackson, Christoph Preuss, Casey J Acklin, Rita O'Rourke, Rebecca Buchanan, Travis L Cossette, Stacey J Sukoff Rizzo, Ileana Soto, Gregory W Carter, Gareth R Howell
Publikováno v:
PLoS Genetics, Vol 15, Iss 5, p e1008155 (2019)
Classical laboratory strains show limited genetic diversity and do not harness natural genetic variation. Mouse models relevant to Alzheimer's disease (AD) have largely been developed using these classical laboratory strains, such as C57BL/6J (B6), a
Externí odkaz:
https://doaj.org/article/0d81041fb4e046249530dd01712fb4ef
Autor:
Ravi S. Pandey, Rita O'Rourke, Dylan Garceau, Harriet M. Williams, Michael Sasner, Kate E. Foley, Gregory W. Carter, Sarah O'Rourke, Peter Bor-Chian Lin, Daria Bednarycek, Cynthia M. Ingraham, Paul R. Territo, Lara M. Mangravite, Melisa Belanger, Asli Uyar, Gareth R. Howell, Kevin P. Kotredes, Zackary A. Cope, Benjamin A. Logsdon, Bruce T. Lamb, Stacey J. Sukoff Rizzo, Adrian L. Oblak
Publikováno v:
Frontiers in Aging Neuroscience
Frontiers in Aging Neuroscience, Vol 13 (2021)
Frontiers in Aging Neuroscience, Vol 13 (2021)
Late-onset Alzheimer’s disease (AD; LOAD) is the most common human neurodegenerative disease, however, the availability and efficacy of disease-modifying interventions is severely lacking. Despite exceptional efforts to understand disease progressi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b108c84cc15101c441ddabd65b919a37
https://pubmed.ncbi.nlm.nih.gov/35197847
https://pubmed.ncbi.nlm.nih.gov/35197847
Autor:
Lara M. Mangravite, Harriet M. Williams, Adrian L. Oblak, Cynthia M. Ingraham, Paul R. Territo, Kate E. Foley, Bruce T. Lamb, Benjamin A. Logsdon, Dylan Garceau, Rita O'Rourke, Ravi S. Pandey, Stacey J. Sukoff Rizzo, Gregory W. Carter, Kevin P. Kotredes, Michael Sasner, Zackary A. Cope, Sarah O'Rourke, Melisa Belanger, Daria Bednarycek, Peter Bor-Chian Lin, Asli Uyar, Gareth R. Howell
Late-onset Alzheimer’s disease (LOAD) is the most common human neurodegenerative disease. Legacy amyloidogenic mouse models have been useful for understanding disease progression, however in the face of failing human trials more focus on disease tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::30cff630bbb5bdc098c7e8cc8680a3e6
https://doi.org/10.21203/rs.3.rs-580913/v1
https://doi.org/10.21203/rs.3.rs-580913/v1
Autor:
Asli Uyar, Gareth R. Howell, Michael Sasner, Gregory W. Carter, Benjamin A. Logsdon, Ravi S. Pandey, Cynthia M. Ingraham, Paul R. Territo, Peter Bor-Chian Lin, Lara M. Mangravite, Dylan Garceau, Stacey J. Sukoff Rizzo, Kate E. Foley, Harriet M. Williams, Kevin P. Kotredes, Sarah O'Rourke, Rita O'Rourke, Daria Bednarczyk, Zackary A. Cope, Adrian L. Oblak, Melisa Belanger, Bruce T. Lamb
Background: Late-onset Alzheimer’s Disease (AD) (LOAD) is the most common neurodegenerative disease. Despite extensive efforts to understand disease progression there are currently no approved disease modifying interventions to delay or reverse neu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b470468dbdc16b1eaae6d419ee02b704
https://doi.org/10.21203/rs.3.rs-135213/v1
https://doi.org/10.21203/rs.3.rs-135213/v1
Autor:
Nils Gastoukian, Kwangbom Choi, Gareth R. Howell, Jeffrey M. Harder, Gregory W. Carter, Amanda A. Hewes, Michael Sasner, Daniel A. Skelly, Rita O'Rourke, Kristen D. Onos, Kelly J. Keezer, Cory Diemler, Sarah O'Rourke, Hongtian Stanley Yang
Publikováno v:
Alzheimer's & Dementia. 16
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1a0d675f123e0ceeb00508eebfae1ccd
https://doi.org/10.1002/alz.044978
https://doi.org/10.1002/alz.044978
Autor:
Dina Fathalla, Harriet M. Jackson, Kate E. Foley, Tim Stearns, Gareth R. Howell, Rita O'Rourke, B. Paul Morgan
Publikováno v:
BMC Genetics, Vol 21, Iss 1, Pp 1-16 (2020)
BMC Genetics
BMC Genetics
Background The complement cascade is increasingly implicated in development of a variety of diseases with strong immune contributions such as Alzheimer’s disease and Systemic Lupus Erythematosus. Mouse models have been used to determine function of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d6c38cfc900895bf7eb5f57b6eca768
https://doi.org/10.1186/s12863-020-00893-9
https://doi.org/10.1186/s12863-020-00893-9